Síndrome de edema transitorio de médula ósea en tibia. A propósito de un caso

El término "Síndrome de edema transitoro de médula ósea" (SETMO) se utiliza para definir un modelo de edema óseo difuso en imágenes por RNM, en ausencia de osteopenia demostrada radiológicamente y en el cual se descarte otro diagnóstico. La localización más frecuente es a nivel femoral proximal, aunque puede observare en rodillas, tobillos, y con menor frecuencia a nivel de diáfisis tibial, donde han sido descritos cuatro casos. En nuestro trabajo presentamos un caso de SETMO localizado en diáfisis de tibia, resuelto espontáneamente a los 4 meses, y que tras un periodo de seguimiento de tres años permanece asintomático.The term "Transient bone marrow edema" (TBME like Síndrome) is utilized to define a model of bone marrow edema diffuse in images by MR, in absence of osteopenia shown by means of radiologic diagnosis and in which another diagnosis be discarded. The most frequent locating is in the proximal femur, although can be observed in knee, ankle, and with smaller frequency to level of tibial diaphysis, where they have been described four cases. In our study we present a case of TBME located in tibial diaphysis, resolved spontaneously to the 4 months, and that after a period of follow-up of three years remains without symptoms

Reading-related Cognitive Deficits in Spanish Developmental Dyslexia

AbstractSpanish-speaking children learn to read words written in a relatively transparent orthography. Variations in orthographic transparency may shape the manifestation of reading difficulties. This study was intended to help clarify the nature of developmental dyslexia in Spanish. Developmentally Dyslexic children (DD) were compared to a chronological age-matched control group (CA). Measures included rapid automated naming, verbal working memory, phonological short-term memory, and phonemic awareness. Results demonstrated that developmental dyslexics show reading-related cognitive deficits in areas such as naming speed, verbal working memory, phonological short-term memory, and phonemic awareness. Our results are consistent with studies conducted in the Spanish language and in other transparent orthographies

Nested species-rich networks of scavenging vertebrates support high levels of interspecific competition

Disentangling the processes that shape the organization of ecological assemblages and its implications for species coexistence is one of the foremost challenges of ecology. Although insightful advances have recently related community composition and structure with species coexistence in mutualistic and antagonistic networks, little is known regarding other species assemblages, such as those of scavengers exploiting carrion. Here we studied seven assemblages of scavengers feeding on ungulate carcasses in mainland Spain. We used dynamical models to investigate if community composition, species richness and structure (nestedness) affect species coexistence at carcasses. Scavenging networks showed a nested pattern in sites where highly efficient, obligate scavengers (i.e., vultures) were present and a non- nested pattern everywhere else. Griffon Vulture ( Gyps fulvus ) and certain meso- facultative mammalian scavengers (i.e., red fox, Vulpes vulpes, and stone marten, Martes foina ) were the main species contributing to nestedness. Assemblages with vultures were also the richest ones in species. Nested species- rich assemblages with vulture presence were associated with high carcass consumption rates, indicating higher interspecific competition at the local scale. However, the proportion of species stopping the consumption of carrion (as derived from the competitive dynamic model) stabilized at high richness and nestedness levels. This suggests that high species richness and nestedness may characterize scavenging networks that are robust to high levels of interspecific competition for carrion. Some facilitative interactions driven by vultures and major facultative scavengers could be behind these observations. Our findings are relevant for understanding species' coexistence in highly competitive systemsE. Sebastián- González and P. R. Guimarães benefited from FAPESP Research Foundation grants numbers 2011/17968- 2 and 2009/054422- 8, respectively; E. Sebastián- González is currently funded under the NSF grant NSF Award #1345247, M. Moleón by a postdoctoral grant from the Spanish Ministry of Education (Plan Nacional de I+D+I 2008- 2011), J. P. Gibert by an Other Fellowship and SBS Special Funds (U. of N.), and P. Mateo-Tomás by a postdoctoral grant of the Junta de Comunidades de Castilla-La Mancha and Fondo Social Europeo. The study was supported by the Spanish Ministry of Science and Innovation through projects 23/2007 ICTS- RBD, CGL2009- 12753- C02- 02, and CGL2012- 40013- C02- 02, FEDER funds, the Generalitat Valenciana through project ACOMP/2012/147, and the Junta de Andalucía through project RNM- 192

Nested species- rich networks of scavenging vertebrates support high levels of interspecific competition.

Disentangling the processes that shape the organization of ecological assemblages and its implications for species coexistence is one of the foremost challenges of ecology. Although insightful advances have recently related community composition and structure with species coexistence in mutualistic and antagonistic networks, little is known regarding other species assemblages, such as those of scavengers exploiting carrion. Here we studied seven assemblages of scavengers feeding on ungulate carcasses in mainland Spain. We used dynamical models to investigate if community composition, species richness and structure (nestedness) affect species coexistence at carcasses. Scavenging networks showed a nested pattern in sites where highly efficient, obligate scavengers (i.e., vultures) were present and a non- nested pattern everywhere else. Griffon Vulture ( Gyps fulvus ) and certain meso- facultative mammalian scavengers (i.e., red fox, Vulpes vulpes, and stone marten, Martes foina ) were the main species contributing to nestedness. Assemblages with vultures were also the richest ones in species. Nested species- rich assemblages with vulture presence were associated with high carcass consumption rates, indicating higher interspecific competition at the local scale. However, the proportion of species stopping the consumption of carrion (as derived from the competitive dynamic model) stabilized at high richness and nestedness levels. This suggests that high species richness and nestedness may characterize scavenging networks that are robust to high levels of interspecific competition for carrion. Some facilitative interactions driven by vultures and major facultative scavengers could be behind these observations. Our findings are relevant for understanding species' coexistence in highly competitive systems

Body composition and somatotype in professional men's handball according to playing positions

Se realizó un estudio descriptivo transversal en 19 jugadores profesionales del Club Balonmano Valladolid. Las mediciones antropométricas fueron realizadas según el protocolo estándar. Se estimaron la masa grasa y ósea, se calculó el somatotipo y se analizaron las diferencias entre las variables en función de la posición. Como resultados, se obtuvo que los pivotes fueron los jugadores más pesados (con mayor porcentaje de masa grasa); los extremos, los más ligeros y los laterales, junto con los pivotes, los más altos. No se observaron diferencias en el IMC en los grupos. En la somatocarta los centrales y laterales se situaron en la zona central; los extremos y los pivotes en la endomorfa-mesomorfa y los porteros en la ecto-endomorfa. Así se evidenció que las variables antropométricas, los datos de composición corporal y la somatocarta de los deportistas confirman las características morfológicas básicas de los jugadores para la posición para la que son más aptosA cross-sectional descriptive study was accomplished in 19 professional players from Valladolid Handball Club. Anthropometric measurements were performed according to standard protocol. Body fat and bone mass were estimated, and the somatotype was calculated. As results, the line players were significantly the heaviest players; the wings were lightest and the backs, with the line players, the tallest. Nevertheless, no significant differences in BMI were observed. Regarding the body composition, the line players showed the highest values of fat-mass. No differences in BMI were observed in the groups. With respect to the somatochart, the center backs and backs were in the central area; wings and line players showed an endomorph-mesomorph development, and goalkeepers were in the ectoendomorph area. As conclusions, anthropometric variables, body composition data and the somatochart of the athletes evaluated confirm the basic morphological characteristics of the players for the position for which they are best suite

Functional traits driving species role in the structure of terrestrial vertebrate scavenger networks

Species assemblages often have a non-random nested organization, which in vertebrate scavenger (carrion-consuming) assemblages is thought to be driven by facilitation in competitive environments. However, not all scavenger species play the same role in maintaining assemblage structure, as some species are obligate scavengers (i.e., vultures) and others are facultative, scavenging opportunistically. We used a database with 177 vertebrate scavenger species from 53 assemblages in 22 countries across five continents to identify which functional traits of scavenger species are key to maintaining the scavenging network structure. We used network analyses to relate ten traits hypothesized to affect assemblage structure with the “role” of each species in the scavenging assemblage in which it appeared. We characterized the role of a species in terms of both the proportion of monitored carcasses on which that species scavenged, or scavenging breadth (i.e., the species “normalized degree”), and the role of that species in the nested structure of the assemblage (i.e., the species “paired nested degree”), therefore identifying possible facilitative interactions among species. We found that species with high olfactory acuity, social foragers, and obligate scavengers had the widest scavenging breadth. We also found that social foragers had a large paired nested degree in scavenger assemblages, probably because their presence is easier to detect by other species to signal carcass occurrence. Our study highlights differences in the functional roles of scavenger species and can be used to identify key species for targeted conservation to maintain the ecological function of scavenger assemblages.Generalitat Valenciana SEJI/2018/024, APOSTD/2019/016, CIDEGENT/ 2020/030, ACIF/2019/056Ministerio de Educación y Cultura CI-2017-32149, FJCI-2015-25632, IJC2018-036642-I, YC-2019-027216-I, RYC-2015-19231, RYC-2017-2273, GL2012-40013-C02-01/02, CGL2015- 66966-C2-1-R, CGL2015-66966-C2-1-R2, CGL2017-89905-R, RTI2018-099609-B-C21, RTI2018-099609-B-C22Govern de les Illes Balears PD/039/201National Science Centre in Poland 2013/08/M/ NZ9/00469, 2016/22/Z/NZ8/00Slovenian Research Agency P4-0059US Department of Energy DE- EM000439USA National Science Foundation #1255913California Department of Fish & Wildlife P0880013Junta de Andalucía RNM-192

Clinical factors associated with discontinuation of ts/bDMARDs in rheumatic patients from the BIOBADASER III registry

Altres ajuts: Spanish Agency of Medicines and Medical Devices (AEMPS); Biogen; Bristol Myers-Squibb (BMS); Celltrion Healthcare; Lilly; Merck; Novartis; Pfizer; Regeneron Pharmaceuticals; Samsung Bioepis.Biologic and targeted synthetic disease-modifying antirheumatic drugs (ts/bDMARDs) play a pivotal role in the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Persistence of therapy provides an index of a drug's overall effectiveness. The objective of the study was to identify factors associated with discontinuation of ts/bDMARDs in a real-world dataset. The study population comprised patients diagnosed with RA, PsA, and AS included in the BIOBADASER registry for whom follow-up data were available until November 2019. Patient features and treatment data were included in the analysis. The Kaplan-Meier method was used to study survival of the different drugs according to the reason for discontinuation. Factors associated with discontinuation were studied using Cox regression models and bivariate and multivariate analyses. P values of less than 0.05 were regarded as statistically significant. The study population comprised 4,752 patients who received a total of 8,377 drugs, of which 4,411 (52.65%) were discontinued. The Kaplan-Meier curves showed that survival for first-line treatment was greater in all 3 groups (p < 0.001). Patients with RA had a greater risk of discontinuation if they were younger (HR, 0.99; 95% CI 0.99-1.00), if they were receiving anti-TNFα agents (HR, 0.61; 95% CI 0.54-0.70), and if they had more comorbid conditions (HR, 1.09; 95% CI 1.00-1.17). Patients with PsA had a higher risk if they were women (HR, 1.36; 95% CI 1.15-1.62) and if they were receiving other ts/bDMARDs (HR, 1.29; 95% CI 1.05-1.59). In patients with AS, risk increased with age (HR, 1.01; 95% CI 1.00-1.02), as did the number of comorbid conditions (HR, 1.27; 95% CI 1.12-1.45). The factors that most affected discontinuation of ts/bDMARDs were line of treatment, age, type of drug, sex, comorbidity and the year of initiation of treatment. The association with these factors differed with each disease, except for first-line treatment, which was associated with a lower risk of discontinuation in all 3 diseases

An extensive study of dynamical friction in dwarf galaxies: the role of stars, dark matter, halo profiles and MOND

We investigate the in-spiraling timescales of globular clusters in dwarf spheroidal (dSph) and dwarf elliptical (dE) galaxies, due to dynamical friction. We address the problem of these timescales having been variously estimated in the literature as much shorter than a Hubble time. Using self-consistent two-component (dark matter and stars) models, we explore mechanisms which may yield extended dynamical friction timescales in such systems in order to explain why dwarf galaxies often show globular cluster systems. As a general rule, dark matter and stars both give a comparable contribution to the dynamical drag. By exploring various possibilities for their gravitational make-up, it is shown that these studies help constrain the parameters of the dark matter haloes in these galaxies, as well as to test alternatives to dark matter. Under the assumption of a dark haloes having a constant density core, dynamical friction timescales are naturally extended upwards of a Hubble time. Cuspy dark haloes yield timescales $\lesssim$ 4.5 Gyr, for any dark halo parameters in accordance with observations of stellar line-of-sight velocity dispersion in dwarf spheroidal galaxies. We find that under the hypothesis of MOND dynamics, due to the enhanced dynamical drag of the stars, the dynamical friction timescales would be extremely short. Taking the well-measured structural parameters of the Fornax dSph and its globular cluster system as a case study, we conclude that requiring dynamical friction timescales comparable to the Hubble time strongly favours dark haloes with a central core.Comment: 18 pages, four figures, final version, accepted in MNRA

Contribución al conocimiento de la biodiversidad fúngica del Parque Nacional de Ordesa y Monte Perdido II

This paper continues the taxonomic revision of the species collected during the campaign of 2015 in the National Park of Ordesa and Monte Perdido. 409 taxa are added to the previous inventory, some of them from alpine-subalpine ecology, of which 76% correspond to phylum Basidiomycota and 22.2% to Ascomycota. They are presented in the form of a check-list, followed by 20 selected taxonomic descriptions of interesting, infrequent species, and those though to be new in the peninsular territory. Among the species determined, six species were included in the proposals for the inventory of protected species of the Iberian Peninsula and/or Aragon. This paper presents a first approximation, as a platform for later evaluations, of the beech conservation degree in some forests from the Park through the occurrence of indicator species.En este trabajo se continúa con la revisión taxonómica de las especies recolectadas durante la campaña de 2015 en el Parque Nacional de Ordesa y Monte Perdido. Se añaden al catálogo previo 409 taxones, algunos de ellos de ecología alpina-subalpina, de los cuales el 76% corresponde al phylum Basidiomycota y el 22,2% al Ascomycota. Se presentan en forma de listado, y a continuación una selección de 20 descripciones taxonómicas completas, que corresponden con especies interesantes, poco frecuentes y posiblemente nuevas en el territorio peninsular. De las especies estudiadas se han encontrado seis que han sido propuestas para el inventario de especies protegidas de la península ibérica y/o Aragón. Se presenta en este trabajo una primera aproximación, a modo de punta de lanza para evaluaciones posteriores, del grado de conservación de algunos hayedos del Parque a través de la ocurrencia de especies indicadoras

Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment : Data from the BIOBADASER III register

To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA). All patients in the BIOBADASER registry diagnosed with RA, AS, and PsA, and classified as young ( 75 years old) at start of biological treatment were included. Factors associated with the appearance of a first AE using adjusted incidence rate ratios (IRR) (Poisson regression) were analyzed. Survival to first AE was studied by Kaplan-Meier analysis and hazard ratios (HR) by Cox regression. 2483 patients were included: 1126 RA, 680 PsA, and 677 AS. Age group stratification was as follows: 63 young, 2127 adults, 237 elderly, and 56 very elderly. Regression model revealed an increased probability of suffering a first AE at age 65 years or older [IRR elderly: 1.42 (CI95% 1.13-1.77)]. Other characteristics associated with AE were female gender, the use of DMARDs, including methotrexate, the presence of comorbidities, and the time of disease duration. Factors that had the greatest impact on survival over a first AE were age > 75 years [HR 1.50 (1.01-2.24)] and female gender [HR 1.42 (1.22-1.64)]. Age at the start of treatment and female gender are key factors associated with the appearance of a first AE with biologics. Other factors related to patient status and treatment were also associated with a first AE in rheumatic patients treated with biologics