18 research outputs found
The omega rho pi coupling in the VMD model revisited
- Author
- Publication venue
- 'World Scientific Pub Co Pte Lt'
- Publication date
- 08/08/2012
- Field of study
We determine the value of the \omega -\rho- \pi mesons coupling
(g_{\omega\rho\pi}), in the context of the vector meson dominance model, from
radiative decays, the \omega \rightarrow 3\pi decay width and the e^+e^-
\rightarrow 3\pi cross section. For the last two observables we consider the
effect of either a heavier resonance (\rho'(1450)) or a contact term. A
weighted average of the results from the set of observables yields
g_{\omega\rho\pi} =14.7 \pm 0.1 GeV^{-1} in absence of those contributions, and
g_{\omega\rho\pi} =11.9 \pm 0.2 GeV^{-1} or g_{\omega\rho\pi} =11.7 \pm 0.1
GeV^{-1} when including the \rho' or contact term respectively. The inclusion
of these additional terms makes the estimates from the different observables to
lay in a more reduced range. Improved measurements of these observables and the
\rho'(1450) meson parameters are needed to give a definite answer on the
pertinence of the inclusion of this last one in the considered processes.Comment: 14 pages, 5 figures. Extended analysis including SND and CMD2 data.
References added. Matches published versio
Form Factors in the radiative pion decay
- Author
- A. Pich
- A.A. Poblaguev
- A.A. Poblaguev
- A.P. Bakulev
- B. Moussallam
- B.L. Ioffe
- B.R. Holstein
- C.Q. Geng
- D. Becirevic
- D. Gómez Dumm
- D.A. Bryman
- E. Frlez
- E. Witten
- E. Witten
- E.A. Kuraev
- E.G. Floratos
- F. Guerrero
- G. Amorós
- G. Ecker
- G. Ecker
- G. Hooft ’t
- G.P. Lepage
- H.X. He
- I. Rosell
- J. Bijnens
- J. Bijnens
- J. Bijnens
- J. Bijnens
- J. Gasser
- J. Gasser
- J. Portolés
- J. Portolés
- J. Portolés
- J. Wess
- J.H. Kühn
- L. Ametller
- L.S. Kisslinger
- M. Jamin
- M. Jamin
- M. Knecht
- M. Knecht
- M.V. Chizhov
- M.V. Chizhov
- N.S. Craigie
- P. Ball
- P. Ball
- P. Herczeg
- P.A. Quin
- P.D. Ruiz-Femenia
- P.D. Ruiz-Femenía
- S. Peris
- S. Peris
- S. Weinberg
- V. Cirigliano
- V. Cirigliano
- V. Cirigliano
- V. Mateu
- V.M. Belyaev
- V.M. Braun
- V.N. Bolotov
- W.M.R. Yao
- Y.Y. Komachenko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
We perform an analysis of the form factors that rule the structure-dependent
amplitude in the radiative pion decay. The resonance contributions to pion -> e
nu_e gamma decays are computed through the proper construction of the vector
and axial-vector form factors by setting the QCD driven asymptotic properties
of the three-point Green functions VVP and VAP, and by demanding the smoothing
of the form factors at high transfer of momentum. A comparison between
theoretical and experimental determinations of the form factors is also carried
out. We also consider and evaluate the role played by a non-standard tensor
form factor. We conclude that, at present and due to the hadronic incertitudes,
the search for New Physics in this process is not feasible.Comment: 14 pages, no figures. Typos corrected. Accepted for publication in
The European Physical Journal
Recommended from our members
The European Solar Telescope
- Author
- Aboudarham J.
- Allegri D.
- Alsina Ballester E.
- Amans J.P.
- Asensio Ramos A.
- Aulanier G.
- Bailén F.J.
- Balaguer M.
- Baldini V.
- Balthasar H.
- Barata T.
- Barczynski K.
- Barreto Cabrera M.
- Baur A.
- Beck C.
- Bello-González N.
- Bellot Rubio L.R.
- Belluzzi L.
- Belío-Asín M.
- Bentley R.D.
- Berdyugina S.V.
- Berghmans D.
- Berkefeld T.
- Berlicki A.
- Berrilli F.
- Bettonvil F.
- Bianda M.
- Bienes Pérez J.
- Bommier V.
- Bonaque-González S.
- Bourdin P.-A.
- Brajša R.
- Burgos Martín J.
- Béchet C.
- Calchetti D.
- Calcines A.
- Calvo Tovar J.
- Campbell R.J.
- Carballo-Martín Y.
- Carbone V.
- Carlin E.S.
- Carlsson M.
- Castro López J.
- Cauzzi G.
- Cavaller L.
- Cavallini F.
- Cecconi M.
- Chulani H.M.
- Cirami R.
- Collados M.
- Consolini G.
- Coretti I.
- Cosentino R.
- Cózar-Castellano J.
- Dalmasse K.
- Danilovic S.
- De Juan Ovelar M.
- de la Cruz Rodríguez J.
- Del Moro D.
- del Pino Alemán T.
- del Toro Iniesta J. C.
- Denker C.
- Dhara S.K.
- Di Marcantonio P.
- Diercke A.
- Dineva E.
- Doerr H.-P.
- Doyle G.
- Díaz Baso C.J.
- Díaz-García J.J.
- Erdelyi R.
- Ermolli I.
- Escobar Rodríguez A.
- Esteban Pozuelo S.
- Faurobert M.
- Feijoo Amoedo N.
- Felipe T.
- Feller A.
- Femenía Castellá B.
- Fernandes J.
- Ferro Rodríguez I.
- Figueroa I.
- Fletcher L.
- Franco Ordovas A.
- Gafeira R.
- Gardenghi R.
- Gelly B.
- Giorgi F.
- Giovannelli L.
- Gisler D.
- González García M.
- González Manrique S.J.
- González F.
- González J.B.
- González-Cava J.M.
- Gracia F.
- Grauf B.
- Greco V.
- Grivel C.
- Guerreiro N.
- Guglielmino S.L.
- Gunár S.
- Gömöry P.
- Hammerschlag R.
- Hanslmeier A.
- Hansteen V.
- Heinzel P.
- Hernández Suárez E.
- Hernández-Delgado A.
- Hidalgo S.L.
- Hill F.
- Hizberger J.
- Hofmeister S.
- Janett G.
- Jarolim R.
- Jess D.
- Jiménez Mejías D.
- Jolissaint L.
- Jurčák J.
- Jägers A.
- Kamlah R.
- Kapitán J.
- Kašparová J.
- Keller C.U.
- Kentischer T.
- Khomenko E.
- Kiselman D.
- Kleint L.
- Klvana M.
- Kontogiannis I.
- Krishnappa N.
- Kuckein C.
- Kučera A.
- Labrosse N.
- Lafon M.
- Laforgue D.
- Lagg A.
- Landi Degl’Innocenti E.
- Langlois M.
- Le Men C.
- Leenaarts J.
- Lepori B.
- Lepreti F.
- Lilje P.B.
- Lindberg B.
- López Ariste A.
- López Fernández V.A.
- López Jiménez A.C.
- López López R.
- Löfdahl M.G.
- Manso Sainz R.
- Marassi A.
- Marco de la Rosa J.
- Marino J.
- Marrero J.
- Martín Gálvez A.
- Martín Hernando Y.
- Martín A.
- Martínez González M.
- Masciadri E.
- Mathioudakis M.
- Mato A.
- Matta-Gómez A.
- Matthews S.
- Mein P.
- Merlos García F.
- Moity J.
- Molinaro M.
- Molodij G.
- Montilla I.
- Montoya L.M.
- Munari M.
- Murabito M.
- Nelson C.J.
- Núñez Cagigal M.
- Oliviero M.
- Orozco Suárez D.
- Ortiz A.
- Padilla-Hernández C.
- Paletou F.
- Pancorbo J.
- Pastor Cañedo A.
- Pastor Yabar A.
- Paéz Mañá E.
- Peat A.W.
- Pedichini F.
- Peixinho N.
- Peter H.
- Petrovay K.
- Peñate J.
- Piazzesi R.
- Pietropaolo E.
- Pleier O.
- Podladchikova T.
- Poedts S.
- Prieto G.
- Pérez de Taoro A.
- Pötzi W.
- Quintero Nehrkorn J.
- Quintero Noda C.
- Ramelli R.
- Ramos Sapena Y.
- Rasilla J.L.
- Reardon K.
- Rebolo R.
- Regalado Olivares S.
- Reyes García-Talavera M.
- Riethmüller T.L.
- Rimmele T.
- Rodríguez Delgado H.
- Rodríguez González N.
- Rodríguez Ramos L.F.
- Rodríguez-Losada J.A.
- Romano P.
- Roth M.
- Rouppe van der Voort L.
- Rudawy P.
- Ruiz de Galarreta C.
- Rybák J.
- Salvade A.
- Sangiorgi M.
- Sayède F.
- Scharmer G.
- Scheiffelen T.
- Schlichenmaier R.
- Schmidt W.
- Schmieder B.
- Scirè C.
- Scuderi S.
- Siegel B.
- Sigwarth M.
- Simões P.J.A.
- Sliepen G.
- Snik F.
- Sobotka M.
- Socas-Navarro H.
- Sola La Serna P.
- Solanki S. K.
- Soler Trujillo M.
- Soltau D.
- Sordini A.
- Sosa Méndez A.
- Stangalini M.
- Steiner O.
- Stenflo J.O.
- Strassmeier K.G.
- Sudar D.
- Suematsu Y.
- Sánchez Rodríguez M.L.
- Sánchez-Capuchino J.
- Sütterlin P.
- Tallon M.
- Temmer M.
- Tenegi F.
- Tritschler A.
- Trujillo Bueno J.
- Tsiropoula G.
- Turchi A.
- Tziotziou K.
- Utz D.
- van Harten G.
- van Noort M.
- van Werkhoven T.
- Vansintjan R.
- Vaz Cedillo J.J.
- Vega Reyes N.
- Verma M.
- Veronig A.M.
- Viavattene G.
- Vitas N.
- Volkmer R.
- von der Lühe O.
- Vögler A.
- Waldmann T.A.
- Walton D.
- Wisniewska A.
- Zeman J.
- Zeuner F.
- Zhang L.Q.
- Zuccarello F.
- Štěpán J.
- Publication venue
- Les Ulis : EDP Sciences
- Publication date
- 01/01/2022
- Field of study
The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope, the German Vacuum Tower Telescope and GREGOR, the French Télescope Héliographique pour l'Étude du Magnétisme et des Instabilités Solaires, and the Dutch Open Telescope. With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems
Instanton-mediated baryon number violation in non-universal gauge extended models
- Author
- A Pich
- AA Belavin
- AM Polyakov
- B Borasoy
- B Kubis
- C-W Chiang
- D Gómez Dumm
- DE Morrissey
- DJ Muller
- E Malkawi
- F Wilczek
- G Ecker
- I Affleck
- J Beringer
- J. Fuentes-Martín
- J. Portolés
- JF Donoghue
- K Hsieh
- KY Lee
- KY Lee
- LHCb collaboration
- M Claudson
- MJ Gibbs
- N Cabibbo
- O Espinosa
- P Herrera-Siklódy
- P Mergell
- P Nath
- P. Ruiz-Femenía
- Q-H Cao
- RS Chivukula
- S Weinberg
- SJ Brodsky
- T Jezo
- W-S Hou
- WJ Marciano
- X Li
- Y Aoki
- Y Miyazaki
- YG Kim
- YG Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The European Solar Telescope
- Author
- Aboudarham J
- Allegri D
- Alsina Ballester E
- Amans JP
- Asensio Ramos A
- Aulanier G
- Bailén FJ
- Balaguer M
- Baldini V
- Balthasar H
- Barata T
- Barczynski K
- Barreto Cabrera M
- Baur A
- Beck C
- Bello-González N
- Bellot Rubio LR
- Belluzzi L
- Belío-Asín M
- Bentley RD
- Berdyugina SV
- Berghmans D
- Berkefeld T
- Berlicki A
- Berrilli F
- Bettonvil F
- Bianda M
- Bienes Pérez J
- Bommier V
- Bonaque-González S
- Bourdin P-A
- Brajša R
- Burgos Martín J
- Béchet C
- Calchetti D
- Calcines A
- Calvo Tovar J
- Campbell RJ
- Carballo-Martín Y
- Carbone V
- Carlin ES
- Carlsson M
- Castro López J
- Cauzzi G
- Cavaller L
- Cavallini F
- Cecconi M
- Chulani HM
- Cirami R
- Collados M
- Consolini G
- Coretti I
- Cosentino R
- Cózar-Castellano J
- Dalmasse K
- Danilovic S
- De Juan Ovelar M
- de la Cruz Rodríguez J
- Del Moro D
- del Pino Alemán T
- del Toro Iniesta JC
- Denker C
- Dhara SK
- Di Marcantonio P
- Diercke A
- Dineva E
- Doerr H-P
- Doyle G
- Díaz Baso CJ
- Díaz-García JJ
- Erdelyi R
- Ermolli I
- Escobar Rodríguez A
- Esteban Pozuelo S
- Faurobert M
- Feijoo Amoedo N
- Felipe T
- Feller A
- Femenía Castellá B
- Fernandes J
- Ferro Rodríguez I
- Figueroa I
- Fletcher L
- Franco Ordovas A
- Gafeira R
- Gardenghi R
- Gelly B
- Giorgi F
- Giovannelli L
- Gisler D
- González García M
- González Manrique SJ
- González F
- González JB
- González-Cava JM
- Gracia F
- Grauf B
- Greco V
- Grivel C
- Guerreiro N
- Guglielmino SL
- Gunár S
- Gömöry P
- Hammerschlag R
- Hanslmeier A
- Hansteen V
- Heinzel P
- Hernández Suárez E
- Hernández-Delgado A
- Hidalgo SL
- Hill F
- Hizberger J
- Hofmeister S
- Janett G
- Jarolim R
- Jess D
- Jiménez Mejías D
- Jolissaint L
- Jurčák J
- Jägers A
- Kamlah R
- Kapitán J
- Kašparová J
- Keller CU
- Kentischer T
- Khomenko E
- Kiselman D
- Kleint L
- Klvana M
- Kontogiannis I
- Krishnappa N
- Kuckein C
- Kučera A
- Labrosse N
- Lafon M
- Laforgue D
- Lagg A
- Landi Degl’Innocenti E
- Langlois M
- Le Men C
- Leenaarts J
- Lepori B
- Lepreti F
- Lilje PB
- Lindberg B
- López Ariste A
- López Fernández VA
- López Jiménez AC
- López López R
- Löfdahl MG
- Manso Sainz R
- Marassi A
- Marco de la Rosa J
- Marino J
- Marrero J
- Martín Gálvez A
- Martín Hernando Y
- Martín A
- Martínez González M
- Masciadri E
- Mathioudakis M
- Mato A
- Matta-Gómez A
- Matthews S
- Mein P
- Merlos García F
- Moity J
- Molinaro M
- Molodij G
- Montilla I
- Montoya LM
- Munari M
- Murabito M
- Nelson CJ
- Núñez Cagigal M
- Oliviero M
- Orozco Suárez D
- Ortiz A
- Padilla-Hernández C
- Paletou F
- Pancorbo J
- Pastor Cañedo A
- Pastor Yabar A
- Paéz Mañá E
- Peat AW
- Pedichini F
- Peixinho N
- Peter H
- Petrovay K
- Peñate J
- Piazzesi R
- Pietropaolo E
- Pleier O
- Podladchikova T
- Poedts S
- Prieto G
- Pérez de Taoro A
- Pötzi W
- Quintero Nehrkorn J
- Quintero Noda C
- Ramelli R
- Ramos Sapena Y
- Rasilla JL
- Reardon K
- Rebolo R
- Regalado Olivares S
- Reyes García-Talavera M
- Riethmüller TL
- Rimmele T
- Rodríguez Delgado H
- Rodríguez González N
- Rodríguez Ramos LF
- Rodríguez-Losada JA
- Romano P
- Roth M
- Rouppe van der Voort L
- Rudawy P
- Ruiz de Galarreta C
- Rybák J
- Salvade A
- Sangiorgi M
- Sayède F
- Scharmer G
- Scheiffelen T
- Schlichenmaier R
- Schmidt W
- Schmieder B
- Scirè C
- Scuderi S
- Siegel B
- Sigwarth M
- Simões PJA
- Sliepen G
- Snik F
- Sobotka M
- Socas-Navarro H
- Sola La Serna P
- Solanki SK
- Soler Trujillo M
- Soltau D
- Sordini A
- Sosa Méndez A
- Stangalini M
- Steiner O
- Stenflo JO
- Strassmeier KG
- Sudar D
- Suematsu Y
- Sánchez Rodríguez ML
- Sánchez-Capuchino J
- Sütterlin P
- Tallon M
- Temmer M
- Tenegi F
- Tritschler A
- Trujillo Bueno J
- Tsiropoula G
- Turchi A
- Tziotziou K
- Utz D
- van Harten G
- van Noort M
- van Werkhoven T
- Vansintjan R
- Vaz Cedillo JJ
- Vega Reyes N
- Verma M
- Veronig AM
- Viavattene G
- Vitas N
- Volkmer R
- von der Lühe O
- Vögler A
- Waldmann TA
- Walton D
- Wisniewska A
- Zeman J
- Zeuner F
- Zhang LQ
- Zuccarello F
- Štěpán J
- Publication venue
- 'EDP Sciences'
- Publication date
- 01/01/2022
- Field of study
The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope, the German Vacuum Tower Telescope and GREGOR, the French Télescope Héliographique pour l’Étude du Magnétisme et des Instabilités Solaires, and the Dutch Open Telescope. With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
- Adams C.
- Adams E.L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Agüero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich A.
- Al Harthi F.
- Al Mutairi A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A.E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I.A.M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Z.
- Allen L.
- Allen M.
- Allen S.
- Allibone S.
- Allison K.S.
- Allos R.
- Almaden-Boyle C.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi A.
- Amitrano S.
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson M.
- Anderson P.
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew A.
- Andrew B.
- Andrew G.
- Andrews E.
- Andrews S.J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe D.
- Antinori A.
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino M.
- Arabi Y.M.
- Aravindan L.
- Arbane G.
- Archer K.
- Arden T.
- Arias S.S.
- Arif S.
- Armstrong J.
- Armstrong L.
- Armstrong R.
- Arning N.
- Arnold S.
- Arranz M.J.
- Arribas E.
- Artuso R.
- Arumugam P.
- Arumugam P.
- Ascolillo S.
- Ashraf S.
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain R.
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin K.
- Austin P.
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R.R.
- Baillie J.K.
- Baillie J.K.
- Baillie J.K.
- Baines B.
- Baines D.
- Baines K.
- Baird Y.
- Bakthavatsalam D.
- Balaconis M.K.
- Baldassarri M.
- Ball C.A.
- Baltzell A.H.
- Bamford A.
- Bamford P.
- Banach D.
- Bancroft H.
- Band G.
- Bandini M.
- Bandla N.
- Bano S.
- Baptista D.
- Barakeh D.
- Baras A.
- Baras A.
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- Zainy T.
- Zak A.
- Zaki A.
- Zamikula J.
- Zanella I.
- Zborowski A.C.
- Zeberg H.
- Zechner M.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J.H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Zöllner S.
- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- Agüero Daiana
- Ahmadi Saeideh
- Akhtar Shaheen
- Aksentijevich Alexandra
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich W. C.
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Angelantonio Emanuele Di
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Anwar Mohammad
- Arabi Yaseen M.
- Arciero Elena
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Samina
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- AZARZAR Samira
- Bachetti Tiziana
- Baillie J. Kenneth
- Balaconis Mary K.
- Baldassarri Margherita
- Ball Catherine A.
- Baltzell Asher Haug
- Band Gavin
- Bandini Maria
- Baraka Dona
- Baras Aris
- Baratti Stefano
- Barbieri Chiara
- Barda B.
- Bargagli Elena
- Barhoush Eman
- Barnes Kathleen C.
- Baroni Silvia
- Bartels Meike
- Bassetti Matteo
- Batini Chiara
- Baya Nikolas
- Beck Andrew
- Beckmann Noam D.
- Bedini Josep L.
- Bee Catherine E.
- Beguin Yves
- Belbin Gillian M.
- Belhaj Yasmine
- Beligni Giada
- Belisle Alexandre
- Belli Mary Ann
- Below Jennifer
- Benetti Elisa
- Bennett David
- Bergantini Laura
- Bergomi Paola
- Berkowitz Nathan
- Bernardo David
- Biagio Antonio Di
- Bianchi Francesco
- Bibert Stéphanie
- Bibert Stéphanie
- Biesecker Les
- Biscarini Filippo
- Blay Natalia
- Bochud M.
- Bochud P. Y.
- Bochud P. Y.
- Bochud Pierre-Yves
- Bochud Pierre-Yves
- Boezen Marike
- Boillat Noémie
- Boillat-Blanco N.
- Bottà Giordano
- Bouab Meriem
- Boughton Andrew P.
- Bouras K.
- Bradford Yuki
- Brahier T.
- Brassard Nathalie
- Breen Gerome
- Brenner Bluma
- Britvan Bari
- Brumpton Ben M.
- Bruno Raffaele
- Bruttini Mirella
- Bryant Sam
- Bryant Sam
- Buring Julie E.
- Busani Stefano
- Bussotti Maurizio
- Butler-Laporte Guillaume
- Butterworth Adam S.
- Buxbaum Joseph D.
- Caldarelli Gian Piero
- Callier Shawneequa
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Canaccini Anna
- Cantarini Luca
- Cantor Michael N.
- Capasso Mario
- Capitani Katia
- Cappelli Silvia
- Carella Massimo
- Carey Dave J.
- Carreras Anna
- Carriero Miriam Lucia
- Castaño-Vinyals Gemma
- Castelli Francesco
- Castori Marco
- Catena Emanuele
- Caulfield Mark J.
- Ceri Stefano
- Cerny A.
- Chamnanphon Monpat
- Chan Georgia
- Chang Xiao
- Chang Xiao
- Chariyavilaskul Pajaree
- Charney Alexander W.
- Chasman Daniel I.
- Chassot J.
- Chassé Michaël
- Chaudhary Kumardeep
- Chavan Sameer
- Chen Hung-Hsin
- Cheng Nathan
- Chetruengchai Wanna
- Chittoor Geetha
- Cho Judy H.
- Cho Kelly
- Choi Sam
- Chowdhury Maharun
- Chung Raymond
- Churchhouse Claire
- Chwialkowska Karolina
- Claassen Sabine
- Claringbould Annique
- Clerc O.
- Coignet Marie
- Coiro Gabriella
- Colligan Grainne
- Collins Brett L.
- Colobrán Roger
- Colombo Riccardo
- Conen A.
- Conticini Edoardo
- Cordioli Mattia
- Cordioli Mattia
- Corridi Marta
- Cortés Beatriz
- Cossarizza Andrea
- Coto Eliecer
- Coviello Domenico A.
- Croci Leonardo
- Croci Susanna
- Crook Derrick W.
- Crooks Kristy
- Crotti Lia
- Cullell Natalia
- Curtis Charles J.
- Cusick Caroline
- Cárcel-Márquez Jara
- Daga Sergio
- Dalmau David
- Daly Mark
- Daly Mark J.
- Danesh John
- Darcis Gilles
- Davis Lea
- Daya Michelle
- de Cid Rafael
- de Felipe Mimbrera Alicia
- de geus Eco E. J. C.
- de la Cal-Sabater Paloma
- DeDiego Marta L.
- Deelen Patrick
- Dei Simona
- Deloukas Panos
- Desanctis Elena
- Desgranges F.
- di Bartolomeo C.
- Dietl Beatriz
- Do Ron
- Dobaño Carlota
- Doddato Gabriella
- Domenico Paolo Di
- Domingo Carlos
- Domínguez-Mayoral Anna
- Donati Alice
- Donner Kati
- Durand Madeleine
- Durham Ceri
- D’Acremont V.
- D’Alessandro Miriana
- D’Arminio Monforte Antonella
- D’Mellow Kenton
- Earle Sarah G.
- Egger T.
- Eid Mohammed A.
- El-Jawhari Jehan J.
- El-Lawaty Walaa M.
- El-shanshory Mohamed R.
- El-Sherbiny Yasser M.
- Elhadidy Tamer A.
- Elnagdy Marwa H.
- Eltoukhy Madonna M.
- Emiliozzi Arianna
- Emma Duncan
- Erard Véronique
- Erard Véronique
- Esko Tõnu
- Estoppey Younes S.
- Fabbiani Massimiliano
- Falcone Marco
- Fallerini Chiara
- Farré Xavier
- Fava Francesca
- Fawns-Ritchie Chloe
- Fawns-Ritchie Chloe
- fawzy Mohammad S.
- Felemban Walaa A.
- Feng Yen-Chen Anne
- Feri Marco
- Fernandez-Cadenas Israel
- Ferreira Manuel A. R.
- Ferri Claudio
- Filipovic M.
- Filippidis P.
- Finer Sarah
- Finer Sarah
- Finucane Hilary
- Fiorentino Giuseppe
- Fiz-López Aida
- Forgetta Vincenzo
- Foucras S.
- Fowler Tom
- Franchi Federico
- Francisci Daniela
- Franco Giulianini
- Franke Lude
- Frediani Bruno
- Free Robert C.
- Frenckell Christian Von
- Friolet R.
- Frippiat Frédéric
- Frischknecht M.
- Frithiof Robert
- Frullanti Elisa
- Furini Simone
- Gabbi Chiara
- Gabrieli Arianna
- Gaddis Michael
- Galván-Femenía Iván
- Ganna Andrea
- Garcia-Aymerich Judith
- García-Clemente Marta
- García-Madrona Sebastian
- Gass Matthew C.
- Gatti Francesca
- Gaziano J. Michael
- Georges Michel
- Gettler Kyle
- Ghosh Biswarup
- Giannattasio Ferdinando
- Gignoux Christopher R.
- Giliberti Annarita
- Giorli Alessia
- Giot Jean-Baptiste
- Girardis Massimo
- Girshick Ahna
- Glessner Joseph R.
- Glessner Joseph T.
- Gofflot Stéphanie
- Goldstein Jacqueline I.
- Gomez Juan
- Gonseth Nussle S.
- González-Villa Esther
- Gori Marco
- Grassi Davide
- Green Robert C.
- Griffiths Chris
- Griffiths Christopher J.
- Grip Jonathan
- Guarnaccia Alessandra
- Guerrini Susanna
- Guidelli Luca
- Guillet A.
- Guindo-Martinez Marta
- Guiot Julien
- Guntz Julien
- Gupta Rahul
- Guturu Harendra
- Guyat-Jacques C.
- Guyatt Anna L.
- Guzman Charlotte
- Guéry B.
- Haefliger D.
- Hakonarson Hakon
- Hakonarson Hakon
- Halawani Roaa T.
- Harerimana Nadia
- Harris Jennifer R.
- Harthi Fawz Al
- Hasanato Rana
- Hayward Caroline
- Hayward Caroline
- Hegazy Mohamed A. F.
- Helgeland Øyvind
- Henry Danielle
- Hensen Kati
- Hiester Liam L.
- Hirankarn Nattiya
- Ho Yuk-Lam
- Hoggart Clive
- Hollox Edward J.
- Hong Eurie L.
- Horowitz Julie E.
- Hosseini Abdolmajid
- Hottenga Jouke Jan
- Huang Qin Qin
- Huang Qin Qin
- Huckins Laura M.
- Huffman Jennifer E.
- Hultström Michael
- Hunt Karen A.
- Hunt Karen A.
- Hurles Matt
- Hussain Shapna
- Huynen Pascale
- Hveem Kristian
- Hügli O.
- Iglesias Lara Lloret
- Ikram M. Arfan
- Iolascon Achille
- Islam Kamrul
- Itan Yuval
- Jacques Jessica
- Jantarabenjakul Watsamon
- Jaquet M.
- Jiménez-Xarrié Elena
- John Catherine
- Jordan Daniel M.
- Josyula Navya Shilpa
- Jung Junghyun
- Justice Anne E.
- Kahlert C. R.
- Kallaste Anne
- Kamdar Dhryata
- Kamdar Dhryata
- Kampouri E. E.
- Kanai Masahiro
- Kanai Masahiro
- Karczewski Konrad J.
- Karjalainen Juha
- Karlson Elizabeth W.
- Karp Avromie
- Kaufmann Daniel E.
- Kaunisto Mari
- Keller Katherine
- Kenny Eimear E.
- Kerchberger V. Eric
- Kerr Shona M.
- Khafaga Walid T.
- Khan Ahsan
- Khan Amara
- Khattab Amin K.
- Kimchi Nofar
- King Daniel
- Kisand Kai
- Kivinen Katja
- Kleger G-R.
- Knapp C.
- Knight Spencer
- Koelling Nils
- Kogevinas Manolis
- Koskelainen Sami
- Kosmicki Jack A.
- Kousathanas Athanasios
- Kristiansson Kati
- Laane Edward
- Labkowsky Alexander
- Laisk Triin
- Lambermont Bernard
- Lannepoudenx Y.
- Lanting Pauline
- Lathrop G. Mark
- Lauren Petty E.
- Laurent Laetitia
- Lavery Cath
- Leader Joseph B.
- Lee Paul H.
- Lee Sang Hyuck
- Lee Sulggi
- Lee Yunsung
- LeFaive Jonathon
- Lena Fabio
- Lepage Pierre
- Lepamets Maarja
- Lerner Robin
- Levy Tess
- Li Binglan
- Li Kevin W.
- Li Rui
- Liao Rachel G.
- Lin Shang-Kuan
- Lipcsey Miklos
- Lista Mirjam
- Llucià-Carol Laia
- Loos Ruth J. F.
- Lopera Esteban
- Lorubbio Maria
- Lozano Francisco
- Lu Wenhan
- Lucas Anastasia
- Luchi Sauro
- Ludovisi Serena
- Läll Kristi
- Léonard Philippe
- MacArthur Daniel
- MacLaughlin Bev
- Maggiolo Franco
- Magnus Per
- Mahmoud Ebrahim S.
- Malaise Olivier
- Mamlouk Noor
- Mancarella Sandro
- Mandalà Marco
- Mangino Massimo
- Mangul Serghei
- Manson JoAnn E.
- Mantovani Stefania
- Manuel O.
- Marcantonio Simona
- MARCHETTI Oreste
- Marciano Carmen
- Mari Francesca
- Maricic Tomislav
- Martin Alicia R.
- Martin Hilary
- Martin Hilary C.
- Martinelli Enrico
- Martí-Fàbregas Joan
- Martín-Nalda Andrea
- Martínez Alba Parra
- Masjuan Jaime
- Mason Dan
- Mason Dan
- Massadeh Salam
- Masucci Luca
- Mazzei Maria Antonietta
- McCormick Joseph B.
- McCurdy Shannon
- Medina-Gomez Carolina
- Meigs James B.
- Meloni Ilaria
- Menatti Elisabetta
- Mencarelli Maria Antonietta
- Menéndez-Valladares Paloma
- Mercader Josep
- Mercader Josep Maria
- Merla Giuseppe
- Metsalu Kristjan
- Metspalu Andres
- Meuris Christelle
- Meuwly J. Y.
- Miah Shefa
- Milani Lili
- Miraglia Federica Gaia
- Mirshahi Tooraj
- Misset Benoît
- Moahmed Hanteera S.
- Moghaddam Seyed Behrooz Mohseni
- Mohamed Attia A. S.
- Mondelli Mario Umberto
- Monica Matteo Della
- Montagnani Francesca
- Montillier P.
- Mooser Vincent
- Moreno Victor
- Morris Marcela
- Morrison David R.
- Moutschen Michel
- Moutsianas Loukas
- Muiño Elena
- Munting A.
- Murphy Shawn N.
- Mussini Cristina
- Mutairi Amal Al
- Márquez Leonardo
- Mägi Reedik
- Naaber Paul
- Naderpour Zeinab
- Nadkarni Girish N.
- Nakanishi Tomoko
- Neale Benjamin M.
- Neale Benjamin M.
- Negro T. Rochat
- Nencioni Cesira
- Neofytos Dionysios
- Neofytos Dionysios
- Newman Bill
- Nguyen Huy
- Niavarani Ahmadreza
- Niblo Kristi
- Niemi Mari E. K.
- Nilaratanakul Voraphoj
- Nivard Michel M. G.
- Nkambul Lindo
- Nkambul Lindokuhle
- Nkambule Lindokuhle
- Nkambule Lindokuhle
- North Kari
- Noto Keith
- Nussle Semira Gonseth
- Oddo M.
- Odhams Christopher A.
- Ognibene Agostino
- Okasha Kamal
- Oliveira Maureen
- Ori Anil P. S.
- O’Connell Anne Marie
- O’Donnell Christopher J.
- O’Mahony L.
- O’Reilly Paul
- Paciosi Francesco
- Packer Richard J.
- Pagani J. L.
- Pagani J. L.
- Palmer Duncan S.
- Palmieri Maria
- Palotie Aarno
- Palotie Aarno
- Pancrazzi Alessandro
- Panese Sandro
- Pantet O.
- Papadimitriou-Olivgeris M.
- Parati Gianfranco
- Parisi Saverio Giuseppe
- Park Danny
- Parravicini Pierpaolo
- Partha Raghavendran
- Pasko Dorota
- Pathak Gita A.
- Pavlovic Milos
- Peloso Gina
- Perez Emma F.
- Perez-Tur Jordi
- Perna Rita
- Perola Markus
- Perrella Antonio
- Perret A.
- Peruggia Michael
- Pessina Gloria
- Pesukova Jaana
- Peterson Pärt
- Petitjean Louis
- Petrocelli Paola
- Phokaew Chureerat
- Piacentini Paolo
- Picchiotti Nicola
- Pietro Massimo Di
- Pigazzini Sara
- Pinoli Pietro
- Pinto Anna Maria
- Pirinen Matti
- Piscopo Carmelo
- Planas Anna M.
- Polikowski Hannah
- Polimanti Renato
- Polymeropoulos Christos
- Polymeropoulos Mihael H.
- Polymeropoulos Vasilios
- Pongpanich Monnat
- Porteous David J.
- Porteous David J.
- Portopena L.
- Poscente Monica
- Preuss Michael
- Priest James
- Przychodzen Bartlomiej P.
- Pugin J.
- Putchareon Opass
- Puthanakit Thanyawee
- Puusepp Mairo
- Quinodoz Mathieu
- Quinodoz Mathieu
- Quiros-Roldan Eugenia
- Rader Daniel
- Rafaels Nicholas
- Raggi Pamela
- Ragoussis Jiannis
- Rahmouni Souad
- Raimondi Francesco
- Rancan Ilaria
- Rand Kristin
- Ravaglia Sabrina
- Regina J.
- Reimann Ene
- Rendon Augusto
- Renieri Alessandra
- Rezk Nardin
- Rhead Brooke
- Rhodes Daniel
- Richards J. Brent
- Richmond Anne
- Richmond Anne
- Rico Veronica
- Ridker Paul M.
- Rime M.
- Ringmets Inge
- Ripamonti Diego
- Ripatti Samuli
- Ritchie Marylyn D.
- Riva Agostino
- Rivolta Carlo
- Rivolta Carlo
- Rizzi Marco
- Rizzo Caterina Lo
- Roberts Genevieve
- Robles Veronica
- Rochat-Stettler L.
- Rogne Tormod
- Rojo Silvia
- Romani Davide
- Rooyackers Olav
- Rossetti Barbara
- Rovere Maria Teresa La
- Rudkin Justine K.
- Ruiz Luong
- Ruiz-Jaén Francisca
- Ruotsalainen Sanni
- Rusconi Stefano
- Russo Roberta
- Sabrina Ravaglia
- Saeedi Morteza
- Safa Nishat
- Safieh Leen Abu
- Salerni Lorenzo
- Salib Irene
- Samir Amr
- Sanarico Maurizio
- Sanguinetti Maurizio
- Sankaran Vijay G.
- Sarma Gopal
- Sarno Laura Di
- Sarzi-Braga Simona
- Satterstrom F. Kyle
- Sauvage Anne-Sophie
- Sawaji Mona
- Scaggiante Renzo
- Scala Raffaele
- Schadt Eric E.
- Schiaroli Elisabetta
- Schurr Erwin
- Scolletta Sabino
- Scott Richard H.
- Scotton Pier Giorgio
- Sealfon Stuart C.
- Sebra Robert P.
- Seed Cotton
- Segala Francesco Vladimiro
- Segura Tomás
- Serra-Llovich Alex
- Serrano-Heras Gemma
- Sesso Howard D.
- Shahin Doaa
- Sharififard Bahareh
- Shaw Douglas M.
- Shortt Jonathan
- Shotelersuk Vorasuk
- Shrine Nick
- Siano Matteo
- Sloofman Laura G.
- Smieszek Sandra P.
- Smith Albert V.
- Smoller Jordan W.
- Sobh Ali
- Sodsai Pimpayao
- Soler Pere
- Solligard Erik
- Solomonson Matthew
- Solomonson Matthew
- Soranzo Nicole
- Soriano Alex
- Spargi Genni
- Spector Tim D.
- Spencer Chris C. A.
- Spertilli Chiara
- Squeo Gabriella Maria
- Starkopf Joel
- Stella Alessandra
- Stevens Christine
- Stuckey Alex
- Suardi Claudia
- Suchartlikitwong Pintip
- Suh N.
- Suh Noémie
- Suliman Bandar A.
- Sumoy Lauro
- Sun Yan V.
- Suttels V.
- Suttichet Thitima B.
- Tabri Jekaterina
- Tacconi Danilo
- Tadi Hengameh Ansari
- Tadini E.
- Tahmasebi Farah
- Tamm Anu
- Tanfoni Marco
- Tang Lara
- Tardif Nicolas
- Tavecchia Luisa
- Tenesa Albert
- Thompson Ryan C.
- THYS Marie
- Timmers Paul R. H. J.
- Tiseo Giusy
- Tita Rossella
- Tobin Martin D.
- Tommasi Andrea
- Torky Mohamed S.
- Torrents David
- Torvorapanit Pattama
- Trankiem Amy
- Trembath Richard C.
- Trembath Richard C.
- Trivedi Bhavi
- Trivedi Bhavi
- Trogstad Lill-Iren S.
- Trotta Tullio
- Tsao Phil
- Tschopp J.
- Tselios Chris
- Tsuo Kristin
- Tumbarello Mario
- Turley Patrick
- Uitterlinden Andre G.
- Underwood Slayton J.
- Vaghi Massimo
- Valente Serafina
- Valentino Floriana
- van Blokland Irene
- van Heel David
- van Heel David A.
- van Heel David A.
- Van Singer M.
- Vecchia Marco
- Veerapen Kumar
- Venn Laura D.
- Venturelli Sophie
- Vergori Alessandra
- Verma Anurag
- Verma Shefali S.
- Verzuri Agnese
- Viala B.
- Villalonga Joan Montaner
- Vincenti Antonella
- Viollet R. Merlet
- Vivo Oreste De
- Voide Cathy
- Voide Cathy
- Vollenweider P.
- Vollenweider P.
- von Hohenstaufen Kathrin Aprile
- von Mering C.
- Vonk Judith. M.
- Vulesevic Branka
- Wain Louise V.
- Walker Susan
- Walters Raymond K.
- Wang Jiongming
- Wang Xueyang
- Wanying Zhu
- Warmerdam Robert
- Weiss Scott T.
- Wicks Stephen J.
- Willer Cristen
- Williams Alexander T.
- Wilson Daniel J.
- Wilson James F.
- Wolford Brooke
- Wolford Brooke
- Wolford Brooke
- Woolley Ann E.
- Wozniak H.
- Wright John
- Wright John
- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
- Yassen Amr M.
- Zanella Isabella
- Zeberg Hugo
- Zguro Kristina
- Zhang Miao
- Zhao Jing Hua
- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- zu Bentrup F. Meyer
- Zucchi Patrizia
- Zyndorf Marissa
- Zöllner Sebastian
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
peer reviewe