Las relaciones centro/periferia en el Valle del Guadalquivir del III milenio ANE: La circulación de hojas de caliza oolítica silicificada

Este estudio presenta una interpretación, en términos de relaciones centro-periferia, por medio de un análisis petrológico, morfométrico, espacial y contextual de las hojas de caliza oolítica silicificada documentadas en yacimientos arqueológicos fechados en el III milenio ANE, en el sur de la Península Ibérica. Este análisis documenta la existencia de redes de circulación supra-regionales de productos acabados, altamente estandarizados, sobre una distancia de más de 500 km, y un área de más de 222.000 km2. Adicionalmente, convierte a las hojas de caliza oolítica silicificada en un indicador arqueológico de las rutas, tipos y contenidos de las relaciones intersociales de y en torno al marco de jerarquización entre asentamientos del Valle del Guadalquivir desde 3000 hasta 2500 ANE, señalando la emergencia y colapso de un sistema político.This study offers an alternative explanation, in terms of core/periphery relationships, by means of a petrologic, morphometric, spatial and contextual analysis of the silicified oolitic limestone blades found in archaeological sites dated back to the third millennium ANE in southern Iberia. This suggests the existence of a supra-regional circulation of highly standardized, finished products, which spread over a distance of more than 500 km, and an area of over 222.000 km2. In this sense, the blades have become the first archaeological indicator of the paths, types and contents of the relationships developed within and around the inter-settlement hierarchical framework of the Guadalquivir Valley from 3000 to 2500 BC, accounting for the emergence and collapse of a political system

Development and evaluation of equations to predict body weight of Pelibuey ewes using heart girth

The aim of this study was to develop and evaluate equations to predict body weight (BW) using heart girth (HG) in Pelibuey ewes. For model develop a data set composed by 366, 3-year-old, non-pregnant and non-lactating ewes; with a mean BW of 45.7±9.16 kg and HG of 87.55± 7.93 cm was used. A linear equation was fitted: BW= -47.97 (±2.01*) + 1.07 (±0.02**)×HG (R2 = 0.86, RMSE = 3.46, , y n = 366). A second data set composed by 67 animals, with similar characteristics (BW of 38.25± 8.62 kg and HG of 80.37± 7.03 cm) was used to evaluate the developed equations. For the evaluation, the relationship between observed and predicted values of BW by linear regression, the mean squared error of prediction (MSEP) and root MSEP (RMSEP), and concordance correlation coefficient analysis were used. The proposed equation was highly precise (r2 =0.913) and accurate (Cb=0.996) with a reproducibility index of 0.95. The MEF have indicates a higher efficiency of prediction with higher proportion of the total variance of the observed values been explained by the predicted data (0.91). The partition of the MSEP have indicated a very small mean bias (0.082). The systematic bias have shown that only 1.93% of the error of prediction was associated with the slope and most of the error was explained by the random component indicating small biases with the predictions. The proposed equation accurately and precisely estimated the BW of Pelibuey ewe using HG and therefore is recommended to be used

Mediterranean lifestyle index and 24-h systolic blood pressure and heart rate in community-dwelling older adults

Specifc foods, nutrients, dietary patterns, and physical activity are associated with lower blood pressure (BP) and heart rate (HR), but little is known about the joint efect of lifestyle factors captured in a multidimensional score. We assessed the association of a validated Mediterranean-lifestyle (MEDLIFE) index with 24-h-ambulatory BP and HR in everyday life among community-living older adults. Data were taken from 2,184 individuals (51% females, mean age: 71.4 years) from the SeniorsENRICA-2 cohort. The MEDLIFE index consisted of 29 items arranged in three blocks: 1) Food consumption; 2) Dietary habits; and 3) Physical activity, rest, and conviviality. A higher MEDLIFE score (0–29 points) represented a better Mediterranean lifestyle adherence. 24-h-ambulatory BP and HR were obtained with validated oscillometric devices. Analyses were performed with linear regression adjusted for the main confounders. The MEDLIFEhighest quintile (vs Q1) was associated with lower nighttime systolic BP (SBP) (-3.17 mmHg [95% CI: -5.25, -1.08]; p-trend=0.011), greater nocturnal-SBP fall (1.67% [0.51, 2.83]; p-trend=0.052), and lower HR (-2.04 bpm [daytime], -2.33 bpm [nighttime], and -1.93 bpm [24-h]; all p-trend<0.001). Results were similar for each of the three blocks of MEDLIFE and by hypertension status (yes/no). Among older adults, higher adherence to MEDLIFE was associated with lower nighttime SBP, greater nocturnal-SBP fall, and lower HR in their everyday life. These results suggest a synergistic BP-related protection from the components of the Mediterranean lifestyle. Future studies should determine whether these results replicate in older adults from other Mediterranean and non-Mediterranean countriesThis work was supported by FIS grants 19/319, 20/00896, and 22/1164 from the Carlos III Health Institute, the Secretary of R+D+I, and the European Regional Development Fund/European Social Fund; and by International; REACT EU Program. Comunidad de Madrid and European Regional Development Fund (ERDF), European Union: FACINGLCOVID-CM project, Comunidad de Madrid and European Regional Development Fund (ERDF), European Union. MSP holds a Ramón y Cajal contract (RYC2018–025069-I) from the Spanish Ministry of Science, Innovation and Universitie

Pelletized Forage-Based Rations as Alternative Feeds for Improving Goat Productivity

Goat farming is very popular in the Philippines as it is considered by many to be a viable rural enterprise. Despite this, the goat industry is faced with many challenges, including problems relating to high pre-weaning mortality, poor nutrition and lack of strategic approaches to accelerate genetic improvement. The long term rate of increase of goat numbers is only 0.97% per annum, due to high offtake rates and low productivity. Thus, the Philippine goat population is only expected to reach 4.27million by 2020 (compared with the target of 6.2 million), given the 3.88million population in 2010 (Alo 2012). Interventions are needed to accelerate growth of the goat population. Goats are typically fed on locally available resources which are characterised by low quality and highly variable availability. These characteristics can be overcome through processing techniques such as sun drying and pelleting to ensure year round feed supply. Pelleting offers particular advantages. Feeding animals with pellets provides better feed efficiency, greater starch digestibility, less feed waste, non-selective feeding, better handling and storage, and increased income due to more efficient feeding and higher productivity. While pellets are available for swine, poultry and buffalo in the Philippine market, pellets for goats are not currently available. The aim of this study was to develop pelletized forage-based rations for goats and evaluate them for their technical and financial viability

Molecular survey of pyrethroid resistance mechanisms in Mexican field populations of Rhipicephalus (Boophilus) microplus

Susceptibility to synthetic pyrethroids (SP´s) and the role of two major resistance mechanisms were evaluated in Mexican Rhipicephalus microplus tick populations. Larval packet test (LPT), knock-down (kdr) PCR allele-specific assay (PASA) and esterase activity assays were conducted in tick populations for cypermethrin, flumethrin and deltamethrin. Esterase activity did not have a significant correlation with SP´s resistance. However a significant correlation (p < 0.01) was found between the presence of the sodium channel mutation, and resistance to SP´s as measured by PASA and LPT respectively. Just over half the populations (16/28) were cross-resistant to flumethrin, deltamethrin and cypermethrine, 21.4% of the samples (6/28) were susceptible to all of the three pyrethroids 10.7 of the samples (3/28) were resistant to flumethrin, 3.4 of the samples (1/28) were resistant to deltamethrin only and 7.1% (2/28) were resistant to flumethrin and deltamethrin. The presence of the kdr mutation correlates with resistance to the SP´s as a class. Target site insensitivity is the major mechanism of resistance to SP´s in Mexican R. microplus field strains, involving the presence of a sodium channel mutation, however, esterase-based, other mutations or combination of mechanisms can also occur

Evaluation of rK39 rapid diagnostic tests for canine visceral leishmaniasis : longitudinal study and meta-analysis

Canine visceral leishmaniasis is a vector-borne disease caused by the intracellular parasite Leishmania infantum. It is an important veterinary disease, and dogs are also the main animal reservoir for human infection. The disease is widespread in the Mediterranean area, and parts of Asia and South and Central America, and is potentially fatal in both dogs and humans unless treated. Diagnosis of canine infections requires serological or molecular tests. Detection of infection in dogs is important prior to treatment, and in epidemiological studies and control programmes, and a sensitive and specific rapid diagnostic test would be very useful. Rapid diagnostic tests (RDTs) have been developed, but their diagnostic performance has been reported to be variable. We evaluated the sensitivity of a RDT based on serological detection of the rK39 antigen in a cohort of naturally infected Brazilian dogs. The sensitivity of the test to detect infection was relatively low, but increased with time since infection and the severity of infection. We then carried out a meta-analysis of published studies of rK39 RDTs, evaluating the sensitivity to detect disease and infection. The results suggest that rK39 RDTs may be useful in a veterinary clinical setting, but the sensitivity to detect infection is too low for operational control programmes

The common marmoset genome provides insight into primate biology and evolution

We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application. © 2014 Nature America, Inc