Improved methods for the travelling salesperson problem with hotel selection

In this talk, a new formulation and a new metaheuristic solution procedure for the travelling salesperson problem with hotel selection (TSPHS) is presented. The metaheuristic is a multi-start procedure that outperforms existing heuristics on all benchmark instances. We also provide a number of new optimal solutions found by a commercial solver extended with a dedicated cutting plane procedure, as well as new best known solutions for most benchmark instances

The Relationship between Grade-Level and Breakfast Skipping among Adolescents: The Mediating Effects of Dietary Autonomy

Breakfast skipping among adolescents in the United States is a public health issue because it has adverse consequences on dietary intake and body mass index. The primary aim of this study is to examine the relationship between grade level and reported breakfast skipping among adolescents and whether it is mediated by dietary autonomy. Analyses were based on self-reported data from Wave I of the National Longitudinal Study of Adolescent Health, a nationally representative sample of adolescents in the United States surveyed in 1995. Logistic regression analysis was used to evaluate the effects of grade level and dietary autonomy on adolescents’ reported breakfast skipping. Following MacKinnon and Dwyer, we tested whether the effect of grade level on breakfast skipping was mediated by adolescents’ dietary autonomy. After controlling for sex, race, exercise, parental education, and household income, both grade level (OR = 2.005, 95% CI = 1.684-2.387) and dietary autonomy (OR = 1.435, 95% CI = 1.157-1.780) were each significant predictors of breakfast skipping when tested separately. Mediation analysis showed that dietary autonomy partially mediated the relationship between grade-level and breakfast skipping. Since adolescents in higher grades and those with more dietary autonomy are more likely to skip breakfast, nutritional messages may need to continue beyond the lower grades and emphasize that healthy eating habits can demonstrate autonomy

Optimism and Planning for Future Care Needs Among Older Adults

Aging is associated with an increase in need for assistance. Preparation for future care (PFC) is related to improved coping ability as well as better mental and physical health outcomes among older adults. We examined the association of optimism with components of PFC among older adults. We also explored race differences in the relationship between optimism and PFC. In Study 1, multiple regression showed that optimism was positively related to concrete planning. In Study 2, optimism was related to gathering information. An exploratory analysis combining the samples yielded a race interaction: For Whites higher optimism, but for Blacks lower optimism was associated with more planning. High optimism may be a barrier to future planning in certain social and cultural contexts

Persistent clinical efficacy and safety of anti-tumour necrosis factor \textgreeka therapy with infliximab in patients with ankylosing spondylitis over 5 years: evidence for different types of response

Background: There is insufficient evidence for the long-term efficacy and safety of anti-tumour necrosis factor therapy in patients with ankylosing spondylitis (AS). This is the first report on the treatment with infliximab over 5 years.Methods: As part of a multicentre randomised trial, 69 patients with active AS at baseline (BL) have been continuously treated with infliximab (5 mg/kg i.v. every 6 weeks)---except for a short discontinuation after 3 years (FU1). The primary outcome of this extension was remission according to the ASsessment in Ankylosing Spondylitis (ASAS) criteria at the end of year 5 of the study (FU2).Results: Of the 43 patients who completed year 3, 42 agreed to continue, 38 of which (90.5%) finished year 5 (55% of 69 initially). Partial clinical remission was achieved in 13 of 38 patients (34.2%) at FU1 and FU2. At FU2, the mean Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was 2.5±1.9 (BL:6.4, FU1:2.5). BASDAI values <4 were seen in 79% of patients at both, FU1 and FU2. ASAS 20% and 40% responses were seen in 32 (84%) and 24 (63%) patients at FU2, respectively. Most patients classified as non-responders at FU2 were part-time responders, as all but one patient achieved an ASAS 20% response at least once within the last 2 years. Three types of responders were identified. No major side effects occurred during years 4 and 5 of infliximab therapy.Conclusions: Infliximab is safe and efficacious in AS patients over 5 years. The majority of the patients remained on treatment and had rather persistent levels of low disease activity. Different response types could be identified

The Unusual Distributions of Ionized Material and Molecular Hydrogen in NGC 6881: Signposts of Multiple Events of Bipolar Ejection in a Planetary Nebula

The planetary nebula NGC 6881 displays in the optical a quadrupolar morphology consisting of two pairs of highly collimated bipolar lobes aligned along different directions. An additional bipolar ejection is revealed by the hydrogen molecular emission, but its wide hourglass morphology is very different from that of the ionized material. To investigate in detail the spatial distribution of molecular hydrogen and ionized material within NGC 6881, and to determine the prevalent excitation mechanism of the H2 emission, we have obtained new near-IR Br-gamma and H2 and optical H-alpha and [N II] images, as well as intermediate resolution JHK spectra. These observations confirm the association of the H2 bipolar lobes to NGC 6881 and find that the prevalent excitation mechanism is collisional. The detailed morphology and very different collimation degree of the H2 and ionized bipolar lobes of NGC 6881 not only imply that multiple bipolar ejections have occurred in this nebula, but also that the dominant shaping agent is different for each bipolar ejection: a bipolar stellar wind most likely produced the H2 lobes, while highly collimated outflows are carving out the ionized lobes into the thick circumstellar envelope. The asymmetry between the southeast and northwest H2 bipolar lobes suggests the interaction of the nebula with an inhomogeneous interstellar medium. We find evidence that places NGC 6881 in the H II region Sh 2-109 along the Orion local spiral arm.Comment: 9 pages, 7 figures, 4 table

Recurrence is required to capture the representational dynamics of the human visual system.

The human visual system is an intricate network of brain regions that enables us to recognize the world around us. Despite its abundant lateral and feedback connections, object processing is commonly viewed and studied as a feedforward process. Here, we measure and model the rapid representational dynamics across multiple stages of the human ventral stream using time-resolved brain imaging and deep learning. We observe substantial representational transformations during the first 300 ms of processing within and across ventral-stream regions. Categorical divisions emerge in sequence, cascading forward and in reverse across regions, and Granger causality analysis suggests bidirectional information flow between regions. Finally, recurrent deep neural network models clearly outperform parameter-matched feedforward models in terms of their ability to capture the multiregion cortical dynamics. Targeted virtual cooling experiments on the recurrent deep network models further substantiate the importance of their lateral and top-down connections. These results establish that recurrent models are required to understand information processing in the human ventral stream