549 research outputs found

    Application of Publish/Subscribe Messaging for Management of Streaming Water Resource Data

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    2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

    Augmenting Hydrologic Information Systems with Streaming Water Resource Data

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    2010 S.C. Water Resources Conferences - Science and Policy Challenges for a Sustainable Futur

    Diagnostic, regenerative or fossil-free- exploring stakeholder perceptions of Swedish food system sustainability

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    In an analysis of food system sustainability challenges and solutions among Swedish food system actors using Q -methodology, five perspectives were identified. One of the main three perspectives placed the highest priority on reduced meat consumption, food waste, and climate impact in agriculture, but downplayed strategies highlighted in the national food strategy and social aspects, and can be interpreted as a diagnostic climate mitigation-oriented perspective that does not reflect current negotiated policy processes or 'softer' values of food. In an alternative regenerative perspective, industrialized large-scale farming and lack of internalization of external costs were regarded as the main problems, and diversity, soil health, and organic farming as the main solutions. Proponents of a third perspective regarded phasing out fossil fuels, increased profitability of companies, increased meat production, and self-sufficiency as high priorities. These contrasting views can be a major barrier to transforming the Swedish food system. However, a number of entry points for change (i.e. aspects highly important for some and neutral for others) were identified, including focusing on healthy diets and increased production of fruit and vegetables. Focusing on these can build trust among stakeholders before moving to discussions about the larger and more sensitive systemic changes needed

    Book Reviews

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    Greater Trochanteric Pain Syndrome

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135686/1/jum201635112413.pd

    Abstract Swiss cheese space and classicalisation of Swiss cheeses

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    Swiss cheese sets are compact subsets of the complex plane obtained by deleting a sequence of open disks from a closed disk. Such sets have provided numerous counterexamples in the theory of uniform algebras. In this paper, we introduce a topological space whose elements are what we call “abstract Swiss cheeses”. Working within this topological space, we show how to prove the existence of “classical” Swiss cheese sets (as discussed in [6]) with various desired properties. We first give a new proof of the Feinstein–Heath classicalisation theorem [6]. We then consider when it is possible to “classicalise” a Swiss cheese while leaving disks which lie outside a given region unchanged. We also consider sets obtained by deleting a sequence of open disks from a closed annulus, and we obtain an analogue of the Feinstein–Heath theorem for these sets. We then discuss regularity for certain uniform algebras. We conclude with an application of these techniques to obtain a classical Swiss cheese set which has the same properties as a non-classical example of O’Farrell

    Stories of Hell and Healing: Internet Users’ Construction of Benzodiazepine Distress and Withdrawal

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    Abstract Benzodiazepines are a group of drugs used mainly as sedatives, hypnotics, antiepileptics, and muscle relaxants. Consumption is recommended for 2 to 4 weeks only, due to fast onset of dependency and potentially distressing withdrawal symptoms. Few peer-review studies have drawn on the user experiences and language to appreciate firsthand experiences of benzodiazepine withdrawal or discontinuation syndrome. We looked extensively at patient stories of benzodiazepine withdrawal and recovery on Internet support sites and YouTube. Our analysis indicated that users employ rich metaphors to portray the psychologically disturbing and protracted nature of their suffering. We identified seven major themes: hell and isolation, anxiety and depression, alienation, physical distress, anger and remorse, waves and windows, and healing and renewal. By posting success stories, ex-users make known that “healing” can be a long, unpredictable process, but distress does lessen, and recovery can happen

    Tuning Between Quenching and Energy Transfer in DNA-Templated Heterodimer Aggregates

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    Molecular excitons, which propagate spatially via electronic energy transfer, are central to numerous applications including light harvesting, organic optoelectronics, and nanoscale computing; they may also benefit applications such as photothermal therapy and photoacoustic imaging through the local generation of heat via rapid excited-state quenching. Here we show how to tune between energy transfer and quenching for heterodimers of the same pair of cyanine dyes by altering their spatial configuration on a DNA template. We assemble “transverse” and “adjacent” heterodimers of Cy5 and Cy5.5 using DNA Holliday junctions. We find that the transverse heterodimers exhibit optical properties consistent with excitonically interacting dyes and fluorescence quenching, while the adjacent heterodimers exhibit optical properties consistent with nonexcitonically interacting dyes and disproportionately large Cy5.5 emission, suggestive of energy transfer between dyes. We use transient absorption spectroscopy to show that quenching in the transverse heterodimer occurs via rapid nonradiative decay to the ground state (∌31 ps) and that in the adjacent heterodimer rapid energy transfer from Cy5 to Cy5.5 (∌420 fs) is followed by Cy5.5 excited-state relaxation (∌700 ps). Accessing such drastically different photophysics, which may be tuned on demand for different target applications, highlights the utility of DNA as a template for dye aggregation

    Overstating the evidence - double counting in meta-analysis and related problems

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    Background: The problem of missing studies in meta-analysis has received much attention. Less attention has been paid to the more serious problem of double counting of evidence. Methods: Various problems in overstating the precision of results from meta-analyses are described and illustrated with examples, including papers from leading medical journals. These problems include, but are not limited to, simple double-counting of the same studies, double counting of some aspects of the studies, inappropriate imputation of results, and assigning spurious precision to individual studies. Results: Some suggestions are made as to how the quality and reliability of meta-analysis can be improved. It is proposed that the key to quality in meta-analysis lies in the results being transparent and checkable. Conclusions: Existing quality check lists for meta-analysis do little to encourage an appropriate attitude to combining evidence and to statistical analysis. Journals and other relevant organisations should encourage authors to make data available and make methods explicit. They should also act promptly to withdraw meta-analyses when mistakes are found
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