Le lettere del Marino e la cultura di primo Seicento

The essay examines the corpus of Giovan Battista Marino's known letters and, acknowledging how many letters have been lost, seeks to reconstruct the geographical and chronological distribution of the recipients. The second part includes close readings of several letters that are expressive Marino's passion for works of art (drawings and paintings by early seventeenth-century artists) and several in which he passes judgment on the works of some contemporary poets.

Writing the Liberata. On the Revision of Canto XVIII

El artículo pretende reconstruir las etapas finales de la composición de la Gerusalemme liberata de Torquato Tasso, profundizando en la escritura de una serie de octavas del canto XVIII, cuya edición crítica se brinda aquí, a partir del manuscrito autógrafo conservado en Ferrara (Biblioteca Ariostea, II 475). En virtud de dicho análisis, se proponen también consideraciones generales con vistas a una nueva edición crítica del poema.This paper aims to rebuild the final stages of composition of Torquato Tasso’s Gerusalemme liberata, and in particular delves into the writing of several octaves of Canto XVIII, which are transcribed in a critical edition based on the autograph manuscript preserved in Ferrara (Biblioteca Ariostea, II 475). On the basis of this analysis, some general considerations are proposed with a view to a new critical edition of the poem

Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice

Acknowledgments We thank Luca Giordano, Giovanni Esposito and Angelo Russo for technical assistance and Dr. Livio Luongo (Second University of Naples–Italy) for critical discussions. This work was supported by a Grant PRIN from Ministry of Education, Universities and Research (MIUR), Italy, to A.C. and the Wellcome Trust (WT098012) to L.K.H. and BBSRC (BB/K001418/1) to L.K.H. and G.D’A. G.D’A. received partial supports from a “FORGIARE” post-doctoral fellowship cofounded by the Polo delle Scienze e Tecnologie per la Vita, University of Naples Federico II and Compagnia di San Paolo Foundation, Turin, Italy (2010–2012).Peer reviewedPublisher PD

Analysis of Fluid-structure Interaction for a Submerged Floating Tunnel

Abstract The behavior of a submerged floating tunnel (SFT) exposed to a water current of variable velocity is investigated through complex numerical analyses based on the Computational Fluid Dynamics (CFD) and the Finite Element Method (FEM) implemented in the ABAQUS code. An accurate modelling of turbulent phenomena is made, based on both Implicit Large Eddy Simulation and the RANS-based Spalart-Allmaras model, followed by a co-simulation procedure in which the fluid dynamics and the structural analysis are carried out separately and interfaced with each other. Circular and elliptical cross sections are considered, each of them fitted for combined railway and motorway services. The analysis is carried out in both static and dynamic way, by varying the current velocity with a given value of the residual buoyancy of the tunnel. The results emphasize the effect of the main parameters investigated, evidencing the great potentials of the adopted calculation tool for carrying out further investigations aimed at achieving useful elements for the design and optimization of the SFT

Présentation du répertoire Autografi dei letterati italiani

Le projet L’idée première d’un recensement des manuscrits autographes des hommes de lettres italiens est née vers 2003. Au cours de nos travaux de doctorat sur la littérature et la langue de la Renaissance, nous avions été confrontés à la difficulté d’identifier et d’attribuer non seulement certains manuscrits d’auteur mais également des textes imprimés comportant des annotations : l’absence d’outils permettant de s’orienter dans ce panorama complexe nous a conduits à imaginer un répertoire d..

Conversazione con Giulia Raboni ed Emilio Russo

Questo fascicolo monografico su «Storie di edizioni» avrebbe dovuto essere presentato in un seminario nel maggio del 2020: la diffusione del virus Covid-19 ha reso impossibile l’incontro previsto, nel quale – insieme agli autori dei saggi – avrebbero dovuto intervenire, aprendo i lavori con le loro riflessioni, Giulia Raboni (dell’Università degli Studi di Parma) e Emilio Russo (dell’Università di Roma La Sapienza). Abbiamo pensato di coinvolgere comunque i due studiosi, chiudendo il numero on line e mandandolo in stampa, e di invitarli a una conversazione sulle tante questioni che la storia delle edizioni può portare in primo piano. La conversazione – realizzata grazie alla loro disponibilità – viene qui proposta ad apertura (e a commento) dei saggi dedicati a singole edizioni e alla loro storia.This monographic issue of "Storie di edizioni" was to have been presented at a seminar in May 2020: the spread of the Covid-19 virus made it impossible to hold the planned meeting, in which - together with the authors of the essays - Giulia Raboni (of the University of Parma) and Emilio Russo (of the University of Rome La Sapienza) were to have opened the proceedings with their reflections. We decided to involve the two scholars anyway, closing the online issue and sending it to print, inviting them to a conversation on the many topics that the history of editions can bring to the fore. The conversation - made possible thanks to their willingness - is offered here as an opening (and commentary) to the essays devoted to individual editions and their history

Identification and analysis of single nucleotide polymorphisms in the myosin VA (MYO5A) gene and its exclusion as the causative gene of the dilute coat colour locus in rabbit

[EN] Classical genetic studies have identified different coat colour loci in rabbit and comparative analyses have established corresponding loci across species. In particular, the rabbit dilute locus is determined by a recessive coat colour mutation that modifies the basic colours influenced by the agouti and extension mutations. In mice, similar phenotypic effects are determined by a similarly named locus. This locus encodes the myosin VA (Myo5a) gene, whose protein product is an unconventional myosin that plays an essential role in melanosome transport in the melanocytes. We selected the same gene as a strong candidate for explaining the dilute coat colour in rabbit. To this end, 1399 bp were re-sequenced, spanning 4 exons out of 41 exons and a portion of intronic regions of the rabbit MYO5A gene to identify polymorphisms that could be useful to confirm or exclude this gene as causative of the rabbit dilute locus. Nine polymorphisms were identified, one of which was used to follow the segregation of the blue and black colours in a Checkered Giant F1 family. The single nucleotide polymorphism (SNP) analysed did not co-segregate with the two colours. These results excluded the MYO5A gene as determinant of the dilute locus in rabbit. The two alleles of this SNP were also present in several other breeds with different coat colours, further indicating that this marker is not associated with the dilute mutation in rabbits. Other candidates should be investigated to identify the causative gene of this locus in rabbit.We thank several rabbit breeders and Associazione Nazionale Coniglicoltori Italiani (ANCI) for their collaboration in the sampling of biological materials. This work was supported by RFO and FAGenomicH project funds from the University of Bologna.Fontanesi, L.; Scotti, E.; Dall'olio, S.; Oulmouden, A.; Russo, V. (2012). Identification and analysis of single nucleotide polymorphisms in the myosin VA (MYO5A) gene and its exclusion as the causative gene of the dilute coat colour locus in rabbit. World Rabbit Science. 20(1):35-41. https://doi.org/10.4995/wrs.2012.1033SWORD354120

Investigation of a short interspersed nuclear element polymorphic site in the porcine vertnin gene: Allele frequencies and association study with meat quality, carcass and production traits in Italian Large White pigs

A 291 bp short interspersed nuclear element (SINE) insertion in the porcine vertnin (VRTN) gene on porcine chromosome 7 was shown to affect vertebral number and several production traits: allele Q (with the insertion) increases vertebral number compared to the wild type allele (WT, without insertion). In this study we genotyped this polymorphism in eight pig breeds (Italian Large White, Italian Duroc, Italian Landrace, Cinta Senese, Mora Romagnola, Casertana, Apulo Calabrese, and Nero Siciliano) and in Italian wild boars to evaluate allele frequency distribution of the two alleles. Allele Q was the most frequent in Italian Landrace and Italian Duroc (0.738 and 0.545, respectively) whereas it was the less frequent in all other breeds and was absent in wild boars. Association study was carried out in two Italian Large White samples. These two groups of animals were constituted by performance tested pigs for which estimated breeding values (EBV) and random residuals (RR) for several traits (average daily gain, back fat thickness, feed: gain ratio, lean cuts and ham weight) were calculated: i) 270 pigs chosen without any criteria (random group), that were also measured for several meat quality traits; ii) 560 gilts with extreme and divergent EBV for back fat thickness. For these animals vertebral number was not available. Results of the association analyses indicated that allele Q was associated with a lower ham weight, confirming indirectly, the negative correlation reported by other studies between vertebral number and this trait. No other trait was associated with the analysed VRTN polymorphism

Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2′-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice

We evaluated the effects of ACEA (selective cannabinoid (CB)1 receptor agonist), WIN 55,212-2 mesylate (WIN; non-selective CB1 and CB2 receptor agonist) and N-palmitoylethanolamine (PEA; an endogenous fatty acid of ethanolamide) in DBA/2 mice, a genetic model of reflex audiogenic epilepsy. PEA, ACEA or WIN intraperitoneal (i.p.) administration decreased the severity of tonic-clonic seizures. We also studied the effects of PEA, WIN or ACEA after co-administration with NIDA-41020 (CB1 receptor antagonist) or GW6471 (PPAR-α antagonist) and compared the effects of WIN, ACEA and PEA in order to clarify their mechanisms of action. PEA has anticonvulsant features in DBA/2 mice mainly through PPAR-α and likely indirectly on CB1 receptors, whereas ACEA and WIN act through CB1 receptors. The co-administration of ineffective doses of ACEA, PEA and WIN with some antiepileptic drugs (AEDs) was examined in order to identify potential pharmacological interactions in DBA/2 mice. We found that PEA, ACEA and WIN co-administration potentiated the efficacy of carbamazepine, diazepam, felbamate, gabapentin, phenobarbital, topiramate and valproate and PEA only also that of oxcarbazepine and lamotrigine whereas, their co-administration with levetiracetam and phenytoin did not have effects. PEA, ACEA or WIN administration did not significantly influence the total plasma and brain levels of AEDs; therefore, it can be concluded that the observed potentiation was only of pharmacodynamic nature. In conclusion, PEA, ACEA and WIN show anticonvulsant effects in DBA/2 mice and potentiate the effects several AEDs suggesting a possible therapeutic relevance of these drugs and their mechanisms of action