Anatomical Retinal Changes after Photodynamic Therapy in Chronic Central Serous Chorioretinopathy

Purpose. To evaluate anatomical retinal changes measured by spectral-domain optical coherence tomography (SD-OCT), after applying photodynamic therapy (PDT) for treatment of chronic central serous chorioretinopathy (CSC). Methods. A retrospective analysis was conducted on 43 patients (48 eyes) with chronic CSC treated with PDT. Visual acuity (VA), central retinal thickness (CRT), outer nuclear layer (ONL) thickness, subretinal fluid (SRF), and photoreceptor ellipsoid zone (EZ) measured by SD-OCT were collected at baseline and at 3, 6, and 12 months after PDT. Differences between normally distributed variables were calculated by a paired-sample t-test; p < 0 05 was considered statistically significant. Results. Mean age was 50 +/- 9.8 years. Mean time from diagnosis to PDT was 12.5 months. Baseline VA was 0.51 +/- 0.24 and significantly improved (p < 0 001) to 0.74 +/- 0.26 one year after PDT. CRT and SRF significantly decreased (p < 0 001) at 3, 6, and 12 months after treatment. ONL thickness and EZ did not significantly change at any point during follow-up. Conclusions. Not significant changes were found in the ONL or EZ 12 months after PDT

Cambios anatómicos retinianos tras la terapia fotodinámica en la coroiditis serosa central crónica

Propósito: Evaluar los cambios anatómicos sobre la retina objetivados mediante tomografía de coherencia óptica de dominio espectral (SD-OCT), tras realizar terapia fotodinámica (TFD) para el tratamiento de la coroiditis serosa central (CSC) crónica. Material y Métodos: Análisis retrospectivo de 75 pacientes con CSC crónica tratados con TFD, de los cuáles 43 pacientes (48 ojos) cumplieron los criterios de inclusión. Se recogieron las características basales de agudeza visual (AV), el espesor macular central, de la capa nuclear externa (CNE), desprendimiento neurosensorial (DNS) y el epitelio pigmentario de la retina (EPR) mediante SD-OCT, y en los meses 3, 6 y 12 posteriores a la TFD. Para la comparación de las medias de dichas variables se utilizó el t-test pareado, considerando diferencias estadísticamente significativas si p<0.05 Resultados: La edad media fue de 50 ± 9,8 años. El tiempo medio desde el diagnóstico hasta el tratamiento fue de 12,5 meses. La AV media antes del tratamiento fue de 0,51 ± 0,24 y se observó una mejora a 0,74 ± 0,26 (p<0,001) al finalizar el tratamiento. El espesor macular central y el DNS se redujeron significativamente (p<0,001) a los 3, 6 y 12 meses tras el tratamiento. El espesor de la CNE y el EPR no se modificaron tras la TFD. Conclusiones: La TFD no produjo cambios significativos en la CNE ni en el EPR tras 1 año de tratamiento

Material sólido cerámico de alta biocompatibilidad

Referencia OEPM: P9901295.-- Fecha de solicitud: 10/06/1999.-- Titular: Consejo Superior de Investigaciones Científicas (CSIC).Material sólido cerámico de alta biocompatibilidad. El objeto de la presente invención es un material sólido cerámico de alta biocompatibilidad para utilizarlo como implante óseo o dental formado por partículas de hidroxiapatito (Ca5(PO4)3OH) nanométricas y cristalinas inmersas en una matriz de sílice amorfa. La síntesis del material se realiza en tres etapas, a) preparación de un gel de sílice de pH superior a 10, b) difusión de iones calcio a través de esa matriz polimérica y c) secado del material resultante.Peer reviewe

Analysis of the interrelationship between applied loads and resulting displacement components after fitting synthetic tibiae with fixation implants.

This Final Degree Project aims to fill the knowledge gap about the interrelationship between applied loads and resulting displacement components after fitting synthetic fourth-generation composite tibiae with fixation implants. For this purpose, two devices have been designed: the upper device consists of a fiberglass mold that allows to replicate the connection of the tibia with the knee; the lower device, which replicates a cardanic joint (ankle), allowing rotation in the sagittal and coronal planes. These designs are intended to mimic the in vivo mechanical conditions to which the tibia is subjected. Once the design, manufacture, and assembly of the devices in the servo-hydraulic machine was completed, calibration of the system was performed before beginning the loading procedure. The mechanical testing protocol consisted of four consecutive loading regimes with increasing amplitudes corresponding to different percentages of body weight (taken to be of an average adult, 82kg). Complementary to the force imposition is the full field displacement measurements, done by acquiring images (DIC) of the flattest surface on the lateral side of the tibia (located between ~89-140 mm from the upper mold edge). Three synthetic bones were used as part of this experimental investigation to elucidate the mechanical behavior of healthy tibia using full-field measurements. In all three tests, flexural fracture of the specimens occurred, showing the critical zone in which a biomechanical and physiological study of the best bicortical screw arrangement (number and bicortical bicortical (number and direction) to ensure good intramedullary nail fixation for rapid patient recovery.<br /