Calling for awareness and knowledge: perspectives on religiosity, spirituality and mental health in a religious sample from Portugal (a mixed-methods study)

Recent studies have demonstrated that when suffering or in psychological distress, religious clients tend to recover faster and with better outcomes when mental health professionals (MHPs) seek to integrate their clients' religious beliefs and practices in psychotherapy. As described in the literature and highly-recommended by the American Psychological Association (APA) guidelines, promotion of an accurate and sensitive integration of a client's religious and spiritual beliefs is implied among MHPs: the awareness of the particularities, the differences and barriers that religious clients might encounter when seeking help; the knowledge and respect of those specific characteristics and needs; and the development of specific competencies. A mixed-methods approach was used to conduct this study, with the aim of understanding the role which religiosity and spirituality play in mental health and the psychotherapeutic processes of religious members and clients in Portugal. Eight focus groups and three in-depth interviews were conducted, with a total of 41 participants. Participants stated their religiosity as vital aspects in their life and reported religious/spiritual practices as their primary coping strategies. They recognised that their religiosity should not be concealed or marginalised in the context of their psychological and/or psychiatric treatment, but revealed apprehensions, dilemmas and barriers prior to disclosure. MHPs and services were seen as a possible source of help, but often as a last resort. Participants who sought professional help overall seemed to be satisfied with the service provided to them, although such treatment was mostly related to symptoms relief. Also, many concerns were shared, among them were both their wish for a religious match/similarity with their MHP, and the perception of a lack of sensibility by their MHP towards religious and spiritual issues. Conclusions and implications for research are provided.info:eu-repo/semantics/publishedVersio

A call for collaboration: perception of religious and spiritual leaders on mental health (a Portuguese sample)

To assess the relationship and collaborations between mental health professionals and religious and spiritual leaders, eleven representatives of ten different religious affiliations in Portugal participated in this qualitative study. Major findings reported showed that religious leaders perceive themselves as important agents in promoting and preserving their congregants’ mental health, as well as aiding their recovery processes; however this occurs without much referral to or collaboration with mental health professionals. These findings are discussed, as well as why and how a healthy collaboration between mental health professionals and religious leaders can positively impact the psychotherapeutic relationship and clinical outcomes with religious/spiritual clients.info:eu-repo/semantics/acceptedVersio

Hospital outbreak of carbapenem-resistant Enterobacterales associated with a bla OXA-48 plasmid carried mostly by Escherichia coli ST399

A hospital outbreak of carbapenem-resistant Enterobacterales was detected by routine surveillance. Whole genome sequencing and subsequent analysis revealed a conserved promiscuous blaOXA-48 carrying plasmid as the defining factor within this outbreak. Four different species of Enterobacterales were involved in the outbreak. Escherichia coli ST399 accounted for 35 of all the 55 isolates. Comparative genomics analysis using publicly available E. coli ST399 genomes showed that the outbreak E. coli ST399 isolates formed a unique clade. We developed a mathematical model of pOXA-48-like plasmid transmission between host lineages and used it to estimate its conjugation rate, giving a lower bound of 0.23 conjugation events per lineage per year. Our analysis suggests that co-evolution between the pOXA-48-like plasmid and E. coli ST399 could have played a role in the outbreak. This is the first study to report carbapenem-resistant E. coli ST399 carrying blaOXA-48 as the main cause of a plasmid-borne outbreak within a hospital setting. Our findings suggest complementary roles for both plasmid conjugation and clonal expansion in the emergence of this outbreak

Maintaining order in the drug game: Applying harm reduction principles to drug detective work

Drug war rhetoric is losing favour in the political arena due to its increasingly obvious failures and there is a growing consensus amongst governing elites that something ought to change. Against this backdrop, the concept of ‘harm reduction’ has moved to the foreground of the research agenda and some policing agencies appear to be reconfiguring their enforcement interventions to focus on managing drug markets in a way that minimises the various associated harms. This article draws on the findings of an ethnographic study of specialist detective units in two English police services to examine how recent developments in drug policy discourse have been received and implemented at an operational level. Although there have been some positive advancements, it argues that changes to the prohibition regime are largely superficial and strong cultural resistance remains. The discussion considers how harm reduction principles might be better applied to the policing of drug markets

Psychological characteristics of religious delusions

Purpose Religious delusions are common and are considered to be particularly difficult to treat. In this study we investigated what psychological processes may underlie the reported treatment resistance. In particular, we focused on the perceptual, cognitive, affective and behavioural mechanisms held to maintain delusions in cognitive models of psychosis, as these form the key treatment targets in cognitive behavioural therapy. We compared religious delusions to delusions with other content. Methods Comprehensive measures of symptoms and psychological processes were completed by 383 adult participants with delusions and a schizophrenia spectrum diagnosis, drawn from two large studies of cognitive behavioural therapy for psychosis. Results Binary logistic regression showed that religious delusions were associated with higher levels of grandiosity (OR 7.5; 95 % CI 3.9–14.1), passivity experiences, having internal evidence for their delusion (anomalous experiences or mood states), and being willing to consider alternatives to their delusion (95 % CI for ORs 1.1–8.6). Levels of negative symptoms were lower. No differences were found in delusional conviction, insight or attitudes towards treatment. Conclusions Levels of positive symptoms, particularly anomalous experiences and grandiosity, were high, and may contribute to symptom persistence. However, contrary to previous reports, we found no evidence that people with religious delusions would be less likely to engage in any form of help. Higher levels of flexibility may make them particularly amenable to cognitive behavioural approaches, but particular care should be taken to preserve self-esteem and valued aspects of beliefs and experiences

Ultraconserved Elements in the Olig2 Promoter

. basal promoter and found that it represses expression in undifferentiated embryonic stem cells. expression during development

Epidemiology of Escherichia coli bacteraemia in England: results of an enhanced sentinel surveillance programme

Background: Escherichia coli causes over one third of the bacteraemia cases in England each year, and the incidence of these infections is increasing. Aim: To determine the underlying risk factors associated with E. coli bacteraemia. Methods: A three month enhanced sentinel surveillance study involving 35 National Health Service hospitals was undertaken in the winter of 2012/13 to collect risk factor information and further details on the underlying source of infection to augment data already collected by the English national surveillance programme. Antimicrobial susceptibility results for E. coli isolated from blood and urine were also collected. Findings: A total of 1,731 cases of E. coli bacteraemia were included. The urogenital tract was the most commonly reported source of infection (51.2% of cases) with prior treatment for a urinary tract infection being the largest independent effect associated with this infection source. Half of all patients had prior healthcare exposure in the month prior to the bacteraemia with antimicrobial therapy and urinary catheterisation being reported in one third and one fifth of these patients. Prior healthcare exposure was associated with a higher proportion of antibiotic non-susceptibility in the blood culture isolates (P=0.001). Conclusion: Analysis of risk factors suggests potential community and hospital-related interventions particularly better use of urinary catheters and improved antibiotic management of urinary tract infections. As part of the latter strategy, antibiotic resistance profiles need to be closely monitored to ensure treatment guidelines are up to date to limit inappropriate empiric therapy

Diversity of 23S rRNA Genes within Individual Prokaryotic Genomes

The concept of ribosomal constraints on rRNA genes is deduced primarily based on the comparison of consensus rRNA sequences between closely related species, but recent advances in whole-genome sequencing allow evaluation of this concept within organisms with multiple rRNA operons. was the only species in which intragenomic diversity >3% was observed among 4 paralogous 23S rRNA genes.These findings indicate tight ribosomal constraints on individual 23S rRNA genes within a genome. Although classification using primary 23S rRNA sequences could be erroneous, significant diversity among paralogous 23S rRNA genes was observed only once in the 184 species analyzed, indicating little overall impact on the mainstream of 23S rRNA gene-based prokaryotic taxonomy