53 research outputs found
Bioactive Sesterterpenes and Triterpenes from Marine Sponges: Occurrence and Pharmacological Significance
Marine ecosystems (>70% of the planet’s surface) comprise a continuous resource of immeasurable biological activities and immense chemical entities. This diversity has provided a unique source of chemical compounds with potential bioactivities that could lead to potential new drug candidates. Many marine-living organisms are soft bodied and/or sessile. Consequently, they have developed toxic secondary metabolites or obtained them from microorganisms to defend themselves against predators [1]. For the last 30–40 years, marine invertebrates have been an attractive research topic for scientists all over the world. A relatively small number of marine plants, animals and microbes have yielded more than 15,000 natural products including numerous compounds with potential pharmaceutical potential. Some of these have already been launched on the pharmaceutical market such as Prialt® (ziconotide; potent analgesic) and Yondelis® (trabectedin or ET-743; antitumor) while others have entered clinical trials, e.g., alpidin and kahalalide F. Amongst the vast array of marine natural products, the terpenoids are one of the more commonly reported and discovered to date. Sesterterpenoids (C25) and triterpenoids (C30) are of frequent occurrence, particularly in marine sponges, and they show prominent bioactivities. In this review, we survey sesterterpenoids and triterpenoids obtained from marine sponges and highlight their bioactivities
GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15
Prostate cancer and supportive care: a systematic review and qualitative synthesis of men's experiences and unmet needs
Sympatric population divergence within a highly pelagic seabird species complex (Hydrobates spp.)
acceptedVersio
Leachs_stormpetrel_microsatellite_data
Microsatellite data from all birds used in our study (including from H. leucorhoa leucorhoa, H. l. chapmani, H. socorroensis and H. cheimomnestes)
Leachs_stormpetrels_mitochondroalControlRegion_and_outgroup
Mitochondrial control region sequences for all Leach's storm-petrels used in our study (including from Hydrobates leucorhoa leucorhoa, H. l. chapmani, H. socorroensis, H. cheimomnestes, and outgroup sequences from H. castro)
Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis.
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