Anomalies, absence of local equilibrium and universality in 1-d particles systems

One dimensional systems are under intense investigation, both from theoretical and experimental points of view, since they have rather peculiar characteristics which are of both conceptual and technological interest. We analyze the dependence of the behaviour of one dimensional, time reversal invariant, nonequilibrium systems on the parameters defining their microscopic dynamics. In particular, we consider chains of identical oscillators interacting via hard core elastic collisions and harmonic potentials, driven by boundary Nos\'e-Hoover thermostats. Their behaviour mirrors qualitatively that of stochastically driven systems, showing that anomalous properties are typical of physics in one dimension. Chaos, by itslef, does not lead to standard behaviour, since it does not guarantee local thermodynamic equilibrium. A linear relation is found between density fluctuations and temperature profiles. This link and the temporal asymmetry of fluctuations of the main observables are robust against modifications of thermostat parameters and against perturbations of the dynamics.Comment: 26 pages, 16 figures, revised text, two appendices adde

Dissipation function: Nonequilibrium physics and dynamical systems

An exact response theory has recently been developed within the field of Nonequilibrium Molecular Dynamics. Its main ingredient is known as the Dissipation Function, W. This quantity determines nonequilbrium properties like thermodynamic potentials do with equilibrium states. In particular, Ω can be used to determine the exact response of particle systems obeying classical mechanical laws, subjected to perturbations of arbitrary size. Under certain conditions, it can also be used to express the response of a single system, in contrast to the standard response theory, which concerns ensembles of identical systems. The dimensions of Ω are those of a rate, hence Ω can be associated with the entropy production rate, provided local thermodynamic equilibrium holds. When this is not the case for a particle system, or generic dynamical systems are considered, Ω can equally be defined, and it yields formal, thermodynamic-like, relations. While such relations may have no physical content, they may still constitute interesting characterizations of the relevant dynamics. Moreover, such a formal approach turns physically relevant, because it allows a deeper analysis of Ω and of response theory than possible in case of fully fledged physical models. Here, we investigate the relation between linear and exact response, pointing out conditions for the validity of the response theory, as well as difficulties and opportunities for the physical interpretation of certain formal results

The Levels of DAHP Synthase, the First Enzyme of the Shikimate Pathway, Are Related to Free Aromatic Amino Acids and Glutamine Content in Nicotiana plumbaginifolia Cell Cultures

Aromatic amino acid homeostasis was investigated in cell suspension cultures of Nicotiana plumbaginifolia and was related to the activity of the first enzyme in aromatic biosynthesis, 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase. An inverse relationship was found between the intracellular content of free phenylalanine, tyrosine and tryptophan and enzyme specific activity levels, suggesting the occurrence of end-product control mechanisms. Two DAHP synthase isogenes are present in wild tobacco that showed a different expression pattern during the culture growth cycle. Intracellular levels of aromatic amino acids were increased or decreased by adding the culture medium with phenylalanine, tyrosine and tryptophan, or with sublethal doses of the shikimate pathway inhibitor glyphosate, respectively. As a consequence, enzyme levels varied in the opposite direction. The concomitant exogenous supply of glutamine further reduced enzyme activity in mid-log cells, suggesting induction by both aromatic amino acid depletion and nitrogen starvation

Sensing of gaseous malodors characteristic of landfills and waste treatment plants

Abstract. We approached the problem of sensing gaseous pollutants and malodors originating as a result of decomposition of organic compounds via chemoresistive sensors. A set of four screen-printed films based on two types of mixed tin and titanium oxides, mixed tungsten and tin oxides, and zinc oxide has been tested vs. the main gaseous components of malodors. N-butanol was also considered because of its importance as a reference gas in the odorimetric intensity scale. We found that, under proper working conditions, the films can sensitively detect such gases either in dry or in wet environments, within the range of concentrations of interest for their monitoring. We also demonstrated that the array is robust under solicitation by harmful interference gases such as CO, C6H6, NO2 and NO

Order Picking Systems: A Queue Model for Dimensioning the Storage Capacity, the Crew of Pickers, and the AGV Fleet

Designing an order picking system can be very complex, as several interrelated control variables are involved. We address the sizing of the storage capacity of the picking bay, the crew of pickers, and the AGV fleet, which are the most important variables from a tactical viewpoint in a parts-to-pickers system. Although order picking is a widely explored topic in the literature, no analytical model that can simultaneously deal with these variables is currently available. To bridge this gap, we introduce a queue model for Markovian processes, which enables us to jointly optimise the aforementioned control variables. A discrete-event simulation is then used to validate our model, and we then test our proposal with real data under different operative scenarios, with the aim of assessing the usefulness of the proposal in real settings

On the transient behavior of frictional melt during seismic slip

In a recent work on the problem of sliding surfaces under the presence of frictional melt (applying in particular to earthquake fault dynamics), we derived from first principles an expression for the steady state friction compatible with experimental observations. Building on the expressions of heat and mass balance obtained in the above study for this particular case of Stefan problem (phase transition with a migrating boundary) we propose here an extension providing the full time-dependent solution (including the weakening transient after pervasive melting has started, the effect of eventual steps in velocity and the final decelerating phase). A system of coupled equations is derived and solved numerically. The resulting transient friction and wear evolution yield a satisfactory fit (1) with experiments performed under variable sliding velocities (0.9-2 m/s) and different normal stresses (0.5-20 MPa) for various rock types and (2) with estimates of slip weakening obtained from observations on ancient seismogenic faults that host pseudotachylite (solidified melt). The model allows to extrapolate the experimentally observed frictional behavior to large normal stresses representative of the seismogenic Earth crust (up to 200 MPa), high slip rates (up to 9 m/s) and cases where melt extrusion is negligible. Though weakening distance and peak stress vary widely, the net breakdown energy appears to be essentially independent of either slip velocity and normal stress. In addition, the response to earthquake-like slip can be simulated, showing a rapid friction recovery when slip rate drops. We discuss the properties of energy dissipation, transient duration, velocity weakening, restrengthening in the decelerating final slip phase and the implications for earthquake source dynamics

A non-contact optical technique for vehicle tracking along bounded trajectories

This paper presents a method for measuring the non-controlled trajectory of a cart along a bounded rectilinear path. The method uses non-contact measurement devices to identify the position of a movable laser scanner working in helical mode in order to reconstruct the 3D model of bridges. The main idea of the proposed method is to use vision systems in order to identify the coordinates of the laser scanner placed on the cart with respect to the global reference system. A fit-to-purpose vision system has been implemented: the system uses three CCD's cameras mounted on the cart to identify the relative rotations with respect to the environment. Two lasers pointers and a laser distance meter are fixed at the starting point of the trajectory and pointing in the direction of motion of the cart, creating three dots on a plane placed on the cart. One of the camera detects the cart displacements and rotations in the plane using a blob analysis procedure. The method described in this paper has a constant uncertainty and the measurement range only depends on the lasers power. The theoretical accuracy of the measurement system is close to 1 mm for the translation along the motion direction and around 0.5 mm along the other two directions. Orientations measurement have a theoretical accuracy of less than 0.1 °. The solution has been implemented for the 3D reconstruction of concrete bridge; preliminary experimental results are presented and discussed

Clinical validation results of an innovative non-invasive device for colorectal cancer preventive screening through fecal exhalation analysis

Screening is recommended to reduce both incidence and mortality of colorectal cancer. Currently, many countries employ fecal occult blood test (FOBT). In Emilia-Romagna (Italy), since 2005, FOBT immunochemical version (FIT) is performed every two years on people aged between 50 and 69 years. A colonoscopy is then carried out on those who are FIT positive. However, FIT shows approximately 65% false positives (non-tumoral bleedings), leading to many negative colonoscopies. The use of an economic and easy-to-use method to check FOBT-positives will improve screening effectiveness, reducing costs to the national health service. This work illustrates the results of a three-year clinical validation protocol (started in 2016) of a patented device composed of a core of nanostructured gas sensors. This device was designed to identify CRC presence by fecal volatile compounds, with a non-invasive, in vitro and low-cost analysis. Feces are, in fact, affected by tumor-volatile biomarkers, produced by cellular peroxidation and metabolic alterations. The protocol consisted in the analysis of fecal samples of FIT-positive subjects, using colonoscopy as a gold standard. A total of 398 samples were analyzed with machine learning techniques, leading to a sensitivity and specificity of 84.1% and 82.4%, respectively, and a positive predictive value of 72% (25–35% for FIT)

Influence of calcified canals localization on the accuracy of guided endodontic therapy: a case series study

This study aimed to evaluate the precision of the guided endodontic technique applied to calcified canals in anterior teeth in relation to demographic and dental variables. The present observational study was conducted during the period 2020–2021. The patients were consecutive referrals at the Department of Endodontics and Conservative Dentistry of the University Hospital of Siena. The guided endodontics protocol was applied using 0.75 mm diameter burs for the lower teeth and 0.90 mm for the upper teeth. The inclusion criteria were as follows: (i) teeth with pulp canal obliteration (PCO) associated with a periapical lesion (periapical index (PAI) ≥ 2); (ii) teeth with PCO that require the placement of a root canal post for the execution of a prosthetic treatment; (iii) teeth in which surgical treatment was not justified. Socio-demographic characteristics of the patients were recorded and related to the drill path accuracy through the guide in the calcified endodontic canal, evaluated through a radiographic analysis, and classified as optimal (in the center of the root canal) and acceptable (deviated peripherally/tangentially). A logistic regression model was built to predict the factors that influence the poor precision of the technique. Seventeen patients (mean age 48 years) with eighteen calcified single-rooted teeth were enrolled. All teeth were associated with periapical lesions with PAI scores from 2 to 5 (mean PAI: 3.055). From the model, it is evident that the presence of a calcification affecting the apical area of the root increases the probability of being off-center with the bur by about 15 times. In addition, a previous attempt at endodontic treatment and the position in the lower arch increases the probability of non-centrality of the drill, although in a non-statistically significant way. In any of the analyzed cases, the guided endodontic technique applied to PCO did not determine the presence of iatrogenic errors, such as perforations. However, the apical localization of the obliteration increases the probability of being off-center with the drill during the instrumentation phase by about 15 times