Análisis del aprovechamiento del programa Absys en Andalucía hasta marzo de 1999

The degree of implementation of the Absys library programme in the centres included in the corporate license held by the Andalusian regional government is analysed focussing on 4 aspects: library/centre resources, use of the 8 basic functions of Absys, reference manuals and technical support. Of the 109 questionnaires sent to the 8 Andalusian provinces, 104 were returned fully answered: 6 from Almeria, 5 from Cadiz, 16 from Cordoba, 18 from Granada, 19 from Huelva, 4 from Jaen, 15 from Malaga and 21 from Seville. The province where there are the highest number of installations of the programme is Seville, followed by Huelva, Granada, Málaga and Cordoba

The hematopoietic stem-cell niche in health and leukemia.

Research in the last decade has shown that hematopoietic stem cells (HSCs) interact with and are modulated by a complex multicellular microenvironment in the bone marrow, which includes both the HSC progeny and multiple non-hematopoietic cell types. Intense work is gradually throwing light on the composition of the HSC niche and the molecular cues exchanged between its components, which has implications for HSC production, maintenance and expansion. In addition, it has become apparent that bidirectional interactions between leukemic cells and their niche play a previously unrecognized role in the initiation and development of hematological malignancies. Consequently, targeting of the malignant niche holds considerable promise for more specific antileukemic therapies. Here we summarize the latest insights into HSC niche biology and recent work showing multiple connections between hematological malignancy and alterations in the bone marrow microenvironment.This work was supported by core support grants from the Wellcome Trust and MRC to the Cambridge Stem Cell Institute, the Spanish Ministry of Economy and Competitiveness (SAF-2011-30308), Pro-CNIC Foundation, Severo Ochoa Center of Excellence award SEV-2015-0505 to CNIC, TerCel (Spanish Cell Therapy Network), Ramón y Cajal Program grants RYC-2011-09726 to AS-A and RYC-2009-04703 to SM-F), Marie Curie Career Integration Program grants (FP7-PEOPLE-2011-RG-294262/294096) to AS-A and SM-F; and a ConSEPOC-Comunidad de Madrid grant (S2010/BMD-2542) and Horizon2020 (ERC-2014-CoG-64765 grant to SM-F. This research was partly funded by a European Hematology Association Research Fellowship awarded to AS-A and an International Early Career Scientist Grant from the Howard Hughes Medical Institute to SM-F.This is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s00018-016-2306-

Video-based assistance system for training in minimally invasive surgery

In this paper, the development of an assisting system for laparoscopic surgical training is presented. With this system, we expect to facilitate the training process at the first stages of training in laparoscopic surgery and to contribute to an objective evaluation of surgical skills. To achieve this, we propose the insertion of multimedia contents and outlines of work adapted to the level of experience of trainees and the detection of the movements of the laparoscopic instrument into the monitored image. A module to track the instrument is implemented focusing on the tip of the laparoscopic tool. This tracking method does not need the presence of artificial marks or special colours to distinguish the instruments. Similarly, the system has another method based on visual tracking to localize support multimedia content in a stable position of the field of vision. Therefore, this position of the support content is adapted to the movements of the camera or the working area. Experimental results are presented to show the feasibility of the proposed system for assisting in laparoscopic surgical training

Uso del análisis isotópico del carbono y del nitrógeno en la trazabilidad de productos derivados del cerdo ibérico

La producción tradicional de cerdo Ibérico es un claro ejemplo de sistema extensivo de producción animal sostenible, respetuosa con el entorno, en la línea marcada por las tendencias actuales de la Política Agraria de los países de la Unión Europea. La pureza racial y la alimentación basada en la bellota, en la fase fi nal de cebo durante la montanera en la dehesa mediterránea, son los dos principales factores que afectan a la calidad de los productos derivados de la industria del cerdo Ibérico. El alto valor económico que alcanzan los productos curados cuando proceden de animales producidos en las citadas condiciones hace necesaria la regulación e identifi cación de los productos que cumplen estos requisitos. Las relaciones isotópicas 15N/14N y 13C/12C determinadas en tejidos de cerdo Ibérico al sacrifi cio tienen cierto valor potencial como método de identificación y control del tipo de alimentación al que ha estado sometido el animal durante la fase final de cebo previa al sacrificio, es decir, constituyen una herramienta prometedora en la trazabilidad de materiales para diferenciar animales de bellota, recebo y cebo a pienso. Se analizan las variaciones en estas relaciones isotópicas debidas a los tres tipos de alimentación mencionados, en un trabajo de carácter preliminar realizado en colaboración con el Grupo de Biogeoquímica de Isótopos estables de la Estación Experimental del Zaidín

Environmental movements and management alternatives from a sustainability and environmental ethics scope

El presente texto describe las raíces conceptuales de la gestión ambiental y presenta la crítica desde la ética ambiental, para lo cual hace una lectura de los autores representativos. Así, ambientalismo conservacionista, ambientalismo moderado y humanismo crítico se identifican como las corrientes referentes de la gestión ambiental actual, al tiempo que existen otras posturas o visiones alternativas que merecen ser consideradas para el abordaje de la gestión ambiental territorial.This paper describes de conceptual roots of environmental management and offers a criticism from an environmental ethics point of view, for which it makes a reading of representative authors. This way, conservative environmentalism, Moderate Environmentalism and Critical Humanism are identified as currents that serve as referents of current environmental management. At the same time other existent postures and alternative visions deserve to be considered for the territorial environmental management approachO presente texto descreve as raízes conceituais da gestão ambientale apresenta a crítica desde a ética ambiental, para o qual faz uma leitura dos autores representativos. Assim, Ambientalismo Conservacionista, Ambientalismo Moderado e Humanismo Crítico se identificam como as correntes referentes da gestão ambiental atual, ao mesmo tempo em que existem outras posturas ou visões alternativas que merecem ser consideradas para a abordagem da gestão ambiental territorial

Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study

Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 lowgrade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.La Marato de TV-3 553/C/2019 PID2020-114921RB-C21 PI18/0191 PI22/0412CIBERFES CB16/10/00269Instituto de Salud Carlos III Spanish GovernmentEuropean Union (EU)Generalitat de Catalunya's Agency AGAUR 2021SGR00687Maria de Maeztu Unit of Excellence CEX2021-001234-MMICIN/AEI/FEDER, UEEuropean Union (EU) 2005328Department of Epidemiology and Biostatistics, School of Public HealthDanish Cancer SocietyLigue nationale contre le cancerInstitut Gustave RoussyMutuelle Generale de l'Education NationaleInstitut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeHelmholtz AssociationGerman Institute of Human Nutrition Potsdam-Rehbruecke (DIfE)Federal Ministry of Education & Research (BMBF)Fondazione AIRC per la ricerca sul cancroCompagnia di San PaoloDutch Ministry of Public Health, Welfare and Sports (VWS)Netherlands Cancer Registry (NKR)LK Research FundsDutch Prevention FundsNetherlands Organization for Scientific Research (NWO)Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII)Regional Governments of Andalucia, Asturias, Basque Country, Murcia and NavarraCatalan Institute of Oncology-ICO (Spain)Swedish Cancer SocietySwedish Research Council and County Councils of Skane and Vaesterbotten (Sweden)Cancer Research UK 14136 C8221/A29017UK Research & Innovation (UKRI) Medical Research Council UK (MRC) 1000143 MR/M012190/1Sara Borrell CPII20/00009Generalitat de Catalunya's Agency AGAUR 2021SGR00481Miguel Servet IIInstituto de Salud Carlos III Spanish Governmen