Abdalla, N.

Lachaine, J.

Lapierre, M.E.

Rouleau, A.

Stip, E.

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 VA L U E  I N  H E A LT H  1 7  ( 2 0 1 4 )  A 1 - A 2 9 5  A215
were matched from each cohort. The bipolar cohort had higher percentages of inpa-
tient stays (18.72% vs. 2.56%, p< 0.0001) and emergency room (ER) (22.51% vs. 7.82%, 
p< 0.0001), physician office (99.40% vs. 55.89%, p< 0.0001), outpatient (99.55% vs. 
56.73%, p< 0.0001) and pharmacy visits (91.83% vs. 54.65%, p< 0.0001). Bipolar disorder 
patients also incurred higher inpatient ($6,126 vs. $775, p< 0.0001), ER visit ($265 vs. 
$72, p< 0.0001), physician office visit ($4,149 vs. $1,365, p< 0.0001), outpatient visit 
($4,566 vs. $1,538), pharmacy ($952 vs. $414, p< 0.0001) and total costs ($11,645 vs. 
$2,728, p< 0.0001) compared to patients without the disorder. ConClusions: In this 
study, bipolar disorder was associated with higher health care resource utilization 
and a significantly higher economic burden.
PMH40
ResouRce use and associated costs of long acting injectable 
antiPsycHotics: a RaMQ database analysis
Lachaine J.1, Lapierre M.E.1, Abdalla N.2, Rouleau A.3, Stip E.4
1University of Montreal, Montreal, QC, Canada, 2Lundbeck Canada Inc., Montreal, QC, Canada, 
3Lundbeck SAS, Issy-les-Moulineaux, France, 4Montreal, QC, Canada
objeCtives: The purpose of this study was to describe the resource use before, and 
after, initiation of long-acting injectable antipsychotics (LAI-AP) using the provincial 
public drug reimbursement program database of the Régie de l’assurance maladie du 
Québec (RAMQ). Methods: Patients who were incident users (no use in the previous 
12 months) of a LAI-AP prescribed between January 1st 2008 and March 31st 2012, 
at least 20 years old, with a diagnosis of schizophrenia/schizoaffective disorder 
and with continuous enrollment during the study period were selected. Resource 
utilization and associated costs were analyzed both during the year before LAI-AP 
initiation (pre-initiation period) and the year after (post-initiation period). Results: 
A total of 1,992 patients met the inclusion criteria. The average age was 43.5 years 
(SD= 14.3). In pre-initiation period, 1,484 patients had at least one hospitalization, 
compared to 958 in post-initiation period (p< 0.001), and the number of days hospi-
talized was reduced by half (40.5 days [SD= 39.6] vs. 21.2 days [SD= 29.9]; p< 0.001). 
The number of patients having at least one emergency room visit decreased from 
1,372 to 813 patients (p< 0.001), but the number of patients with at least one outpa-
tient clinic visit increased from 1,572 to 1,726 patients (p< 0.001). The pre-initiation 
inpatient costs were CDN$21,312 (SD= 27,303), compared to CDN$7,199 (SD= 16,419) 
in post-initiation period (p< 0.001). The outpatient costs were CDN$1,209 (SD= 1,173) 
during the pre-initiation period, and CDN$1,296 (SD= 1,284) in the post-initiation 
period (p= 0.002), while cost of medication were CDN$1,861 (SD= 2,515) vs. CDN$4,595 
(SD= 3,910) (p< 0.001). Total cost of health care resource, including LAI-AP, were 
CDN$24,382 (SD= 27,234) in the pre-initiation period, compared to CDN$13,090 
(SD= 16,987) in the post-initiation period (p< 0.001). ConClusions: The initiation 
of LAI-AP resulted in significantly lower health care resource and cost reduction, 
with the primary driver being a reduction in number of hospitalizations, days of 
hospitalization and visits to the emergency room.
PMH41
Recent tRends in Post-tRauMatic stRess disoRdeR-Related 
HosPitalizations in tHe united states
Candrilli S.D., Karve S.J.
RTI Health Solutions, Research Triangle Park, NC, USA
objeCtives: Even with increasing attention given to post-traumatic stress disor-
der (PTSD), limited data exist documenting PTSD-related economic burden. This 
study documents annual rates of PTSD-related hospitalizations in the US (2000-
2010), along with associated costs and length of stay [LOS]. Methods: Adult (18+ 
years old) PTSD-related hospitalizations (those with an ICD-9-CM diagnosis code 
of 309.81 [primary or secondary]) from the 2000 through 2010 HCUP Nationwide 
Inpatient Samples (NIS) were analyzed. Annual rates of PTSD hospitalization per 
100,000 adults (adjusted to 2010 US population) were estimated using NIS sampling 
weights and US Census population denominators. Additionally, cost (in 2013 $) and 
LOS estimates were calculated. Results: Rates of hospitalizations with a primary 
diagnosis of PTSD have increased over time, from 2.5/100,000 adults (5,139 hospi-
talizations) in 2000 to 4.1/100,000 (9,175 hospitalizations) in 2010, a 61.6% increase, 
and by over 200% for hospitalizations with any diagnosis of PTSD, from 28.6/100,000 
to 87.7/100,000. For hospitalizations with PTSD as the primary diagnosis, the mean 
(standard deviation [SD]) LOS increased slightly, from 5.7 (7.6) days in 2000 to 6.0 
(6.9) days in 2010, while mean (SD) costs increased by 23.2%, from $5,138 ($6,440) 
in 2000 to $6,330 ($7,281) in 2010. Finally, from 2000 to 2010, the estimated total 
(aggregate) cost of PTSD-related hospitalizations increased by 129% ($26.3 million 
to $60.3 million) for primary PTSD diagnosis hospitalizations and 471% ($435 million 
to $2.49 billion) for any PTSD diagnosis. ConClusions: PTSD-related hospitaliza-
tion rates in the US have increased during the first decade of the 2000s, with the 
total inpatient cost burden increasing at an even greater rate. Further research to 
better understand factors which may be influencing the observed growth in rates of 
PTSD-related hospitalization in the US (e.g., changing diagnostic criteria; increasing 
numbers of servicemen and women returning from military combat settings, which 
is an established PTSD risk factor) is warranted.
PMH42
tHe iMPact of tReatMent duRation on RelaPse Rates and HealtH 
caRe costs aMong Medicaid Patients witH oPioid dePendence 
tReated witH buPRenoRPHine/naloxone
Kharitonova E.1, Zah V.2, Clay E.1, Ruby J.3, Aballéa S.4, Toumi M.4
1Creativ-Ceutical, Paris, France, 2ZRx Outcomes Research Inc., Mississauga, ON, Canada, 3Reckitt 
Benckiser Pharmaceuticals, Inc./NA, Richmond, VA, USA, 4University Claude Bernard Lyon 1, 
Lyon, France
objeCtives: Buprenorphine/naloxone (BUP/NAL) combination is a treatment for 
the opioid dependence. Earlier studies showed that some patients, here, alternated 
between periods on and off treatment. The aim of this study was to compare health 
care resource utilization and costs between these patients and patients treated 
continuously. Methods: Statistical analyses were conducted on a Medicaid insur-
disorders (26.5% vs. 13.6%; p< 0.001). In the follow-up period, high-cost patients 
continued to have higher rates of non-opioid substance abuse diagnoses (53.0% 
vs. 47.2%; p< 0.001) and psychotic disorders (67.1% vs. 47.5%; p< 0.001). The mean 
follow-up period health care costs of high-cost patients was $89,177 (vs. $11,653 
for low-cost patients (p< 0.001)), of which 38.8% was attributed to inpatient, 21.9% 
to outpatient, 18.6% to emergency department , 4.9% to rehabilitation facility, and 
11.0% to prescription drugs costs. ConClusions: High-cost patients diagnosed 
with opioid abuse are complicated patients with high rates of pre-existing and 
concurrent chronic comorbidities and mental health conditions.
PMH37
cost of caRe attRibutable to alzHeiMeR’s disease foR MedicaRe 
enRollees
Juarez D.1, Davis J.2
1University of Hawaii at Hilo, Honolulu, HI, USA, 2John A. Burns School of Medicine, Honolulu, 
HI, USA
objeCtives: In the US, over 5 million people suffer from Alzheimer’s Disease (AD). 
The objective of this study is to estimate direct medical costs attributable to AD for 
Medicare enrollees in 2008 and 2010 according to cost category. Methods: Data 
were from the Centers for Medicare & Medicaid Services (CMS) chronic conditions 
public use files in which each record is a profile defined by all combinations of age 
category, gender, chronic conditions, and dual-eligibility status. For each profile, cost 
measures generated from claims data are provided in the form of averages by cost 
category. Our study population (n= 23.7m) included Medicare enrollees in years 2008 
and 2010 who: 1) had 12 months enrollment; 2) did not have dual eligibility; 3) were 
age 65 and over. We examined costs of hospital admissions, skilled nursing facility, 
physician and other provider visits, outpatient visits, and prescriptions medica-
tions. To determine the cost associated with AD, we estimated multivariable OLS 
linear regression models with cost as the dependent variable and a dichotomous 
AD indicator as the primary independent variable, adjusted for age, gender and 
other chronic conditions and weighted using frequency counts. Results: Adjusted 
costs associated with AD were highest for skilled nursing facility use, medications, 
and inpatient services, at $1680, $1280 and $1114, respectively, in 2010. Of the 11 
chronic conditions examined, AD was the most costly in terms of added medication 
expenditures, with added annual costs $300 more than the next closest condition, 
chronic obstructive pulmonary disorder (COPD, Table). It was also the second most 
costly condition in terms of skilled nursing facility costs, surpassed only by stroke in 
adjusted analyses. ConClusions: Interventions, including treatment for reversible 
causes, lifestyle modification, and use of cost-effective treatments, may be needed 
to stem cost increases attributable to AD, particularly as the population ages.
PMH38
HosPitalization costs in scHizoPHRenia (sc) and PRojection of 
costs witH tHe adoPtion of a long-teRM Release foRMulation of 
PaliPeRidone PalMitate (lRPP): Real woRld data analysis
Meneses J.M.1, Clark O.A.C.2, Nishikawa A.M.2
1Centro de Hematologia e Hemoterapia do Ceará, Fortaleza, Brazil, 2Evidências, Campinas, Brazil
objeCtives: Schizophrenia is a mental disease of chronic nature that may often 
require long time hospitalizations to be controlled. One of the major issues in con-
trolling Sc is adherence to treatment. Long-term release paliperidone palmitate 
administered intramuscularly once a month improved treatment compliance and 
diminished hospitalization rates. Our goal was to estimate the costs of hospitaliza-
tion for schizophrenic patients in Brazil (private setting) and to calculate the mon-
etary impact of adopting LRPP in an outpatient scenario. Methods: We searched a 
database of claims of five health plans in order to identify patients with schizophre-
nia. Then, we retrieved all hospitals bills for each patient and determined the final 
cost of admissions. Only direct costs were considered: medication, medical visits, 
ancillary fees, etc. To project the impact of the adoption of LRPP, we estimated that 
hospitalization rates would be reduced by 31.5% for patients admitted for less than 
one year and 35.9% for those hospitalized for up to two years, according to data from 
randomized trials. Results: We identified 18 admissions due to schizophrenia. 
Patients had a mean age of 43.4 years. Mean length of hospitalization was 126.4 days, 
corresponding to a total of 2275 days for all patients. Total hospitalization cost was 
R$ 604 889 (US$ 252 037), mean of R$ 33 604 (US$ 14 000) per hospitalization. If LRPP 
was adopted, the cost to treat these patients would be cut down to R$ 130 974 (US$ 
54 572), a reduction of 21,65%. ConClusions: Based on real world data, Sc hospi-
talization costs may be reduced by 21% if outpatient treatment with LRPP is adopted.
PMH39
exaMining tHe buRden of illness of united states veteRan Patients 
diagnosed witH biPolaR disoRdeR
Baser O.1, Wang L.2, Huang A.2, Wang Y.3, Kariburyo M.F.3, Xie L.3
1STATinMED Research and The University of Michigan, Ann Arbor, MI, USA, 2STATinMED 
Research, Dallas, TX, USA, 3STATinMED Research, Ann Arbor, MI, USA
objeCtives: To examine the economic burden and health care utilizations of bipo-
lar disorder patients in the U.S. veteran population. Methods: A retrospective data-
base analysis was performed using the Veterans Health Administration Medical SAS 
datasets from October 1, 2007 through September 30, 2012. Adult patients diagnosed 
with bipolar disorder were identified using International Classification of Disease, 
9th Revision, Clinical Modification (ICD-9-CM) diagnosis codes 296.0x, 296.1x, 296.4x, 
296.5x, 296.6x, 296.7x and 296.8x. The first diagnosis date was defined as the index 
date for the bipolar disorder cohort. A comparator cohort of patients without a 
bipolar disorder diagnosis was created using 1:1 propensity score matching to adjust 
for demographic characteristics and baseline Charlson Comorbidity Index scores. 
The index date for the comparator cohort was randomly chosen to reduce selec-
tion bias. One-year continuous enrollment was required before and after the index 
date for both cohorts. Study outcomes, including health care costs and utilizations, 
were compared between the disease and comparator cohorts. Results: After 1:1 
matching, a total of 187,530 patients with proportionate baseline characteristics 


PMH40 Resource use and associated costs of long acting injectable antipsychotics: A RAMQ database analysis 

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PMH40 Resource use and associated costs of long acting injectable antipsychotics: A RAMQ database analysis

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