Simulations of core convection in rotating A-type stars: Differential rotation and overshooting

We present the results of 3--D simulations of core convection within A-type stars of 2 solar masses, at a range of rotation rates. We consider the inner 30% by radius of such stars, thereby encompassing the convective core and some of the surrounding radiative envelope. We utilize our anelastic spherical harmonic (ASH) code, which solves the compressible Navier-Stokes equations in the anelastic approximation, to examine highly nonlinear flows that can span multiple scale heights. The cores of these stars are found to rotate differentially, with central cylindrical regions of strikingly slow rotation achieved in our simulations of stars whose convective Rossby number (R_{oc}) is less than unity. Such differential rotation results from the redistribution of angular momentum by the nonlinear convection that strongly senses the overall rotation of the star. Penetrative convective motions extend into the overlying radiative zone, yielding a prolate shape (aligned with the rotation axis) to the central region in which nearly adiabatic stratification is achieved. This is further surrounded by a region of overshooting motions, the extent of which is greater at the equator than at the poles, yielding an overall spherical shape to the domain experiencing at least some convective mixing. We assess the overshooting achieved as the stability of the radiative exterior is varied, and the weak circulations that result in that exterior. The convective plumes serve to excite gravity waves in the radiative envelope, ranging from localized ripples of many scales to some remarkable global resonances.Comment: 48 pages, 16 figures, some color. Accepted to Astrophys. J. Color figures compressed with appreciable loss of quality; a PDF of the paper with better figures is available at http://lcd-www.colorado.edu/~brownim/core_convectsep24.pd

The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer

Background: Both preoperative cardiopulmonary exercise test (CPET)-derived measures of fitness and postoperative C-reactive protein (CRP) concentrations are associated with complications following surgery for colorectal cancer. The aim of the present pilot study was to examine the relationship between CPET and postoperative CRP concentrations in this patient group. Methods: Patients who had undergone CPET prior to elective surgery for histologically confirmed colorectal cancer in a single centre between September 2008 and April 2017 were included. Preoperative VO2 at the anaerobic threshold (AT) and peak exercise were recorded, along with preoperative modified Glasgow Prognostic Score (mGPS) and CRP on each postoperative day. Results: Thirty-eight patients were included. The majority were male (30, 79%), over 65 years old (30, 79%), with colonic cancer (23, 61%) and node-negative disease (24, 63%). Fourteen patients (37%) had open surgery and 24 (63%) had a laparoscopic resection. A progressive reduction in VO2 at peak exercise was significantly associated with both increasing American Society of Anesthesiology (ASA) grade (median, ml/kg/min: ASA 1 = 22, ASA 2 = 19, ASA 3 = 15, ASA 4 = 12, p = 0.014) and increasing mGPS (median, ml/kg/min: mGPS 0 = 18, mGPS 1 = 16, mGPS 2 = 14, p = 0.039) There was no significant association between either VO2 at the AT or peak exercise and postoperative CRP. Conclusions: The present pilot study reports a possible association between preoperative CPET-derived measures of exercise tolerance, and the preoperative systemic inflammatory response, but not postoperative CRP in patients undergoing surgery for colorectal cancer

The impact of preoperative dexamethasone on the magnitude of the postoperative systemic inflammatory response and complications following surgery for colorectal cancer

Background: The magnitude of the postoperative systemic inflammatory response (SIR), as evidenced by C-reactive protein (CRP), is associated with both short- and long-term outcomes following surgery for colorectal cancer. The present study examined the impact of preoperative dexamethasone on the postoperative SIR and complications following elective surgery for colorectal cancer. Methods: Patients who underwent elective surgery, with curative intent, for colorectal cancer at a single center between 2008 and 2016 were included (n = 556) in this study. Data on the use of preoperative dexamethasone were obtained from anesthetic records, and its impact on CRP on postoperative days (PODs) 3 and 4, as well as postoperative complications, was assessed using propensity score matching (n = 276). Results: In the propensity score-matched cohort, preoperative dexamethasone was associated with fewer patients exceeding the established CRP threshold of 150 mg/L on POD 3 (odds ratio [OR] 0.42, 95% confidence interval [CI] 0.26–0.70, p < 0.001) and fewer postoperative complications (OR 0.53, 95% CI 0.33–0.86, p = 0.009). Similar results for both POD 3 CRP and complications were observed when using propensity score-adjusted regression (OR 0.40, 95% CI 0.28–0.57 and OR 0.57, 95% CI 0.41–0.80, respectively) and propensity score stratification (OR 0.41, 95% CI 0.25–0.57 and OR 0.53, 95% CI 0.33–0.86, respectively). Conclusions: Preoperative dexamethasone was associated with a lower postoperative SIR and fewer complications following elective surgery for colorectal cancer

The nature of p-modes and granulation in HD 49933 observed by CoRoT

Context: Recent observations of HD49933 by the space-photometric mission CoRoT provide photometric evidence of solar type oscillations in a star other than our Sun. The first published reduction, analysis, and interpretation of the CoRoT data yielded a spectrum of p-modes with l = 0, 1, and 2. Aims: We present our own analysis of the CoRoT data in an attempt to compare the detected pulsation modes with eigenfrequencies of models that are consistent with the observed luminosity and surface temperature. Methods: We used the Gruberbauer et al. frequency set derived based on a more conservative Bayesian analysis with ignorance priors and fit models from a dense grid of model spectra. We also introduce a Bayesian approach to searching and quantifying the best model fits to the observed oscillation spectra. Results: We identify 26 frequencies as radial and dipolar modes. Our best fitting model has solar composition and coincides within the error box with the spectroscopically determined position of HD49933 in the H-R diagram. We also show that lower-than-solar Z models have a lower probability of matching the observations than the solar metallicity models. To quantify the effect of the deficiencies in modeling the stellar surface layers in our analysis, we compare adiabatic and nonadiabatic model fits and find that the latter reproduces the observed frequencies better.Comment: accepted to be published in A&A, 9 pages, 5 figure

How and why systemic inflammation worsens quality of life in patients with advanced cancer

Introduction: The presence of an innate host systemic inflammatory response has been reported to be a negative prognostic factor in a wide group of solid tumour types in both the operable and advanced setting, both local and distant. In addition, this host systemic inflammatory response is associated with both clinician reported patient performance status and self-reported measures of quality of life in patients with cancer. Areas covered: A variety of mechanisms are thought to underlie this, including the influence of the host immune response on physical symptoms such as pain and fatigue, its effect on organ systems associated with physical ability and well being such as skeletal muscle, and bone marrow. Furthermore, this innate inflammatory response is thought to have a direct negative impact on mood through its action on the central nervous system. Expert commentary: It is clear that the host systemic inflammatory response represents a target for intervention in terms of both improving quality of life and prognosis in patients with advanced cancer. Based on this paradigm, future research should focus both on pathways which might be targeted by novel agents, but also on whether existing anti-inflammatory drugs might be of benefit

No evidence of a significant role for CTLA-4 in multiple sclerosis

Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore this logical candidate more thoroughly, we genotyped 771 multiple sclerosis trio families from the United Kingdom for the 3? untranslated region variable number tandem repeat, the CT60 single nucleotide polymorphism (SNP) and five haplotype-tagging SNPs. No individual marker or common haplotype showed evidence of association with disease. These data suggest that any effect of CTLA-4 on multiple sclerosis susceptibility is likely to be very small

On detecting the large separation in the autocorrelation of stellar oscillation times series

The observations carried out by the space missions CoRoT and Kepler provide a large set of asteroseismic data. Their analysis requires an efficient procedure first to determine if the star is reliably showing solar-like oscillations, second to measure the so-called large separation, third to estimate the asteroseismic information that can be retrieved from the Fourier spectrum. We develop in this paper a procedure, based on the autocorrelation of the seismic Fourier spectrum. We have searched for criteria able to predict the output that one can expect from the analysis by autocorrelation of a seismic time series. First, the autocorrelation is properly scaled for taking into account the contribution of white noise. Then, we use the null hypothesis H0 test to assess the reliability of the autocorrelation analysis. Calculations based on solar and CoRoT times series are performed in order to quantify the performance as a function of the amplitude of the autocorrelation signal. We propose an automated determination of the large separation, whose reliability is quantified by the H0 test. We apply this method to analyze a large set of red giants observed by CoRoT. We estimate the expected performance for photometric time series of the Kepler mission. Finally, we demonstrate that the method makes it possible to distinguish l=0 from l=1 modes. The envelope autocorrelation function has proven to be very powerful for the determination of the large separation in noisy asteroseismic data, since it enables us to quantify the precision of the performance of different measurements: mean large separation, variation of the large separation with frequency, small separation and degree identification.Comment: A&A, in pres

Global asteroseismic properties of solar-like oscillations observed by Kepler : A comparison of complementary analysis methods

We present the asteroseismic analysis of 1948 F-, G- and K-type main-sequence and subgiant stars observed by the NASA {\em Kepler Mission}. We detect and characterise solar-like oscillations in 642 of these stars. This represents the largest cohort of main-sequence and subgiant solar-like oscillators observed to date. The photometric observations are analysed using the methods developed by nine independent research teams. The results are combined to validate the determined global asteroseismic parameters and calculate the relative precision by which the parameters can be obtained. We correlate the relative number of detected solar-like oscillators with stellar parameters from the {\em Kepler Input Catalog} and find a deficiency for stars with effective temperatures in the range $5300 \lesssim T_\mathrm{eff} \lesssim 5700$\,K and a drop-off in detected oscillations in stars approaching the red edge of the classical instability strip. We compare the power-law relationships between the frequency of peak power, $\nu_\mathrm{max}$, the mean large frequency separation, $\Delta\nu$, and the maximum mode amplitude, $A_\mathrm{max}$, and show that there are significant method-dependent differences in the results obtained. This illustrates the need for multiple complementary analysis methods to be used to assess the robustness and reproducibility of results derived from global asteroseismic parameters.Comment: 14 pages, 9 figures, accepted for publication in Monthly Notices of the Royal Astronomical Societ

Renal function in Palestine sunbirds: elimination of excess water does not constrain energy intake

Copyright © 2004 Company of BiologistsAlthough the renal responses of birds to dehydration have received significant attention, the consequences of ingesting and processing large quantities of water have been less studied. Nectar-feeding birds must often deal with exceptionally high water intake rates in order to meet their high mass-specific energy demands. Birds that ingest large volumes of water may either eliminate excess water in the kidney or regulate the volume of water absorbed in the gastrointestinal tract. Because water absorption in the gastrointestinal tract of Palestine sunbirds (Nectarinia osea) decreases with increasing water ingestion rate, we predicted that glomerular filtration rate (GFR) in these birds would not be unusually high in spite of large ingested water loads. When feeding on dilute sucrose solutions, sunbirds ingested between 4 and 6 times their body mass in nectar per day, yet they were able to compensate for varying nectar energy density and increased thermoregulatory energy demands with no apparent difficulty. GFR was lower than predicted (1976.22±91.95 µl h-1), and was not exceptionally sensitive to water loading. Plasma glucose concentrations were high, and varied 1.8-fold between fasted (16.08± 0.75 mmol l-1) and fed (28.18±0.68 mmol l-1) sunbirds, but because GFR was low, glucose filtered load also remained relatively low. Essentially the entire glucose filtered load (98%) was recovered by the kidney. Renal fractional water reabsorption (FWR) decreased from 0.98 to 0.64 with increasing water intake. The ability of Palestine sunbirds to reduce the absorption of ingested water in the gastrointestinal tract may resolve the potential conflict between filtering a large excess of absorbed water in the kidney and simultaneously retaining filtered metabolites.Todd J. McWhorter, Carlos Martínez del Rio, Berry Pinshow and Lizanne Roxburg

Mode identification in rapidly rotating stars

Context: Recent calculations of pulsation modes in rapidly rotating polytropic models and models based on the Self-Consistent Field method have shown that the frequency spectrum of low degree pulsation modes can be described by an empirical formula similar to Tassoul's asymptotic formula, provided that the underlying rotation profile is not too differential. Aims: Given the simplicity of this asymptotic formula, we investigate whether it can provide a means by which to identify pulsation modes in rapidly rotating stars. Methods: We develop a new mode identification scheme which consists in scanning a multidimensional parameter space for the formula coefficients which yield the best-fitting asymptotic spectra. This mode identification scheme is then tested on artificial spectra based on the asymptotic formula, on random frequencies and on spectra based on full numerical eigenmode calculations for which the mode identification is known beforehand. We also investigate the effects of adding random frequencies to mimic the effects of chaotic modes which are also expected to show up in such stars. Results: In the absence of chaotic modes, it is possible to accurately find a correct mode identification for most of the observed frequencies provided these frequencies are sufficiently close to their asymptotic values. The addition of random frequencies can very quickly become problematic and hinder correct mode identification. Modifying the mode identification scheme to reject the worst fitting modes can bring some improvement but the results still remain poorer than in the case without chaotic modes