Dimensionado de un almacén automático para palés con envases de pintura/barniz

El objetivo de este trabajo es dimensionar un almacén automático para palés con envases de pintura/barniz para aumentar la capacidad de almacenamiento del producto terminado, disminuir el coste del mismo y mejorar la eficiencia de la preparación de los pedidos. Se realiza el análisis económico de las posibles opciones. El concepto fundamental es la sustitución del actual sistema de trabajo basado en “Operario a Producto” (el operario se desplaza por la planta con carretillas elevadoras a la búsqueda y recogida del producto solicitado) por el sistema de “Producto a Operario” (el producto terminado se lleva automáticamente al puesto de preparación del pedido donde es recogido por el operario sin que éste se desplace).El trabajo se realiza considerando dos perspectivas básicas: Stock = Selección de productos a almacenar, cantidades y ubicación. Preparación de pedidos = Transporte y movimiento de los palés. Partiendo de: Situación actual:• Stock actual = cantidad y tipología• Necesidad de amplificación por infra capacidad del almacén• Estanterías convencionales de baja altura• Elevado número de referencias de producto en ubicaciones no aptas para su recogida manual• Largos recorridos repetitivos para las carretillas/operarios• Históricos de pedidos y líneas por pedidos Previsión futura• Aumento del número de referencias a almacenar• Incremento notable del picking• Disminución del tamaño de pedidos• Mayor exigencia del servicio a cliente Se seleccionará de los diferentes tipos de envases de producto terminado los más convenientes a automatizar, se calculará el número de palés necesario, se diseñarán y calcularán los posibles lay out de pasillos, huecos, alturas y ubicaciones y se realizará el análisis económico de la inversión en sus diferentes opciones comparándolo con el coste equivalente del actual sistema de trabajo.<br /

Developing active chitosan-based edible film for extending the shelf life of guacamole

This study aimed to evaluate the effect of edible films (EFs) on important parameters of fresh guacamole and to select the best EF for evaluating its stability and protection effect after 28 days of storage (at 4 and 20°C). EFs based on chitosan (2%), glycerol (1%), citric acid (1.5–2.5%), and lemon-onion extract (0–2%) were applied on the surface of fresh guacamole to evaluate its effect in its color and microbiological and antioxidant properties after 48 h of storage (at 4 and 20°C). Results indicated that EFs delay the total color change and increase the antioxidant capacity of guacamole, while the microbial count was less than 100 CFU/g and 10 CFU/g for mesophylls and molds plus yeasts, respectively. According to the lowest total color change (7.93–14.92) and highest antioxidant capacity (1201.22 mg Trolox/100 g), EF1 (2% chitosan, 1% glycerol, 1.5% citric acid, and 2% lemon-onion extract) was selected for its analysis during the storage. After 28 d of storage at 4 and 20°C, a slight change in the physical characteristics of the EF was observed, while microbial load and antioxidant properties remained constant. Moreover, the selected EF maintained its capacity to avoid guacamole browning, being well-accepted by consumers (I like - I like much) who did not detect the application of EF, even after 24 h of its application onto the fresh guacamole. Results presented in this study indicated that developed EF maintained the quality characteristics of guacamole, and its effect did not change after 28 d of storage

Ten years of local water resource management : Integrating satellite remote sensing and geographical information systems

On 2002, a novel initiative was undertaken by the local water administration of Catalonia (the Agència Catalana de l'Aigua) and the Universitat Autònoma de Barcelona, leading to a ten-year project where a high number of medium resolution satellite images (MODIS and Landsat) were integrated to the daily water management to improve decision making effectiveness. This paper describes the methodology followed in the successful application of remote sensing, as well as the main problems that had to be overcome during its execution. It also presents the products that have been calculated. These are integrated into the Agency's corporate GIS and immediately available via the intranet for the staff, and a selection is available on the Internet

Effect of sex in systemic psoriasis therapy: Differences in prescription, effectiveness and safety in the BIOBADADERM prospective cohort

The effect of sex on systemic therapy for psoriasis has not been well studied. The aim of this study was to analyse a large multicentre Spanish cohort of 2,881 patients with psoriasis (58.3% males), followed from January 2008 to November 2018, to determine whether sex influences prescription, effectiveness of therapy, and the risk of adverse events. The results show that women are more likely than men to be pre-scribed biologics. There were no differences between men and women in effectiveness of therapy, measur-ed in terms of drug survival. Women were more likely to develop adverse events, but the difference in risk was small and does not justify different management. Study limitations include residual confounding and the use of drug survival as a proxy for effectiveness.The BIOBADADERM project is promoted by the Fundación Piel Sana Academia Española de Dermatología y Venereología, which receives financial support from the Spanish Medicines and Health Products Agency (Agencia Española de Medicamentos y Productos Sanitarios) and from pharmaceutical companies (Abbott/Abbvie, Pfizer, MSD, Novartis, Lilly, Janssen and Almirall)

Taller Integrado I "Orgía Mecánica". Innovación Educativa

Un espacio pedagógico de convergencia para el aprendizaje y la práctica dialógica de la Aequitectura. Memoria de la experiencia realizada en la Escuela Técnica Superior de Arquitectura de Madrid en Noviembre de 200

Genetic Structure of the Spanish Population

<p>Abstract</p> <p>Background</p> <p>Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.</p> <p>Results</p> <p>In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts.</p> <p>Conclusions</p> <p>In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.</p

Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients

Producción CientíficaBackground: Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients. Methods: Levels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagnosis at three Spanish hospitals. Results: There were 100 patients with infection, 95 with sepsis and 57 with septic shock. Seven biomarkers indicating endothelial dysfunction (mid-regional proadrenomedullin (MR-ProADM), syndecan 1, thrombomodulin, angiopoietin 2, endothelial cell-specific molecule 1, vascular cell adhesion molecule 1 and E-selectin) had stronger associations with sepsis than infection alone. MR-ProADM had the highest odds ratio (OR) in multivariable analysis (OR 11·53, 95 per cent c.i. 4·15 to 32·08; P = 0·006) and the best area under the curve (AUC) for detecting sepsis (0·86, 95 per cent c.i. 0·80 to 0·91; P < 0·001). In a comparison of sepsis with septic shock, two biomarkers of neutrophil degranulation, proteinase 3 (OR 8·09, 1·34 to 48·91; P = 0·028) and lipocalin 2 (OR 6·62, 2·47 to 17·77; P = 0·002), had the strongest association with septic shock, but lipocalin 2 exhibited the highest AUC (0·81, 0·73 to 0·90; P < 0·001). Conclusion: MR-ProADM and lipocalin 2 could be alternatives to the SOFA score in the detection of sepsis and septic shock respectively in surgical patients with infection.Instituto de Salud Carlos III (grants PI15/01959, PI15/01451 and PI16/01156

A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis

BACKGROUND: Non-hereditary colorectal cancer (CRC) is a complex disorder resulting from the combination of genetic and non-genetic factors. Genome-wide association studies (GWAS) are useful for identifying such genetic susceptibility factors. However, the single loci so far associated with CRC only represent a fraction of the genetic risk for CRC development in the general population. Therefore, many other genetic risk variants alone and in combination must still remain to be discovered. The aim of this work was to search for genetic risk factors for CRC, by performing single-locus and two-locus GWAS in the Spanish population. RESULTS: A total of 801 controls and 500 CRC cases were included in the discovery GWAS dataset. 77 single nucleotide polymorphisms (SNP)s from single-locus and 243 SNPs from two-locus association analyses were selected for replication in 423 additional CRC cases and 1382 controls. In the meta-analysis, one SNP, rs3987 at 4q26, reached GWAS significant p-value (p = 4.02×10(-8)), and one SNP pair, rs1100508 CG and rs8111948 AA, showed a trend for two-locus association (p = 4.35×10(-11)). Additionally, our GWAS confirmed the previously reported association with CRC of five SNPs located at 3q36.2 (rs10936599), 8q24 (rs10505477), 8q24.21(rs6983267), 11q13.4 (rs3824999) and 14q22.2 (rs4444235). CONCLUSIONS: Our GWAS for CRC patients from Spain confirmed some previously reported associations for CRC and yielded a novel candidate risk SNP, located at 4q26. Epistasis analyses also yielded several novel candidate susceptibility pairs that need to be validated in independent analyses