A Client mobile application for Chinese-Spanish statistical machine translation

This show and tell paper describes a client mobile application for Chinese-Spanish machine translation. The system combines a standard server-based statistical machine translation (SMT) system, which requires online operation, with different input modalities including text, optical character recognition (OCR) and automatic speech recognition (ASR). It also includes an index-based search engine for supporting off-line translation.Postprint (published version

Cross-language document retrieval by using non-linear semantic mapping

Se propone un procedimiento no-lineal de mapeado semántico para extraer información multilingüe. El método consiste en utilizar una técnica de reducción de espacio no-lineal para agrupar colecciones de documentos multilingües. En el método propuesto, se construyen para cada lengua agrupaciones independientes de la colección multilingüe y se usan las similitudes de las expresiones semánticas para extraer documentos multilingües. Se implementan dos variantes del método y se comparan con técnicas de extracción de información multilingüe. El método propuesto, para unas tareas específicas, mejora el convencional.A non-linear semantic mapping procedure is proposed for cross-language document retrieval. The method relays on a non-linear space reduction technique for constructing semantic embeddings of multilingual document collections. In the proposed method, an independent embedding is constructed for each language in the multilingual collection and the similarities among the resulting semantic representations are used for cross-language document retrieval. Two variants of the proposed method are implemented and compared with a state-of-the-art cross-language information retrieval technique. It is shown that, for some specific tasks, the proposed method outperforms the conventional one

Uso de mapas semánticos para la búsqueda crosslingue de oraciones paralelas

Este trabajo presenta el uso de una técnica de recuperación de infor-mación crossling¨ue basada en escalamiento multidimensional para la iden-tificación de oraciones paralelas entre lenguas diferentes. El método prop-uesto permite hacer una reducción no-lineal del espacio de representación de las oraciones que se puede aprovechar para identificar similitudes semánti-cas entre conjuntos de oraciones en distintas lenguas. La técnica se ilustra con una colección pentaling¨ue extrai´da de la Constitución Española, la cual está disponible en las cuatro lenguas oficiales del estado español e inglés. Presentamos una evaluación comparativa entre nuestro método y un sistema de búsqueda crossling¨ue basado en la traducción automática de las consultas. Los resultados muestran que nuestro sistema mejora consistentemente en las 20 direcciones experimentales de búsqueda crossling¨ue que permite nuestra colección de datosPostprint (published version

Functional characterization of two enhancers located downstream FOXP2

Background: Mutations in the coding region of FOXP2 are known to cause speech and language impairment. However, it is not clear how dysregulation of the gene contributes to language deficit. Interestingly, microdeletions of the region downstream the gene have been associated with cognitive deficits. Methods: Here, we investigate changes in FOXP2 expression in the SK-N-MC neuroblastoma human cell line after deletion by CRISPR-Cas9 of two enhancers located downstream of the gene. Results: Deletion of any of these two functional enhancers downregulates FOXP2, but also upregulates the closest 3′ gene MDFIC. Because this effect is not statistically significant in a HEK 293 cell line, derived from the human kidney, both enhancers might confer a tissue specific regulation to both genes. We have also found that the deletion of any of these enhancers downregulates six well-known FOXP2 target genes in the SK-N-MC cell line. Conclusions: We expect these findings contribute to a deeper understanding of how FOXP2 and MDFIC are regulated to pace neuronal development supporting cognition, speech and language.Spanish National Research and Development Plan PI14/01884Instituto de Salud Carlos III PI14/01884FEDER PI14/0188

Using collocation segmentation to augment the phrase table

This paper describes the 2010 phrase-based statistical machine translation system developed at the TALP Research Center of the UPC1 in cooperation with BMIC2 and VMU3. In phrase-based SMT, the phrase table is the main tool in translation. It is created extracting phrases from an aligned parallel corpus and then computing translation model scores with them. Performing a collocation segmentation over the source and target corpus before the alignment causes that di erent and larger phrases are extracted from the same original documents. We performed this segmentation and used the union of this phrase set with the phrase set extracted from the nonsegmented corpus to compute the phrase table. We present the con gurations considered and also report results obtained with internal and o cial test sets.Postprint (published version

Axes of relationship value between manufacturers and retailers

Purpose - The purpose of this paper is to define the relationship strategy of manufacturers with their retail customers through the identification of axes for the creation of relationship value. Design/methodology/approach - A survey was carried out and 219 valid questionnaires were completed and returned by the purchasing managers of retail companies in the furniture sector. The model was estimated using the partial least squares approach. Findings - The results revealed three axes of value creation: the core axis, the information and communication technologies (ICTs) axis, and the access axis. These axes included the benefits and costs related to the product and the service provided, the ICTs of the manufacturing project, and the relationships with the sales personnel. Research limitations/implications - Due to the size of the sample, the authors were unable to analyse the potential unobserved heterogeneity of the sample. The authors would suggest that this aspect should be analysed in future research in order to attempt to segment clients. Practical implications - Seller support is the main element of value creation. The importance of the efforts made by management to strengthen the capacities of the field force may be highlighted. Originality/value - The main contribution of this study has been to increase the level of abstraction of the study of relationship value through the identification and modelling of its axes of creation for the under-researched retailers-suppliers relationship

Antioxidant Profile of Pepper (Capsicum annuum L.) Fruits Containing Diverse Levels of Capsaicinoids

Capsicum is the genus where a number of species and varieties have pungent features due to the exclusive content of capsaicinoids such as capsaicin and dihydrocapsaicin. In this work, the main enzymatic and non-enzymatic systems in pepper fruits from four varieties with different pungent capacity have been investigated at two ripening stages. Thus, a sweet pepper variety (Melchor) from California-type fruits and three autochthonous Spanish varieties which have different pungency levels were used, including Piquillo, Padrón and Alegría riojana. The capsaicinoids contents were determined in the pericarp and placenta from fruits, showing that these phenyl-propanoids were mainly localized in placenta. The activity profiles of catalase, total and isoenzymatic superoxide dismutase (SOD), the enzymes of the ascorbate–glutathione cycle (AGC) and four NADP-dehydrogenases indicate that some interaction with capsaicinoid metabolism seems to occur. Among the results obtained on enzymatic antioxidants, the role of Fe-SOD and the glutathione reductase from the AGC is highlighted. Additionally, it was found that ascorbate and glutathione contents were higher in those pepper fruits which displayed the greater contents of capsaicinoids. Taken together, all these data indicate that antioxidants may contribute to preserve capsaicinoids metabolism to maintain their functionality in a framework where NADPH is perhaps playing an essential role

Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation

Aortic aneurysm; Marfan syndrome; VersicanAneurisma aòrtic; Síndrome de Marfan; VersicanAneurisma aortico; Síndrome de Marfan; VersicanThoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition associated with Marfan syndrome (MFS), a disease caused by fibrillin-1 gene mutations. While various conditions causing TAAD exhibit aortic accumulation of the proteoglycans versican (Vcan) and aggrecan (Acan), it is unclear whether these ECM proteins are involved in aortic disease. Here, we find that Vcan, but not Acan, accumulated in Fbn1C1041G/+ aortas, a mouse model of MFS. Vcan haploinsufficiency protected MFS mice against aortic dilation, and its silencing reverted aortic disease by reducing Nos2 protein expression. Our results suggest that Acan is not an essential contributor to MFS aortopathy. We further demonstrate that Vcan triggers Akt activation and that pharmacological Akt pathway inhibition rapidly regresses aortic dilation and Nos2 expression in MFS mice. Analysis of aortic tissue from MFS human patients revealed accumulation of VCAN and elevated pAKT-S473 staining. Together, these findings reveal that Vcan plays a causative role in MFS aortic disease in vivo by inducing Nos2 via Akt activation and identify Akt signaling pathway components as candidate therapeutic targets.The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation), the CBMSO is supported by Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid. CBMSO and CNIC are Severo Ochoa Centers of Excellence (grants CEX2021-001154-S and CEX2020-001041-S, respectively) funded by MICIN/AEI/10.13039/501100011033. The project leading to these results has received funding from “La Caixa” Banking Foundation under project codes HR18-00068 (to MRC and JMR); Spanish Ministerio de Ciencia e Innovación grant RTI2018-099246-B-I00 (MICIU/AEI/FEDER, UE) to JMR, and grants PID2020-115217RB-100 and PID2021-122388OB-100 to MRC and JMR, respectively, funded by MCIN/AEI/10.13039/501100011033; Instituto de Salud Carlos III (CIBER-CV CB16/11/00264 and CB16/11/00479; and grants PI17/00381 to GT-T and PI21/00084 (co-funded by Fondo Europeo de Desarrollo Regional (FEDER)) to JFN); Fundacio La Marato TV3 (20151330 to JMR); Instituto de Investigación Sanitaria Marqués de Valdecilla (IDIVAL) (INNVAL 21/24) to JFN; The Marfan Foundation USA Faculty grant 2017 MRF/1701 (to JMR); Fundación MERCK-Fundación Española de Enfermedades Raras 2022 and V-Ayudas “Muévete por los que no pueden 2021” (to JO); and Spanish Ministerio de Ciencia e Innovación contracts FPI (BES-2016-077649) to MJR-R; Sara Borrell (CD18/00028) and Juan de la Cierva (IJC2020-044581-I) to MT; Ramón y Cajal (RYC2021-033343-I) to JO; and FPU (20/04814) to IA-R

SIGPAC y series multitemporales LANSAT 15 TM como estrategia híbrida de clasificación de usos de suelo para aplicaciones hidrológicas

El objetivo de este trabajo consiste en la obtención de un mapa de usos y coberturas de suelo para su integración en un modelo hidrológico de balance de agua a lo largo de 2009. Los resultados de dicha aplicación (evapotranspiración, humedad de suelo, necesidades de riego) se obtienen a escala de parcela, con escala temporal diaria y contemplando los usos y coberturas más frecuentes en la zona. La herramienta diseñada para aplicar el modelo (HidroMORE, Modelo Hidrológico de Estimación de Recarga y Evapotranspiración) proporciona los resultados en forma de mapa imagen. Con este fin, se presenta una alternativa híbrida de clasificación consistente en la combinación de la base de datos vectorial del Sistema de Información Geográfica de Parcelas Agrícolas (SIGPAC), junto con una serie multitemporal de imágenes Landsat 5 TM (Thematic Mapper) del año 2009. El primero aporta la definición parcelaria, mientras que la segunda provee la información suficiente para resolver clases poco definidas en el SIGPAC, especialmente la categoría ‘tierra arable’. Se utilizaron metodologías de teledetección como la clasificación, la segmentación multitemporal y el NDVI (Normalized Difference Vegetation Index), junto con herramientas SIG. El método propuesto supuso una mejora global de la precisión respecto a un método de clasificación supervisada convencional del 20% para la zona de estudio en 2009, y con un coste operacional muy bajo.The aim of this work consists on retrieving a land use-land cover map in order to integrate it in a water balance model along 2009. The results of this application, i.e., evapotranspiration, soil moisture, irrigation rates, are obtained at field scale, in a daily basis, and over the most representative agricultural uses. The model is implemented in a computerized tool, HidroMORE, which provides image maps of the results. A hybrid alternative of classification is presented for such hydrological application. It consisted in a combination of the vectorial database from the Spanish Geographic Information System for Agricultural Plots (SIGPAC) and a Landsat 5 TM multitemporal series of images for the year of study. The SIGPAC affords the spatial shape of the plots, whereas the images allow the segmentation of some ambiguous categories, i.e., ‘agricultural plots’. Remote sensing techniques (classification, segmentation, and NDVI, Normalized Difference Vegetation Index) were used, as well as GIS tools. The proposed method improved by 20% the global accuracy comparing to a typical supervised classification in the study area along 2009, while the computational cost is low

Rapid Climate Changes in the Westernmost Mediterranean (Alboran Sea) Over the Last 35 kyr: New Insights From Four Lipid Paleothermometers (UK' 37, TEXH 86, RI-OH', and LDI)

This study was supported by Grant PID2019-104624RB-I00 funded by MCIN/AEI/ 10.13039/501100011033, Grants FEDER/Junta de Andalucia-Consejeria de Economia y Conocimiento P18-RT-3804 and P18-RT- 4074, and Research Group RNM-179 (Junta de Andalucia). The authors also thank the Unidad Cientifica de Excelencia UCE-PP2016-05 (University of Granada). This study also received funding from the Netherlands Earth System Science Center (NESSC) through a gravitation grant (024.002.001) to J. S. Sinninghe Damste and S. Schouten from the Dutch Ministry for Education, Culture and Science. M. Rodrigo-Gamiz acknowledges funding from the Andalucia Talent Hub Program co-funded by the European Union's Seventh Framework Program (COFUND-Grant Agreement No 291780) and the Junta de Andalucia and from the Juan de la Cierva-Incorporacion program in the University of Granada (IJCI-2017-33,755) from Secretaria de Estado de I + D + i, Spain. We thank the captain, crew, and participants of the Gasalb cruise onboard R/V Pelagia for assistance during sampling. We are also grateful to the Poznan Radiocarbon Laboratory (Poland), the Leibniz Laboratory for Radiometric Dating and Stable Isotope Research (Germany), and the Centre for Scientific Instrumentation (CIC, Spain) for analyses. The authors thank Jort Ossebaar, Anchelique Mets, Marianne Baas and Karsten Dekker (all at NIOZ) for laboratory assistance. Thanks to Prof. Giuseppe Siani (Universite Paris-Sud Orsay) and Jose Manuel Mesa Fernandez for their help and comments on the age model. We thank the Associate Editor, Dr. Yige Zhang, two anonymous reviewers, and Dr. Felix J. Elling for their helpful comments that improved the manuscript substantially. Funding for open access charge from Universidad de Granada/CBUA.The westernmost Mediterranean is one of the most sensitive areas to global climate change and high sedimentation rates allow recording high frequency variability. We present a high-resolution paleotemperature reconstruction over the last 35 kyr using, for the first time, four independent organic sea surface temperature (SST) proxies (UK' 37, TEXH 86, RI-OH' and LDI) based on alkenones, (hydroxy) isoprenoid GDGTs, and long-chain diols. We also generated a δ18O of planktonic foraminifera G. bulloides record together with records of bulk parameters (total organic carbon content, δ13Corg) and the accumulation rates of different biomarkers to provide insights into terrestrial input and primary producers. All derived-SST records showed similar trends over the last 35 kyr, revealing abrupt temperature variations during the last seven Dansgaard- Oeschger (D/O) cycles, the three Heinrich (H) events, the Last Glacial Maximum, and the Younger Dryas. H3 is recognized as the coldest event, while H1 was recorded by all SST proxies as the most abrupt one. In general, TEXH 86-, RI-OH'- and LDI-SST estimates were lower than those obtained from UK' 37. The LDI paleothermometer recorded the largest range of absolute SSTs over the whole period (ca. 20°C) followed by RI-OH' (ca. 16°C). TEXH 86, RI-OH' and LDI proxies reflected sudden SST changes during the D/O 6 and 5 particularly well. Low BIT values and the abundance of C32 1,15-diol in range with typical marine values indicated only minor input of continental organic matter. Accumulation rates of different lipid biomarkers were generally modulated by D/O cycles, suggesting enhanced productivity during D/O interstadials and the Bölling- Alleröd period.Grants FEDER/Junta de Andalucia-Consejeria de Economia y Conocimiento PID2019-104624RB-I00 MCIN/AEI/ 10.13039/501100011033 P18-RT-3804 P18-RT- 4074Research Group RNM-179Unidad Cientifica de Excelencia UCE-PP2016-05Netherlands Earth System Science Center (NESSC) through a gravitation grant 024.002.001Andalucia Talent Hub Program - European Union's Seventh Framework Program (COFUND-Grant) 291780 Junta de AndaluciaJuan de la Cierva-Incorporacion program in the University of Granada from Secretaria de Estado de I + D + i, Spain IJCI-2017-33,755Universidad de Granada/CBU