Entrepreneurship, innovation and the triple helix model: evidence from Oxfordshire and Cambridgeshire

This paper focuses on how regions become entrepreneurial and the extent to which the actors in the triple helix model are dominant at particular stages in development. It uses the case studies of Oxfordshire and Cambridgeshire in the UK to explore this theme. Both can now be described as ‘regional triple helix spaces’ (Etzkowitz 2008), and form two points of the Golden Triangle of Oxford, Cambridge and London universities. As entrepreneurial regions, however, they differ in a number of respects. This is not surprising given their differing geo-historical contexts. However, by comparing the two similar counties but which have their own distinctive features we are able to explore different dynamics which lead to the inception, implementation, consolidation and renewal (Etzkowitz and Klofsten 2005) of regions characterised by very high levels of technology-based entrepreneurship

Resilience in leaders: conceptualisation and changes brought about by coaching

Resilience has emerged as a topic of growing interest in the leadership coaching context but little empirical research exists merging the three areas of resilience, leadership and coaching. Two significant gaps were identified. Firstly, numerous resilience measures exist but the leadership experience of resilience remains relatively unexplored, meaning that it is unclear to what degree leadership resilience can be integrated and consolidated with existing resilience approaches. Secondly, the broad scope of definitions and conceptualisations of resilience can mean that coaches seeking to work with resilience lack a coherent model appropriate for coaching. These two gaps give rise to a lack of common understanding about resilience between coaches and their leadership clients. As a result we know little about the degree to which coaching may influence resilience. This grounded theory study gathers interview data from eight leaders to elucidate how leaders experience resilience and what role they felt previous coaching had on their resilience. Eight executive coaches were subsequently interviewed about their experiences of executive coaching where they felt resilience was relevant. Together these perspectives shed new light on the concept of resilience in the leadership coaching context. Existing definitions of resilience often emphasise recovery or ‗bounce back‘ yet leaders in this study saw resilience as vital to dealing with the future, as well as the past. This led to a temporal perspective on resilience identifying a common thread that exists across the past, present and future. In addition, a wider conceptualisation of resilience is proposed that includes both capabilities and the capacity for resilience. Capabilities encompass skills that are often the focus of resilience training, while capacity reflects the resources required to apply these resilience capabilities. Together these aspects bring a more coherent approach to resilience. Coaching was found to already be influencing resilience in leaders in five ways and a new model is proposed to support leadership coaching practice

Modeling Pine as a Carbon Sequestering Crop in Arkansas

Carbon Sequestration, Loblolly Pine, Carbon Offset, Carbon Policy, Environmental Economics and Policy, Land Economics/Use, Resource /Energy Economics and Policy,

Science, innovation and technology transfer pathways in translational research: a study of divergent trajectories in the healthcare sector in Europe

The geography of the biomedical sector, that of clustering in particular regions, presents an opportunity for place-specific understanding of processes involved in translational research in medical sciences, particularly with regard to the role of public policy and its outcomes in four bioscience regions in Europe

Regional environments and sector developments: the biotech sector in Oxfordshire

This paper explores the interdependence between national policy, the local characteristics of the UK’s biotechnology sectoral system of innovation and the growth of Oxfordshire’s biotech sector. It considers on the one hand the county’s research capacity and on the other its innovation performance. The latter is captured by a series of indicators from a recently completed study of the sector, recording the sector’s evolution both in the number of firms and their employment size, their status (independent, merged/acquired), product group and contribution to local employment and wealth creation. It considers the implications of the relative weaknesses in the system of innovation in this sector which relate to an underperformance of its firms in relation to the strength of the science base

Policies for new path development: the case of Oxfordshire

This chapter reflects on how evolutionary economic geography (EEG) can be extended to incorporate public policy in its explanations of path development. A weakness of EEG is the poor conceptualisation of the role of the state (central, regional, local) in regional path development. It is therefore argued that a multi-scalar perspective of policy is required and that a large set of policies deserve attention. Oxfordshire in the UK is used to explore the link between public policy and path development

Innovation capacity in the healthcare sector and historical anchors: examples from the UK, Switzerland and the US

Innovation is an integral part of economic development in developed economies. In the post 2008 period, a key policy agenda is that of sustainable development, which calls for innovation in all aspects of value-chains. In this paper, we focus on innovation from the biotech—pharma perspective to see whether or not this will lead to a sustainable future for the regions where there are clusters of firms in this sector. We examine data from a recently completed European Union study of innovation in the Healthcare sector from the UK and Switzerland, countries with an historical base in pharma, to understand how innovation pathways vary at the regional level in the broader life sciences, which incorporate biotech and more. Innovation in the healthcare sector in two regions, Oxfordshire in the UK and Zurich in Switzerland are compared. We contextualize our discussion by drawing on studies that focus on the sector in the US, specifically Boston. The analytical framework comprises three elements: innovation systems and national and regional economic development theories are the first two, followed by approaches which consider organizational or institutional activity. This framework is used to help explain and understand the complexity of how innovation is organized at the sub-national level. The overall context is that it is increasing becoming a condition for government financing of research that it has more immediate application in industry or have the possibility of commercialisation (e.g., translational research)

Regulation of CD1 Antigen-presenting Complex Stability

For major histocompatibility complex class I and II molecules, the binding of specific peptide antigens is essential for assembly and trafficking and is at the center of their quality control mechanism. However, the role of lipid antigen binding in stabilization and quality control of CD1 heavy chain (HC).beta(2)-microglobulin (beta(2)m) complexes is unclear. Furthermore, the distinct trafficking and loading routes of CD1 proteins take them from mildly acidic pH in early endososmal compartments (pH 6.0) to markedly acidic pH in lysosomes (pH 5.0) and back to neutral pH of the cell surface (pH 7.4). Here, we present evidence that the stability of each CD1 HC.beta(2)m complex is determined by the distinct pH optima identical to that of the intracellular compartments in which each CD1 isoform resides. Although stable at acidic endosomal pH, complexes are only stable at cell surface pH 7.4 when bound to specific lipid antigens. The proposed model outlines a quality control program that allows lipid exchange at low endosomal pH without dissociation of the CD1 HC.beta(2)m complex and then stabilizes the antigen-loaded complex at neutral pH at the cell surface

Dust heating sources in galaxies: the case of M33 (HERM33ES)

Dust emission is one of the main windows to the physics of galaxies and to star formation as the radiation from young, hot stars is absorbed by the dust and reemitted at longer wavelengths. The recently launched Herschel satellite now provides a view of dust emission in the far-infrared at an unequaled resolution and quality up to 500 \mu m. In the context of the Herschel HERM33ES open time key project, we are studying the moderately inclined Scd local group galaxy M33 which is located only 840 kpc away. In this article, using Spitzer and Herschel data ranging from 3.6 \mu m to 500 \mu m, along with HI, H\alpha\ maps, and GALEX ultraviolet data we have studied the emission of the dust at the high spatial resolution of 150 pc. Combining Spitzer and Herschel bands, we have provided new, inclination corrected, resolved estimators of the total infrared brightness and of the star formation rate from any combination of these bands. The study of the colors of the warm and cold dust populations shows that the temperature of the former is, at high brightness, dictated by young massive stars but, at lower brightness, heating is taken over by the evolved populations. Conversely, the temperature of the cold dust is tightly driven by the evolved stellar populations.Comment: 29 pages, 12 figures, accepted for publication in A

Proof of the Hyperplane Zeros Conjecture of Lagarias and Wang

We prove that a real analytic subset of a torus group that is contained in its image under an expanding endomorphism is a finite union of translates of closed subgroups. This confirms the hyperplane zeros conjecture of Lagarias and Wang for real analytic varieties. Our proof uses real analytic geometry, topological dynamics and Fourier analysis.Comment: 25 page