Magnetomotive drive and detection of clamped-clamped mechanical resonators in water

We demonstrate magnetomotive drive and detection of doubly clamped string resonators in water. A compact 1.9 T permanent magnet is used to detect the fundamental and higher flexural modes of $\mathrm{200 \mu m}$ long resonators. Good agreement is found between the magnetomotive measurements and optical measurements performed on the same resonator. The magnetomotive detection scheme can be used to simultaneously drive and detect multiple sensors or scanning probes in viscous fluids without alignment of detector beams.Comment: 4 pages, 3 figure

Lateral hypothalamus is required for context-induced reinstatement of extinguished reward seeking

We studied the role of lateral hypothalamus (LH) in context-induced reinstatement (renewal) of reward seeking. Rats were trained to respond for 4% (v/v) alcoholic beer or 10% (w/v) sucrose reward in one context (Context A) before extinction training in a second context (Context B). On test, rats were returned to the training context, A (ABA), or the extinction context, B (ABB). Return to the training context (ABA) produced robust reinstatement. Reversible inactivation of LH via baclofen/muscimol infusion prevented context-induced reinstatement of beer and sucrose seeking. This prevention was specific to bilateral infusions into LH. We then used the retrograde neuronal tracer cholera toxin b subunit (CTb) combined with detection of the c-Fos protein to identify activated afferents to LH during context-induced reinstatement of beer seeking. Double labeling for c-Fos and CTb revealed a significant recruitment of LH-projecting neurons in nucleus accumbens shell (AcbSh) during reinstatement. These afferents could be classified into two anatomically and functionally distinct groups. First, afferents in the ventral AcbSh projecting to LH were activated during reinstatement. Second, afferents in the dorsomedial AcbSh projecting to LH were activated during test in the extinction context. These recruitments were specific to an AcbSh–LH pathway because they were not observed following CTb injection into the immediately adjacent perifornical hypothalamus. These results show that LH is critical for context-induced reinstatement of reward seeking and that parallel striatal-hypothalamic pathways are recruited following return to the training versus extinction contexts

Prototyping the BOPTEST framework for simulation-based testing of advanced control strategies in buildings

Advanced control strategies are becoming increasingly necessary in buildings in order to meet and balance requirements for energy efficiency, demand flexibility, and occupant comfort. Additional development and widespread adoption of emerging control strategies, however, ultimately require low implementation costs to reduce payback period and verified performance to gain control vendor, building owner, and operator trust. This is difficult in an already first-cost driven and risk-averse industry. Recent innovations in building simulation can significantly aid in meeting these requirements and spurring innovation at early stages of development by evaluating performance, comparing state-of-the-art to new strategies, providing installation experience, and testing controller implementations. This paper presents the development of a simulation framework consisting of test cases and software platform for the testing of advanced control strategies (BOPTEST - Building Optimization Performance Test). The objectives and requirements of the framework, components of a test case, and proposed software platform architecture are described, and the framework is demonstrated with a prototype implementation and example test case

Never Stop Thinking About Our Students: Reading with Hogan and Sathy’s Inclusive Teaching

This paper considers the concept of inclusivity in the postsecondary classroom. We use narrative writing to describe experiences catalyzed by a book study of Hogan and Sathy’s Inclusive Teaching at Memorial University of Newfoundland and Labrador, Canada. We reflect on our thoughts and fears about teaching and about changes to our inclusive teaching practices that span specific actionable strategies to overarching pedagogies. We argue that while there can be institutional barriers that can prevent or discourage large changes, our commitment to continuing to reflect on our practices and learning from each other will help promote equity across Memorial’s classrooms

Drink driving among Aboriginal and Torres Strait Islander Australians: what has been done and where to next?

The Australian Government will set the direction for addressing road safety over the next decade with its 2021–2030 National Road Safety Strategy. This road map will detail objectives and goals agreed upon by all Australian states and territories. Similar to previous national strategies, Aboriginal and Torres Strait Islander (Indigenous) Australians are a high priority population. Indigenous Australians are over-represented in serious injury and fatal road crashes, with alcohol a leading factor. Therapeutic and educational programs are a major strategy among the suite of measures designed to reduce and prevent drink driving in Australia. The release of this new strategy provides a timely opportunity to reflect on what is known about drink driving among Indigenous Australians and to consider the suitability of existing therapeutic and educational drink driving programs for Indigenous Australian contexts. Here, we summarise factors that contribute to drink driving in this population and identify outstanding knowledge gaps. Then, we present an overview of drink driving programs available for Indigenous Australians along with suggestions for why tailored programs are needed to suit local contexts. The response to address drink driving among Indigenous Australians has been fragmented Australia-wide. A coordinated national response, with ongoing monitoring and evaluation, would improve policy effectiveness and inform more efficient allocation of resources. Together this information can help create suitable and effective drink driving programs for Indigenous drivers and communities Australia-wide

After the Left–Right (Dis)continuum: Globalization and the Remaking of Europe’s Ideological Geography

This article examines the status of globalization as a causal factor in political mobilization and proposes a research agenda for diagnosing the impact of global socio-economic dynamics on ideological orientation in national polities. Focusing on Europe’s established democracies, the article outlines recent shifts in Europe’s ideological landscape and explores the mechanisms generating a new pattern of political conflict and electoral competition. It advances the hypothesis that the knowledge economy of open borders has brought about a political cleavage inti- mately linked to citizens’ perceptions of the social impact of global eco- nomic integration. In this context, the polarization of life chances is determined by institutionally mediated exposure to both the economic opportunities and the hazards of globalization. Fostered by the increas- ing relevance of the international for state-bound publics, new fault-lines of social conflict are emerging, giving shape to a new, ‘‘opportunity- risk,’’ axis of political competition. As the novel political cleavage challenges the conventional left–right divide, it is likely to radically alter Europe’s ideological geography

Fabrication and characterisation of nanocrystalline graphite MEMS resonators using a geometric design to control buckling

The simulation, fabrication and characterisation of nanographite MEMS resonators is reported in this paper. The deposition of nanographite is achieved using plasma-enhanced chemical vapour deposition directly onto numerous substrates such as commercial silicon wafers. As a result, many of the reliability issues of devices based on transferred graphene are avoided. The fabrication of the resonators is presented along with a simple undercutting method to overcome buckling, by changing the effective stress of the structure from 436 MPa compressive, to 13 MPa tensile. The characterisation of the resonators using electrostatic actuation and laser Doppler vibrometry is reported, demonstrating resonator frequencies from 5–640 kHz and quality factor above 1819 in vacuum obtained

Vertical flight training: An overview of training and flight simulator technology with emphasis on rotary-wing requirements

The principal purpose of this publication is to provide a broad overview of the technology that is relevant to the design of aviation training systems and of the techniques applicable to the development, use, and evaluation of those systems. The issues addressed in our 11 chapters are, for the most part, those that would be expected to surface in any informed discussion of the major characterizing elements of aviation training systems. Indeed, many of the same facets of vertical-flight training discussed were recognized and, to some extent, dealt with at the 1991 NASA/FAA Helicopter Simulator Workshop. These generic topics are essential to a sound understanding of training and training systems, and they quite properly form the basis of any attempt to systematize the development and evaluation of more effective, more efficient, more productive, and more economical approaches to aircrew training. Individual chapters address the following topics: an overview of the vertical flight industry: the source of training requirements; training and training schools: meeting current requirements; training systems design and development; transfer of training and cost-effectiveness; the military quest for flight training effectiveness; alternative training systems; training device manufacturing; simulator aero model implementation; simulation validation in the frequency domain; cockpit motion in helicopter simulation; and visual space perception in flight simulators

Therapeutic Drug Monitoring of Biologics: Current Practice, Challenges and Opportunities – a Workshop Report

Therapeutic drug monitoring (TDM) for dose modification of biologics has the potential to improve patient outcomes. The US Food and Drug Administration (FDA) and the American Association of Pharmaceutical Scientists (AAPS) hosted the first US-based public workshop on TDM of biologics with contributions from a broad array of interested parties including healthcare providers, clinical pharmacologists, test developers, bioanalysis and immunogenicity scientists, health economics and outcomes research (HEOR) experts and regulators. The key insight was that despite a body of evidence to support TDM in certain therapeutic areas, there remain substantial challenges to widespread clinical implementation. There is a lack of consensus regarding the integration of TDM in clinical guidelines, and a lack of consensus on the cost-effectiveness of TDM; both factors contribute to the difficulty that healthcare providers face in obtaining reimbursement for TDM (both coverage of testing itself, and coverage of potential dosing modifications). The HEOR experts outlined alternative routes to obtaining reimbursement and suggested advocating for changes in coverage policies to promote TDM use in the clinic. Reaching alignment across policy makers, patients and advocacy groups, payers, and healthcare providers, on specific treatment settings where TDM will be clearly beneficial, was identified as an important step to advancing TDM implementation for the benefit of patients.<br/