Contemporary librarianship and special collections issues: a case study in manuscript collections of Timbuktu and other Malian cities

The article addresses the issues and challenges of special collections management through the case study of Timbuktu manuscript collections. The dual issues of preservation and access are presented in the light of current librarianship trends, highlighting the potential weaknesses of special collections libraries when faced with new missions. Given that inclusion and civil growth are part of Lyon’s declaration on libraries, we should check to which extent we are able to comply with these requirements also with respect to special collections. The Malian projects provide a good point of view because of the number of activities that are currently being performed: the main activities and the way the work is organised are described, addressing at the same time the issue of access and scholar needs. A reflection is developed on the role of special collections in the changing landscape of libraries’ activities and missions.The article addresses the issues and challenges of special collections management through the case study of Timbuktu manuscript collections. The dual issues of preservation and access are presented in the light of current librarianship trends, highlighting the potential weaknesses of special collections libraries when faced with new missions. Given that inclusion and civil growth are part of Lyon’s declaration on libraries, we should check to which extent we are able to comply with these requirements also with respect to special collections. The Malian projects provide a good point of view because of the number of activities that are currently being performed: the main activities and the way the work is organised are described, addressing at the same time the issue of access and scholar needs. A reflection is developed on the role of special collections in the changing landscape of libraries’ activities and missions

Li-ion batteries. Characterization of the thermal runaway reactions using a DSC

Lithium-ion batteries are widely used in many applications due to their formidable performance and characteristics. Numerous accidents involving lithium-ion batteries have occurred in recent years and this has led to focus on safety issues related to their extensive use. In this work the Panasonic’s NCR18650 lithium-ion cylindrical cells were investigated by Differential Scanning Calorimetry. The aim is to identify and characterize the main reactions that occur at the anode under thermal abuse conditions and which can lead to thermal runaway. The kinetics of these reactions are assessed using the Kissinger and Ozawa methods. Furthermore, the results show the relationship between the initial state of charge of the cell and the progress of reactions

A numerical method for the generalized Love integral equation in 2D

This paper deals with the numerical solution of the generalized Love integral equation defined on the square. The method is of Nyström type and is based on the approximation of the integral by a product cubature rule whose coefficients are approximated by a “dilation” scheme. The theoretical analysis of the presented method is discussed by proving its stability and convergence in weighted spaces equipped with the uniform norm. To support the theoretical estimates, some numerical tests are presented

Waterborne outbreak of Norwalk-like virus gastroenteritis at a tourist resort, Italy.

In July 2000, an outbreak of gastroenteritis occurred at a tourist resort in the Gulf of Taranto in southern Italy. Illness in 344 people, 69 of whom were staff members, met the case definition. Norwalk-like virus (NLV) was found in 22 of 28 stool specimens tested. The source of illness was likely contaminated drinking water, as environmental inspection identified a breakdown in the resort water system and tap water samples were contaminated with fecal bacteria. Attack rates were increased (51.4%) in staff members involved in water sports. Relative risks were significant only for exposure to beach showers and consuming drinks with ice. Although Italy has no surveillance system for nonbacterial gastroenteritis, no outbreak caused by NLV has been described previously in the country

Simulation of People Evacuation in the Event of a Road Tunnel Fire

AbstractThis paper presents basic findings obtained by means of a simulation model for representing an evacuation process from a curved bi-directional Italian road tunnel in the event of a fire. Simulations were carried out by using the STEPS people evacuation model associated with a CFD model simulating the fire. It was found that the evacuation time is primarily influenced by the walking time and to a less extent by the pre-movement time in all scenarios studied. The presence of an alarm system reduced the evacuation time for most the tunnel users, allowing them to reach the tunnel exit in safety

Resting state functional thalamic connectivity abnormalities in patients with post-stroke sleep apnoea: a pilot case-control study

OBJECTIVE: Sleep apnoea is common after stroke, and has adverse effects on the clinical outcome of affected cases. Its pathophysiological mechanisms are only partially known. Increases in brain connectivity after stroke might influence networks involved in arousal modulation and breathing control. The aim of this study was to investigate the resting state functional MRI thalamic hyper connectivity of stroke patients affected by sleep apnoea (SA) with respect to cases not affected, and to healthy controls (HC). PATIENTS AND METHODS: A series of stabilized strokes were submitted to 3T resting state functional MRI imaging and full polysomnography. The ventral-posterior-lateral thalamic nucleus was used as seed. RESULTS: At the between groups comparison analysis, in SA cases versus HC, the regions significantly hyper-connected with the seed were those encoding noxious threats (frontal eye field, somatosensory association, secondary visual cortices). Comparisons between SA cases versus those without SA, revealed in the former group significantly increased connectivity with regions modulating the response to stimuli independently to their potentiality of threat (prefrontal, primary and somatosensory association, superolateral and medial-inferior temporal, associative and secondary occipital ones). Further significantly functionally hyper connections were documented with regions involved also in the modulation of breathing during sleep (pons, midbrain, cerebellum, posterior cingulate cortices), and in the modulation of breathing response to chemical variations (anterior, posterior and para-hippocampal cingulate cortices). CONCLUSIONS: Our preliminary data support the presence of functional hyper connectivity in thalamic circuits modulating sensorial stimuli, in patients with post-stroke sleep apnoea, possibly influencing both their arousal ability and breathing modulation during sleep

Separase prevents genomic instability by controlling replication fork speed

Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development. Sister chromatid separation is triggered by Separase, an evolutionary conserved protease that cleaves the cohesin complex, allowing the dissolution of sister chromatid cohesion. Here we provide evidence that Separase participates in genomic stability maintenance by controlling replication fork speed. We found that Separase interacted with the replication licensing factors MCM2-7, and genome-wide data showed that Separase co-localized with MCM complex and cohesin. Unexpectedly, the depletion of Separase increased the fork velocity about 1.5-fold and caused a strong acetylation of cohesin's SMC3 subunit and altered checkpoint response. Notably, Separase silencing triggered genomic instability in both HeLa and human primary fibroblast cells. Our results show a novel mechanism for fork progression mediated by Separase and thus the basis for genomic instability associated with tumorigenesis

Separase prevents genomic instability by controlling replication fork speed

Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development. Sister chromatid separation is triggered by Separase, an evolutionary conserved protease that cleaves the cohesin complex, allowing the dissolution of sister chromatid cohesion. Here we provide evidence that Separase participates in genomic stability maintenance by controlling replication fork speed. We found that Separase interacted with the replication licensing factors MCM2-7, and genome-wide data showed that Separase co-localized with MCM complex and cohesin. Unexpectedly, the depletion of Separase increased the fork velocity about 1.5-fold and caused a strong acetylation of cohesin's SMC3 subunit and altered checkpoint response. Notably, Separase silencing triggered genomic instability in both HeLa and human primary fibroblast cells. Our results show a novel mechanism for fork progression mediated by Separase and thus the basis for genomic instability associated with tumorigenesis