Phase mixing of a three dimensional magnetohydrodynamic pulse

Phase mixing of a three dimensional magnetohydrodynamic (MHD) pulse is studied in the compressive, three-dimensional (without an ignorable coordinate) regime. It is shown that the efficiency of decay of an Alfvénic part of a compressible MHD pulse is related linearly to the degree of localization of the pulse in the homogeneous transverse direction. In the developed stage of phase mixing (for large times), coupling to its compressive part does not alter the power-law decay of an Alfvénic part of a compressible MHD pulse. The same applies to the dependence upon the resistivity of the Alfvénic part of the pulse. All this implies that the dynamics of Alfvén waves can still be qualitatively understood in terms of the previous 2.5D models. Thus, the phase mixing remains a relevant paradigm for the coronal heating applications in the realistic 3D geometry and compressive plasma

Impact of wear time criteria upon physical activity estimates in children

Paper presented at 14th meeting of the International Society of Behavioral Nutrition and Physical Activity: Advancing Behavior Change Science, June 2015, EdinburghPurpose: Lack of compliance with accelerometer wear time requirements can potentially lead to selection bias within a study. In an attempt to maximize participant numbers researchers may be tempted to employ more lenient wear time criteria. However, this may lead to misclassification of physical activity (PA) and sedentary time (ST), both through reducing the monitoring period and through failure to capture distinct periods of the day, resulting in inaccurate estimates of PA and ST and masking of true relationships between PA, ST and health. The present study aimed to explore the misclassification that may occur using three distinct 10 hour periods across the day in comparison to 24 hour continuous wear in children. Methods: 149 children were asked to wear a GENEActiv accelerometer on their left wrist for 24 hours a day, for a period of 7 days. Including only children who complied with the full wear time protocol (n = 78), weekly average estimates of ST and time spent in light, moderate and vigorous PA were created for the full 24 hour criteria and for three 10 hour periods (8am – 6pm, 10am – 8pm, 12pm – 10pm) . Repeated Measures ANOVA were used to assess for significant differences across monitoring periods. Results: In comparison to complete observation (24hours), the 10 hour periods across the day resulted in an underestimation of time spend sedentary and in each activity intensity (ps < 0.05). ST was underestimated by an average of 269 minutes, whilst Moderate to Vigorous PA (MVPA) was underestimated by 30 minutes. Between the 10 hour periods, higher rates of ST were accumulated in the latest period (12pm – 10pm), whilst higher estimates of MVPA were apparent between 8am and 6pm. Conclusions: Time in PA and ST was underestimated with the use of shorter wear periods and researchers may be unknowingly misclassifying PA and ST by not accounting for which period of the day was measured. Future studies should use longer monitoring periods to gain accurate assessment of PA and to establish relationships with health variables

High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes

blique plane microscopy (OPM) is a form of light sheet microscopy that uses a single high numerical aperture microscope objective for both fluorescence excitation and collection. In this paper, measurements of the relative collection efficiency of OPM are presented. An OPM system incorporating two sCMOS cameras is then introduced that enables single isolated cardiac myocytes to be studied continuously for 22 seconds in two dimensions at 667 frames per second with 960 × 200 pixels and for 30 seconds with 960 × 200 × 20 voxels at 25 volumes per second. In both cases OPM is able to record in two spectral channels, enabling intracellular calcium to be studied via the probe Fluo-4 AM simultaneously with the sarcolemma and transverse tubule network via the membrane dye Cellmask Orange. The OPM system was then applied to determine the spatial origin of spontaneous calcium waves for the first time and to measure the cell transverse tubule structure at their point of origin. Further results are presented to demonstrate that the OPM system can also be used to study calcium spark parameters depending on their relationship to the transverse tubule structure

Nonlinear oscillations of coalescing magnetic flux ropes

An analytical model of highly nonlinear oscillations occurring during a coalescence of two magnetic flux ropes, based upon two-fluid hydrodynamics, is developed. The model accounts for the effect of electric charge separation, and describes perpendicular oscillations of the current sheet formed by the coalescence. The oscillation period is determined by the current sheet thickness, the plasma parameter β, and the oscillation amplitude. The oscillation periods are typically greater or about the ion plasma oscillation period. In the nonlinear regime, the oscillations of the ion and electron concentrations have a shape of a narrow symmetric spikes

Electric field generation by the electron beam filamentation instability: Filament size effects

The filamentation instability (FI) of counter-propagating beams of electrons is modelled with a particle-in-cell simulation in one spatial dimension and with a high statistical plasma representation. The simulation direction is orthogonal to the beam velocity vector. Both electron beams have initially equal densities, temperatures and moduli of their nonrelativistic mean velocities. The FI is electromagnetic in this case. A previous study of a small filament demonstrated, that the magnetic pressure gradient force (MPGF) results in a nonlinearly driven electrostatic field. The probably small contribution of the thermal pressure gradient to the force balance implied, that the electrostatic field performed undamped oscillations around a background electric field. Here we consider larger filaments, which reach a stronger electrostatic potential when they saturate. The electron heating is enhanced and electrostatic electron phase space holes form. The competition of several smaller filaments, which grow simultaneously with the large filament, also perturbs the balance between the electrostatic and magnetic fields. The oscillations are damped but the final electric field amplitude is still determined by the MPGF.Comment: 14 pages, 10 plots, accepted for publication in Physica Script

Improved Si:As BIBIB (Back-Illuminated Blocked-Impurity-Band) hybrid arrays

Results of a program to increase the short wavelength (less than 10 microns) detective quantum efficiency, eta/beta, of Si:As Impurity Band Conduction arrays are presented. The arrays are epitaxially grown Back-Illuminated Blocked (BIB) Impurity-Band (BIBIB) 10x50 detectors bonded to switched-FET multiplexers. It is shown that the 4.7 microns detective quantum efficiency increases proportionately with the thickness of the infrared active layer. A BIB array with a thick active layer, designed for low dark current, exhibits eta/beta = 7 to 9 percent at 4.7 microns for applied bias voltages between 3 and 5 V. The product of quantum efficiency and photoelectric gain, etaG, increases from 0.3 to 2.5 as the voltage increases from 3 to 5 V. Over this voltage range, the dark current increases from 8 to 120 e(-)s(-1) at a device temperature of 4.2 K and is under 70 e(-)s(-1) for all voltages at 2 K. Because of device gain, the effective dark current (equivalent photon rate) is less than 3 e(-)s(-1) under all operating conditions. The effective read noise (equivalent photon noise) is found to be less than 12 electrons under all operating conditions and for integration times between 0.05 and 100 seconds

17O NMR spectroscopy as a tool to study hydrogen bonding of cholesterol in lipid bilayers

Cholesterol is a crucial component of biological membranes and can interact with other membrane components through hydrogen bonding. NMR spectroscopy has been used previously to investigate this bonding, however this study represents the first 17O NMR spectroscopy study of isotopically enriched cholesterol. We demonstrate the 17O chemical shift is dependent on hydrogen bonding, providing a novel method for the study of cholesterol in bilayers

PIC Simulations of the Temperature Anisotropy-Driven Weibel Instability: Analyzing the perpendicular mode

An instability driven by the thermal anisotropy of a single electron species is investigated in a 2D particle-in-cell (PIC) simulation. This instability is the one considered by Weibel and it differs from the beam driven filamentation instability. A comparison of the simulation results with analytic theory provides similar exponential growth rates of the magnetic field during the linear growth phase of the instability. We observe in accordance with previous works the growth of electric fields during the saturation phase of the instability. Some components of this electric field are not accounted for by the linearized theory. A single-fluid-based theory is used to determine the source of this nonlinear electric field. It is demonstrated that the magnetic stress tensor, which vanishes in a 1D geometry, is more important in this 2-dimensional model used here. The electric field grows to an amplitude, which yields a force on the electrons that is comparable to the magnetic one. The peak energy density of each magnetic field component in the simulation plane agrees with previous estimates. Eddy currents develop, which let the amplitude of the third magnetic field component grow, which is not observed in a 1D simulation.Comment: accepted by Plasma Physics and Controlled Fusio

Prolonged Unilateral Disuse Osteopenia 14 Years Post External Fixator Removal: A Case History and Critical Review

Disuse osteopenia is a complication of immobilisation, with reversal generally noted upon remobilisation. This case report focuses on a patient who was seen 18 years following a road traffic collision when multiple fractures were sustained. The patient had an external fixator fitted for a tibia and fibula fracture, which remained in situ for a period of 4 years. Following removal, the patient was mobilised but, still required a single crutch to aid walking. Fourteen years post removal of the fixator, the patient had a DXA scan which, demonstrated a T-score 2.5 SD lower on the affected hip. This places the patient at an increased risk of hip fracture on this side, which requires monitoring. There appear to be no current studies investigating prolonged disuse-osteopenia in patients following removal of long-term external fixators. Further research is required to quantify unilateral long-term effects to bone health and fracture risk in this population