Splenic and hepatic artery aneurysm: a case report

Visceral artery aneurysms (VAA) have an incidence of 0.01-2% and are mainly diagnosed as an incidental finding in imaging studies done for other reasons. Their mortality when ruptured can be as high has 75%. We present a rare case of multiple visceral artery aneurysms that presented as dull abdominal pain and were managed with open surgery in accordance to specific treatment criteria

Jejuno-colonic anastomosis to restore intestinal continuity in a case of intestinal failure due to type I short bowel syndrome

Short bowel syndrome is a rare surgical complication associated with high morbidity and mortality, significant decrease in quality of life and increasing costs to the healthcare system. In some cases, this condition can be mitigated and even reversed if the intestinal transit is restored with a minimum of 75-100 centimeters of small intestine and a segment of the colon. Some of the surgical techniques available within autologous gastrointestinal reconstruction are Serial transverse enteroplasty (STEP), Longitudinal intestinal lengthening (LILT), and as a last resort, intestinal transplantation. We presented a case of intestinal failure due to type I short bowel syndrome who improved in clinical stage from D4 to D2 after intestinal continuity restitution was performed with a jejuno-colonic anastomosis

Violencia política contra las candidatas en el proceso electoral del 2021 en Ecuador por parte de los programas radiales de mayor sintonía: caso Santo Domingo

The objective of this research was to analyze political violence against women in the 2021 elections. The qualitative approach was used to study two radio programs in the city of Santo Domingo that have the largest audience. For data collection, interviews were applied to experts on gender issues and candidates who participated in the electoral process. Similarly, the information published on social networks by both media in 2020 from the pre-electoral campaign was observed. Metricool software was used to categorize, code and tabulate the interviews; and case studies to interpret the information. As main findings, forms of violence were identified at the time of addressing the interviews with the candidates by the interviewers, such as: the use of language, confrontation, the number of interviewees and the reduced interview time. The permanent pressure exerted by journalists when addressing issues with the candidates was also observed, which lack political and social relevance by not responding to campaign proposals but to actions from their private lives.La presente investigación tuvo por objetivo analizar la violencia política contra las mujeres en las elecciones 2021. Se utilizó el enfoque cualitativo con el cual se estudiaron dos programas radiales de la ciudad de Santo Domingo que cuentan con mayor audiencia. Para la recolección de datos se aplicaron entrevistas a expertas en temas de género y a candidatas que participaron en el proceso electoral. De igual manera, se observó la información publicada en redes sociales por ambos medios en el 2020 a partir de la pre-campaña electoral. Se utilizó el software Metricool para categorizar, codificar y tabular las entrevistas; y el estudio de casos para interpretar la información. Como principales hallazgos se identificaron formas de violencia al momento de abordar las entrevistas con las candidatas por parte de los entrevistadores, tales como: el uso del lenguaje, la confrontación, el número de entrevistadas y el reducido tiempo de entrevista. También se observó la presión permanente que ejercen los periodistas al momento de abordar los temas con las candidatas, los cuales carecen de relevancia política y social al no responder a las propuestas de campaña sino a acciones de sus vidas privada

Percepción de la seguridad turística en el Cerro San Cristóbal, Lima, 2020

turística en el Cerro San Cristóbal”, Lima, 2020, tuvo como objetivo determinar la percepción de la seguridad turística en el Cerro San Cristóbal. La metodología presentó un tipo de investigación aplicada con un enfoque cuantitativo y un diseño no experimental de corte transaccional de nivel descriptivo. Se consideró como población a todos los residentes limeños que hayan visitado el destino al menos una vez en los últimos 5 años, teniendo como muestra de 69 personas, a quienes se les aplicó un cuestionario como instrumento de recopilación de datos, el cual permitió llegar a los resultados respecto a nuestra variable de estudio. Los resultados obtenidos permitieron determinar el nivel de percepción de la seguridad turística en el Cerro San Cristóbal Lima, 2020, obteniendo así un nivel medio con un 72.5%, un nivel bajo con el 20.3% y un nivel alto con un 7.2%. Concluyendo que no existe una seguridad turística adecuada y que se necesita una mejor gestión

A pilot study applying the plant Anchored Hybrid Enrichment method to New World sages (Salvia subgenus Calosphace; Lamiaceae)

We conducted a pilot study using Anchored Hybrid Enrichment to resolve relationships among a mostly Neotropical sage lineage that may have undergone a recent evolutionary radiation. Conventional markers (ITS, trnL-trnF and trnH-psbA) have not been able to resolve the relationships among species nor within portions of the backbone of the lineage. We sampled 12 representative species of subgenus Calosphace and included one species of Salvia´s s.l. closest relative, Lepechinia, as outgroup. Hybrid enrichment and sequencing were successful, yielding 448 alignments of individual loci with an average length of 704. bp. The performance of the phylogenomic data in phylogenetic reconstruction was superior to that of conventional markers, increasing both support and resolution. Because the captured loci vary in the amount of net phylogenetic informativeness at different phylogenetic depths, these data are promising in phylogenetic reconstruction of this group and likely other lineages within Lamiales. However, special attention should be placed on the amount of phylogenetic noise that the data could potentially contain. A prior exploration step using phylogenetic informativeness profiles to detect loci with sites with disproportionately high substitution rates (showing "phantom" spikes) and, if required, the ensuing filtering of the problematic data is recommended. In our dataset, filtering resulted in increased support and resolution for the shallow nodes in maximum likelihood phylogenetic trees resulting from concatenated analyses of all the loci. Additionally, it is expected that an increase in sampling (loci and taxa) will aid in resolving weakly supported, short deep internal branches.Fil: Fragoso Martínez, Itzi. Universidad Nacional Autónoma de México; México. Institute Of Biology Of Unam;Fil: Salazar, Gerardo A.. Universidad Nacional Autónoma de México; MéxicoFil: Martínez Gordillo, Martha. Universidad Nacional Autónoma de México; MéxicoFil: Magallón, Susana. Universidad Nacional Autónoma de México; MéxicoFil: Sánchez-Reyes, Luna. Universidad Nacional Autónoma de México; MéxicoFil: Moriarty Lemmon, Emily. Florida State University; Estados UnidosFil: Lemmon, Alan R.. Florida State University; Estados UnidosFil: Sazatornil, Federico David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Granados Mendoza, Carolina. Instituto Potosino de Investigación Científica y Tecnológica; México. Universidad Nacional Autónoma de México; Méxic

Loss of smell and taste can accurately predict COVID-19 infection: a machine-learning approach

The COVID-19 outbreak has spread extensively around the world. Loss of smell and taste have emerged as main predictors for COVID-19. The objective of our study is to develop a comprehensive machine learning (ML) modelling framework to assess the predictive value of smell and taste disorders, along with other symptoms, in COVID-19 infection. A multicenter case-control study was performed, in which suspected cases for COVID-19, who were tested by real-time reversetranscription polymerase chain reaction (RT-PCR), informed about the presence and severity of their symptoms using visual analog scales (VAS). ML algorithms were applied to the collected data to predict a COVID-19 diagnosis using a 50-fold cross-validation scheme by randomly splitting the patients in training (75%) and testing datasets (25%). A total of 777 patients were included. Loss of smell and taste were found to be the symptoms with higher odds ratios of 6.21 and 2.42 for COVID-19 positivity. The ML algorithms applied reached an average accuracy of 80%, a sensitivity of 82%, and a specificity of 78% when using VAS to predict a COVID-19 diagnosis. This study concludes that smell and taste disorders are accurate predictors, with ML algorithms constituting helpful tools for COVID-19 diagnostic prediction.Junta de Andalucí

Topical Application of Glycolipids from Isochrysis galbana Prevents Epidermal Hyperplasia in Mice

Chronic inflammatory skin diseases such as psoriasis have a significant impact on society. Currently, the major topical treatments have many side effects, making their continued use in patients difficult. Microalgae have emerged as a source of bio-active molecules such as glycolipids with potent anti-inflammatory properties. We aimed to investigate the effects of a glycolipid (MGMG-A) and a glycolipid fraction (MGDG) obtained from the microalga Isochrysis galbana on a TPA-induced epidermal hyperplasia murine model. In a first set of experiments, we examined the preventive effects of MGMG-A and MGDG dissolved in acetone on TPA-induced hyperplasia model in mice. In a second step, we performed an in vivo permeability study by using rhodamine-containing cream, ointment, or gel to determinate the formulation that preserves the skin architecture and reaches deeper. The selected formulation was assayed to ensure the stability and enhanced permeation properties of the samples in an ex vivo experiment. Finally, MGDG-containing cream was assessed in the hyperplasia murine model. The results showed that pre-treatment with acetone-dissolved glycolipids reduced skin edema, epidermal thickness, and pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6, IL-17) in epidermal tissue. The in vivo and ex vivo permeation studies showed that the cream formulation had the best permeability profile. In the same way, MGDG-cream formulation showed better permeation than acetone-dissolved preparation. MGDG-cream application attenuated TPA-induced skin edema, improved histopathological features, and showed a reduction of the inflammatory cell infiltrate. In addition, this formulation inhibited epidermal expression of COX-2 in a similar way to dexamethasone. Our results suggest that an MGDG-containing cream could be an emerging therapeutic strategy for the treatment of inflammatory skin pathologies such as psoriasis.Ministerio de Economía y Competitividad IPT-2012-1370-060000Junta de Andalucía P12-AGR-43

Why don't we share data and code? Perceived barriers and benefits to public archiving practices

The biological sciences community is increasingly recognizing the value ofopen, reproducible and transparent research practices for science and societyat large. Despite this recognition, many researchers fail to share their dataand code publicly. This pattern may arise from knowledge barriers abouthow to archive data and code, concerns about its reuse, and misalignedcareer incentives. Here, we define, categorize and discuss barriers to dataand code sharing that are relevant to many research fields. We explorehow real and perceived barriers might be overcome or reframed in thelight of the benefits relative to costs. By elucidating these barriers and thecontexts in which they arise, we can take steps to mitigate them and alignour actions with the goals of open science, both as individual scientistsand as a scientific community

Maraviroc Failed to Control Progressive Multifocal Leukoencephalopathy-Associated IRIS in a Patient with Advanced HIV Infection

Due to the lack of therapeutic options for patients with progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-associated IRIS), maraviroc has generated expectations among the medical community. However, we report a patient with advanced HIV infection, who developed PML-associated IRIS and had a fatal outcome despite the addition of maraviroc to suppressive ART. Future studies are required to define the therapeutic role of maraviroc in PML-associated IRIS and differentiate individuals who may benefit from maraviroc from those who may develop neurological deterioration

Simulación de una planta para la hidratación de etileno empleando el simulador ProMax 3.2

En el presente trabajo se realizó la simulación de las diversas etapas que conforman una planta de producción de etanol, de la cual se utilizó etileno como materia prima, empleando el simulador ProMax 3.2 (Bryan Research & Engineering, Inc.), en dicho proceso se considera una producción de 210 Kg / h. Para el desarrollo del proyecto se realizó el balance de materia y energía correspondiente para cada operación unitaria que en conjunto constituyen el proceso químico; además se determinaron las condiciones óptimas de operación de las corrientes pertinentes. Adicionalmente se determinó eficiencia de operación del reactor, también los rendimientos de los intercambiadores de calor y bombas, por último, se determinaron las dimensiones óptimas de las piezas de los componentes en cada operación unitaria; para concluir se determinó el valor promedio para construcción de la planta.In this work, we performed the simulation of the various stages that make up an ethanol production plant, from which ethylene was used as raw material, using the ProMax 3.2 simulator (Bryan Research & Engineering, Inc.), in this process it’s consider a 210 kg / h for production. For the development of the project, the material and energy balance for each unit operation that together constitute the chemical process was made; in addition, the optimum operating conditions of the relevant currents were determined. In addition, reactor operating efficiency, yields of heat exchangers and pumps were also determined; finally, the optimum dimensions of the component parts were determined in each unit operation; to conclude, the average value for the construction of the plant was determined