Early Maladaptive Schemas among children: a new way to screen for depressed child

How can children’s schemas evolve into adult schemas that are responsible for depression? To answer this question, we translated Schmidt, Joiner, Young, and Telch’s (1995) Early Maladaptive Schema Questionnaire into French and adapted it to children. We administered the questionnaire to two groups of children in years seven to ten (N = 252), one group containing children suffering from depression and the other containing children with no psychiatric disorders. The results provided insight into the structure of depression schemas. From a clinical perspective, we stress the possibility of using this tool to individually or collectively detect «normal» and «abnormal» schemas in children Early maladaptive schemas among children: a new way to screen for depressed child

Purging the HIV-1 reservoir through the disruption of the PD-1 pathway

International audiencen.

Photoelectrochemical characterization of electrodeposited polyaniline

Photoelectrochemistry is based on interfacial electron transfer, where one of the phases is the excited state of a semiconductor. We used the a.c. impedance technique in order to investigate these interface processes. Polyaniline films galvanostatically grown on platinum electrodes showed variation of photocurrent responses with d.c. bias with two maxima, 0.4 and 0.7 V, and a minimum at 0.65 V. Electrochemical impedance spectra were used to model the interface in terms of the variation of space-charge layer capacitance with d.c. bias, observed in lower frequencies. The flat-band potential, in the order of 0.65 V versus Ag/AgCl, was determined from Mott-Schottky plots and was also observed in photoelectrochemical experiments. From the slope of the Mott-Schottky plot we observed that the charge carriers concentration is higher when polyaniline is irradiated. The polyaniline gap, 2.85 eV, was determined by the Kubelka-Munk function. (C) 1997 Elsevier Science S.A.89316716

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4⁺ T cells from ART-suppressed individuals.

HIV persists in latently infected CD4 <sup>+</sup> T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. However, whether PD-1 plays a functional role in HIV latency and reservoir persistence remains unknown. Using CD4 <sup>+</sup> T cells from HIV-infected individuals, we show that the engagement of PD-1 inhibits viral production at the transcriptional level and abrogates T-cell receptor (TCR)-induced HIV reactivation in latently infected cells. Conversely, PD-1 blockade with the monoclonal antibody pembrolizumab enhances HIV production in combination with the latency reversing agent bryostatin without increasing T cell activation. Our results suggest that the administration of immune checkpoint blockers to HIV-infected individuals on ART may facilitate latency disruption

Pricing variance swaps under the Hawkes jump-diffusion process

This paper presents an analytical approach for pricing variance swaps with discrete sampling times when the underlying asset follows a Hawkes jump-diffusion process characterized with both stochastic volatility and clustered jumps. A significantly simplified method, with which there is no need to solve partial differential equations, is used to derive a closed-form pricing formula. A distinguished feature is that many recently published formulas can be shown to be special cases of the one presented here. Some numerical examples are provided with results demonstrating that jump clustering indeed has a significant impact on the price of variance swaps