Addressing research integrity challenges: from penalising individual perpetrators to fostering research ecosystem quality care

Concern for and interest in research integrity has increased significantly during recent decades, both in academic and in policy discourse. Both in terms of diagnostics and in terms of therapy, the tendency in integrity discourse has been to focus on strategies of individualisation (detecting and punishing individual deviance). Other contributions to the integrity debate, however, focus more explicitly on environmental factors, e.g. on the quality and resilience of research ecosystems, on institutional rather than individual responsibilities, and on the quality of the research culture. One example of this is the Bonn PRINTEGER Statement. This editorial to the LSSP thematic series (article collection) entitled Addressing integrity challenges in research: the institutional dimension invites authors to contribute to the research integrity debate. Notably, we are interested in submissions addressing issues such as institutional responsibilities, changes in the research climate, duties of research managers and research performing or research funding organisations (RPOs and RFOs) as well as new approaches to integrity education

α7 And β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes That Are Expressed In The Human Cortex And Display Distinct Pharmacological Properties

The existence of α7β2 nicotinic acetylcholine receptors (nAChRs) has recently been demonstrated in both the rodent and human brain. Since α7-containing nAChRs are promising drug targets for schizophrenia and Alzheimer\u27s disease, it is critical to determine whether α7β2 nAChRs are present in the human brain, in which brain areas, and whether they differ functionally from α7 nAChR homomers. We used α-bungarotoxin to affinity purify α7-containing nAChRs from surgically excised human temporal cortex, and found that α7 subunits co-purify with β2 subunits, indicating the presence of α7β2 nAChRs in the human brain. We validated these results by demonstrating co-purification of β2 from wild-type, but not α7 or β2 knock-out mice. The pharmacology and kinetics of human α7β2 nAChRs differed significantly from that of α7 homomers in response to nAChR agonists when expressed in Xenopus oocytes and HEK293 cells. Notably, α7β2 heteromers expressed in HEK293 cells display markedly slower rise and decay phases. These results demonstrate that α7 subunits in the human brain form heteromeric complexes with β2 subunits, and that human α7β2 nAChR heteromers respond to nAChR agonists with a unique pharmacology and kinetic profile. α7β2 nAChRs thus represent an alternative mechanism for the reported clinical efficacy of α7 nAChR ligands

The Q/U Imaging Experiment: Polarization Measurements of Radio Sources at 43 and 95 GHz

We present polarization measurements of extragalactic radio sources observed during the Cosmic Microwave Background polarization survey of the Q/U Imaging Experiment (QUIET), operating at 43 GHz (Q-band) and 95 GHz (W-band). We examine sources selected at 20 GHz from the public, $>$40 mJy catalog of the Australia Telescope (AT20G) survey. There are $\sim$480 such sources within QUIET's four low-foreground survey patches, including the nearby radio galaxies Centaurus A and Pictor A. The median error on our polarized flux density measurements is 30--40 mJy per Stokes parameter. At S/N $> 3$ significance, we detect linear polarization for seven sources in Q-band and six in W-band; only $1.3 \pm 1.1$ detections per frequency band are expected by chance. For sources without a detection of polarized emission, we find that half of the sources have polarization amplitudes below 90 mJy (Q-band) and 106 mJy (W-band), at 95% confidence. Finally, we compare our polarization measurements to intensity and polarization measurements of the same sources from the literature. For the four sources with WMAP and Planck intensity measurements $>1$ Jy, the polarization fraction are above 1% in both QUIET bands. At high significance, we compute polarization fractions as much as 10--20% for some sources, but the effects of source variability may cut that level in half for contemporaneous comparisons. Our results indicate that simple models---ones that scale a fixed polarization fraction with frequency---are inadequate to model the behavior of these sources and their contributions to polarization maps.Comment: 16 pages, 10 figures. Submitted to Ap

Institutionalised corruption in Indonesian irrigation: An analysis of the upeti system

This article analyzes the internal logic of the upeti system in Indonesian irrigation and brings to light how corruption rules are shaped through complex socio-political relationships reflected in the organizational culture of the irrigation agency. Based on 100 interviews with water sector professionals the article highlights: (1) the importance of social relations in shaping institutionalized corruption, (2) how the upeti system justifies corruption practices as the prevailing social norm, and (3) the need for structural change to eradicate corruption. Illustrating how corruption rules are embedded in project management procedures, with projects highly dependent on donor funding, the article highlights the importance of the issue for international agencies and the need to be more politically grounded in promoting their development agenda