Elastic suspension of a wind tunnel test section

Experimental verification of the theory describing arbitrary motions of an airfoil is reported. The experimental apparatus is described. A mechanism was designed to provide two separate degrees of freedom without friction or backlash to mask the small but important aerodynamic effects of interest

Standing on Shaky Ground: Americans' Experiences With Economic Insecurity

Based on 2009 Surveys of Economic Risk Perceptions and Insecurity, examines Americans' experience of economic insecurity, such as frequency and duration, buffers against hardship, and concerns by income, family structure, race/ethnicity, and education

The impact of high grade glial neoplasms on human cortical electrophysiology

ObjectiveThe brain's functional architecture of interconnected network-related oscillatory patterns in discrete cortical regions has been well established with functional magnetic resonance imaging (fMRI) studies or direct cortical electrophysiology from electrodes placed on the surface of the brain, or electrocorticography (ECoG). These resting state networks exhibit a robust functional architecture that persists through all stages of sleep and under anesthesia. While the stability of these networks provides a fundamental understanding of the organization of the brain, understanding how these regions can be perturbed is also critical in defining the brain's ability to adapt while learning and recovering from injury.MethodsPatients undergoing an awake craniotomy for resection of a tumor were studied as a unique model of an evolving injury to help define how the cortical physiology and the associated networks were altered by the presence of an invasive brain tumor.ResultsThis study demonstrates that there is a distinct pattern of alteration of cortical physiology in the setting of a malignant glioma. These changes lead to a physiologic sequestration and progressive synaptic homogeneity suggesting that a de-learning phenomenon occurs within the tumoral tissue compared to its surroundings.SignificanceThese findings provide insight into how the brain accommodates a region of "defunctionalized" cortex. Additionally, these findings may have important implications for emerging techniques in brain mapping using endogenous cortical physiology

Comparison of Methods for Determining the Composition of Pyrolysis Products from the Degradation of Ablative Composites. Status report.

Determining composition of pyrolysis products from degradation of ablative material

ATP prevents Woronin bodies from sealing septal pores in unwounded cells of the fungus Zymoseptoria tritici

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.Septa of filamentous ascomycetes are perforated by septal pores that allow communication between individual hyphal compartments. Upon injury, septal pores are plugged rapidly by Woronin bodies (WBs), thereby preventing extensive cytoplasmic bleeding. The mechanism by which WBs translocate into the pore is not known, but it has been suggested that wound-induced cytoplasmic bleeding "flushes" WBs into the septal opening. Alternatively, contraction of septum-associated tethering proteins may pull WBs into the septal pore. Here, we investigate Woronin body dynamics in the wheat pathogen Zymoseptoria tritici. Ultrastructural studies showed that 3.4 ± 0.2 WBs reside on each side of a septum and that single WBs of 128.5 ± 3.6 nm in diameter seal the septal pore (41±1.5 nm). Live cell imaging of green-fluorescent ZtHex1, a major protein in WBs, and the integral plasma membrane protein ZtSso1 confirms WB translocation into the septal pore. This was associated with the occasional formation of a plasma membrane "balloon", extruding into the dead cell, suggesting that the plasma membrane rapidly seals the wounded septal pore wound. Minor amounts of fluorescent ZtHex1-eGFP appeared associated with the "ballooning" plasma membrane, indicating that cytoplasmic ZtHex1-eGFP is recruited to the extending plasma membrane. Surprisingly, in ~15% of all cases, WBs moved from the ruptured cell into the septal pore. This translocation against the cytoplasmic flow suggests that an active mechanism drives in WB plugging. Indeed, treatment of unwounded and intact cells with the respiration inhibitor CCCP induced WB translocation into the pores. Moreover, CCCP treatment recruited cytoplasmic ZtHex1-eGFP to the lateral plasma membrane of the cells. Thus, keeping the WBs out of the septal pores, in Z. tritici, is an ATP-dependent process

On the role of the corpus callosum in interhemispheric functional connectivity in humans

Resting state functional connectivity is defined in terms of temporal correlations between physiologic signals, most commonly studied using functional magnetic resonance imaging. Major features of functional connectivity correspond to structural (axonal) connectivity. However, this relation is not one-to-one. Interhemispheric functional connectivity in relation to the corpus callosum presents a case in point. Specifically, several reports have documented nearly intact interhemispheric functional connectivity in individuals in whom the corpus callosum (the major commissure between the hemispheres) never develops. To investigate this question, we assessed functional connectivity before and after surgical section of the corpus callosum in 22 patients with medically refractory epilepsy. Section of the corpus callosum markedly reduced interhemispheric functional connectivity. This effect was more profound in multimodal associative areas in the frontal and parietal lobe than primary regions of sensorimotor and visual function. Moreover, no evidence of recovery was observed in a limited sample in which multiyear, longitudinal follow-up was obtained. Comparison of partial vs. complete callosotomy revealed several effects implying the existence of polysynaptic functional connectivity between remote brain regions. Thus, our results demonstrate that callosal as well as extracallosal anatomical connections play a role in the maintenance of interhemispheric functional connectivity

Recycling Argon through Metamorphic Reactions: the Record in Symplectites

The 40Ar/39Ar ages of metamorphic micas that crystallized at high temperatures are commonly interpreted as cooling ages, with grains considered to have lost 40Ar via thermally-driven diffusion into the grain boundary network. Recently reported laser-ablation data suggest that the spatial distribution of Ar in metamorphic micas does not always conform to the patterns predicted by diffusion theory and that despite high metamorphic temperatures, argon was not removed efficiently from the local system during metamorphic evolution. In the Western Gneiss Region (WGR), Norway, felsic gneisses preserve microtextural evidence for the breakdown of phengite to biotite and plagioclase symplectites during near isothermal decompression from c. 20–25 to c. 8–12 kbar at ~700°C. These samples provide an ideal natural laboratory to assess whether the complete replacement of one K-bearing mineral by another at high temperatures completely ‘resets’ the Ar clock, or whether there is some inheritance of 40Ar in the neo-crystallized phase. The timing of the high-temperature portion of the WGR metamorphic cycle has been well constrained in previous studies. However, the timing of cooling following the overprint is still much debated. In-situ laser ablation spot dating in phengite, biotite-plagioclase symplectites and coarser, texturally later biotite yielded 40Ar/39Ar ages that span much of the metamorphic cycle. Together these data show that despite residence at temperatures of ~700°C, Ar is not completely removed by diffusive loss or during metamorphic recrystallization. Instead, Ar released during phengite breakdown appears to be partially reincorporated into the newly crystallizing biotite and plagioclase (or is trapped in fluid inclusions in those phases) within a close system. Our data show that the microtextural and petrographic evolution of the sample being dated provides a critical framework in which local 40Ar recycling can be tracked, thus potentially allowing 40Ar/39Ar dates to be linked more accurately to metamorphic history

Subduction-zone structure and magmatic processes beneath Costa Rica constrained by local earthquake tomography and petrological modelling

A high-quality data set of 3790 earthquakes were simultaneously inverted for hypocentre locations and 3-D P-wave velocities in Costa Rica. Tests with synthetic data and resolution estimates derived from the resolution matrix indicate that the velocity model is well constrained in central Costa Rica to a depth of 70 km; northwestern and southeastern Costa Rica are less well resolved owing to a lack of seismic stations and seismicity. Maximum H2O content and seismic wave speeds of mid-ocean ridge basalt and harzburgite were calculated for metamorphic phase transformations relevant to subduction. Both the 3-D P-wave velocity structure and petrological modelling indicate the existence of low-velocity hydrous oceanic crust in the subducting Cocos Plate beneath central Costa Rica. Intermediate-depth seismicity correlates well with the predicted locations of hydrous metamorphic rocks, suggesting that dehydration plays a key role in generating intermediate-depth earthquakes beneath Costa Rica. Wadati-Benioff zone seismicity beneath central Costa Rica shows a remarkable decrease in maximum depth toward southeastern Costa Rica. The presence of asthenosphere beneath southeastern Costa Rica, which entered through a proposed slab window, may explain the shallowing of seismicity due to increased temperatures and associated shallowing of dehydration of the slab. Tomographic images further constrain the existence of deeply subducted seamounts beneath central Costa Rica. Large, low P-wave velocity areas within the lower crust are imaged beneath the southeasternmost volcanoes in central Costa Rica. These low velocities may represent anomalously hot material or even melt associated with active volcanism in central Costa Rica. Tomographic images and petrological modelling indicate the existence of a shallow, possibly hydrated mantle wedge beneath central Costa Ric

Recent developments in effective field theory

We will give a short introduction to the one-nucleon sector of chiral perturbation theory and will address the issue of a consistent power counting and renormalization. We will discuss the infrared regularization and the extended on-mass-shell scheme. Both allow for the inclusion of further degrees of freedom beyond pions and nucleons and the application to higher-loop calculations. As applications we consider the chiral expansion of the nucleon mass to order O(q^6) and the inclusion of vector and axial-vector mesons in the calculation of nucleon form factors.Comment: 8 pages, 6 figures, invited talk given at International School of Nuclear Physics, 29th Course "Quarks in Hadrons and Nuclei", Erice, Sicily, 16 - 24 September 200