82 research outputs found

    Deep Theorizing in International Relations

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    This paper starts from the observation that, at a time when the popularity of grand theory is in decline among IR scholars, they do not agree on what they mean by theory. In fact, the celebration of theoretical pluralism is accompanied by the relative absence of a serious conversation about what ‘theory’ is, could, or should be. Taking the view that we need such a conversation, this puts forward the notion of ‘deep theorizing’. Countering both the shallow theorizing of modern scholarship that conflates theory with scientific method, and the postmodern view that abstract narratives must be deconstructed and rejected, it offers a reading of the parameters along which substantial theorizing proceeds. Specifically, it suggests that ‘deep theorizing’ is the conceptual effort of explaining (inter)action by developing a reading of drives/basic motivations and the ontology of its carrier through an account of the human condition, that is, a particular account of how the subject (the political actor) is positioned in social space and time. The paper illustrates the plausibility of this meta-theoretical angle in a discussion of realist, liberal and postcolonial schools of thought

    Large Fragment Pre-S Deletion and High Viral Load Independently Predict Hepatitis B Relapse after Liver Transplantation

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    Hepatitis B virus (HBV) associated end-stage liver diseases are the leading causes of liver transplantation (LT) in Taiwan. Relapse of hepatitis B occurs after LT, raising the risk of graft failure and reducing patient survival. Although several oral antiviral agents have been approved for anti-HBV treatment, lamivudine (LAM) remained to be the most widely used preventive regimen in Taiwan. While several clinical predictors have been identified for hepatitis B relapse, the predictive roles of the histopathological characteristics in liver explants as well as the genotypic features of the viruses in pre-LT serum samples have not been assessed. Between September 2002 and August 2009, 150 consecutive hepatitis B surface antigen (HBsAg) positive patients undergoing LT were included for outcome analysis following assessment of the clinicopathological and virological factors prior to LT. Kaplan-Meier analyses discovered that pre-operative LAM treatment ≤3 months; membranous distribution and higher expression of tissue HBsAg in liver explants; preoperative viral load ≧106 copies/ml; and presence of large fragment (>100 base pairs) pre-S deletion (LFpreSDel) correlated significantly with hepatitis B relapse. Multivariate Cox regression analysis showed that the presence of LFpreSDel (P = 0.001) and viral load ≧106 copies/mL (P = 0.023) were independent predictors for hepatitis B relapse. In conclusion, besides high viral load, LFpreSDel mutation is an important independent predictor for hepatitis B relapse after LT. More aggressive preventive strategies should be applied for patients carrying these risk factors

    ENVIRONMENTAL AND TRADE REGIMES: COMPARISON OF HYPERGRAPHS MODELING THE RATIFICATIONS OF UN MULTILATERAL TREATIES

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    International audienceIn analyzing the ratifications of Multilateral Environmental Agreements (MEAs) and United Nations-based trade agreements, this study pursues two goals: first, to provide evidence of the limitations of the role played by the United Nations in promoting sustainable development as a bridge between both regimes, although member states are roughly the same; second, on a methodological side, to contribute to the exploration of the use of hypergraphs to model a dynamic in International Relations, as illustrated by analyzing empirical data easily accessible and available on the web. We use 3550 ratification dates of MEAs (1979-2015) and 834 ratifications of trade agreements (1963-2014) available on the website of the United Nations Treaty Collection. The hypergraph-based analysis of the temporal successions of ratifications highlights informal communities of countries whose contours emerge through this uncoordinated process of ratification. The European countries and more specifically members of the European Union, and their Atlantic allies stand out as having the leadership of the construction of a global environmental order. However, no formally established community of countries emerges from the chronology of ratification of the United Nations trade agreements. In this particular UN context, none of the contemporary trade powers is even central to this dynamic. Indeed, most trade negotiations take place outside the United Nations arena, particularly in the framework of the World Trade Organization, or in regional, bilateral, or even minilateral partnerships

    ENVIRONMENTAL AND TRADE REGIMES: COMPARISON OF HYPERGRAPHS MODELING THE RATIFICATIONS OF UN MULTILATERAL TREATIES

    No full text
    International audienceIn analyzing the ratifications of Multilateral Environmental Agreements (MEAs) and United Nations-based trade agreements, this study pursues two goals: first, to provide evidence of the limitations of the role played by the United Nations in promoting sustainable development as a bridge between both regimes, although member states are roughly the same; second, on a methodological side, to contribute to the exploration of the use of hypergraphs to model a dynamic in International Relations, as illustrated by analyzing empirical data easily accessible and available on the web. We use 3550 ratification dates of MEAs (1979-2015) and 834 ratifications of trade agreements (1963-2014) available on the website of the United Nations Treaty Collection. The hypergraph-based analysis of the temporal successions of ratifications highlights informal communities of countries whose contours emerge through this uncoordinated process of ratification. The European countries and more specifically members of the European Union, and their Atlantic allies stand out as having the leadership of the construction of a global environmental order. However, no formally established community of countries emerges from the chronology of ratification of the United Nations trade agreements. In this particular UN context, none of the contemporary trade powers is even central to this dynamic. Indeed, most trade negotiations take place outside the United Nations arena, particularly in the framework of the World Trade Organization, or in regional, bilateral, or even minilateral partnerships
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