Cardiovascular Risk Factors and their Responses to a 10 Weeks Training Program in Young Qatari Adults

Rapid development in Qatar in recent years has led to numerous changes, particularly the increased prevalence of lifestyle related health risks, with almost 50% obesity rates amongst Qataris of all ages. We investigated the effects of a ten-week exercise training program aimed at young Qatari male adults, on a number of cardiovascular risk (CVD) factors. With institutional approval, we screened 89 Qatari young adult male volunteers from Qatar University for CVR factors of hypertension indicated by systolic (SBP) and diastolic (DBP) blood pressure, overweight and obesity indicated by body fat percentage (%BF), body weight (BW) and body mass index (BMI). 20 participants (23% of total number) were identified with one or more risk factors (hypertension and overweight), and were enrolled to follow a ten-week recreational-type exercise training program. The training involved 30-45 min of either walking, cycling, jogging and swimming at an exercise intensity corresponding to 50-85% of each participant’s maximum heart rate, on 3-5 times/week. The intervention significantly reduced BW (93.4±14.1 vs. 86.7±14.5, p<0.05), BMI (31.0±3.6 vs. 28.7±3.9, p<0.05) and BF% (31.2±9.0 vs. 21.2±4.4, p<0.05). Furthermore, there was a significant reduction in diastolic blood pressure (83.4±5.3 vs. 76.0±9.2 mmHg, p<0.05), and a non-significant reduction in systolic blood pressure (133.8±10.7 vs. 130.5±9.1 mmHg, p = 0.516). This recreational-type exercise intervention was effective in substantially reducing the CVD indices. However, the alarmingly high prevalence of sedentary-related CVD risks amongst Qatari young adult males, especially those related to obesity, overweight and hypertension necessitate further public health interventions in this age-group as an early prevention strategy.This study was made possible by a Qatar Foundation’s Qatar National Research Fund grant award (UREP 12-048-3-009)

The effectiveness of a ten-week exercise intervention to reduce cardiovascular risk factors amongst young male Qatari adults

Rapid development in Qatar in the recent years has led to numerous changes, particularly the increased prevalence of lifestyle related health risks, with almost 50% obesity rates amongst Qataris of all ages. We investigated the effects of a tenweek exercise training program aimed at young Qatari male adults, on a number of cardiovascular risk factors (CVR). With institutional approval, we screened 89 Qatari young adult male volunteers from Qatar University for CVR factors of hypertension indicated by systolic (SBP) and diastolic (DBP) blood pressure, overweight and obesity indicated by body fat percentage (%BF), body weight (BW) and body mass index (BMI). 20 participants (23% of total number) were identified with one or more risk factors (hypertension and overweight), and were enrolled to follow a ten-week recreational-type exercise training program. The training involved 30-40 min of either walking, cycling, jogging and swimming at an exercise intensity corresponding to 50-85% of each participant’s maximum heart rate, on 3-5 times/week. The intervention significantly reduced BW (93.4±14.1 vs. 86.7±14.5, p<0.05), BMI (31.0±3.6 vs. 28.8±3.9, p<0.05) and BF% (31.2±9.0 vs. 21.2±4.4, p<0.05). Furthermore, there was a significant reduction in diastolic blood pressure (83.4±5.3 vs. 76.0±9.2 mmHg, p<0.05), and a non-significant reduction in (133.8±10.7 vs. 130.5±9.1 mmHg, p=0.516). This recreational-type exercise intervention was effective in substantially reducing the CVR indices. However, the alarmingly high prevalence of sedentary-related CVR amongst Qatari young adult males, especially those related to obesity, overweight and hypertension necessitate further public health interventions in this agegroup as an early prevention strategy

Effect of Segment-Body Vibration on Strength Parameters

Background In this study, we examine the biomechanical advantage of combining localized vibrations to hamstring muscles involved in a traditional resistance training routine. Methods Thirty-six male and female participants with at least 2 years of experience in resistance training were recruited from the German Sport University Cologne. The participants were randomized into two training groups: vibration training group (VG) and traditional training group (TTG). Both groups underwent a 4-week training phase, where each participant worked out at 70 % of the individual 1 repeat maximum (RM—maximum load capacity of a muscle for one lift to fatigue) (4 sets with 12 repetitions each). For participants in the VG group, local vibration was additionally applied directly to hamstring muscles during exercise. A 2-week examination phase preceded the pretests. After the pretests, the subjects underwent a prescribed training for 4 weeks. At the conclusion of the training, a 2-week detraining was imposed and then the study concluded with posttests and retest. Results The measured parameters were maximum isometric force of the hamstrings and maximum range of motion and muscle tension at maximum knee angle. The study revealed a significant increase in maximum isometric force in both training groups (VG = 21 %, TTG = 14 %). However, VG groups showed an increase in their range of motion by approximately 2 %. Moreover, the muscle tension at maximum knee angle increased less in VG (approximately 35 %) compared to TG (approximately 46 %). Conclusions We conclude that segment-body vibrations applied in resistance training can offer an effective tool to increase maximum isometric force, compared to traditional training. The cause for these findings can be attributed to the additional local vibration stimulus.NPRP award NPRP 05-086-2-031 from the Qatar National Research Fund (a member of The Qatar Foundation)

Tobacco Use and Its Health Effects among Professional Athletes in Qatar

The objective of the study was to determine the effects of tobacco use on selected markers of health and lung function in professional athletes. A total of 108 male professional athletes participated in the study from ten ball game teams in the same sport league in Qatar (age = 26.4 ± 5.1 yrs, height = 190.6 ± 11.9 cm, and weight = 91.5 ± 16.4 kg). The athletes have been playing professionally for about 6.3 years on average. In addition to demographic and tobacco use status, the following clinical variables were measured: resting blood pressure, heart rate, FVC, FEV1 sec, and PEF. The prevalence of tobacco use among the athletes was 27.7%. The FVC, FVC%, and FEV1% were significantly lower among the smokers compared to the nonsmokers ( = 0.003, 0.044, and 0.001, resp.). There were no significant differences between cigarettes smokers and nonsmokers in BP, HR, FEV1, FEV1/FVC, PEF, and PEF%. Similarly, those who smoked shisha had lower FEV1% values as compared to those who did not smoke shisha ( = 0.001). The decrease of FEV1 and FVC among smokers compared to nonsmokers is similar to what has been reported in the literature about other populations.Scopu

A Preoperative Clinical Risk Score Including C-Reactive Protein Predicts Histological Tumor Characteristics and Patient Survival after Surgery for Sporadic Non-Functional Pancreatic Neuroendocrine Neoplasms:An International Multicenter Cohort Study

Background: Oncological survival after resection of pancreatic neuroendocrine neoplasms (panNEN) is highly variable depending on various factors. Risk stratification with preoperatively available parameters could guide decision-making in multidisciplinary treatment concepts. C-reactive Protein (CRP) is linked to inferior survival in several malignancies. This study assesses CRP within a novel risk score predicting histology and outcome after surgery for sporadic non-functional panNENs. Methods: A retrospective multicenter study with national exploration and international validation. CRP and other factors associated with overall survival (OS) were evaluated by multivariable cox-regression to create a clinical risk score (CRS). Predictive values regarding OS, disease-specific survival (DSS), and recurrence-free survival (RFS) were assessed by time-dependent receiver-operating characteristics. Results: Overall, 364 patients were included. Median CRP was significantly higher in patients >60 years, G3, and large tumors. In multivariable analysis, CRP was the strongest preoperative factor for OS in both cohorts. In the combined cohort, CRP (cut-off >= 0.2 mg/dL; hazard-ratio (HR):3.87), metastases (HR:2.80), and primary tumor size >= 3.0 cm (HR:1.83) showed a significant association with OS. A CRS incorporating these variables was associated with postoperative histological grading, T category, nodal positivity, and 90-day morbidity/mortality. Time-dependent area-under-the-curve at 60 months for OS, DSS, and RFS was 69%, 77%, and 67%, respectively (all p <0.001), and the inclusion of grading further improved the predictive potential (75%, 84%, and 78%, respectively). Conclusions: CRP is a significant marker of unfavorable oncological characteristics in panNENs. The proposed internationally validated CRS predicts histological features and patient survival

Feedforward and feedback pathways of nociceptive and tactile processing in human somatosensory system: A study of dynamic causal modeling of fMRI data

Nociceptive and tactile information is processed in the somatosensory system via reciprocal (i.e., feedforward and feedback) projections between the thalamus, the primary (S1) and secondary (S2) somatosensory cortices. The exact hierarchy of nociceptive and tactile information processing within this ‘thalamus-S1-S2’ network and whether the processing hierarchy differs between the two somatosensory submodalities remains unclear. In particular, two questions related to the ascending and descending pathways have not been addressed. For the ascending pathways, whether tactile or nociceptive information is processed in parallel (i.e., 'thalamus-S1′ and 'thalamus-S2′) or in serial (i.e., 'thalamus-S1-S2′) remains controversial. For the descending pathways, how corticothalamic feedback regulates nociceptive and tactile processing also remains elusive. Here, we aimed to investigate the hierarchical organization for the processing of nociceptive and tactile information in the ‘thalamus-S1-S2’ network using dynamic causal modeling (DCM) combined with high-temporal-resolution fMRI. We found that, for both nociceptive and tactile information processing, both S1 and S2 received inputs from thalamus, indicating a parallel structure of ascending pathways for nociceptive and tactile information processing. Furthermore, we observed distinct corticothalamic feedback regulations from S1 and S2, showing that S1 generally exerts inhibitory feedback regulation independent of external stimulation whereas S2 provides additional inhibition to the thalamic activity during nociceptive and tactile information processing in humans. These findings revealed that nociceptive and tactile information processing have similar hierarchical organization within the somatosensory system in the human brain

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

A Robotics Environment for Software Engineering Courses

The initial idea of using Lego Mindstorms Robots for student courses had soon to be expanded to a simulation environment as the user base in students grew larger and the need for parallel development and testing arose. An easy to use and easy to set up means of providing positioning data led to the creation of an indoor positioning system so that new users can adapt quickly and successfully, as sensors on the actual robots are difficult to configure and hard to interpret in an environmental context. A global positioning system shared among robots can make local sensors obsolete and still deliver more precise information than currently available sensors, also providing the base necessary for the robots to effectively work on shared tasks as a group. Further more, a simulator for robots programmed with Fujaba and Java which was developed along the way can be used by many developers simultaneously and lets them evaluate their code in a simple way, while close to real-world results