Valoració de la intimitat en l’àmbit sociosanitari

Intimitat; Pacients; Personal assistencialIntimidad; Pacientes; Personal asistencialPrivacy; Patients; Health personnelEl present estudi té com a objectiu principal analitzar el nivell de preservació de la intimitat des del punt de vista dels usuaris com del personal assistencial

On-Surface Thermal Stability of a Graphenic Structure Incorporating a Tropone Moiety

On-surface synthesis, complementary to wet chemistry, has been demonstrated to be a valid approach for the synthesis of tailored graphenic nanostructures with atomic precision. Among the different existing strategies used to tune the optoelectronic and magnetic properties of these nanostructures, the introduction of non-hexagonal rings inducing out-of-plane distortions is a promising pathway that has been scarcely explored on surfaces. Here, we demonstrate that non-hexagonal rings, in the form of tropone (cycloheptatrienone) moieties, are thermally transformed into phenyl or cyclopentadienone moieties upon an unprecedented surface-mediated retro–Buchner-type reaction involving a decarbonylation or an intramolecular rearrangement of the CO unit, respectivel

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016.

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Hidratos de gas marinos: ¿un recurso futuro de gas natural para Europa? M.

Los hidratos de gas son compuestos cristalinos donde una molécula de gas, principalmente metano, queda atrapada en una red de moléculas de agua en forma de hielo. La importancia de los hidratos de gas en la naturaleza es muy alta ya que constituye una fuente alternativa de energía y a su vez juegan un papel importante en el delicado equilibrio del clima a nivel global y en los riesgos geológicos en el ámbito marino. La acción COST MIGRATE está diseñada con el fin de integrar la experiencia de un gran número de grupos de investigación europeos y agentes del sector para promover el desarrollo de conocimientos multidisciplinarios sobre el potencial de los hidratos de gas como fuente de energía en Europa. Dos de los objetivos de esta acción son realizar un inventario europeo de hidratos de gas explotables y evaluar los riesgos ambientales. En este trabajo se muestran los principales indicios de hidratos de gas en los márgenes europeos incluida la Península Ibérica, con una primera aproximación sobre el espesor y situación de la zona de estabilidad de hidratos de gas en el margen Ibérico.Gas hydrates are crystalline compounds where a molecule of gas, mainly methane, is trapped in a cage of icewater molecules. The importance of gas hydrates in nature is very high because it is an alternative source of energy and play a major role in the delicate balance of the global climate and in the marine geological risks. MIGRATE COST action is designed to integrate the experience of a large number of European research groups and industrial players to promote the development of multidisciplinary knowledge on the potential of gas hydrates as energy resource in Europe. Two of the objectives of the action aim to estimate the European inventory of exploitable gas hydrates and to assess environmental risks. In this work we show the occurrences of gas hydrates described in European margins including the Iberian Peninsula, with a first approximation on the thickness and location of the area of stability of gas hydrates in the Iberian margin.COST Action ES1405 (MIGRATE)Versión del edito

Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia

Altres ajuts: This project was supported by the Asociación Española Contra el Cáncer, AECC (project ref.: GC16173697BIGA), Obra Social "La Caixa" and by Celgene Spain. A. Gonzalez-Perez is supported by a Ramon y Cajal fellowship (RYC-2013-14554) of the Educational Ministry (Madrid, Spain). This work was also partially supported by FEDER funds from CIBERONC (CB16/12/00284 and CB16/12/00400), Madrid, Spain).Recurrent deletions of the CDKN2A/ARF/CDKN2B genes encoded at chromosome 9p21 have been described in both pediatric and adult acute lymphoblastic leukemia (ALL), but their prognostic value remains controversial, with limited data on adult T-ALL. Here, we investigated the presence of homozygous and heterozygous deletions of the CDKN2A/ARF and CDKN2B genes in 64 adult T-ALL patients enrolled in two consecutive trials from the Spanish PETHEMA group. Alterations in CDKN2A/ARF/CDKN2B were detected in 35/64 patients (55%). Most of them consisted of 9p21 losses involving homozygous deletions of the CDKNA/ARF gene (26/64), as confirmed by single nucleotide polymorphism (SNP) arrays and interphase fluorescence in situ hybridization (iFISH). Deletions involving the CDKN2A/ARF/CDKN2B locus correlated with a higher frequency of cortical T cell phenotype and a better clearance of minimal residual disease (MRD) after induction therapy. Moreover, the combination of an altered copy-number-value (CNV) involving the CDKN2A/ARF/CDKN2B gene locus and undetectable MRD (≤ 0.01%) values allowed the identification of a subset of T-ALL with better overall survival in the absence of hematopoietic stem cell transplantation

Single origin of sex chromosomes and multiple origins of B chromosomes in fish genus Characidium

Chromosome painting with DNA probes obtained from supernumerary (B) and sex chromosomes in three species of fish genus Characidium (C. gomesi, C. pterostictum and C. oiticicai) showed a close resemblance in repetitive DNA content between B and sex chromosomes in C. gomesi and C. pterostictum. This suggests an intraspecific origin for B chromosomes in these two species, probably deriving from sex chromosomes. In C. oiticicai, however, a DNA probe obtained from its B chromosome hybridized with the B but not with the A chromosomes, suggesting that the B chromosome in this species could have arisen interspecifically, although this hypothesis needs further investigation. A molecular phylogenetic analysis performed on nine Characidium species, with two mtDNA genes, showed that the presence of heteromorphic sex chromosomes in these species is a derived condition, and that their origin could have been unique, a conclusion also supported by interspecific chromosome painting with a CgW probe derived from the W chromosome in C. gomesi. Summing up, our results indicate that whereas heteromorphic sex chromosomes in the genus Characidium appear to have had a common and unique origin, B chromosomes may have had independent origins in different species. Our results also show that molecular phylogenetic analysis is an excellent complement for cytogenetic studies by unveiling the direction of evolutionary chromosome changes.This research was funded by grants from the State of Sao Paulo Research Foundation (FAPESP) to EAS (2013/02143-3), grants from National Council for Research and Development (CNPq) to FF (480449/2012-0), and by Coordenacao de Aperfeicoamento de Pessoal de Nıvel Superior (CAPES)

Observations of the Crab Nebula and pulsar with the large-sized telescope prototype of the Cherenkov Telescope Array

Abe et al.The Cherenkov Telescope Array (CTA) is a next-generation ground-based observatory for gamma-ray astronomy at very high energies. The Large-Sized Telescope prototype (LST-1) is located at the CTA-North site, on the Canary Island of La Palma. LSTs are designed to provide optimal performance in the lowest part of the energy range covered by CTA, down to ≃20 GeV. LST-1 started performing astronomical observations in 2019 November, during its commissioning phase, and it has been taking data ever since. We present the first LST-1 observations of the Crab Nebula, the standard candle of very-high-energy gamma-ray astronomy, and use them, together with simulations, to assess the performance of the telescope. LST-1 has reached the expected performance during its commissioning period—only a minor adjustment of the preexisting simulations was needed to match the telescope's behavior. The energy threshold at trigger level is around 20 GeV, rising to ≃30 GeV after data analysis. Performance parameters depend strongly on energy, and on the strength of the gamma-ray selection cuts in the analysis: angular resolution ranges from 0fdg12–0fdg40, and energy resolution from 15%–50%. Flux sensitivity is around 1.1% of the Crab Nebula flux above 250 GeV for a 50 hr observation (12% for 30 minutes). The spectral energy distribution (in the 0.03–30 TeV range) and the light curve obtained for the Crab Nebula agree with previous measurements, considering statistical and systematic uncertainties. A clear periodic signal is also detected from the pulsar at the center of the Nebula.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo ä Pesquisa do Estado do Rio de Janeiro (FAPERJ), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Fundação de Apoio à Ciência, Tecnologia e Inovação do Paraná—Fundação Araucária, Ministry of Science, Technology, Innovations and Communications (MCTIC), Brasil; Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018, Bulgaria; Croatian Science Foundation, Rudjer Boskovic Institute, University of Osijek, University of Rijeka, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, University of Zagreb, Faculty of Electrical Engineering and Computing, Croatia; Ministry of Education, Youth and Sports, MEYS LM2015046, LM2018105, LTT17006, EU/MEYS CZ.02.1.01/0.0/0.0/16_013/0001403, CZ.02.1.01/0.0/0.0/18_046/0016007 and CZ.02.1.01/0.0/0.0/16_019/0000754, Czech Republic; CNRS-IN2P3, the French Programme d'investissements d'avenir and the Enigmass Labex, This work has been done thanks to the facilities offered by the Univ. Savoie Mont Blanc—CNRS/IN2P3 MUST computing center, France; Max Planck Society, German Bundesministerium für Bildung und Forschung (Verbundforschung / ErUM), Deutsche Forschungsgemeinschaft (SFBs 876 and 1491), Germany; Istituto Nazionale di Astrofisica (INAF), Istituto Nazionale di Fisica Nucleare (INFN), Italian Ministry for University and Research (MUR); ICRR, University of Tokyo, JSPS, MEXT, Japan; JST SPRING—JPMJSP2108; Narodowe Centrum Nauki, grant No. 2019/34/E/ST9/00224, Poland. The Spanish groups acknowledge the Spanish Ministry of Science and Innovation and the Spanish Research State Agency (AEI) through the government budget lines PGE2021/28.06.000X.411.01, PGE2022/28.06.000X.411.01, and PGE2022/28.06.000X.711.04, and grants PID2022-139117NB-C44, PID2019-104114RB-C31, PID2019-107847RB-C44, PID2019-104114RB-C32, PID2019-105510GB-C31, PID2019-104114RB-C33, PID2019-107847RB-C41, PID2019-107847RB-C43, PID2019-107847RB-C42, PID2019-107988GB-C22, PID2021-124581OB-I00, PID2021-125331NB-I00; the "Centro de Excelencia Severo Ochoa" program through grant Nos. CEX2019-000920-S, CEX2020-001007-S, CEX2021-001131-S; the "Unidad de Excelencia María de Maeztu" program through grant Nos. CEX2019-000918-M, CEX2020-001058-M; the "Ramón y Cajal" program through grants RYC2021-032552-I, RYC2021-032991-I, RYC2020-028639-I, and RYC-2017-22665; the "Juan de la Cierva-Incorporación" program through grant Nos. IJC2018-037195-I and IJC2019-040315-I. They also acknowledge the "Atracción de Talento" program of Comunidad de Madrid through grant No. 2019-T2/TIC-12900; the project "Tecnologiás avanzadas para la exploracioń del universo y sus componentes" (PR47/21 TAU), funded by Comunidad de Madrid, by the Recovery, Transformation and Resilience Plan from the Spanish State, and by NextGenerationEU from the European Union through the Recovery and Resilience Facility; the La Caixa Banking Foundation, grant No. LCF/BQ/PI21/11830030; the "Programa Operativo" FEDER 2014-2020, Consejería de Economía y Conocimiento de la Junta de Andalucía (Ref. 1257737), PAIDI 2020 (Ref. P18-FR-1580) and Universidad de Jaén;"Programa Operativo de Crecimiento Inteligente" FEDER 2014-2020 (Ref. ESFRI-2017-IAC-12), Ministerio de Ciencia e Innovación, 15% co-financed by Consejería de Economía, Industria, Comercio y Conocimiento del Gobierno de Canarias; the "CERCA" program and the grant 2021SGR00426, both funded by the Generalitat de Catalunya; and the European Union's "Horizon 2020" GA:824064 and NextGenerationEU (PRTR-C17.I1). State Secretariat for Education, Research and Innovation (SERI) and Swiss National Science Foundation (SNSF), Switzerland; The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement Nos. 262053 and No 317446. This project is receiving funding from the European Union's Horizon 2020 research and innovation programs under agreement No. 676134. ESCAPE (The European Science Cluster of Astronomy & Particle Physics ESFRI Research Infrastructures) has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 824064.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2020-001007-S).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000918-M).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2020-001058-M).Peer reviewe

Percutaneous mitral valve repair : Outcome improvement with operator experience and a second-generation device

Background and aim: Recent randomized data comparing percutaneous mitral valve repair (PMVR) versus optimal medical treatment in patients with functional MR (FMR) seemed to highlight the importance of the learning curve not only for procedural outcomes but also for patient selection. The aim of the study was to compare a contemporary series of patients undergoing PMVR using a second-generation Mitraclip device (Mitraclip NT) with previous cohorts treated with a first-generation system. Methods: This multicenter study collected individual data from 18 centers between 2012 and 2017. The cohort was divided into three groups according to the use of the first-generation Mitraclip during the first (control-1) or second half (control-2) or the Mitraclip NT sys-tem. Results: A total of 545 consecutive patients were included in the study. Among all, 182 (33.3%), 183 (33.3%), and 180 (33.3%) patients underwent mitral repair in the control-1, control-2, and NT cohorts, respectively. Procedural success was achieved in 93.3% of patients without differences between groups. Major adverse events did not statistically differ among groups, but there was a higher rate of pericardial effusion in the control-1 group (4.3%, 0.6%, and 2.6%, respectively; p = 0.025). The composite endpoint of death, surgery, and admission for congestive heart failure (CHF) at 12 months was lower in the NT group (23.5% in control-1, 22.5% in control-2, and 8.3% in the NT group; p = 0.032). Conclusions: The present paper shows that contemporary clinical outcomes of patients undergoing PMVR with the Mitraclip system have improved over time