Preterm birth and/or factors that lead to preterm delivery: effects on the neonatal kidney

Preterm birth (defined as birth prior to 37 completed weeks of gestation), occurs in approximately 10% of all births and is one of the leading causes of neonatal morbidity and mortality worldwide. Preterm infants are born at a time when kidney development is still ongoing, and consequently can lead to renal impairment (in both the short-term and long-term), as well as severe glomerular abnormalities in some preterm infants. Since the glomerular abnormalities are not present in all preterm kidneys, this suggests that it is not preterm birth per se that leads to the glomerular abnormalities but may relate to factors associated with the etiology of the premature delivery, or factors in neonatal care. In this review, we provide an overview of what is currently known of how prenatal and postnatal factors can potentially impact on the immature kidneys of infants born preterm

Protesting too much: Self-deception and self-signaling

von Hippel and Trivers propose that self-deception has evolved to facilitate the deception of others. However, they ignore the subjective moral costs of deception and the crucial issue of credibility in self-deceptive speech. A self-signaling interpretation can account for the ritualistic quality of some self-deceptive affirmations, and for the often-noted gap between what self-deceivers say and what they truly believe

A Data-oriented Transaction Execution Engine and Supporting Tools

Conventional OLTP systems assign each transaction to a worker thread and that thread accesses data, depending on what the transaction dictates. This thread-to-transaction work assignment policy leads to unpredictable accesses. The unpredictability forces each thread to enter a large number of critical sections for the completion of even the simplest of the transactions; leading to poor performance and scalability on modern manycore hardware. This demonstration highlights the chaotic access patterns of conventional OLTP designs which are the source of scalability problems. Then, it presents a working prototype of a transaction processing engine that follows a non-conventional architecture, called data-oriented or DORA. DORA is designed around the thread-to-data work assignment policy. It distributes the transaction execution to multiple threads and offers predictable accesses. By design, DORA can decentralize the lock management service, and thereby eliminate the critical sections executed inside the lock manager. We explain the design of the system and show that it more efficiently utilizes the abundant processing power of modern hardware, always contrasting it against the conventional execution. In addition, we present different components of the system, such as a dynamic load balancer. Finally, we present a set of tools that enable the development of applications that use DORA

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants

BACKGROUND During normal human kidney development, nephrogenesis (the formation of nephrons) is complete by term birth, with the majority of nephrons formed late in gestation. The aim of this study was to morphologically examine nephrogenesis in fetal human kidneys from 20 to 41weeks of gestation. METHODS Kidney samples were obtained at autopsy from 71 infants that died acutely in utero or within 24h after birth. Using image analysis, nephrogenic zone width, the number of glomerular generations, renal corpuscle cross-sectional area and the cellular composition of glomeruli were examined. Kidneys from female and male infants were analysed separately. FINDINGS The number of glomerular generations formed within the fetal kidneys was directly proportional to gestational age, body weight and kidney weight, with variability between individuals in the ultimate number of generations (8 to 12) and in the timing of the cessation of nephrogenesis (still ongoing at 37weeks gestation in one infant). There was a slight but significant (r2=0.30, P=0.001) increase in renal corpuscle cross-sectional area from mid gestation to term in females, but this was not evident in males. The proportions of podocytes, endothelial and non-epithelial cells within mature glomeruli were stable throughout gestation. INTERPRETATION These findings highlight spatial and temporal variability in nephrogenesis in the developing human kidney, whereas the relative cellular composition of glomeruli does not appear to be influenced by gestational age.This study was supported by funding from the National Health and Medical Research Council (NHMRC) (1011136) of Australia and National Institutes of Health (NIH) USA grant 3U01DK094526-04S1 (PI A P McMahon). Author Danica Ryan was the recipient of the Biomedicine Discovery Scholarship from Monash University and author Megan R. Sutherland was supported by a NHMRC CJ Martin Fellowship

A high-tech, low-cost, Internet of Things surfboard fin for coastal citizen science, outreach, and education

Coastal populations and hazards are escalating simultaneously, leading to an increased importance of coastal ocean observations. Many well-established observational techniques are expensive, require complex technical training, and offer little to no public engagement. Smartfin, an oceanographic sensor–equipped surfboard fin and citizen science program, was designed to alleviate these issues. Smartfins are typically used by surfers and paddlers in surf zone and nearshore regions where they can help fill gaps between other observational assets. Smartfin user groups can provide data-rich time-series in confined regions. Smartfin comprises temperature, motion, and wet/dry sensing, GPS location, and cellular data transmission capabilities for the near-real-time monitoring of coastal physics and environmental parameters. Smartfin\u27s temperature sensor has an accuracy of 0.05 °C relative to a calibrated Sea-Bird temperature sensor. Data products for quantifying ocean physics from the motion sensor and additional sensors for water quality monitoring are in development. Over 300 Smartfins have been distributed around the world and have been in use for up to five years. The technology has been proven to be a useful scientific research tool in the coastal ocean—especially for observing spatiotemporal variability, validating remotely sensed data, and characterizing surface water depth profiles when combined with other tools—and the project has yielded promising results in terms of formal and informal education and community engagement in coastal health issues with broad international reach. In this article, we describe the technology, the citizen science project design, and the results in terms of natural and social science analyses. We also discuss progress toward our outreach, education, and scientific goals

The Grizzly, September 19, 2000

Are E-mail Messages on Ursinus Accounts Private? • Lack of Communication the Culprit in Parking Ticket Woes • From Chess to Diving: New Clubs to Make Splash at UC • 942, 944 Main Street Leave Much to be Desired • Family Day Preview: Student Achievement Takes Center Stage • Henninger and Tigget: Profiles of UC Students • Letter to the Editor • Opinion: Fun of Living Like a Freshman; How do Students Stand on Abortion?; Sink or Swim: Students React to Future Fountain; Your Body is a Temple; Campaign 2000: National Missile Defense • On The Fringe for Family Day • Film Society Gets 2 Thumbs Up for Movie Buffs • Volleyball Struggles to Dig Out a Win • Men\u27s Soccer Suffers Upsets Despite Great Effort • Women\u27s Soccer Off to Best Start Ever • Field Hockey Comes Home With First Win • Athletes of the Week: Heidi Rhodes; Kevin Mallon • UC Undiplomatic in 41-7 Drubbing of F+Mhttps://digitalcommons.ursinus.edu/grizzlynews/1472/thumbnail.jp

The Grizzly, September 12, 2000

Student May Lose Squatting Rights, Residence Life Says • Students Peeved at Parking Problems • Freshman Class Elects Student Body Politic • UC Student Organizations Come Alive at Activities Fair • U.S. News Ranks UC High • Freshmen React: New Laptop Receives Praise, Criticism • A PANDA in Bear Country: Local Citizens Fight Against Plans for New Power Plant • In the Ad Campaign, Uber Rocks the Vote! • Letters to the Editor • Editorials: Cutting Education Short; Apathy Lay Dying • Are Freshmen Working Too Hard? • Opinion: Campaign 2000 Presidential Debates • Rugby Looks to Have Tons of Fun in Fifth Season • Field Hockey Still Looking for First Win • Men\u27s Soccer: Win Over Wesley, Shut Out vs. Scranton • Women\u27s Soccer Splits at Pepsi Cardinal Classic • Athletes of the Week: Scott Hussey; Nicole DiMascio • Bears Ground Flying Dutchmen in 39-6 Romp • XC off to Fast Starthttps://digitalcommons.ursinus.edu/grizzlynews/1471/thumbnail.jp

The unseen host galaxy and high dispersion measure of a precisely-localised Fast Radio Burst suggests a high-redshift origin

FRB 20210912A is a fast radio burst (FRB), detected and localised to sub-arcsecond precision by the Australian Square Kilometre Array Pathfinder. No host galaxy has been identified for this burst despite the high precision of its localisation and deep optical and infrared follow-up, to 5-$\sigma$ limits of $R=26.7$ mag and $K_\mathrm{s}=24.9$ mag with the Very Large Telescope. The combination of precise radio localisation and deep optical imaging has almost always resulted in the secure identification of a host galaxy, and this is the first case in which the line-of-sight is not obscured by the Galactic disk. The dispersion measure of this burst, $\mathrm{DM_{FRB}}=1233.696\pm0.006~\mathrm{pc}\ \mathrm{cm}^{-3}$, allows for a large source redshift of $z>1$ according to the Macquart relation. It could thus be that the host galaxy is consistent with the known population of FRB hosts, but is too distant to detect in our observations ($z>0.7$ for a host like that of the first repeating FRB source, FRB 20121102A); that it is more nearby with a significant excess in $\mathrm{DM_{host}}$, and thus dimmer than any known FRB host; or, least likely, that the FRB is truly hostless. We consider each possibility, making use of the population of known FRB hosts to frame each scenario. The fact of the missing host has ramifications for the FRB field: even with high-precision localisation and deep follow-up, some FRB hosts may be difficult to detect, with more distant hosts being the less likely to be found. This has implications for FRB cosmology, in which high-redshift detections are valuable.Comment: 14 pages, 6 figures. Revised based on referee's comments and accepted to MNRA

Long term individual load forecast under different electrical vehicles uptake scenarios

More and more households are purchasing electric vehicles (EVs), and this will continue as we move towards a low carbon future. There are various projections as to the rate of EV uptake, but all predict an increase over the next ten years. Charging these EVs will produce one of the biggest loads on the low voltage network. To manage the network, we must not only take into account the number of EVs taken up, but where on the network they are charging, and at what time. To simulate the impact on the network from high, medium and low EV uptake (as outlined by the UK government), we present an agent-based model. We initialise the model to assign an EV to a household based on either random distribution or social influences - that is, a neighbour of an EV owner is more likely to also purchase an EV. Additionally, we examine the effect of peak behaviour on the network when charging is at day-time, night-time, or a mix of both. The model is implemented on a neighbourhood in south-east England using smart meter data (half hourly electricity readings) and real life charging patterns from an EV trial. Our results indicate that social influence can increase the peak demand on a local level (street or feeder), meaning that medium EV uptake can create higher peak demand than currently expected

A non-repeating fast radio burst in a dwarf host galaxy

We present the discovery of as-of-yet non-repeating Fast Radio Burst (FRB), FRB 20210117A, with the Australian Square Kilometer Array Pathfinder (ASKAP) as a part of the Commensal Real-time ASKAP Fast Transients (CRAFT) Survey. The sub-arcsecond localization of the burst led to the identification of its host galaxy at a $z=0.214(1)$. This redshift is much lower than what would be expected for a source dispersion measure (DM) of 729 pc cm$^{-3}$, given typical contributions from the intergalactic medium and the host galaxy. Optical observations reveal the host to be a dwarf galaxy with little on-going star formation, very different to the dwarf host galaxies of known repeating FRBs 20121102A, and 20190520B. We find an excess DM contribution from the host and attribute it to the FRB's local environment. We do not find any radio emission from the FRB site or host galaxy. The low magnetized environment and lack of a persistent radio source (PRS) indicate that the FRB source is older than those found in other dwarf host galaxies, and establish the diversity of FRB sources in dwarf galaxy environments. We find our observations to be fully consistent with the hypernebula model, where the FRB is powered by accretion-jet from a hyper-accreting black hole. Finally, our high-time resolution analysis reveals burst characteristics similar to those seen in repeating FRBs. We encourage follow-up observations of FRB 20210117A to establish any repeating nature.Comment: 15 pages, 9 figures, 2 Table