1,317 research outputs found
High-performance -type organic field-effect transistors with ionic liquid gates
High-performance -type organic field-effect transistors were developed
with ionic-liquid gates and N,N-bis(n-alkyl)-(1,7 and
1,6)-dicyanoperylene-3,4:9,10-bis(dicarboximide)s single-crystals. Transport
measurements show that these devices reproducibly operate in ambient atmosphere
with negligible gate threshold voltage and mobility values as high as 5.0
cm/Vs. These mobility values are essentially identical to those measured in
the same devices without the ionic liquid, using vacuum or air as the gate
dielectric. Our results indicate that the ionic-liquid and -type organic
semiconductor interfaces are suitable to realize high-quality -type organic
transistors operating at small gate voltage, without sacrificing electron
mobility
Trafficking properties of plasmacytoid dendritic cells in health and disease.
Plasmacytoid dendritic cells (PDCs) represent a subset of circulating leukocytes characterized by the ability to release high levels of type I interferon (IFN). Under homeostatic conditions PDCs are confined to primary and secondary lymphoid organs. This is consistent with the restricted profile of functional chemotactic receptors expressed by circulating PDCs (i.e. CXCR4 and ChemR23). Accumulation of PDCs in non-lymphoid tissue is, however, observed in certain autoimmune diseases, allergic reactions and tumors. Indeed, PDCs are now considered to be involved in the pathogenesis of diseases characterized by a type I IFN-signature and are considered as a promising target for new intervention strategies. Here, current knowledge of the molecular mechanisms involved in the recruitment of PDCs under homeostatic and pathological conditions are summarized
Exploiting coordination geometry to selectively predict the r-donor and p-acceptor abilities of ligands: a back-and-forth journey between electronic properties and spectroscopy
Coordination geometry switches the carbonyl stretching frequency into a selective probe of the σ-donor and π-acceptor abilities of ligands
Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia‐derived cells: Role of PKCβ
In this study, a series of 20 chalcone derivatives was synthesized, and their antiproliferative activity was tested against the human T cell acute lymphoblastic leukemia\u2010derived cell line, CCRF\u2010CEM. On the basis of the structural features of the
most active compounds, a new library of chalcone derivatives, according to the structure\u2013activity relationship design, was synthesized, and their antiproliferative activity was tested against the same cancer cell line. Furthermore, four
of these derivatives (compounds 3, 4, 8, 28), based on lower IC50 values (between 6.1 and 8.9 \u3bcM), were selected for further investigation regarding the modulation of the protein expression of RACK1 (receptor for activated C kinase), protein kinase
C (PKC)\u3b1 and PKC\u3b2, and their action on the cell cycle level. The cell cycle analysis indicated a block in the G0/G1 phase for all four compounds, with a statistically significant decrease in the percentage of cells in the S phase, with no indication of
apoptosis (sub\u2010G0/G1 phase). Compounds 4 and 8 showed a statistically significant reduction in the expression of PKC\u3b1 and an increase in PKC\u3b2, which together with the demonstration of an antiproliferative role of PKC\u3b2, as assessed by treating cells with a selective PKC\u3b2 activator, indicated that the observed antiproliferative effect is likely to be mediated through PKC\u3b2 induction
A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.)
An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient
Vancomycin-Iridium (III) Interaction: An Unexplored Route for Enantioselective Imine Reduction
The chiral structure of antibiotic vancomycin (Van) was exploited as an innovative
coordination sphere for the preparation of an IrCp* based hybrid catalysts. We found that Van is
able to coordinate iridium (Ir(III)) and the complexation was demonstrated by several analytical
techniques such as MALDI-TOF, UV, Circular dichroism (CD), Raman IR, and NMR. The hybrid
system so obtained was employed in the Asymmetric Transfer Hydrogenation (ATH) of cyclic imines
allowing to obtain a valuable 61% e.e. (R) in the asymmetric reduction of quinaldine 2. The catalytic
system exhibited a saturation kinetics with a calculated eciency of Kcat/KM = 0.688 h1mM
Distributed Representations of Signed Networks
Recent successes in word embedding and document embedding have motivated
researchers to explore similar representations for networks and to use such
representations for tasks such as edge prediction, node label prediction, and
community detection. Such network embedding methods are largely focused on
finding distributed representations for unsigned networks and are unable to
discover embeddings that respect polarities inherent in edges. We propose
SIGNet, a fast scalable embedding method suitable for signed networks. Our
proposed objective function aims to carefully model the social structure
implicit in signed networks by reinforcing the principles of social balance
theory. Our method builds upon the traditional word2vec family of embedding
approaches and adds a new targeted node sampling strategy to maintain
structural balance in higher-order neighborhoods. We demonstrate the
superiority of SIGNet over state-of-the-art methods proposed for both signed
and unsigned networks on several real world datasets from different domains. In
particular, SIGNet offers an approach to generate a richer vocabulary of
features of signed networks to support representation and reasoning.Comment: Published in PAKDD 201
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