Nuevos datos documentales sobre Paolo da San Leocadio

Se presenta un documento que aclara la identidad de la que pudo o debió ser la segunda esposa del italiano Paolo da San Leocadio (Reggio Emilia 1447-Valencia 1520), precoz introductor en 1472 de la pintura del Renacimiento en España. Se trata del contrato matrimonial entre Jaume Llopis, cambista de Valencia, y el pintor, quienes acuerdan el enlace entre dicho pintor e Isabel Llopis, hermana de Jaume, que ofreció una importante dote.A document is presented here which clarifies the identity of who could have been or must have been the second wife of the Italian Paolo da San Leocadio (Reggio Emilia 1447-Valencia 1520), one of the first people to introduce Renaissance paintings to Spain in 1472. It is marriage contract between Jaume Llopis, a moneychanger from Valencia, and the painter, who agreed to the marriage between the painter and Isabel Llopis, Jaume’s sister, offering an important dowry

Business Ethics: Moral or Amoral? An analysis from the perspective of Kantian ethics

The aim of this paper is to analyze the phenomenon related to business ethical purposes from a different perspective, using the philosophical lens developed by Immanuel Kant. This work is also oriented to identify the most important research topics related to business ethics through the combination of a different framework. The present paper intends to offer a conceptual contribution to the ongoing debate on the theme of ethics in corporate social responsibility, highlighting the main problematic aspects that emerge from the analysis of the literature and the observation of reality in the light of the philosophical framework of Kant. This paper, therefore, examines and applies the deontological view of Kant and his distinction between the ‘categorical’ and ‘hypothetic’ imperative. This ethical view is useful to prevent instrumental acceptance of ethical codes and sustainability reports; in fact, during the making of the work, several well-known practices are presented, which are far from behaving in a moral way (i.e., General Electrics, Lehman Brothers, and so on)

Sobre pinturas deshonestas, lienzos y naipes protestantes : tres documentos inquisitoriales vinculados a la censura y tráfico de imágenes heréticas en el mundo hispánico del siglo XVI

El temor a la llegada de doctrinas luteranas al territorio hispánico se zanjó con la censura de diversas obras literarias de temática controvertida que pudieran confundir a los fieles e infundirles ideas heréticas. El arte no estuvo exento de esta circunstancia. En nuestro artículo analizamos diversos textos donde se ve el temor por parte de los inquisidores a la transmisión de ideología anticatólica y también planteamos la subjetividad en la argumentación desarrollada en algunos de estos casos.El temor de l'arribada de doctrines luteranes al territori hispànic es va resoldre amb la censura de diverses obres literàries de temàtica controvertida que poguessin confondre els fidels i infondre'ls idees herètiques. L'art no va estar exempt d'aquesta circumstància. En el nostre article analitzem diversos textos on es veu el temor per part dels inquisidors a la transmissió d'ideologia anticatòlica, de la mateixa manera que plantegem la subjectivitat en l'argumentació desenvolupada en alguns d'aquests casos.The fear of the arrival of Lutheran doctrines to Hispanic territory was settled with the censorship of several literary works on controversial topics that may have confused the faithful and encouraged heretical ideas. Art was not exempt from this circumstance. In our paper, we analyze various texts which reveal how the inquisitors feared the transmission of anti-Catholic ideology and also examine the subjectivity of the arguments put forward in some of these cases

Nuevas aportaciones a la pintura del gótico internacional: Berenguer Mateu y el retablo de San Jorge de Jérica (Castellón)

[ES] Bereguer Mateu es un pintor de la Escuela Valenciana del Gótico Internacional, poco conocido, con una actividad artística centrada en el segundo cuarto del siglo XV. Gracias a los nuevos documentos recientemente exhumados en los archivos valencianos podemos vertebrar su biografía y personalidad artística. Se trata de un pintor perteneciente a una importante familia de pintores cuya obra está influenciada indirectamente por el estilo del maestro Pere Nicolau a través de su hermano Jaume Mateu. La documentación que aportamos constata la autoría del retablo de San Jorge conservado en el Museo Municipal de Jérica (Castellón).Este estudio se inscribe en el marco de un Proyecto de Investigación I+D+i del Ministerio de Educación y Ciencia e Innovación de España, que lleva por título: La consolidación de la pintura del Renacimiento en la Corona de Aragón: la extraordinaria influencia del paradigma de Joan de Joanes (HAR2012-32199)Aliaga-Morell, J.; Rusconi, S. (2016). Nuevas aportaciones a la pintura del gótico internacional: Berenguer Mateu y el retablo de San Jorge de Jérica (Castellón). GOYA. 354:3-17. http://hdl.handle.net/10251/149957S31735

The Medieval and Modern Investigation Centre (CIMM). Documentary contributions

The present article is about the study of the medieval and modern painting in the Crown of Aragon with the documentation located for Centre Modern d Investigació Medieval (CIMM) of the Universitat Politècnica of València and the Universitat de Lleida. This study includes a total of eighteen documents, ten of which are previously unpublished. The remaining eight were known, but have been revised and completed in the archives and perfectly transcribed again for this publication. Although the first documents date from before 1450, these documents are very important for a full understanding of the stylistic switch to the late Gothic of Flemish influence that began in Valencia in the mid-fifteenth century, and continued until the early decades of the sixteenth. Although many of the documents on Jacomart are very brief, they contribute to a better overall profile of this important artist, painter to King Alfonso V the Magnanimous.Aliaga-Morell, J.; Company Climent, J.; Tolosa Robledo, LM.; Puig Sanchis, I.; Ramón Marqués, LN.; Rusconi, S.; Franco Llopis, B. (2014). The Medieval and Modern Investigation Centre (CIMM). Documentary contributions. Imago Temporis. Medium Aevum. VIII:329-356. http://hdl.handle.net/10251/65406S329356VII

Evaluation of plan complexity and dosimetric plan quality of total marrow and lymphoid irradiation using volumetric modulated arc therapy

PurposeTo assess the impact of the planner's experience and optimization algorithm on the plan quality and complexity of total marrow and lymphoid irradiation (TMLI) delivered by means of volumetric modulated arc therapy (VMAT) over 2010-2022 at our institute. MethodsEighty-two consecutive TMLI plans were considered. Three complexity indices were computed to characterize the plans in terms of leaf gap size, irregularity of beam apertures, and modulation complexity. Dosimetric points of the target volume (D2%) and organs at risk (OAR) (Dmean) were automatically extracted to combine them with plan complexity and obtain a global quality score (GQS). The analysis was stratified based on the different optimization algorithms used over the years, including a knowledge-based (KB) model. Patient-specific quality assurance (QA) using Portal Dosimetry was performed retrospectively, and the gamma agreement index (GAI) was investigated in conjunction with plan complexity. ResultsPlan complexity significantly reduced over the years (r = -0.50, p < 0.01). Significant differences in plan complexity and plan dosimetric quality among the different algorithms were observed. Moreover, the KB model allowed to achieve significantly better dosimetric results to the OARs. The plan quality remained similar or even improved during the years and when moving to a newer algorithm, with GQS increasing from 0.019 +/- 0.002 to 0.025 +/- 0.003 (p < 0.01). The significant correlation between GQS and time (r = 0.33, p = 0.01) indicated that the planner's experience was relevant to improve the plan quality of TMLI plans. Significant correlations between the GAI and the complexity metrics (r = -0.71, p < 0.01) were also found. ConclusionBoth the planner's experience and algorithm version are crucial to achieve an optimal plan quality in TMLI plans. Thus, the impact of the optimization algorithm should be carefully evaluated when a new algorithm is introduced and in system upgrades. Knowledge-based strategies can be useful to increase standardization and improve plan quality of TMLI treatments

Automatic planning of the lower extremities for total marrow irradiation using volumetric modulated arc therapy

Purpose Total marrow (and lymphoid) irradiation (TMI-TMLI) is limited by the couch travel range of modern linacs, which forces the treatment delivery to be split into two plans with opposite orientations: a head-first supine upper-body plan, and a feet-first supine lower extremities plan. A specific field junction is thus needed to obtain adequate target coverage in the overlap region of the two plans. In this study, an automatic procedure was developed for field junction creation and lower extremities plan optimization. Methods Ten patients treated with TMI-TMLI at our institution were selected retrospectively. The planning of the lower extremities was performed automatically. Target volume parameters (CTV_J-V-98% > 98%) at the junction region and several dose statistics (D-98%, D-mean, and D-2%) were compared between automatic and manual plans. The modulation complexity score (MCS) was used to assess plan complexity. Results The automatic procedure required 60-90 min, depending on the case. All automatic plans achieved clinically acceptable dosimetric results (CTV_J-V-98% > 98%), with significant differences found at the junction region, where D-mean and D-2% increased on average by 2.4% (p < 0.03) and 3.0% (p < 0.02), respectively. Similar plan complexity was observed (median MCS = 0.12). Since March 2022, the automatic procedure has been introduced in our clinic, reducing the TMI-TMLI simulation-to-delivery schedule by 2 days. Conclusion The developed procedure allowed treatment planning of TMI-TMLI to be streamlined, increasing efficiency and standardization, preventing human errors, while maintaining the dosimetric plan quality and complexity of manual plans. Automated strategies can simplify the future adoption and clinical implementation of TMI-TMLI treatments in new centers

Severe asthma features in children: A case-control online survey

Background: Very few studies have explored the distinguishing features of severe asthma in childhood in Europe, and only one study was conducted in Southern Europe. The aim of this study was to provide a detailed characterization of children with severe asthma treated in specialized pediatric asthma centers across Italy. Methods: We conducted a web-based data collection of family, environmental, clinical and laboratory characteristics of 41 patients aged 6-17 years with severe asthma, defined according to the recent guidelines of the European Respiratory Society and the American Thoracic Society, and 78 age-matched peers with non-severe persistent asthma. The patients have been enrolled from 16 hospital-based pediatric pulmonology and allergy centers in Northern, Central, and Southern Italy. Logistic regression analysis assessed the relationship between patients' characteristics and severe asthma or non-severe persistent asthma. Results: Features independently and significantly associated with severe asthma included lifetime sensitization to food allergens [Odds ratio (OR), 4.73; 95 % Confidence Interval (CI), 1.21-18.53; p = 0.03], lifetime hospitalization for asthma (OR, 3.71; 95 % CI, 1.11-12.33; p = 0.03), emergency-department visits for asthma during the past year (OR = 11.98; 95 % CI, 2.70-53.11; p = 0.001), and symptoms triggered by physical activity (OR = 12.78; 95 % CI, 2.66-61.40; p = 0.001). Quality-of-life score was worse in patients with severe asthma than in subjects with non-severe persistent asthma (5.9 versus 6.6, p = 0.005). Self-perception of wellbeing was compromised in more than 40 % of patients in both groups. Children with severe asthma had lower spirometric z scores than non-severe asthmatic peers (all p < 0.001), although 56 % of them had a normal forced expiratory volume in 1 s. No differences were found between the two groups for parental education, home environment, patients' comorbidities, adherence to therapy, exhaled nitric oxide values, and serum eosinophils and IgE . Conclusions: As expected, children with severe asthma had more severe clinical course and worse lung function than peers with non-severe persistent asthma. Unlike previous reports, we found greater sensitization to food allergens and similar environmental and personal characteristics in patients with severe asthma compared to those with non-severe persistent asthma. Psychological aspects are compromised in a large number of cases and deserve further investigation

Impact of the Extremities Positioning on the Set-Up Reproducibility for the Total Marrow Irradiation Treatment

Total marrow (lymph node) irradiation (TMI/TMLI) delivery requires more time than standard radiotherapy treatments. The patient's extremities, through the joints, can experience large movements. The reproducibility of TMI/TMLI patients' extremities was evaluated to find the best positioning and reduce unwanted movements. Eighty TMI/TMLI patients were selected (2013-2022). During treatment, a cone-beam computed tomography (CBCT) was performed for each isocenter to reposition the patient. CBCT-CT pairs were evaluated considering: (i) online vector shift (OVS) that matched the two series; (ii) residual vector shift (RVS) to reposition the patient's extremities; (iii) qualitative agreement (range 1-5). Patients were subdivided into (i) arms either leaning on the frame or above the body; (ii) with or without a personal cushion for foot positioning. The Mann-Whitney test was considered (p &lt; 0.05 significant). Six-hundred-twenty-nine CBCTs were analyzed. The median OVS was 4.0 mm, with only 1.6% of cases ranked &lt; 3, and 24% of RVS &gt; 10 mm. Arms leaning on the frame had significantly smaller RVS than above the body (median: 8.0 mm/6.0 mm, p &lt; 0.05). Using a personal cushion for the feet significantly improved the RVS than without cushions (median: 8.5 mm/1.8 mm, p &lt; 0.01). The role and experience of the radiotherapy team are fundamental to optimizing the TMI/TMLI patient setup

Severe asthma features in children: a case-control online survey

BACKGROUND: Very few studies have explored the distinguishing features of severe asthma in childhood in Europe, and only one study was conducted in Southern Europe. The aim of this study was to provide a detailed characterization of children with severe asthma treated in specialized pediatric asthma centers across Italy. METHODS: We conducted a web-based data collection of family, environmental, clinical and laboratory characteristics of 41 patients aged 6-17 years with severe asthma, defined according to the recent guidelines of the European Respiratory Society and the American Thoracic Society, and 78 age-matched peers with non-severe persistent asthma. The patients have been enrolled from 16 hospital-based pediatric pulmonology and allergy centers in Northern, Central, and Southern Italy. Logistic regression analysis assessed the relationship between patients' characteristics and severe asthma or non-severe persistent asthma. RESULTS: Features independently and significantly associated with severe asthma included lifetime sensitization to food allergens [Odds ratio (OR), 4.73; 95 % Confidence Interval (CI), 1.21-18.53; p = 0.03], lifetime hospitalization for asthma (OR, 3.71; 95 % CI, 1.11-12.33; p = 0.03), emergency-department visits for asthma during the past year (OR = 11.98; 95 % CI, 2.70-53.11; p = 0.001), and symptoms triggered by physical activity (OR = 12.78; 95 % CI, 2.66-61.40; p = 0.001). Quality-of-life score was worse in patients with severe asthma than in subjects with non-severe persistent asthma (5.9 versus 6.6, p = 0.005). Self-perception of wellbeing was compromised in more than 40 % of patients in both groups. Children with severe asthma had lower spirometric z scores than non-severe asthmatic peers (all p < 0.001), although 56 % of them had a normal forced expiratory volume in 1 s. No differences were found between the two groups for parental education, home environment, patients' comorbidities, adherence to therapy, exhaled nitric oxide values, and serum eosinophils and IgE . CONCLUSIONS: As expected, children with severe asthma had more severe clinical course and worse lung function than peers with non-severe persistent asthma. Unlike previous reports, we found greater sensitization to food allergens and similar environmental and personal characteristics in patients with severe asthma compared to those with non-severe persistent asthma. Psychological aspects are compromised in a large number of cases and deserve further investigation