Time is of the essence : Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine

Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed, the acute pharmacological effects of a single ketamine treatment last for only a few hours, whereas the antidepressant effects peak at around 24 hours and are sustained for the following few days. Numerous studies have investigated the acute and long-lasting neurobiological changes induced by ketamine; however, the most dramatic and fundamental change that the brain undergoes each day is rarely taken into consideration. Here, we explore the link between sleep and circadian regulation and rapid-acting antidepressant effects and summarize how diverse phenomena associated with ketamine’s antidepressant actions – such as cortical excitation, synaptogenesis, and involved molecular determinants – are intimately connected with the neurobiology of wake, sleep, and circadian rhythms. We review several recently proposed hypotheses about rapid antidepressant actions, which focus on sleep or circadian regulation, and discuss their implications for ongoing research. Considering these aspects may be the last piece of the puzzle necessary to gain a more comprehensive understanding of the effects of rapid-acting antidepressants on the brain.Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed, the acute pharmacological effects of a single ketamine treatment last for only a few hours, whereas the antidepressant effects peak at around 24 hours and are sustained for the following few days. Numerous studies have investigated the acute and long-lasting neurobiological changes induced by ketamine; however, the most dramatic and fundamental change that the brain undergoes each day is rarely taken into consideration. Here, we explore the link between sleep and circadian regulation and rapid -acting antidepressant effects and summarize how diverse phenomena associated with ketamine's antidepressant actions - such as cortical excitation, synaptogenesis, and involved molecular determinants - are intimately connected with the neurobiology of wake, sleep, and circadian rhythms. We review several recently proposed hypotheses about rapid antidepressant actions, which focus on sleep or circadian regulation, and discuss their implications for ongoing research. Considering these aspects may be the last piece of the puzzle necessary to gain a more comprehensive understanding of the effects of rapid-acting antidepressants on the brain. (c) 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).Peer reviewe

РАСЧЕТ МАГНИТНОГО ПОЛЯ ТРЕХФАЗНЫХ КАБЕЛЬНЫХ ЛИНИЙ ПРИ ДВУСТОРОННЕМ ЗАМЫКАНИИ СОБСТВЕННЫХ ЭКРАНОВ КАБЕЛЕЙ, ОХВАЧЕННЫХ ФЕРРОМАГНИТНЫМИ СЕРДЕЧНИКАМИ

In this paper we obtain compact expressions for the magnetic field shielding factor of a high-voltage three-phase cable line consisting of single-core cables with two-point bonded cable shields and ferromagnetic cores installed. To obtain these expressions we develop the analytical model of the cable line. Following assumptions are made to develop the model: the current distribution in each cable shield is uniform, cylindrical ferromagnetic cores covering the cables are not magnetized to saturation and their magnetic permeability is constant, each of the ferromagnetic cores is magnetized only by the core current and the shield current of the cable that it covers, the magnetic field inside ferromagnetic cores is axisymmetric, the magnetic field is plane-parallel over the entire cable line. We consider common cases of flat and trefoil cable lines. The proposed expressions for the magnetic field shielding factor are verified experimentally. The physical model is made of three cables of the type NA2XSF(L)2Y-110 1´240/70. It is shown that the difference between numerical simulation results and experimental data lays within 15 %.Получены компактные соотношения для расчета эффективности экранирования магнитного поля высоковольтной трехфазной кабельной линии, состоящей из одножильных кабелей, которые охвачены ферромагнитными сердечниками, при двустороннем замыкании собственных экранов. Рассмотрены кабельные линии с укладкой кабелей треугольником и в плоскости. Предложенные соотношения для расчета эффективности экранирования магнитного поля верифицированы экспериментально

Electromagnetic wave refraction at an interface of a double wire medium

Plane-wave reflection and refraction at an interface with a double wire medium is considered. The problem of additional boundary conditions (ABC) in application to wire media is discussed and an ABC-free approach, known in the solid state physics, is used. Expressions for the fields and Poynting vectors of the refracted waves are derived. Directions and values of the power density flow of the refracted waves are found and the conservation of the power flow through the interface is checked. The difference between the results, given by the conventional model of wire media and the model, properly taking into account spatial dispersion, is discussed.Comment: 17 pages, 11 figure

College of Arts and Sciences at Governors State University Announces Winter 2008 Dean’s List

The College of Arts and Sciences at Governors State University recently recognized undergraduate students who earned a 3.7 grade point average or higher during the Winter 2008 trimester

Use of program products for engineering graphics

В работе проведен анализ современных методов повышения эффективности преподавания инженерной графики, используя на занятиях современные технические средства обучения и компьютерные технологии.The analysis of modern methods to improve the effectiveness of engineering graphics teaching using modern teaching aids and computer technology

Innovative forms and methods in the educational process

В работе рассмотрено влияние использования в образовательной деятельности современных инновационных форм и методов представления материала.This article examines the effect of using in the educational activities of contemporary innovative forms and methods presentation of the material

Use of program products for engineering graphics

В работе проведен анализ современных методов повышения эффективности преподавания инженерной графики, используя на занятиях современные технические средства обучения и компьютерные технологии.The analysis of modern methods to improve the effectiveness of engineering graphics teaching using modern teaching aids and computer technology

poST

Publisher Copyright: AuthorThis paper presents the core concepts for the poST language - a process-oriented extension of the IEC 61131-3 Structured Text (ST) language which intends to provide a conceptual consistency of the PLC source code with technological description of the plant operating procedure. The poST can be seamlessly used as a textual programming language for complex PLC software in the context of IEC 61131-3 (3rd Edition). The language combines the advantages of FSM-based programming with the conventional syntax of the ST language which would facilitate its adoption. The poST language assumes that a poST-program is a set of weakly connected concurrent processes, structurally and functionally corresponding to the technological description of the plant. Each process is specified by a sequential set of states. The states are specified by a set of the ST constructs, extended by TIMEOUT operation, SET STATE operation, and START / STOP / check state operations to communicate with other processes. The paper describes the basic syntax of the poST language, demonstrates the usage of the poST language by developing control software for an elevator, and compares the development in poST with pure Structured Text.Peer reviewe