Abordagens plurais nos primeiros anos de escolaridade: reflexões a partir de contextos de intervenção

Tout en cherchant des réponses aux défis qui se placent, aujourd’hui, aux systèmes éducatifs, dans la gestion de multiples diversités, nous voulons dans ce texte réfléchir sur les approches plurielles, notamment sur les possibilités ouvertes par l’éveil aux langues. Les études présentées montrent différentes formes d’éducation des éléves, dès les premières années de scolarité, au plurilinguisme (respect et mise en valeur de l’autre, de ses langues et de ses cultures ; conscience du langage ; compréhension des problèmes du monde), dans un engagement avec le développement durable et l’intercompréhension.Taking into consideration the challenges facing education today, namely the need to deal with the multiple diversities ever more present within the classrooms, it is our goal in this text to reflect upon the possibilities of plural approaches, in particular of the awakening to languages approach, in the first school years. In this sense, we present two studies which show possible ways of educating young children to value and respect Others with their languages and cultures, to become aware and reflect upon language and linguistic diversity, and to understand World issues, in a serious commitment with pluralism, multiculturalism and an education for sustainable development

Práticas de sensibilização à diversidade linguística e cultural nos primeiros anos de escolaridade: reflexões a partir da sala de aula

Integrar a diversidade e o pluralismo na educação nunca foi uma realidade tão premente como nos diasactuais em que os fluxos migratórios e o fenómeno da globalização exigem a convivência entre formas deser e estar muito diferentes. Sobre a educação recai a responsabilidade de acolher toda esta diversidade ede preparar os alunos para viver com o Outro de forma harmoniosa e salutar.Neste quadro, apresentamos alguns projectos de investigação-acção realizados com alunos do 1º Ciclo doEnsino Básico sobre a diversidade linguística e cultural, tecendo algumas considerações sobre aspotencialidades desta abordagem nos primeiros anos de escolaridade, essencialmente no que diz respietoàs temáticas a trabalhar no currículo.</p

An Investigation into the Suitability and Stability of a New Pigmented Wax-Resin Formulation for Infilling and Reintegration of Losses in Paintings

Publisher Copyright: © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.A new Pigmented Wax-Resin (PWR) formulation for infilling and reintegration of losses in paintings is introduced and tested for its suitability and stability. It consists of a mixture of Cosmoloid H80 microcrystalline wax and Regalrez 1126 hydrogenated hydrocarbon resin with dry pigments and/or fillers. Unlike other PWR formulations, including those sold by Gamblin Conservation Colors, it does not contain beeswax. Beeswax is reported to develop bloom and to corrode copper supports. The authors share methodologies and techniques used to characterize and assess the suitability of the new formulation in terms of its physical and optical properties, and to assess its stability to fluctuating relative humidity and temperature, particularly high temperatures. The new formulation was evaluated for its workability, opacity, and flexibility and for its compatibility with a selection of varnish coatings and inpainting media. Results showed that 1.5 parts of Cosmoloid H80 to 1 part of Regalrez 1126 (by weight), mixed with pigments and/or fillers, is a viable alternative to other infilling and inpainting media. It has good optical and working properties, a suitable degree of hardness, and remains stable during fluctuations in relative humidity and temperature, as well as to temperatures as high as 70°C.publishersversionepub_ahead_of_prin

Nutritional characterization of Strychnos madagascariensis fruit flour produced by Mozambican communities and evaluation of Its contribution to nutrient adequacy

The indigenous fruit Strychnos madagascariensis is usually processed to flour, called nfuma, being highly consumed during staple food shortage. This study aimed to evaluate the nutritional composition of nfuma and its nutrient adequacy. Flours from four districts of Mozambique were analyzed using AOAC methods for proximate composition, HPLC for sugar, amino acids (AA), vitamin E and carotenoids and ICP-MS and FAAS for minerals. The results showed that nfuma stands out for its high content of fat (26.3–27.8%), mainly oleic acid, fiber (>6%), vitamin E (6.7 to 8.0 mg/100 g) and carotenes (2.2 to 2.6 mg/100 g). The main amino acids of nfuma protein were Arg, Asp and Glu, and Lys was the limiting one. The mineral composition reveals K (~1200 to 1700 mg/100 g) as the main macromineral followed by Mg > Ca > Na. The main trace element was Mn (~4 mg/100 g) followed by Fe > Zn > Cu > Cr > Co. Aluminum (~3 mg/100 g) was the main non-essential element and Rb, Ni, Sr, Ba, V, Cd were also quantified. Assuming the daily consumption of 50 g, nfuma provides 82% of Vitamin A dietary reference value for toddlers, while the consumption of 100 g contributes to 132% and 60% of Mn and vitamin A DRV for adults, respectively. Despite the nutritional advantages of nfuma, this flour can be a source of Ni, highlighting the importance of the study of good practices in its preparation to decrease the exposure to non-essential elements.info:eu-repo/semantics/publishedVersio

A Metabolomics Study

Funding Information: This work is financed by national funds from Fundação para a Ciência e a Tecnologia (FCT), I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences (UCIBIO) and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB and through the project EXPL/MEDFAR/0203/2021. A. Dias-Carvalho acknowledges FCT and UCIBIO for her PhD grant (UI/BD/151318/2021). V.M.C acknowledges FCT for her grant (SFRH/BPD/110001/2015) that was funded by national funds through FCT under the Norma Transitória–DL57/2016/CP1334/CT0006. A.R.-M. acknowledges FCT for her grant SFRH/BD/129359/2017. Publisher Copyright: © 2023 by the authors.Long-term cognitive dysfunction, or “chemobrain”, has been observed in cancer patients treated with chemotherapy. Mitoxantrone (MTX) is a topoisomerase II inhibitor that binds and intercalates with DNA, being used in the treatment of several cancers and multiple sclerosis. Although MTX can induce chemobrain, its neurotoxic mechanisms are poorly studied. This work aimed to identify the adverse outcome pathways (AOPs) activated in the brain upon the use of a clinically relevant cumulative dose of MTX. Three-month-old male CD-1 mice were given a biweekly intraperitoneal administration of MTX over the course of three weeks until reaching a total cumulative dose of 6 mg/kg. Controls were given sterile saline in the same schedule. Two weeks after the last administration, the mice were euthanized and their brains removed. The left brain hemisphere was used for targeted profiling of the metabolism of glutathione and the right hemisphere for an untargeted metabolomics approach. The obtained results revealed that MTX treatment reduced the availability of cysteine (Cys), cysteinylglycine (CysGly), and reduced glutathione (GSH) suggesting that MTX disrupts glutathione metabolism. The untargeted approach revealed metabolic circuits of phosphatidylethanolamine, catecholamines, unsaturated fatty acids biosynthesis, and glycerolipids as relevant players in AOPs of MTX in our in vivo model. As far as we know, our study was the first to perform such a broad profiling study on pathways that could put patients given MTX at risk of cognitive deficits.publishersversionpublishe

Kamishibai plurilingue: da criação à execução: guia de acompanhamento

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Kamishibai plurilingue: da criação à execução: fichas pedagógicas

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CYP21A2 gene mutations, its nature and frequency in a paediatric Portuguese cohort with congenital adrenal hyperplasia

Introduction: The most common cause of congenital adrenal hyperplasia (CAH) is 21-hydroxylase deficiency (21-OHD) caused by alterations in CYP21A2 gene. The clinical phenotypes of this autosomal recessive disease are classified as classic (saltwasting and simple virilizing) and non-classic forms of CAH. The severity of the disease is directly related with the impairment of the 21-OH enzymatic activity. Genetic testing can confirm the disease and is crucial for familial studies and genetic counseling. Aim: The aim of this work was to perform the clinical and molecular characterization of the patients observed at the Hospital Pediátrico de Coimbra (Portugal) with the clinical suspecion of CAH. Methods: Retrospective analysis of patient medical records of all cases observed in our hospital with suspicion of CAH and detailed literature comparison. CYP21A2 molecular analysis had been performed in 81 unrelated Portuguese patients (51 female, 30 males) with clinical and endocrine laboratorial findings suggestive of CAH, using mini-sequencing, restriction enzyme digestion, Sanger sequencing or/and multiplex ligation-dependent probe amplification (MLPA). Results: CYP21A2 variants were identified in 74/81 (91%) of the patients. Homozygosity for CYP21A2 was found in 39.2% (29/74) of the patients while 55.4% (41/74) were compound heterozygous and, in 5.4% of the cases (4/74), only one pathogenic variant was identified. The most frequent alterations were p.Val281Leu, g.655A/C>G (splicing variant) and p.Ile172Asn, that account for more than 50% of the alleles of this patient’s cohort. All variants were already described except a novel missense variant identified in a salt-wasting patient, g.1173T>C(p.Trp201Arg). The rare variant p.Gly424Ser which was detected in one patient had been previously associated with a possible founder effect in Brazil and the splicing variant g.391G>A, only described in the Portuguese population. Conclusion: Our study provides a detailed clinical and molecular characterization of a large cohort of CAH Portuguese patients. The overall concordance between the clinical phenotype and the inferred phenotype (based on genotype) was 90%.info:eu-repo/semantics/publishedVersio