A taxonomy for key performance indicators management

In recent years, research on Key Performance Indicators (KPIs) management has grown exponentially, giving rise to a multitude of heterogeneous approaches addressing any aspect concerning it. In this paper, we plot the landscape of published works related with KPIs management, organizing and synthesizing them by means of a unified taxonomy that encompasses the aspects considered by other proposals, and it captures the overall characteristics of KPIs. Since most of the literature centers on the definition of KPIs, we mainly focus on such an aspect of KPIs management. Our work is intended to provide remarkable benefits such as enhancing the understanding of KPIs management, or helping users decide about the most suitable solution for their requirements

Impact of chitosan-based nanocarriers on cytoskeleton dynamics: current status and challenges

Chitosan-based nanocarriers (CS-NCs) show a promising role in improving drugs and bioactive compounds delivery for therapy. However, the effects exerted by CS-NCs at the cellular level, including their recognition and uptake, have not been fully investigated yet. Many factors, including size, shape, concentration, and surface chemistry of CS-NCs, play an important role in determining the types of intracellular signals triggered. The mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside cells. In the present work, we discuss the effects induced by CS-NCs per se on the cytoskeleton, a key component in cell architecture and physiology. The focus of this report is made on tumoral and normal biological models in which CS-NCs could differentially affect the cell cytoskeleton. The recent years reports regarding the impact of CS-NCs on cytoskeleton dynamics and the current techniques for its evaluation are summarized and discussed. Understanding mechanisms underlying cytoskeletal impact after cell exposure to CS-NCs is critical for the design of safest value-Added formulations in the biomedical field. Furthermore, this revision points out some interesting aspects of cytoskeletal changes and cell death encompassing anti-Tumoral effects.Fil: Di Santo, Mariana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Alaimo, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Domínguez Rubio, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Pérez, Oscar E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentin

Local adsorption structure and bonding of porphine on Cu(111) before and after self-metalation

We have experimentally determined the lateral registry and geometric structure of free-base porphine (2H-P) and copper-metalated porphine (Cu-P) adsorbed on Cu(111), by means of energy-scanned photoelectron diffraction (PhD), and compared the experimental results to density functional theory (DFT) calculations that included van der Waals corrections within the Tkatchenko-Scheffler approach. Both 2H-P and Cu-P adsorb with their center above a surface bridge site. Consistency is obtained between the experimental and DFT-predicted structural models, with a characteristic change in the corrugation of the four N atoms of the molecule's macrocycle following metalation. Interestingly, comparison with previously published data for cobalt porphine adsorbed on the same surface evidences a distinct increase in the average height of the N atoms above the surface through the series 2H-P, Cu-P, cobalt porphine. Such an increase strikingly anti-correlates the DFT-predicted adsorption strength, with 2H-P having the smallest adsorption height despite the weakest calculated adsorption energy. In addition, our findings suggest that for these macrocyclic compounds, substrate-to-molecule charge transfer and adsorption strength may not be univocally correlated

An HST/NICMOS view of the prototypical giant HII region NGC604 in M33

We present the first high-spatial resolution near-infrared (NIR) imaging of NGC 604, obtained with the NICMOS camera aboard the Hubble Space Telescope (HST). These NICMOS broadband images reveal new NIR point sources, clusters, and diffuse structures. We found an excellent spatial correlation between the 8.4 GHz radio continuum and the 2.2mu-m nebular emission. Moreover, massive young stellar object candidates appear aligned with these radio peaks, reinforcing the idea that those areas are star-forming regions. Three different scaled OB associations are recognized in the NICMOS images. The brightest NIR sources in our images have properties that suggest that they are red supergiant stars, of which one of them was previously known. This preliminary analysis of the NICMOS images shows the complexity of the stellar content of the NGC 604 nebula.Comment: Paper presented in the Workshop "Young massive star clusters: initial conditions and environments" (Granada, Spain - Sept 2007). Astrophysics & Space Science in press, 7 pages, 4 figure

Changes on grape volatile composition after elicitors and nitrogen compounds foliar applications to 'Garnacha', 'Tempranillo' and 'Graciano' vines

Grape volatile compounds determine the wine quality and typicity. The aim of this work was to study the effects of several foliar applications in 'Garnacha', 'Tempranillo', and 'Graciano' grapevines in order to enhance their grape volatile composition. The field trial involved the application of two nitrogen compounds, urea (Ur) and phenylalanine (Phe), and two elicitors, methyl jasmonate (MeJ) and a yeast extract (YE). The analysis of grape volatile compounds was carried out by HS-SPME-GC-MS. For 'Garnacha', most terpenes, and C13 norisoprenoids increased their grape content by applying Ur and Phe, and especially MeJ. For 'Tempranillo', treatments with Ur and MeJ improved the synthesis of most terpenoids. For 'Graciano', a trend to decrease the terpenoids content in grapes with the treatments was observed; however, Phe application increased C13 norisoprenoids content. In conclusion, foliar application of, Phe or Ur, and an elicitor, MeJ, can be a useful tool to improve grape quality

Geocronología de la Terraza Compleja de Arganda en el valle del río Jarama (Madrid, España)

La Terraza Compleja de Arganda (TCA), situada en el tramo bajo del río Jarama (Madrid), está formada por sucesivos apilamientos de secuencias fluviales denominados de abajo a arriba Arganda I, II, III y IV, en los que se han encontrado importantes yacimientos arqueológicos y paleontológicos del Pleistoceno (Áridos 1 y 2, Valdocarros o HAT), y numerosos conjuntos de industria lítica del Paleolítico inferior y medio. Hasta ahora, la única referencia cronológica disponible para la TCA era la proporcionada por el estadio evolutivo de los micromamíferos de los yacimientos Áridos 1 en Arganda I y Valdocarros en Arganda II. En este trabajo, se propone la equivalencia de las distintas unidades de la TCA con terrazas escalonadas y se establece un marco cronológico numérico, obtenido mediante dataciones de termoluminiscencia, luminiscencia ópticamente estimulada y racemización de aminoácidos. Arganda I (≈ T+30-32 m) se situaría hacia el final del MIS 11 o en el inicio del MIS 9, Arganda II (≈T+23-24 m) se correspondería con el inicio del MIS 7, Arganda III (≈T+18-20 m) se situaría entre el MIS 7 y el MIS 5, y Arganda IV comenzaría su deposición en el MIS 5 finalizando su sedimentación en el MIS 1 al sur de Arganda del Rey (Madrid)

Caffeine Encapsulation in Metal Organic Framework MIL-53(Al) at Pilot Plant Scale for Preparation of Polyamide Textile Fibers with Cosmetic Properties

Currently in the marketplace, we can find clothing items able to release skin-friendly ingredients while wearing them. These innovative products with high-added value are based on microencapsulation technology. In this work, due to its lightness, flexibility, porosity, chemical affinity and adsorption capacity, metal-organic framework (MOF) MIL-53(Al) was the selected microcapsule to be synthesized at a large scale and subsequent caffeine encapsulation. The synthesis conditions (molar ratio of reactants, solvents used, reaction time, temperature, pressure reached in the reactor and activation treatment to enhance the encapsulation capacity) were optimized by screening various scaling-up reactor volumes (from lab-scale of 40 mL to pilot plant production of 3.75 L). Two types of Al salts (Al(NO3)3·9H2O from the original recipe and Al2(SO4)3 as commercial SUFAL 8.2) were employed. The liporeductor cosmetic caffeine was selected as the active molecule for encapsulation. Caffeine (38 wt %) was incorporated in CAF@MIL-53(Al) microcapsules, as analyzed by TGA and corroborated by GC/MS and UV-vis after additive extraction. CAF@MIL-53(Al) microcapsules showed a controlled release of caffeine during 6 days at 25 °C (up to 22% of the initial caffeine). These capsules were incorporated through an industrial spinning process (with temperatures up to 260 °C) to manufacture PA-6 fibers with cosmetic properties. Up to 0.7 wt % of capsules were successfully incorporated into the fibers hosting 1700 ppm of caffeine. Fabrics were submitted to scouring, staining, and washing processes, detecting the presence of caffeine in the cosmetic fiber. © 2022 The Authors. Published by American Chemical Society

La disfunción familiar como predisponente de la enfermedad mental. ¿Existe tal asociación?

ObjetivosEl objetivo principal es conocer la relación entre la disfunción familiar y la presencia de trastorno mental. El objetivo secundario es conocer la prevalencia y la distribución de los principales tipos de patología mental en la población atendida en atención primaria.Diseño y emplazamientoEstudio descriptivo y transversal realizado en 6 consultas de medicina de familia de un área básica de salud semiurbana.MétodoSe seleccionaron 280 sujetos mediante muestreo aleatorio sistemático de los que acudieron espontáneamente a la consulta. Mediante entrevista se recogieron las variables de estudio: dinámica familiar (medida mediante el test de APGAR familiar), estructura familiar, variables sociodemográficas y presencia de trastorno mental detectado mediante la Mini International Neuropsyquiatric Interview (MINI-DSM IV).ResultadosAceptaron participar 264 sujetos. Un 64,4% era mujer y la media de edad fue de 45,6 años (DE, 16,7). Se detectó patología mental en 87 participantes (33%), siendo la patología más frecuente trastorno de ansiedad generalizada, distimia y depresión mayor. Se encontró alteración de la dinámica familiar en 32 personas (12,3%). No se observaron diferencias significativas en la frecuencia de presentación de patología mental entre el grupo con disfunción familiar y el resto.ConclusionesLos trastornos de salud mental son frecuentes entre los pacientes que acuden a las consultas de atención primaria. No encontramos asociación entre las alteraciones de la dinámica familiar y los trastornos de salud mental, lo que podría deberse a la dificultad para detectar disfunción familiar con el test de APGAR.ObjectivesThe main purpose is to describe the relationship between family disfunction and mental disorder. The secondary objective is to know the prevalence and distribution of mental disorders in primary care attended population.DesignA cross-sectional study was conducted in a primary care setting.Patients and methodsRandom sample was selected over 280 subjects from consultant population. The variables (family function, family structure, social and economic conditions and mental disorders) were collected through interview. APGAR test and Mini International Neuropsychiatric Interview test were performed.Results264 patients were finally included (64% women). Mean age was 45,6 years (SD 16,7). Mental disorders were detected in 87 patients (33%). The most prevalent disorders were generalized anxiety disorder, dysthymia and major depression. family disfunction was found in 32 patients (12,3%). Prevalence of mental disorders wasn't statistically different in the group with family disfunction.ConclusionMental disorders are a common problem between primary care attended population. There wasn't any association between family disfunction and mental disorders, because of the limitations in the APGAR test in detecting family disfunction