Identification of an average temperature and a dynamical pressure in a multitemperature mixture of fluids

We present a classical approach of a mixture of compressible fluids when each constituent has its own temperature. The introduction of an average temperature together with the entropy principle dictates the classical Fick law for diffusion and also novel constitutive equations associated with the difference of temperatures between the components. The constitutive equations fit with results recently obtained through Maxwellian iteration procedure in extended thermodynamics theory of multitemperature mixtures. The differences of temperatures between the constituents imply the existence of a new dynamical pressure even if the fluids have a zero bulk viscosity. The nonequilibrium dynamical pressure can be measured and may be convenient in several physical situations as for example in cosmological circumstances where - as many authors assert - a dynamical pressure played a major role in the evolution of the early universe.Comment: 16 page

First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer

AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer. METHODS: We designed a single-arm prospective, multicentre, open-label phase II study to evaluate the combination of erlotinib (100 mg/d, orally) and weekly FDR-Gem (1000 mg/m2, infused at 10 mg/m2per minute) in a population of previously untreated patients with locally advanced, inoperable, or metastatic pancreatic cancer. Primary endpoint was the rate of progression-free survival at 6 mo (PFS-6); secondary endpoints were overall response rate (ORR), response duration, tolerability, overall survival (OS), and clinical benefit. Treatment was not considered to be of further interest if the PFS-6 was < 20% (p0 = 20%), while a PFS-6 > 40% would be of considerable interest (p1 = 40%); with a 5% rejection error (α = 5%) and a power of 80%, 35 fully evaluable patients with metastatic disease were required to be enrolled in order to complete the study. Analysis of prognostic factors for survival was also carried out. RESULTS: From May 2007 to September 2009, 46 patients were enrolled (male/female: 25/21; median age: 64 years; median baseline carbohydrate antigen 19-9 (CA 19-9): 897 U/mL; locally advanced/metastatic disease: 5/41). PFS-6 and median PFS were 30.4% and 14 wk (95%CI: 10-19), respectively; 1-year and median OS were 20.2% and 26 wk (95%CI: 8-43). Five patients achieved an objective response (ORR: 10.9%, 95%CI: 1.9-19.9); disease control rate was 56.5% (95%CI: 42.2-70.8); clinical benefit rate was 43.5% (95%CI: 29.1-57.8). CA 19-9 serum levels were decreased by > 25% as compared to baseline in 14/23 evaluable patients (63.6%). Treatment was well-tolerated, with skin rash being the most powerful predictor of both longer PFS (P < 0.0001) and OS (P = 0.01) at multivariate analysis (median OS for patients with or without rash: 42 wk vs 15 wk, respectively, Log-rank P = 0.03). Additional predictors of better outcome were: CA 19-9 reduction, female sex (for PFS), and good performance status (for OS). CONCLUSION: Primary study endpoint was not met. However, skin rash strongly predicted erlotinib efficacy, suggesting that a pharmacodynamic-based strategy for patient selection deserves further investigation

First principles theory of fluctuations in vortex liquids and solids

Consistent perturbation theory for thermodynamical quantities in type II superconductors in magnetic field at low temperatures is developed. It is complementary to the existing expansion valid at high temperatures. Magnetization and specific heat are calculated to two loop order and compare well to existing Monte Carlo simulations and experiments.Comment: 3 .ps fig. In press Phys. Rev.

Manipulation of micro-components using vacuum grippers.

SUMMARY. During the past decades several microproducts have been fabricated for a great variety of applications in the traditional fields, including the medical and biomedical sectors, automotive, aeronautics and aerospace, Information Technology and telecommunication as well as in more innovative areas, such as household appliances, entertainment and sport equipment. Nevertheless, hybrid three dimensional micro products have still great difficulty in penetrating the market, mainly due to the limits of the fabrication processes that require manipulation and final assembly of microcomponents. These processes, being not yet automated, strongly affect the cost of products. Therefore, new market perspectives can be reached automating the assembly phase. The main challenge is due to the new physical scenario that appears when dealing with the assembly of millimetric and sub-millimetric parts. Indeed, at the microscale the high surface to volume ratio leads to the predominance of the superficial forces (e.g. electrostatic, van der Waals and surface tension forces) over the gravitational force; this results in an unpredictable behaviour of the traditional manipulating mechanisms, whereas an efficient and precise control of the grasp and release of thousands of microscopic and fragile parts is required. For this reason the downscaling of traditional handling strategies and the development of new handling techniques require further studies. Several solutions can be found in literature, with their advantages and limitations, i.e.: friction and jaw microgrippers, magnetic and electrical fields used to levitate objects, adhesive grippers exploiting capillary force. Also vacuum grippers can be miniaturized. Due to their intrinsic simplicity, vacuum grippers are very cheap and appear a promising solution for industrial applications, if some improvements are carried out. In this context, an experimental setup for the automatic manipulation of microcomponents through some vacuum grippers was developed. Moreover, an innovative design of a nozzle for a vacuum gripper was fabricated and tested, comparing its performance with traditional needles. The design was conceived in order to reduce the frequency of occlusions of the nozzle and handle a wide range of particles. The tests described in this paper concern mainly the success and the precision of the release of objects from the gripper. Indeed, this is one the crucial aspect of micromanipulation because microparts tend to stick to the gripper preventing the successful performance of manipulation tasks

Entropy Principle and Recent Results in Non-Equilibrium Theories

We present the state of the art on the modern mathematical methods of exploiting the entropy principle in thermomechanics of continuous media. A survey of recent results and conceptual discussions of this topic in some well-known non-equilibrium theories (Classical irreversible thermodynamics CIT, Rational thermodynamics RT, Thermodynamics of irreversible processes TIP, Extended irreversible hermodynamics EIT, Rational Extended thermodynamics RET) is also summarized

Silicon epitaxy below 200°C: Towards thin crystalline solar cells

International audienceLow temperature plasma processes provide a toolbox for etching, texturing and deposition of a wide range of materials. Here we present a bottom up approach to grow epitaxial crystalline silicon films (epi-Si) by standard RF-PECVD at temperatures below 200°C. Booth structural and electronic properties of the epitaxial layers are investigated. Proof of high crystalline quality is deduced from spectroscopic ellipsometry and HRTEM measurements. Moreover, we build heterojunction solar cells with intrinsic epitaxial absorber thickness in the range of a few microns, grown at 175 °C on highly doped (100) substrates, in the wafer equivalent approach. Achievement of a fill factor as high as 80 % is a proof that excellent quality of epitaxial layers can be produced at such low temperatures. While 8.5 % conversion efficiency has already been achieved for a 3.4 µm epitaxial silicon absorber, the possibility of reaching 15 % conversion efficiency with few microns epi-Si is discussed based on a detailed opto-electrical modeling of current devices

Why the lowest Landau level approximation works in strongly type II superconductors

Higher than the lowest Landau level contributions to magnetization and specific heat of superconductors are calculated using Ginzburg - Landau equations approach. Corrections to the excitation spectrum around solution of these equations (treated perturbatively) are found. Due to symmetries of the problem leading to numerous cancellations the range of validity of the LLL approximation in mean field is much wider then a naive range and extends all the way down to $H = {H_{c2}(T)}/13$. Moreover the contribution of higher Landau levels is significantly smaller compared to LLL than expected naively. We show that like the LLL part the lattice excitation spectrum at small quasimomenta is softer than that of usual acoustic phonons. This enhanses the effect of fluctuations. The mean field calculation extends to third order, while the fluctuation contribution due to HLL is to one loop. This complements the earlier calculation of the LLL part to two loop order.Comment: 20 pages, Latex file, three figure

Predicting PM2.5 and PM10 Levels during Critical Episodes Management in Santiago, Chile, with a Bivariate Birnbaum-Saunders Log-Linear Model

Improving air quality is an important environmental challenge of our time. Chile currently has one of the most stable and emerging economies in Latin America, where human impact on natural resources and air quality does not go unperceived. Santiago, the capital of Chile, is one of the cities in which particulate matter (PM) levels exceed national and international limits. Its location and climate cause critical conditions for human health when interaction with anthropogenic emissions is present. In this paper, we propose a predictive model based on bivariate regression to estimate PM levels, related to PM2.5 and PM10, simultaneously. Birnbaum-Saunders distributions are used in the joint modeling of real-world PM2.5 and PM10 data by considering as covariates some relevant meteorological variables employed in similar studies. The Mahalanobis distance is utilized to assess bivariate outliers and to detect suitability of the distributional assumption. In addition, we use the local influence technique for analyzing the impact of a perturbation on the overall estimation of model parameters. In the predictions, we check the categorization for the observed and predicted cases of the model according to the primary air quality regulations for PM

Detection of serum antibodies to hepatitis E virus in domestic pigs in Italy using a recombinant swine HEV capsid protein

Background: The hepatitis E virus (HEV) has been detected in both humans and animals, particularly pigs, worldwide. Several evidences, including human infection following consumption of raw contaminated meat, suggest a zoonotic transmission of HEV. In Italy, large circulation of genotype 3 HEV has been reported in swine, and recent studies have confirmed the involvement of this genotype in autochthonous human cases. Result: In this study 111 sera collected from healthy pigs in two Italian regions were tested for anti-HEV IgG antibodies. For specific HEV antibody detection in swine, we developed ELISA and Western blotting methods, using a truncated capsid (ORF2) protein lacking the first 111 amino acids of a swine HEV genotype 3 strain. The ORF2-based ELISA revealed anti-HEV antibodies in 104 out of 111 pigs compared with 102 detected with a commercial ELISA kit. A lower number of sera reacted with the recombinant ORF2 protein in a Western blotting format (81/111). Using a Latent class analysis (LCA), the estimated sensitivities for ELISA-ORF2 and ELISA-kit tests were 0.961 and 0.936, respectively, whereas specificities were 0.599 and 0.475. The estimated sensitivity of Western blotting was 0.775, and the specificity was 0.944. Conclusions: The overall results confirm the high prevalence of HEV seropositive healthy pigs in Italy. Through comparisons with a commercial ELISA test, the swine genotype 3 HEV antigen produced in this study was proven suitable to detect anti-HEV antibodies in pig sera by both ELISA and Western Blotting