Investigating order release dimensions of workload control mechanisms.

A variety of order release mechanisms have been developed for workload control. In this paper the effectiveness of order release mechanisms in a job shop environment is assessed by studying the influence of single order release dimensions, instead of comparing different mechanisms as a whole. In particular, the paper aims at improving the basis for selecting the workload accounting over time and the workload control strategies, through the understanding of its impact on the overall system performance. The robustness of these order release strategies to environmental perturbations is also assessed through a plan of experiments based on the Taguchi method. Simulation results provide important insights for the implementation of order release mechanisms

Distributed design of product oriented manufacturing systems

Manufacturing leanness and agility are requirements of today’s manufacturing systems. Leanness call for a best fit of the manufacturing systems to products, therefore requiring product oriented manufacturing systems (POMS). Manufacturing agility can be achieved through easy systems reconfiguration to fit changing manufacturing requirements, which may mean dynamically configuring POMS. For this a suitable design system is required. Due to complexity of this design, and to the need for using suitable design methods, which may not be available locally, distributed sources of design services can be used. This paper presents and describes a prototype of a Distributed Design system for POMS based on a POMS design methodology and distributed suppliers of design services

Linking dietary intake, circadian biomarkers, and clock genes on obesity: A study protocol

BackgroundThe prevalence of obesity continues to rise, and although this is a complex disease, the screening is made simply with the value of the Body Mass Index. This index only considers weight and height, being limited in portraying the multiple existing obesity phenotypes. The characterization of the chronotype and circadian system as an innovative phenotype of a patient's form of obesity is gaining increasing importance for the development of novel and pinpointed nutritional interventions. ObjectiveThe present study is a prospective observational controlled study conducted in Portugal, aiming to characterize the chronotype and determine its relation to the phenotype and dietary patterns of patients with obesity and healthy participants. MethodsAdults with obesity (study group) and healthy adults (control group), aged between 18 and 75, will be enrolled in this study. Data will be collected to characterize the chronotype, dietary intake, and sleep quality through validated questionnaires. Body composition will also be assessed, and blood samples will be collected to quantify circadian and metabolic biomarkers. DiscussionThis study is expected to contribute to a better understanding of the impact of obesity and dietary intake on circadian biomarkers and, therefore, increase scientific evidence to help future therapeutic interventions based on chronobiology, with a particular focus on nutritional interventions

Aumento da probabilidade diagnóstica de síndrome de cushing subclínica em uma amostra populacional de pacientes adultos obesos com diabetes mellitus tipo 2

Endogenous Cushing s Syndrome (CS) is unusual. Patients with subclinical CS (SCS) present altered cortisol dynamics without obvious manifestations. CS occurs in 2-3% of obese poorly controlled diabetics. We studied 103 overweight adult outpatients with type 2 diabetes to examine for cortisol abnormalities and SCS. All collected salivary cortisol at 23:00 h and salivary and serum cortisol after a 1 mg dexamethasone suppression test (DST). Patients whose results were in the upper quintile for each test (253 ng/dL, 47 ng/dL, and 1.8 mg/dL, respectively for the 23:00 h and post-DST saliva and serum cortisol) were re-investigated. Average values from the upper quintile group were 2.5-fold higher than in the remaining patients. After a confirmatory 2 mg x 2 day DST the investigation for CS was ended for 61 patients with all normal tests and 33 with only one (false) positive test. All 8 patients who had two abnormal tests had subsequent normal 24h-urinary cortisol, and 3 of them were likely to have SCS (abnormal cortisol tests and positive imaging). However, a final diagnosis could not to be confirmed by surgery or pathology. Although not confirmatory, the results of this study suggest that the prevalence of SCS is considerably higher in populations at risk than in the general population.A síndrome de Cushing (SC) endógena é rara. Pacientes com SC subclínica (SCS) apresentam hipercortisolismo sem manifestações clínicas. SC ocorre em 2-3% de diabéticos mal controlados. Estudamos 103 pacientes adultos obesos ambulatoriais com diabetes mellitus tipo 2 para avaliar alterações do cortisol e SCS. Todos coletaram cortisol salivar às 23:00 h e cortisol salivar e sérico após teste de supressão com 1 mg de dexametasona (DST). Pacientes cujos resultados de qualquer teste estavam no quintil superior (253 ng/dL, 47 ng/dL e 1,8 mg/dL, respectivamente para cortisol salivar 23:00 h e salivar e sérico pós-DST) foram reavaliados. Os valores médios desse grupo encontravam-se 2,5 vezes acima dos valores dos demais pacientes. Após um teste confirmatório com 2 mg x 2 dias DST, a investigação da SC foi encerrada para 61 pacientes com todos os testes normais e 33 com apenas um teste (falso) positivo. Todos os 8 pacientes com dois testes alterados apresentaram cortisol urinário normal, mas 3 deles mostraram maior probabilidade diagnóstica de SCS (hipercortisolismo e alterações em exames de imagem). Contudo, o diagnóstico final não pode ser confirmado por cirurgia ou patologia em nenhum deles. Embora não confirmatórios, os resultados deste estudo sugerem que a prevalência de SCS seja maior em populações de risco do que na população geral.Federal University of São Paulo Department of Medicine Division of EndocrinologyUNIFESP, Department of Medicine Division of EndocrinologySciEL

Persistence of Left Superior Vena Cava Associated to Esophageal Atresia: Presentation of 5 Cases

Objectivos: A atresia do esófago está associada a uma variedade de malformações congénitas de outros órgãos. A persistência da veia cava superior esquerda e uma das malformações venosas torácicas mais comuns, ocorrendo em 0,3% da população. O objectivo deste estudo é caracterizar a persistência da veia cava superior esquerda nos doentes com atresia do esófago tratados no Hospital Dona Estefânia. Métodos: Estudo retrospectivo dos doentes admitidos por atresia do esófago desde Janeiro 2002 a Dezembro 2013. As seguintes variáveis foram estudadas, considerando, idade gestacional, o peso à nascença, o sexo, tipo de atresia do esófago, ecocardiograma no pré-operatório, malformações associadas, abordagem cirúrgica, eventual ecocardiograma no pós-operatório e angioressonância. Resultados: De um total de 107 doentes, em cinco casos foi diagnosticada persistência da veia cava superior esquerda. Destes, apenas um tinha diagnostico pré-natal. A restante investigação revelou um doente com atresia duodenal e outro com malformação do aparelho urinário, coloboma e malformação bilateral dos pavilhões auriculares. Todos os cinco doentes foram submetidos a toracotomia, esofagoesofagostomia primária após laqueação da fístula traqueo-esofágica e angio-ressonância para caracterizar a malformação vascular. Não houve registo de complicações, quer intra-operatórias quer pós-operatórias. Conclusão: Apesar do estudo pré-operatório, apenas se diagnosticou persistência da veia cava superior esquerda num dos doentes. O diagnóstico é geralmente feito de forma incidental durante a colocação rotineira de catéteres venosos centrais à esquerda. É importante identificar estes doentes e caracterizar o seu padrão de retorno venoso cardíaco, pelo risco de complicações embó1icas paradoxais para o sistema arterial

Obesity-related knowledge and body mass index : a national survey in Portugal

© 2019 Springer Nature Switzerland AG. Part of Springer Nature.Purpose: Obesity-related knowledge predicts weight control but previous studies only comprise individuals with excessive weight and assess very specific aspects of knowledge. This study aims to evaluate several domains of obesity-related knowledge according to the body mass index (BMI) in a representative sample of Portuguese-speaking dwellers in mainland Portugal. Methods: A sample of 1624 participants aged 16–79 years was analyzed. Eighteen questions comprising eight obesity domains were asked: prevalence, physical activity, number of calories, adiposity location, causes, diagnosis, treatment and consequences; each one was dichotomized into correct/incorrect knowledge. Results: The majority of Portuguese-speaking dwellers recognized the benefits of physical activity, the risks of abdominal obesity and most consequences of excessive weight, independently of their BMI. However, knowledge gaps were identified regarding prevalence, calories and BMI diagnosis. BMI influenced specific obesity-related knowledge: participants with a normal BMI knew the BMI formula more often, identified 22 as normal BMI more frequently and had the highest proportion of correct knowledge regarding the number of calories an adult should eat; obese individuals identified natural products as not being good treatments for obesity more often. After adjusting for age, sex and educational level, obese individuals identified natural products and supplements as not being good obesity treatments more often. Conclusions: Obesity-related knowledge gaps (prevalence, calories, and diagnosis) were identified among Portuguese adults. Moreover, correct knowledge does not necessarily translate into a healthier BMI. Besides the dissemination of accurate information, public health interventions should focus on the transfer of knowledge to behaviors that will guarantee better weight management. Evidence-based medicine rankings: Level V: Opinions of respected authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.This study was supported by FEDER funds through Operational Programme Competitiveness and Internationalization and by national funding from The Portuguese Foundation for Science and Technology—FCT (Portuguese Ministry of Education and Science) within the project (HMSP-IISE/SAU-ICT/0004/2009) and within the Epidemiology Research Unit—Institute of Public Health, University of Porto (EPIUnit) (POCI-01-0145-FEDER-006862; Ref. UID/ DTP/04750/2013). Additionally, we gratefully acknowledge the FCT Investigator contract IF/01674/2015 (Susana Silva) and also a Scientifc Employment Stimulus contract CEECIND/01793/2017 (Ana Henriques). The funding source had no role in the study design, collection, analysis, or interpretation of data, writing the manuscript, or the decision to submit the manuscript for publication.info:eu-repo/semantics/publishedVersio

Characterization of natural cork agglomerate functionalised by plasma treatment

This work intends to study the chemical and physical modifications of natural cork agglomerate after plasma treatment using dielectric barrier discharge (DBD). Different experimental techniques were used to evaluate the surface alterations of the substrate pre- treated with DBD plasma, namely, static and dynamic contact angle, surface energy, Fourier transform infrared spectroscopy (FTIR), energy dispersive spectroscopy (EDS), scanning electronic microscopy (SEM) and differential scanning calorimetry (DSC). Plasma discharge greatly increases the wettability and surface energy of the samples. Chemical and physical analyses of the cork agglomerate confirmed considerable surface modification.The authors gratefully acknowledge the CsF – CNPq and CAPES Foundation, Brazil, for the doctoral grants 202539/2011-3 and BEX0978/12-4. We would also like to thank the Project no 2011/19280 (“COLTEC”), FCT and FEDER-COMPETE funding PEt-C/CTM/UI0264/2011

Caracterización de recubrimientos de hidroxiapatita depositadas sobre la aleación Ti6Al7Nb a través de aspersión térmica a plasma

Hydroxyapatite (HA) coated onto titanium alloys by atmospheric plasma-arc spraying is a promising technique for improving biocompatibility of materials. The tissue adherence to the HA coating increases when compared to the provided by the natural environment of the human body. Hidroxyapatite coating applied to a Ti-6Al-7Nb alloy substrate by plasma spray was characterized morphologically via Scanning Electron Microscopy (SEM) and X-Ray diffraction. X-Ray diffraction results of the HA layer indicated the presence of crystalline HA, amorphous phase and another constituents, like tricalcium phosphate (TCP) and calcium oxide. However, after annealing at a temperature of 600oC there was recristalisation of the amorphous phase and transformation of some of the TCP to HA. SEM results revealed a lamellar morphology which is typical of plasma sprayed surfaces. The HA/alloy interface exhibited some irregularities, however these are not present in the majority of the interfacial area.Peer Reviewe

The role of serum levels of vitamin D in children’s muscle strength: A systematic review

This review aims to investigate the different levels of vitamin D and its role in muscle strength in healthy children and non-athletes. A search conducted in three databases (PubMed, Scopus, and Psycinfo) resulted in 655 articles, which were systematically analyzed and selected based on the following criteria: (a) original cross-sectional studies and clinical trials; (b) healthy children aged 5-11 years; (c) no language restriction or year of publication; and (d) studies that assessed the possible relationship between vitamin D levels and muscle strength. Six studies were included because they met all the inclusion criteria. According to the findings of this review, factors such as sex, skin color, and vitamin D supplementation early in life modulate the levels of vitamin D in the body, and there is a relationship between muscle strength and vitamin D levels. Interestingly, vitamin D supplementation is not always significantly associated with increased muscle grip strength. However, there is a scarcity of studies that aim to analyze the possible effects of different levels of vitamin D on muscle function and neuromuscular variables in physically inactive children and non-athletes without previously diagnosed disease. Further studies are warranted in the future to address the gap in the literature

Functionalization of cork agglomerate composite with pcm microcapsules after dbd plasma treatment

This research intends to study the influence of dielectric barrier discharge (DBD) plasma treatment on the adsorption of Phase Change Materials (PCM) microcapsules applied to cork agglomerate laminated with a polymer membrane. Several experimental techniques were used to evaluate cork and membrane surface modification after plasma treatment and the influence on the microcapsules adsorption, namely, Static and Dynamic Contact Angle, Energy Dispersive Spectroscopy (EDS), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Tensile Strength. The plasma treatment greatly increases the hydrophilicity of both materials, justifying that more microcapsules are adsorbed on this composite. Chemical and physical characterization of the cork agglomerate and polymer membrane confirmed significant surface alteration.The authors gratefully acknowledge the financial support from - Programme CsF–CNPq and CAPES Foundation, Brazil, for the doctoral grants 202539/2011-3 and BEX0978/12-4. The authors would also like to express their acknowledgment to FCT and FEDER-COMPETE funding, under the project PEst-C/CTM/UI0264/2011