Lista actualizada de la diversidad de los mamíferos del Perú y una propuesta para su actualización

The most recent list of mammals in Peru, published in 2020, compiled a total of 569 species, including 82 endemic species. However, several taxonomic changes have occurred in this short time, and it makes necessary to publish an updated list of all mammalian species recorded in Peru. This new list is updated until November 2021 and includes 573 species, 223 genera, 51 families and 13 orders: Didelphimorphia (47), Paucituberculata (2), Sirenia (1), Cingulata (5), Pilosa (7), Primates (42), Lagomorpha (2), Eulipotyphla (3), Carnivora (33), Perissodactyla (2), Artiodactyla (46, including 32 cetaceans), Rodentia (194) and Chiroptera (189); of which 87 species are endemic to the country. On the other hand, the need to have valid and updated taxonomic lists for use in decision-making, leads us to propose as an optimal strategy that the Asociación de Mastozoólogos del Perú (AMP) assume the role to produce and maintain an updated list to satisfy the needs of different users, as similar organizations are doing in neighboring countries with the support of the State and NGOs.La lista de mamíferos del Perú más reciente, publicada en el año 2020, compiló un total de 569 especies y 82 especies endémicas, sin embargo, en corto tiempo varios cambios taxonómicos han ocurrido y obligan a presentar otra lista actualizada de todas las especies de mamíferos con registros en el Perú. Esta nueva lista actualizada hasta noviembre de 2021 incluye 573 especies, 223 géneros, 51 familias y 13 órdenes: Didelphimorphia (47), Paucituberculata (2), Sirenia (1), Cingulata (5), Pilosa (7), Primates (42), Lagomorpha (2), Eulipotyphla (3), Carnivora (33), Perissodactyla (2), Artiodactyla (46, incluyendo 32 cetáceos), Rodentia (194) y Chiroptera (189); de las cuales, 87 especies son endémicas para el país. Por otro lado, la necesidad de contar con listas taxonómicas válidas y actualizadas para el uso en toma de decisiones, nos lleva a proponer como una estrategia óptima que la Asociación de Mastozoólogos del Perú (AMP) asuma el rol de mantener actualizada una lista que cubra las necesidades de los diferentes usuarios, tal como organizaciones similares lo vienen haciendo en países vecinos con el apoyo del Estado y ONGs

Altered innate immune profile in blood of systemic mastocytosis patients

[Background]: Mast cells (MC) from systemic mastocytosis (SM) patients release MC mediators that lead to an altered microenvironment with potential consequences on innate immune cells, such as monocytes and dendritic cells (DC). Here we investigated the distribution and functional behaviour of different populations of blood monocytes and DC among distinct diagnostic subtypes of SM. [Methods]: Overall, we studied 115 SM patients - 45 bone marrow mastocytosis (BMM), 61 indolent SM (ISM), 9 aggressive SM (ASM)- and 32 healthy donors (HD). Spontaneous and in vitro-stimulated cytokine production by blood monocytes, and their plasma levels, together with the distribution of different subsets of blood monocytes and DCs, were investigated. [Results]: SM patients showed increased plasma levels and spontaneous production by blood monocytes of IL1β, IL6, IL8, TNFα and IL10, associated with an exhausted ability of LPS + IFNγ-stimulated blood monocytes to produce IL1β and TGFβ. SM (particularly ISM) patients also showed decreased counts of total monocytes, at the expense of intermediate monocytes and non-classical monocytes. Interestingly, while ISM and ASM patients had decreased numbers of plasmacytoid DC and myeloid DC (and their major subsets) in blood, an expansion of AXL+ DC was specifically encountered in BMM cases. [Conclusion]: These results demonstrate an altered distribution of blood monocytes and DC subsets in SM associated with constitutive activation of functionally impaired blood monocytes and increased plasma levels of a wide variety of inflammatory cytokines, reflecting broad activation of the innate immune response in mastocytosis.This study has been funded by Instituto de Salud Carlos III (ISCIII) (grant number PI19/01166; and Centro de Investigación Biomédica en Red de Cáncer [CIBERONC] programme, grant number CB16/12/00400) and co-funded by the European Union (EU). We thank the support of the Spanish National DNA Bank Carlos III (www.bancoadn.org; biobank ID B.0000716; supported by ISCIII and co-founded by EU [grant number PT20/00085]) for providing plasma samples. APP was supported by a grant of the Government of Castilla y León (Orden EDU/556/2019), Spain; co-financed with the “European Regional Development Fund” (BDNS, Identif.:422058). We thank the support of the Spanish Association of Mastocytosis and Related Diseases

Performance of standardised colposcopy to detect cervical precancer and cancer for triage of women testing positive for human papillomavirus : results from the ESTAMPA multicentric screening study

Correspondence to: Dr Joan Valls, Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer, Lyon 69366, France. [email protected]. Colposcopy, currently included in WHO recommendations as an option to triage human papillomavirus (HPV)-positive women, remains as the reference standard to guide both biopsy for confirmation of cervical precancer and cancer and treatment approaches. We aim to evaluate the performance of colposcopy to detect cervical precancer and cancer for triage in HPV-positive women. Methods. This cross-sectional, multicentric screening study was conducted at 12 centres (including primary and secondary care centres, hospitals, laboratories, and universities) in Latin America (Argentina, Bolivia, Colombia, Costa Rica, Honduras, Mexico, Paraguay, Peru, and Uruguay). Eligible women were aged 30–64 years, sexually active, did not have a history of cervical cancer or treatment for cervical precancer or a hysterectomy, and were not planning to move outside of the study area. Women were screened with HPV DNA testing and cytology. HPV-positive women were referred to colposcopy using a standardised protocol, including biopsy collection of observed lesions, endocervical sampling for transformation zone (TZ) type 3, and treatment as needed. Women with initial normal colposcopy or no high-grade cervical lesions on histology (less than cervical intraepithelial neoplasia [CIN] grade 2) were recalled after 18 months for another HPV test to complete disease ascertainment; HPV-positive women were referred for a second colposcopy with biopsy and treatment as needed. Diagnostic accuracy of colposcopy was assessed by considering a positive test result when the colposcopic impression at the initial colposcopy was positive minor, positive major, or suspected cancer, and was considered negative otherwise. The main study outcome was histologically confirmed CIN3+ (defined as grade 3 or worse) detected at the initial visit or 18-month visit. Findings. Between Dec 12, 2012, and Dec 3, 2021, 42 502 women were recruited, and 5985 (14·1%) tested positive for HPV. 4499 participants with complete disease ascertainment and follow-up were included in the analysis, with a median age of 40·6 years (IQR 34·7–49·9). CIN3+ was detected in 669 (14·9%) of 4499 women at the initial visit or 18-month visit (3530 [78·5%] negative or CIN1, 300 [6·7%] CIN2, 616 [13·7%] CIN3, and 53 [1·2%] cancers). Sensitivity was 91·2% (95% CI 88·9–93·2) for CIN3+, whereas specificity was 50·1% (48·5–51·8) for less than CIN2 and 47·1% (45·5–48·7) for less than CIN3. Sensitivity for CIN3+ significantly decreased in older women (93·5% [95% CI 91·3–95·3] in those aged 30–49 years vs 77·6% [68·6–85·0] in those aged 50–65 years; p<0·0001), whereas specificity for less than CIN2 significantly increased (45·7% [43·8–47·6] vs 61·8% [58·7–64·8]; p<0·0001). Sensitivity for CIN3+ was also significantly lower in women with negative cytology than in those with abnormal cytology (p<0·0001). Interpretation. Colposcopy is accurate for CIN3+ detection in HPV-positive women. These results reflect ESTAMPA efforts in an 18-month follow-up strategy to maximise disease detection with an internationally validated clinical management protocol and regular training, including quality improvement practices. We showed that colposcopy can be optimised with proper standardisation to be used as triage in HPV-positive women.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarrollo14-INV-036PINV18-25

Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America : the ESTAMPA screening study protocol

Q1Q1Introduction Human papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. The ESTAMPA (EStudio multicéntrico de TAMizaje y triaje de cáncer de cuello uterino con pruebas del virus del PApiloma humano; Spanish acronym) study will: (1) evaluate the performance of different triage techniques to detect cervical precancer and (2) inform on how to implement HPV-based screening programmes in LMIC. Methods and analysis Women aged 30–64 years are screened with HPV testing and Pap across 12 study centres in Latin America. Screened positives have colposcopy with biopsy and treatment of lesions. Women with no evident disease are recalled 18 months later for another HPV test; those HPV-positive undergo colposcopy with biopsy and treatment as needed. Biological specimens are collected in different visits for triage testing, which is not used for clinical management. The study outcome is histological high-grade squamous intraepithelial or worse lesions (HSIL+) under the lower anogenital squamous terminology. About 50 000 women will be screened and 500 HSIL+ cases detected (at initial and 18 months screening). Performance measures (sensitivity, specificity and predictive values) of triage techniques to detect HSIL+ will be estimated and compared with adjustment by age and study centre. Ethics and dissemination The study protocol has been approved by the Ethics Committee of the International Agency for Research on Cancer (IARC), of the Pan American Health Organisation (PAHO) and by those in each participating centre. A Data and Safety Monitoring Board (DSMB) has been established to monitor progress of the study, assure participant safety, advice on scientific conduct and analysis and suggest protocol improvements. Study findings will be published in peer-reviewed journals and presented at scientific meetings. Trial registration number NCT01881659Revista Internacional - Indexad

Aprendiendo a enseñar y a fomentar el ajuste psicosocial a través de una experiencia de aprendizaje-servicio de enseñanza del español a alumnos ucranianos y otros migrantes

Memoria ID2022-173 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2022-2023

Plant trait and vegetation data along a 1314 m elevation gradient with fire history in Puna grasslands, Perú

Alpine grassland vegetation supports globally important biodiversity and ecosystems that are increasingly threatened by climate warming and other environmental changes. Trait-based approaches can support understanding of vegetation responses to global change drivers and consequences for ecosystem functioning. In six sites along a 1314 m elevational gradient in Puna grasslands in the Peruvian Andes, we collected datasets on vascular plant composition, plant functional traits, biomass, ecosystem fluxes, and climate data over three years. The data were collected in the wet and dry season and from plots with different fire histories. We selected traits associated with plant resource use, growth, and life history strategies (leaf area, leaf dry/wet mass, leaf thickness, specific leaf area, leaf dry matter content, leaf C, N, P content, C and N isotopes). The trait dataset contains 3,665 plant records from 145 taxa, 54,036 trait measurements (increasing the trait data coverage of the regional flora by 420%) covering 14 traits and 121 plant taxa (ca. 40% of which have no previous publicly available trait data) across 33 families

Radiation hardness of MALTA2 monolithic CMOS imaging sensors on Czochralski substrates

MALTA2 is the latest full-scale prototype of the MALTA family of Depleted Monolithic Active Pixel Sensors (DMAPS) produced in Tower Semiconductor 180 nm CMOS sensor imaging technology. In order to comply with the requirements of high energy physics (HEP) experiments, various process modifications and front-end changes have been implemented to achieve low power consumption, reduce random telegraph signal (RTS) noise, and optimise the charge collection geometry. Compared to its predecessors, MALTA2 targets the use of a high-resistivity, thick Czochralski (Cz) substrates in order to demonstrate radiation hardness in terms of detection efficiency and timing resolution up to 3 × 1015 1 MeV neq/cm2 with backside metallisation to achieve good propagation of the bias voltage. This manuscript shows the results that were obtained with non-irradiated and irradiated MALTA2 samples on Cz substrates from the CERN SPS test beam campaign from 2021 to 2023 using the MALTA telescope

Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution

I Jornada de Aulas Abiertas: Encuentro de Docentes de la Facultad de Ciencias Económicas

La Jornada de Aulas Abiertas quiere ser una oportunidad para que los docentes de la Facultad de Ciencias Económicas nos encontremos en un espacio de reflexión y revisión de nuestras prácticas, distendido, cálido y respetuoso, que nos permita compartir nuestras experiencias cotidianas en las aulas, tanto presenciales como virtuales. Es la posibilidad de conocernos, intercambiar, aprender y contagiarnos de las inquietudes y el entusiasmo que muchos docentes ponen en juego cotidianamente. En el marco de propuestas de enseñanza, se analizaron recursos multimediales, materiales de estudio, aulas virtuales, redes sociales, aplicaciones web, juegos y actividades de evaluación y coevaluación originales; también se abordaron problemáticas y propuestas para favorecer vinculaciones con la práctica profesional. Estas fueron algunas de las cuestiones abordadas y compartidas en las presentaciones de nuestros colegas. Distintas propuestas, pero siempre con el propósito de favorecer las oportunidades de aprendizaje de nuestros estudiantes. Esta publicación pretende ampliar el alcance de esta actividad. Es una invitación para que los y las docentes que participaron puedan revisar nuevamente aquellas actividades que les parecieron valiosas, o las que no pudieron presenciar. Y para aquellos/as que no tuvieron la posibilidad de estar presentes, puedan descubrir cuánto podemos hacer para que nuestros estudiantes aprendan más y mejor, y se animen a iniciar sus propios recorridos. Esperamos repetir este evento para seguir aprendiendo de las iniciativas de los/las docentes de nuestra Facultad, poder hablar de lo que nos preocupa y nos enorgullece, en particular de las propuestas que desarrollamos en el aula para favorecer la comprensión, promover el entusiasmo, abordar temas complejos y errores frecuentes de nuestros estudiantes. Desde el Área de Formación Docente y Producción Educativa queremos agradecer a las autoridades de nuestra Facultad por acompañarnos en este desafío y a los/las docentes que estuvieron presentes compartiendo sus experiencias.Fil: Sabulsky, Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Margaría, Oscar A. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Iturralde, Ivan. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Domenech, Roberto. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Torrico, Julieta. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Estigarribia, Lucrecia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Gohlke, Guillermo. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Rosenfeld, Valeria. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Montenjano, Franco. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Atienza, Bárbara. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Becerra, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Alonso, Micaela. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Tomatis, Karina. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Saunders, Shirley. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: David, María Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Flores, Verónica Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Heckmann, Gerardo. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Vega, Juan José. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Trucchi, Carlos. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Ferro, Flavia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Díaz, Cecilia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Peretto, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Racagni, Josefina. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Guardiola, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: López, Sonia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Beltrán, Natacha. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Russo, Paulo. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Sánchez, Pablo. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Rocha Vargas, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Flores, Norma. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Arévalo, Eliana. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Pacheco, Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Delmonte, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Stanecka, Nancy. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Caminos, Ana Belén. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Ahumada, María Inés. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Caro, Norma Patricia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Bravino, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Giménez, Siria Miriam. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Perona, Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Cuttica, Mariela. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: García, Gladys Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Cohen, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Tapia, Sebastián. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Erazu, Damián. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Torres, César. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Casini, Rosanna Beatriz. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Rosales, Julio. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Infante, Roberto Adrián. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Ricci, María Beatriz. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Römer, Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Goyeneche, Noel. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Marzo, Emanuel. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Olmos, Mariano. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Bottino, Cecilia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Cacciagiú, Victor. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Scidá, María Florencia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Guajardo Molina, Vanesa. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Batistella, Silvana del V. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Huanchicay, Silvia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Jones, Carola. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Cassutti, Marcela Beatriz. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Sánchez, Juan Nicolás. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Arónica, Sandra. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Ortega, Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Peretti, Florencia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Tagle, María Mercedes. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Asís, Gloria Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Ortiz Figueroa, Ana María. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Giménez, Miriam Mónica. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Magnano, Cecilia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Arias, Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality