15 research outputs found
Mediation in Investor-State Dispute Settlement: Government Policy and the Changing Landscape
Full text linkAn observational cross-sectional study of the possible relationship between high levels of cytokines (TNF and IL10) and healthcare-associated and other infections in patients with polytrauma
No full textEffects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children
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Conformation and Stability of Ether−Water Adducts: Free Jet Absorption Millimeter Wave Spectrum of 1,4-Dioxane−Water
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Proton Induced Structural Reorganization of a Few Carbonyl Molecules in the Ground and Excited States
No full textPotential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution
Get PDFThis study evaluated the association of N-hexyl-2-methyl-4-nitroimidazol, a model drug, to aggregates formed by anionic polyelectrolytes on aqueous solution. The alternating copolymers of maleic anhydride and N-vinyl-2-pyrrolidone were synthesized and then modified by reaction of the anhydride groups with aliphatic amines and alcohols of varying length of the alkyl chain. The partition of the model drug between water and the hydrophobic microdomains provided by the copolymers was studied using the pseudo-phase model to determinate the distribution coefficient K S, and the standard free energy of transfer ∆µ°t. The results indicate that all copolymers assessed are potential pharmaceutical reservoirs of the model drug. Nevertheless, the solubility of N-hexyl-2-methyl-4-nitroimidazol on the polymeric solutions is independent from the length of the alkyl chain of the copolymer
