542 research outputs found
The Effect of the Laboratory Specimen on Fatigue Crack Growth Rate
Over the past thirty years, laboratory experiments have been devised to develop fatigue crack growth rate data that is representative of the material response. The crack growth rate data generated in the laboratory is then used to predict the safe operating envelope of a structure. The ability to interrelate laboratory data and structural response is called similitude. In essence, a nondimensional term, called the stress intensity factor, was developed that includes the applied stresses, crack size and geometric configuration. The stress intensity factor is then directly related to the rate at which cracks propagate in a material, resulting in the material property of fatigue crack growth response. Standardized specimen configurations and experimental procedures have been developed for laboratory testing to generate crack growth rate data that supports similitude of the stress intensity factor solution. In this paper, the authors present laboratory fatigue crack growth rate test data and finite element analyses that show similitude between standard specimen configurations tested using the constant stress ratio test method is unobtainable
Particle-stabilized water droplets that sprout millimeter-scale tubes
A layer of colloidal particles will become irreversibly trapped at a fluidâfluid interface if they exhibit partial wettability with both fluid phases. This effect has been exploited to create Pickering emulsions, armored bubbles, and new materials of various kinds. When the interfaces are densely coated with particles, they behave like rigid elastic sheets with moduli that are proportional to the underlying interfacial tension. The interfaces are permeable, a characteristic that can, for example, lead to compositional ripening of Pickering emulsions
Here we show that when particle-stabilized water droplets are created in a bath of toluene with ethanol, millimeter-scale tubes are observed to sprout from the top of the droplets. Growth is driven by the ethanol partitioning from the toluene into the water which leads to an internal overpressure. Vertical growth occurs over many minutes; finally the tube buckles when it can no longer support its own weight (Figure 1). There are several different growth modes controlled by the concentration of ethanol and of silica particles.[1] An alternative way to manipulate the system is by using a different alcohol, leading to insight on the role of the underlying three-fluid phase diagram. Our work paves the way for future studies of droplet growth because the liquid droplets and the interfacial properties can be independently studied.
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The 2011 Workplace Employment Relations Study: first findings
The 2011 Workplace Employment Relations Study (WERS) is the sixth survey of employment relations in Britain. It collected data from a representative sample of 2,680 British workplaces, from: 2,680 workplace managers responsible for employment relations and personnel 1,002 worker representatives 21,981 employee
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Inside the Workplace: First Findings from the 2004 Workplace Employment Relations Survey
Loudly sing cuckoo : More-than-human seasonalities in Britain
This research was funded by a grant from the Arts and Humanities Research Council, grant number AH/E009573/1.Peer reviewedPostprin
Software that goes with the flow in systems biology
A recent article in BMC Bioinformatics describes new advances in workflow systems for computational modeling in systems biology. Such systems can accelerate, and improve the consistency of, modeling through automation not only at the simulation and results-production stages, but also at the model-generation stage. Their work is a harbinger of the next generation of more powerful software for systems biologists
The COPE-Trial-Communicating prognosis to parents in the neonatal ICU: Optimistic vs. PEssimistic: study protocol for a randomized controlled crossover trial using two different scripted video vignettes to explore communication preferences of parents of preterm infants.
BACKGROUND
One of the numerous challenges preterm birth poses for parents and physicians is prognostic disclosure. Prognoses are based on scientific evidence and medical experience. They are subject to individual assessment and will generally remain uncertain with regard to the individual. This can result in differences in prognostic framing and thus affect the recipients' perception. In neonatology, data on the effects of prognostic framing are scarce. In particular, it is unclear whether parents prefer a more optimistic or a more pessimistic prognostic framing.
OBJECTIVE
To explore parents' preferences concerning prognostic framing and its effects on parent-reported outcomes and experiences. To identify predictors (demographic, psychological) of parents' communication preferences.
DESIGN, SETTING, PARTICIPANTS
Unblinded, randomized controlled crossover trial (RCT) at the Division of Neonatology of the University Medical Center Mainz, Germany, including German-speaking parents or guardians of infants born preterm between 2010 and 2019 with a birth weight < 1500âg. Inclusion of up to 204 families is planned, with possible revision according to a blinded sample size reassessment.
INTERVENTION
Embedded in an online survey and in pre-specified order, participants will watch two video vignettes depicting a more optimistic vs. a more pessimistic framing in prognostic disclosure to parents of a preterm infant. Apart from prognostic framing, all other aspects of physician-parent communication are standardized in both videos.
MAIN OUTCOMES AND MEASURES
At baseline and after each video, participants complete a two-part online questionnaire (baseline and post-intervention). Primary outcome is the preference for either a more optimistic or a more pessimistic prognostic framing. Secondary outcomes include changes in state-anxiety (STAI-SKD), satisfaction with prognostic framing, evaluation of prognosis, future optimism and hope, preparedness for shared decision-making (each assessed using customized questions), and general impression (customized question), professionalism (adapted from GMC Patient Questionnaire) and compassion (Physician Compassion Questionnaire) of the consulting physician.
DISCUSSION
This RCT will explore parents' preferences concerning prognostic framing and its effects on physician-parent communication. Results may contribute to a better understanding of parental needs in prognostic disclosure and will be instrumental for a broad audience of clinicians, scientists, and ethicists.
TRIAL REGISTRATION
German Clinical Trials Register DRKS00024466 . Registered on April 16, 2021
Tops and Writhing DNA
The torsional elasticity of semiflexible polymers like DNA is of biological
significance. A mathematical treatment of this problem was begun by Fuller
using the relation between link, twist and writhe, but progress has been
hindered by the non-local nature of the writhe. This stands in the way of an
analytic statistical mechanical treatment, which takes into account thermal
fluctuations, in computing the partition function. In this paper we use the
well known analogy with the dynamics of tops to show that when subjected to
stretch and twist, the polymer configurations which dominate the partition
function admit a local writhe formulation in the spirit of Fuller and thus
provide an underlying justification for the use of Fuller's "local writhe
expression" which leads to considerable mathematical simplification in solving
theoretical models of DNA and elucidating their predictions. Our result
facilitates comparison of the theoretical models with single molecule
micromanipulation experiments and computer simulations.Comment: 17 pages two figure
Structural, item, and test generalizability of the psychopathology checklist - revised to offenders with intellectual disabilities
The Psychopathy ChecklistâRevised (PCL-R) is the most widely used measure of psychopathy in forensic clinical practice, but the generalizability of the measure to offenders with intellectual disabilities (ID) has not been clearly established. This study examined the structural equivalence and scalar equivalence of the PCL-R in a sample of 185 male offenders with ID in forensic mental health settings, as compared with a sample of 1,212 male prisoners without ID. Three models of the PCL-Râs factor structure were evaluated with confirmatory factor analysis. The 3-factor hierarchical model of psychopathy was found to be a good fit to the ID PCL-R data, whereas neither the 4-factor model nor the traditional 2-factor model fitted. There were no cross-group differences in the factor structure, providing evidence of structural equivalence. However, item response theory analyses indicated metric differences in the ratings of psychopathy symptoms between the ID group and the comparison prisoner group. This finding has potential implications for the interpretation of PCL-R scores obtained with people with ID in forensic psychiatric settings
A laboratory study on cold-mix, cold-lay emulsion mixtures
This paper describes laboratory experiments and presents
results for the performances of cold-mix, cold-lay
emulsion mixtures. The main objective of the experiments
was to evaluate and improve the properties of the cold
mixtures. The mixture properties evaluated were:
volumetric properties, indirect tensile stiffness modulus
(ITSM), repeated load axial creep and fatigue. These
properties were compared with conventional hot asphalt
mixtures not containing any waste/recycled materials. To
optimise the performances of the mixtures, a target of
ITSM value of 2000 MPa was selected. At full curing
conditions, the stiffness of the cold mixes was found to be
very similar to that of hot mixtures of the same
penetration grade base bitumen (100 pen). Test results
also show that the addition of 1â2% cement significantly
improved the mechanical performance of the mixes and
significantly accelerated their strength gain. The fatigue
behaviour of the cold mixes that incorporated cement was
comparable with that of the hot mixtures
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