Multicriteria Decision Aid To Implement An On-farm Storage System For Soybeans

Implementing an on-farm storage system for agricultural products becomes a complex decision problem when considering risks, benefits, uncertainties and alternatives. This study aimed at applying the multicriteria decision aid (MCDA) approach to select the infrastructure to be implemented, taking into account variables and farmer's goals. As a result, we concluded that the adopted approach was useful since it allowed a better understanding of the problem and provided decision-making support.3661250126

Multicriteria decision aid to implement an on-farm storage system for soybeans

Implementing an on-farm storage system for agricultural products becomes a complex decision problem when considering risks, benefits, uncertainties and alternatives. This study aimed at applying the multicriteria decision aid (MCDA) approach to select the infrastructure to be implemented, taking into account variables and farmer's goals. As a result, we concluded that the adopted approach was useful since it allowed a better understanding of the problem and provided decision-making support3661250126

Creep and Fracture in Concrete: A Fractional Order Rate Approach

The paper analyses the interaction between strain-softening and time-dependent behaviour in the case of quasi-static fracture of concrete. A viscous element based on a fractional order rate law is coupled with a micromecanical model for the fracture process zone. This approach makes it possible to include a whole range of dissipative mechanisms in a single rheological element. Creep fracture in mode I conditions is analysed through the finite element method, the cohesive (or fictitious) crack model and a new space and time integration scheme. The comparison with creep tests executed on three-point bending conditions shows a good agreement

Occupational Exposure to Metal Engineered Nanoparticles: A Human Biomonitoring Pilot Study Involving Italian Nanomaterial Workers

Advances in nanotechnology have led to an increased use of engineered nanoparticles (ENPs) and the likelihood for occupational exposures. However, how to assess such exposure remains a challenge. In this study, a methodology for human biomonitoring, based on Single Particle Inductively Coupled Plasma Mass Spectrometry (SP-ICP-MS), was developed as a tool to assess the ENPs exposure of workers involved in nanomaterial activities in two Italian Companies. The method was validated for size and number concentration determination of Ag, Au, In2O3, Ir, Pd, Pt, and TiO2 NPs in urine and blood samples. The results showed the presence of In2O3 NPs in blood of exposed workers (mean, 38 nm and 10,371 particles/mL), but not in blood of controls. Silver, Au, and TiO2 NPs were found in urine (mean, Ag 29 nm and 16,568 particles/mL) or blood (mean, Au 15 nm and 126,635 particles/mL; TiO2 84 nm and 27,705 particles/mL) of workers, though these NPs were found also in controls. The presence of ENPs in both workers and controls suggested that the extra-professional exposure is a source of ENPs that cannot be disregarded. Iridium, Pd, and Pt NPs were not detected neither in blood nor in urine. Overall, the findings provided a rational basis to evaluate the exposure assessment to ENPs in cohorts of workers as part of risk assessment and risk management processes in workplaces

How accurate are pedotransfer functions for bulk density for Brazilian soils?

The aim of this study was to evaluate the predictive capability of PTFs available in the literature to estimate soil pb in different regions of Brazil, using different metrics (mean absolute error (MAE), root mean squared error (RMSE), mean error (ME) and regression error characteristic (REC) curve)

The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection

Cellular immune responses are a critical part of the host's defense against intracellular bacterial infections. Immunity to Brucella abortus crucially depends on antigen-specific T cell-mediated activation of macrophages, which are the major effectors of cell-mediated killing of this organism. T lymphocytes that proliferate in response to B. abortus were characterized for phenotype and cytokine activity. Human, murine, and bovine T lymphocytes exhibited a type 1 cytokine profile, suggesting an analogous immune response in these different hosts. In vivo protection afforded by a particular cell type is dependent on the antigen presented and the mechanism of antigen presentation. Studies using MHC class I and class II knockout mice infected with B. abortus have demonstrated that protective immunity to brucellosis is especially dependent on CD8+ T cells. To target MHC class I presentation we transfected ex vivo a murine macrophage cell line with B. abortus genes and adoptively transferred them to BALB/c mice. These transgenic macrophage clones induced partial protection in mice against experimental brucellosis. Knowing the cells required for protection, vaccines can be designed to activate the protective T cell subset. Lastly, as a new strategy for priming a specific class I-restricted T cell response in vivo, we used genetic immunization by particle bombardment-mediated gene transfer

Modelagem computacional do crescimento de cana-de-açúcar para predição de produtividade potencial.

Resumo- Neste artigo é apresentado um modelo ecofisiológico-matemático (BrCane) para predizer a produtividade potencial - sem restrições nutricionais ou de água -, a fim de analisar a sustentabilidade da expansão do cultivo de cana-de-açúcar em novas áreas para produção de etanol. A arquitetura do modelo BRCANE foi concebida para uma planta tipo C4, onde a evolução mensal da biomassa foi estimada em função da temperatura do ar e da radiação incidente. Nas simulações apresentadas a produção de biomassa levou em conta a taxa bruta de fotossíntese subtraídas as perdas para respiração de manutenção, senescência de folhas e morte de perfilhos durante o ciclo da cultura. O modelo BRCANE também foi usado para descrever o comportamento fisiológico em função das condições ambientais relacionadas ao tempo termal. A implementação de tais condições permitiu ajustar os resultados das simulações a resultados experimentais disponíveis na literatura. As estimativas de biomassa foram comparadas com dados obtidos durante o ciclo da cultura em experimentos de campo com irrigação (Cultivares RB72 454, NA 56-79, CB 41-76, CB47-355, CP51-22, Q138 e Q141) no Estado de São Paulo (Brasil) e em Bundaberg e Queensland (Austrália) e os resultados foram expressos em toneladas de colmo por hectare (Mg.ha-1), por meio de uma relação linear para cada variedade (R2 = 0,88). O modelo apresentou resultados consistentes com dados experimetais para crescimento de biomassa no ciclo da cultura da cana-de-açúcar.bitstream/item/65018/1/boletim31.pd

Metabolomics and Lipidomics Profiling of a Combined Mitochondrial Plus Endoplasmic Reticulum Fraction of Human Fibroblasts: A Robust Tool for Clinical Studies

Mitochondria and endoplasmic reticulum (ER) are physically and functionally connected. This close interaction, via mitochondria-associated membranes, is increasingly explored and supports the importance of studying these two organelles as a whole. Metabolomics and lipidomics are powerful approaches for the exploration of metabolic pathways that may be useful to provide deeper information on these organelles\u27 functions, dysfunctions, and interactions. We developed a quick and simple experimental procedure for the purification of a mitochondria-ER fraction from human fibroblasts. We applied combined metabolomics and lipidomics analyses by mass spectrometry with excellent reproducibility. Seventy-two metabolites and 418 complex lipids were detected with a mean coefficient of variation around 12%, among which many were specific to the mitochondrial metabolism. Thus this strategy based on robust mitochondria-ER extraction and "omics" combination will be useful for investigating the pathophysiology of complex diseases