1,496 research outputs found

    Tu envidia es mi progreso: An Ethnographic Account of the Development of Squatter Settlements in San Juan de Miraflores, Lima, Peru.

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    The following dissertation explores the past 60 years of self-help housing in Lima. Specifically, it looks at the uneven development that has occurred in parts of a municipality called San Juan de Miraflores. I argue that self-help housing is part of a larger modernization project that aims to encourage the emergence of a self-regulating individual. Pro-development literature creates a selective history of marginal neighbourhoods, effectively silencing the histories of working class Miraflorinos. The aim of this ethnographic study is to destabilize official histories and representations about development in marginal communities. The bulk of the dissertation looks at the history of a land occupation that occurred in January, 2000. Special attention is given to insert the study in its political, economic, and social context. I conclude that the development process at work in Lima since the end of WWII reflects an unresolved tension in Peruvian urbanization. Common working class people resist the drive toward a progress that favours individual achievement over community well-being. I argue that underprivileged groups have always been included in development schemes. Social inclusion, then, is not the solution to uneven development. Rather, we need to look to the resistances to development that underprivileged classes mount, incorporating their criticisms into a new vision for society that challenges the merits of the kind of individuality promoted by liberal and neoliberal proponents

    Alien Registration- Rouleau, Jean E. (Madawaska, Aroostook County)

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    https://digitalmaine.com/alien_docs/35204/thumbnail.jp

    Niveau de contamination par le mercure des sédiments de surface et des crevettes du fjord du Saguenay

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    De 1947 à 1976, plusieurs dizaines de tonnes de mercure d'origine industrielle ont été déversées dans les eaux de la rivière Saguenay et une grande partie de ce métal toxique se retrouve aujourd'hui dans les sédiments du Fjord. Les sédiments de surface (0-2 cm) de 17 stations réparties sur tout le bassin intérieur du fjord ont été prélevés et analysés pour le mercure total. De plus, environ 150 crevettes (Pandalus borealis) ont été capturées à Sainte-Rose-du-Nord pour fins d'analyse du mercure et pour une expérience de bioaccumulation à partir d'une diète contaminée. L'analyse des données disponibles pour les sédiments de surface montre que les teneurs moyennes (0,93 ± 0,11 µg.g-1 poids sec) en mercure n'ont pas varié de façon significative au cours des dix dernières années dans la région de Sainte-Rose-du-Nord, située dans la moitié amont du bassin intérieur. Les concentrations de mercure dans le muscle comestible des crevettes varient de 0,13 à 0,58 µg.g-1 (poids humide) selon la taille avec une valeur moyenne de 0,36 ± 0,11 µg.g-1. On trouve une concentration moyenne de 0,26 ± 0,09 µg.g-1 dans le céphalothorax et la cuticule. Un accroissement rapide et important du mercure dans, l'appareil digestif a été observé chez tes crevettes adultes soumises à une diète de chair de moules préalablement contaminée (6,0 ± 1,0 µg.g-1). Un taux de bioaccumulation de 0,09 µg.g-1 par jour dans le muscle comestible a été estimé pour les 14 premiers jours de diète contaminée.From 1947 to 1976, many tons of industrial mercury were tipped into the Saguenay River and a large amount of this toxic heavy metal is now in the sediments of the Saguenay Fjord. Surface sediments (0-2 cm) were collected at seventeen stations along the inner basin of the Saguenay Fjord and analysed for total mercury content. About 150 shrimps (Pandalus borealis) fished in the Sainte-Rose-du-Nord area were also used for mercury analyses and the determination of mercury uptake rate from contaminated food. The mercury concentrations in surface sediments ranged from 0.18 to 0.20 µg.g-1 (dry weight) with a mean value of 0.63 µg.g-1. This mean level is about one order of magnitude higher than the background level found in deep sediments. The examination of available data for surface sediments in the Sainte-Rose-du-Nord vicinity, located in the first half of the inner basin, shows the "steady state" of the mercury contamination over the last 10 years. Indeed, the mercury concentrations observed in surface sediments ranged from 0.75 to 1.20 µg.g-1, with a mean value of 0.93 µg.g-1 since 1976. The steady state of mercury contamination can be explained by two hypothesis : (1) an unexpected highly active bioturbation mechanism contributes to the mercury remobilisation from lower sediment layers (10-20 cm) and its vertical transportation up to the surface, or (2) the anthropogenic upstream discharge of mercury was not really stopped in 1976 and one or many unidentified sources are still active along the Saguenay River. The mercury concentrations in the edible part of shrimps (fished in November 1985) ranged from 0.13 to 0.58 µg.g-l (wet weight) with an average value of 0.36 ± 0.11 µg.g-1. A positive and significative linear relationship (r = 0.786) is observed between the Hg concentration in the edible part and the total wet weight of the shrimp. The mean Hg in the edible part found in 1985 is not significantly different from the mean value reported in 1932. The mean concentration found in the cephalothorax and the cuticle (taken together) of shrimps was 0.26 ± 0.09 µg.g-1. In order to estimate the mercury uptake rate by shrimps from contaminated food, a number of adult shrimps were fed with pre-contaminated mussel tissues (0.6 ± 1.0 µg.g-1) for three weeks. A high and rapid increase of mercury concentration was observed in the digestive organs after only 24 hours. The uptake rate in the edible part was estimated at 0.09 µg.g-1 per day during the first fourteen days of the bioassay. These findings clearly indicate the fragility of the balance between the biota and the physical environment and how fast major changes can occur when the level of contamination of the diet is modified

    Biomarker testing in oncology - Requirements for organizing external quality assessment programs to improve the performance of laboratory testing:revision of an expert opinion paper on behalf of IQNPath ABSL

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    In personalized medicine, predictive biomarker testing is the basis for an appropriate choice of therapy for patients with cancer. An important tool for laboratories to ensure accurate results is participation in external quality assurance (EQA) programs. Several providers offer predictive EQA programs for different cancer types, test methods, and sample types. In 2013, a guideline was published on the requirements for organizing high-quality EQA programs in molecular pathology. Now, after six years, steps were taken to further harmonize these EQA programs as an initiative by IQNPath ABSL, an umbrella organization founded by various EQA providers. This revision is based on current knowledge, adds recommendations for programs developed for predictive biomarkers by in situ methodologies (immunohistochemistry and in situ hybridization), and emphasized transparency and an evidence-based approach. In addition, this updated version also has the aim to give an overview of current practices from various EQA providers

    The extinction law in high redshift galaxies

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    We estimate the dust extinction laws in two intermediate redshift galaxies. The dust in the lens galaxy of LBQS1009-0252, which has an estimated lens redshift of zl~0.88, appears to be similar to that of the SMC with no significant feature at 2175 A. Only if the lens galaxy is at a redshift of zl~0.3, completely inconsistent with the galaxy colors, luminosity or location on the fundamental plane, can the data be fit with a normal Galactic extinction curve. The dust in the zl=0.68 lens galaxy for B0218+357, whose reddened image lies behind a molecular cloud, requires a very flat ultraviolet extinction curve with (formally) R(V)=12 +- 2. Both lens systems seem to have unusual extinction curves by Galactic standards.Comment: 15 pages, 3 figures. ApJ in pres

    Confirmation that variants in TTI2 are responsible for autosomal recessive intellectual disability

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    TTI2 (MIM 614126) has been described as responsible for autosomal recessive intellectual disability (ID; MRT39, MIM:615541) in only two inbred families. Here, we give an account of two individuals from two unrelated outbred families harbouring compound heterozygous TTI2 pathogenic variants. Together with severe ID, progressive microcephaly, scoliosis and sleeping disorder are the most striking features in the two individuals concerned. TTI2, together with TTI1 and TELO2, encode proteins that constitute the triple T heterotrimeric complex. This TTT complex interacts with the HSP90 and R2TP to form a super-complex that has a chaperone function stabilising and maturing a number of kinases, such as ataxia-telangiectasia mutated and mechanistic target of rapamycin, which are key regulators of cell proliferation and genome maintenance. Pathogenic variants in TTI2 logically result in a phenotype close to that caused by TELO2 variants
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