NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations.

Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma. Somatic NF2 mutations have also been reported in a variety of cancers, but interestingly these mutations do not cause the same tumors that are common in hereditary neurofibromatosis 2, even though the same gene is involved and there is overlap in the site of mutations. This review highlights cancers in which somatic NF2 mutations have been found, the cell signaling pathways involving NF2/merlin, current clinical trials treating neurofibromatosis 2 patients, and preclinical findings that promise to lead to new targeted therapies for both cancers harboring NF2 mutations and neurofibromatosis 2 patients

Elisée Reclus (1830-1905) : un geògraf francès i un anarquista

Dans la première partie de l'article, consacrée à la biographie d'Elisée Reclus, l'auteur a mis l'accent sur les aspects de sa vie ayant un rapport avec ses deux oeuvres les plus importantes, la Nouvelle Géographie Universelle et L'Homme et la Terre. La deuxième partie est consacrée à l'étude de l'influence de Reclus sur la géographie de son époque mais aussi sur celle d'aujourd'hui. Finalement l'auteur a analysé les influences de l'anarchisme sur les points de vue et le contenu de ses oeuvres.The first part of the article consists of a biographic study of Elisée Reclus, emphasizing above all aspects related to the publication of two of his most important works, Nouvelle Géographie Universelle and L'Homme et la Terre. This study is followed by an analysis of the influence which Reclus exerciced in geographical spheres, not only among his contemporaries but also at present. Finally, the author evaluates the extent to which the anarchist model influenced the perspective and content of his work.En la primera parte del articulo se hace un estudio biográfico de Elisée Reclus insistiendo en aquellos aspectos relacionados con la producción de dos de sus obras más importantes, Nouvelle Géographie Universelle y L'Homme et la Terre. Seguidamente se analiza la influencia que Reclus ejerció en el mundo de la geografia tanto en su momento como en el presente, y finalmente se estudian las influencias que el modelo anarquista tuvo en el enfoque y contenido de su obra

Body Language Without a Body: Nonverbal Communication in Technology Mediated Settings

Humans are wired for face-to-face interaction because this was the only possible and available setting during the long evolutionary process that has led to Homo Sapiens. At the moment an increasingly significant fraction of our interactions take place in technology mediated settings, it is important to investigate how such a wiring - mainly corresponding to neural processes - reacts and adapts to them. This talk focuses in particular on how nonverbal communication - one of the main channels through which people convey socially and psychologically relevant information - plays a role in settings where natural nonverbal cues (facial expressions, vocalizations, gestures, etc.) are no longer available. Such an issue is important not only from a technological point of view (it can help to design interaction and communication technologies that better address human needs), but also from a societal one (it can help to understand major phenomena such as cyberbullyism and virality)

Technology Planning

Planning for technology is a crucial component of success in integrating technology into school environments

Fluctuations and Correlations in Lattice Models for Predator-Prey Interaction

Including spatial structure and stochastic noise invalidates the classical Lotka-Volterra picture of stable regular population cycles emerging in models for predator-prey interactions. Growth-limiting terms for the prey induce a continuous extinction threshold for the predator population whose critical properties are in the directed percolation universality class. Here, we discuss the robustness of this scenario by considering an ecologically inspired stochastic lattice predator-prey model variant where the predation process includes next-nearest-neighbor interactions. We find that the corresponding stochastic model reproduces the above scenario in dimensions 1< d \leq 4, in contrast with mean-field theory which predicts a first-order phase transition. However, the mean-field features are recovered upon allowing for nearest-neighbor particle exchange processes, provided these are sufficiently fast.Comment: 5 pages, 4 figures, 2-column revtex4 format. Emphasis on the lattice predator-prey model with next-nearest-neighbor interaction (Rapid Communication in PRE

Evaluating three levels of environmental taxation in aviation: Global limitation, EU determination and UK self-interest

Although the UK Coalition government has a fondness for nudge policies and proclaimed itself ‘the greenest government ever’, many policies are criticised or failing. In March 2011, the long-intended policy change from Airline Passenger Duty (APD) to Per Plane Tax (PPT) was dropped. Cited as ineffective at reducing aviation consumption in spite of ever-increasing fees, the APD is a transparent tax passed on to customers by airlines with immediacy, whereas the PPT would incentivise airlines to maximise capacity and therefore reduce emissions but would have purportedly breached the Convention on International Civil Aviation 1944 (Chicago Convention). This article discusses central criticisms of the APD, and looks to the Luftverkehrsteuergesetz in Germany, the Taxe de l’aviation civile in France and prospects for an EU Air Tax, to conclude that whilst there is a forward movement along three levels of decision-making (international, European and domestic), the speed and quantum of progress varies

Credit Risk Dynamics in Response to Changes in the Federal Funds Target: The Implication for Firm Short-Term Debt

The recent credit crisis has raised a number of interesting questions regarding the role of the Federal Reserve Bank and the effectiveness of its expected and unexpected interventions in financial markets, especiallyduring the crisis, given its mandate. This paper reviews and evaluates the impact of expected and unexpected changes in the federal funds rate target on credit risk premia. The paper\u27s main innovation is the use of an ACH-VAR (autoregressive conditional hazard VAR) model to generate the Fed\u27s expected and unexpected monetary policy shocks which are then used to determine the effects of a Federal Reserve policy change on counterparty credit risk and more importantly short-term firm debt financing. The findings answer a longstanding question sought by researchers on the effect of policy makers\u27 announcements on firm debt financing. The results clearly show that the Federal Reserve influences short-term debt financing through the credit channel for both expansionary and contractionary monetary policies. In particular, we find that the growth in counterparty risk appears less responsive to anticipated responses in the Fed funds rate that fail to materialize than to an unanticipated increase in the federal funds rate. Finally, we also document that the results appear to validate the Feds interventions in financial markets to stem counterparty risk and to make liquidity more readily available to firms

Multicenter clinical evaluation of the Luminex Aries Flu A/B & RSV assay for pediatric and adult respiratory tract specimens

ABSTRACT Influenza A and B viruses and respiratory syncytial virus (RSV) are three common viruses implicated in seasonal respiratory tract infections and are a major cause of morbidity and mortality in adults and children worldwide. In recent years, an increasing number of commercial molecular tests have become available to diagnose respiratory viral infections. The Luminex Aries Flu A/B &amp; RSV assay is a fully automated sample-to-answer molecular diagnostic assay for the detection of influenza A, influenza B, and RSV. The clinical performance of the Aries Flu A/B &amp; RSV assay was prospectively evaluated in comparison to that of the Luminex xTAG respiratory viral panel (RVP) at four North American clinical institutions over a 2-year period. Of the 2,479 eligible nasopharyngeal swab specimens included in the prospective study, 2,371 gave concordant results between the assays. One hundred eight specimens generated results that were discordant with those from the xTAG RVP and were further analyzed by bidirectional sequencing. Final clinical sensitivity values of the Aries Flu A/B &amp; RSV assay were 98.1% for influenza A virus, 98.0% for influenza B virus, and 97.7% for RSV. Final clinical specificities for all three pathogens ranged from 98.6% to 99.8%. Due to the low prevalence of influenza B, an additional 40 banked influenza B-positive specimens were tested at the participating clinical laboratories and were all accurately detected by the Aries Flu A/B &amp; RSV assay. This study demonstrates that the Aries Flu A/B &amp; RSV assay is a suitable method for rapid and accurate identification of these causative pathogens in respiratory infections.</jats:p