Eficacia de una técnica cognitivo-conductual en pacientes quirúrgicos

El objetivo del estudio consistió en diseñar y comprobar la eficacia de una técnica psicológica en pacientes quirúrgicos, para reducir los niveles de ansiedad y depresión, y facilitar la recuperación. La muestra estuvo compuesta por 30 mujeres que debían someterse a una histerectomía abdominal. Estas mujeres fueron repartidas al azar en dos grupos: experimental y control. La técnica se compuso de diferentes elementos: 1) información; 2) expresión de emociones; 3) respiración, relajación, visualización; 4) ejercicios para facilitar la recuperación; 5) entrega de hojas informativas. Los resultados fueron: el grupo experimental respecto al grupo control, padeció menos ansiedad y depresión postquirúrgicas, sufrió menos dolor y complicaciones después de la operación, necesitó menos analgésicos, recuperó antes sus funciones orgánicas, y se acortó su estancia hospitalaria. Por tanto podemos concluir que la técnica psicológica diseñada se mostró eficaz como facilitadora de la recuperación en pacientes quirúrgicos.The aim of this study was to design and test the efficiency of a psychological technique to reduce levels of anxiety and depression in surgery patients and to facilitate their recovery. The test group was composed of 30 women who were to have a hysterectomy. These women were divided into two groups: an experimental group and a control group . The technique involved various elements: 1) information, 2) the expression of emotions, 3) breathing, relaxation, visualitation, 4) excercises to facilitate recovery, 5) distribution of summary sheets. The results were as follows: compared to the control group, the experimental group suffered less anxiety, less post-surgical depression, less pain and fewer post-operative complications. The women needed fewer painkillers, regained their normal bodily functions and needed a shorter stay in hospital. We can thus conclude that the psychological technique designed, proved efficient in facilitating the recovery of surgical patients

Point of leveling into Mendoza's fresh fruit companies : (Mendoza, Argentina)

Se determinó el punto de equilibrio (punto de nivelación) en las empresas mendocinas empacadoras de frutas según su nivel de producción anual. Para ello, se calculó el costo fijo, mediante inventario del capital y el costo variable por empresa, tomado de trabajos anteriores. Se diseñó un software específico para calcular el ingreso en el punto de equilibrio y el rango de precios dentro del cual la empresa puede operar. Las empresas fueron estratificadas por grupos de especies y por bultos empacados/ año. Se obtuvieron cinco estratos. La mayor producción se encontró en el estrato 3 (100001 a 150 000 bultos). La curva de Lorenz demostró desigualdad moderada en la distribución de la producción empacada. El índice de Gini (41,5 %) revela la baja concentración de la oferta. El 15 % de las empresas quedó comprendido en los estratos con mayor número de bultos empacados, con sólo 36 % del total ofertado. Las mezclas comerciales más frecuentes fueron: Mix completo (24 %), una especie (24 %), predominio de pepita más carozo (20 %), predominio de carozo más uva (16 %) Y predominio de carozo más pepita (16 %),. La movilidad de las mezclas y el bajo grado de concentración de la oferta por empresas explicó el bajo poder de negociación individual de las mismas. La utilización del software y su metodología confirmaron que las empresas más grandes no siempre deben más para alcanzar el punto de equilibrio.This paper searched to determine the point of leveling (point of equilibrium) into Mendoza’s fresh fruit companies, in order to the level of annual production. For this matter calculated fix cost, starting from inventory of capital, and variable cost, taken from previous papers. Oesigned specific software to calculate the money received and the rank inside the companies can move. The companies was stratified in blocks for species and for really box packaged getting 5 stratums. The greater production lounded inside the stratum 3 (100.001 to 150.000 box). The Lorenz’s curve prove a moderating inequality lor distribution 01 packed production The Gini’s index proves a low concentration from the offer. The 15 % from de companies are inside the stratum with de greatest number 01 packed box and only have 36 % lor the offer. Mix commercial more frequent are: complete mix (24 %), one specie (24 %) predominance apples and pear plus fruit’s stone (20 %), predominance fruit’s stone plus grapes (16 %), predominance Iruit’s stone plus apples and pears (16 %).Motility of lhe mixes and low level of concentration from offer for company explicates lhe low power of negotialion individuality, Using the software and their methodology confirm that greater companies no necessary must produce more far obtain the point of leveling.Fil: Antoniolli, Ester Rosa. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Solsona, Juan Esteban. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Gennari, Alejandro. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Roby, Osvaldo. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Cánovas, Laura. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Alturria, Laura. Universidad Nacional de Cuyo. Facultad de Ciencias Agraria

A compressive review about Taxol® : history and future challenges

©2020. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Molecules. To access the final edited and published work see https://doi.org/10.3390/molecules25245986Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to treat over one million patients, making it one of the most widely employed antitumoral drugs. Taxol® was the first microtubule targeting agent described in the literature, with its main mechanism of action consisting of the disruption of microtubule dynamics, thus inducing mitotic arrest and cell death. However, secondary mechanisms for achieving apoptosis have also been demonstrated. Despite its wide use, Taxol® has certain disadvantages. The main challenges facing Taxol® are the need to find an environmentally sustainable production method based on the use of microorganisms, increase its bioavailability without exerting adverse effects on the health of patients and minimize the resistance presented by a high percentage of cells treated with paclitaxel. This review details, in a succinct manner, the main aspects of this important drug, from its discovery to the present day. We highlight the main challenges that must be faced in the coming years, in order to increase the effectiveness of Taxol® as an anticancer agent

New evidence on accelerator performance based on funding and location

Purpose Seed accelerators (SAs) appear as a more advanced version of business incubators. These for-profit organizations in exchange of equity, help setting new start-ups by providing mentoring and funding during its first months. Due to their emergent nature, the impact and expectations of SAs remains largely unknown. Therefore, the purpose of this study is to throw new light on this field by empirically assessing for the first time the performance and prospects of these organizations through a survey of 116 SAs. Design/methodology/approach A model based on the Business Incubators literature is built with four categories covering size, location, age and profitability variables, leading to two hypotheses to be tested empirically over a survey of 116 SAs. Findings Some remarkable findings arise after implementation of both bivariate and multivariate analysis. The results confirm a higher size and performance in the US and in the oldest SAs at statistically significant levels. Research limitations/implications The study is not free from limitations but the findings make a contribution to the still scarce existing literature on SAs, and provide some managerial implications to their stockholders, to investors and to entrepreneurs. Practical implications The findings concerning performance indicators are especially helpful for investors, primarily concerned with the percentage return on investment factor, the period and the investment rounds needed to achieve exit. Another key issue is the SA's role as an employment seedbed. At first glance, the amount of employment, both overall and per company, might seem small given the young age of these firms. The impact of SAs on the generation of new employment is difficult to measure as it usually takes place in further stages of development of the tenant companies, the so-called scale-up process. Nonetheless, at present, the number of new companies being born is remarkable and, in terms of employment, the results are indeed promising. Our findings also offer important implications for entrepreneurs, venture investors and policy-makers. To entrepreneurs, our findings offer insight on the expectations to hold in the accelerator programs. Social implications For policy-makers and would-be accelerator founders, our results support the idea shared in the literature that accelerators can be an effective entrepreneurial intervention, even in small entrepreneurial ecosystems, compared to the strongest entrepreneurial hubs (Hallen et al., 2017). Originality/value SAs are a very recent phenomenon which is blooming all over the world, especially in developed countries. SAs are therefore considered a key agent in the prospects of any entrepreneurial ecosystem. However, no studies have so far analysed the impact and performance of this emerging instrument. This is precisely the main purpose of this paper, to offer for the first time an approximate and exploratory assessment on the impact and prospects of SAs, based on a database

Impacto social y económico de las aceleradoras de emprendimiento: análisis de factores condicionantes e implicaciones para la innovación social

Accelerators are still an emerging tool pointed to speed up the birth and growth of innovative start-ups. The Seed Accelerator programs (SAP) usually provide entrepreneurs with accommodation, mentoring and training during a short period of three to six months, and are believed to be useful for a more effective launch of start-ups. Due to their emergent nature, the impact and expectations of Seed Accelerators remains largely unknown. The main purpose of this study is to approximately assess, for the first time, the Seed Accelerators capacity to make a social contribution in terms of employment generated by the new ventures participating in the acceleration programs. The originality lies in being pioneer in identifying the factors underlying a higher impact of these initiatives in terms of employment and other key performance indicators. This objective will be empirically fulfilled through a sample of Seed Accelerators, assembled from an online Global Seed Accelerator survey with data on SAs and the accelerated companies that have participated in Accelerator Programs.; Este estudio indaga de forma pionera y exploratoria en el desempeño de las Aceleradoras y las start-ups albergadas en ellas en términos del empleo que generan. Los emprendedores que participan en una Aceleradora viven una experiencia que es crucial para la supervivencia, desarrollo y expansión de su start-up. Las Aceleradoras están generando una enorme expectación en España con Valencia a la cabeza, pero son un fenómeno muy reciente por lo que las evidencias empíricas existentes a día de hoy son poco concluyentes o inexistentes. De ahí el carácter pionero de nuestro estudio, el cual ofrece a partir de una muestra de 116 aceleradoras una aproximación al alcance del empleo generado por las start-ups ubicadas en ellas. Las evidencias empíricas encontradas aportan valiosas implicaciones prácticas a tener en cuenta a la hora de generar expectativas realistas acerca de estos instrumentos. Los resultados, de carácter exploratorio, demuestran que las Aceleradoras localizadas en EEUU estimulan la creación de un mayor número de start-ups que en otros países, así como de puestos de trabajo. El estudio identifica las variables que más intensamente inciden en la creación de nuevas empresas y sus niveles de empleo

A novel bio-functional material based on mammalian cell aggresomes

Aggresomes are protein aggregates found in mammalian cells when the intracellular protein degradation machinery is over-titered. Despite that they abound in cells producing recombinant proteins of biomedical and biotechnological interest, the physiological roles of these protein clusters and the functional status of the embedded proteins remain basically unexplored. In this work, we have determined for the first time that, like in bacterial inclusion bodies, deposition of recombinant proteins into aggresomes does not imply functional inactivation. As a model, human α-galactosidase A (GLA) has been expressed in mammalian cells as enzymatically active, mechanically stable aggresomes showing higher thermal stability than the soluble GLA version. Since aggresomes are easily produced and purified, we propose these particles as novel functional biomaterials with potential as carrier-free, self-immobilized catalyzers in biotechnology and biomedicine

The role of the surface evapotranspiration in regional climate modelling: Evaluation and near-term future changes

Surface evapotranspiration (SFCEVP) plays an essential role in the climate, being the link between hydrological and energy cycles. Therefore, how it is approximated and its implication in the regional climate are important aspects to understand the effects of climate change, especially in transitional zones such as the Iberian Peninsula (IP). This study aims to investigate the spatiotemporal patterns of the SFCEVP using a regional climate model (RCM), the Weather Research and Forecasting (WRF) model. To this purpose, a set of WRF simulations were completed using different driving data. On the first hand, a recent present (1980–2017) simulation driven by the ERA-Interim reanalysis was carried out to evaluate the suitability of the RCM performance. On the other hand, two global climate models (GCMs) from the CMIP5 initiative, the CESM1 and the MPI-ESM-LR, were used as driving data to evaluate the GCM-RCM coupling, which is essential to climate change applications. Finally, projected changes were also investigated for a near-term future (2021–2050) paradigm. In general, the results pointed out the WRF model as a valuable tool to study the spatiotemporal patterns of the SFCEVP in the IP, showing an overall and acceptable ability at different spatial and temporal scales. Concerning projections, the results indicate that the IP is likely to undergo significant changes in the SFCEVP in the near future. These changes will be more apparent over the southernmost, and particularly during spring and summer, being in the latter season the SFCEVP fundamentally reduced. These results agree with projected changes in soil moisture, which is probably associated with changes in precipitation patterns. Additionally, the results reveal the major role of SFCEVP in modulating the climate over this region, which is involved in the complex land-atmosphere processes.Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Granad

Metal mobility and bioaccessibility from cyanide leaching heaps in a historical mine site

Unlike acidic sulfide mine wastes, where metal/loid mobility and bioaccessibility has been widely studied, less attention has been paid to alkaline cyanide heap leaching wastes. Thus, the main goal of this study is to evaluate the mobility and bioaccessibility of metal/loids in Fe-rich (up to 55%) mine wastes resulting from historical cyanide leaching activities. Wastes are mainly composed of oxides/oxyhydroxides (i.e. goethite and hematite), oxyhydroxisulfates (i.e. jarosite), sulfates (i.e., gypsum, evaporitic sulfate salts), carbonates (i.e., calcite, siderite) and quartz, with noticeable concentrations of metal/loids (e.g., 1453–6943 mg/kg of As, 5216–15,672 mg/kg; of Pb, 308–1094 mg/kg of Sb, 181–1174 mg/kg of Cu, or 97–1517 mg/kg of Zn). The wastes displayed a high reactivity upon rainfall contact associated to the dissolution of secondary minerals such as carbonates, gypsum, and other sulfates, exceeding the threshold values for hazardous wastes in some heap levels for Se, Cu, Zn, As, and sulfate leading to potential significant risks for aquatic life. High concentrations of Fe, Pb, and Al were released during the simulation of digestive ingestion of waste particles, with average values of 4825 mg/kg of Fe, 1672 mg/kg of Pb, and 807 mg/kg of Al. Mineralogy may control the mobility and bioaccessibility of metal/loids under rainfall events. However, in the case of the bioaccessible fractions different associations may be observed: i) the dissolution of gypsum, jarosite and hematite would mainly release Fe, As, Pb, Cu, Se, Sb and Tl; ii) the dissolution of an un-identified mineral (e.g., aluminosilicate or Mn oxide) would lead to the release of Ni, Co, Al and Mn and iii) the acid attack of silicate materials and goethite would enhance the bioaccessibility of V and Cr. This study highlights the hazardousness of wastes from cyanide heap leaching, and the need to adopt restoration measures in historical mine sites.This work was supported by the Spanish Ministry of Economic and Competitiveness through the projects TRAMPA (PID2020–119196RBC21) and by H2020 European Institute of Innovation and Technology (EIT RawMaterials) through the project Modular recovery process services for hydrometallurgy and water treatment (MORECOVERY). This work was partially supported by FCT (Portugal) through contract UID/ Multi/04349/2019. C.R C´anovas thanks the Spanish Ministry of Science and Innovation for the Postdoctoral Fellowship granted under application reference RYC2019–027949-I. M.D. Basallote thanks the Spanish Ministry of Science and Innovation for the Postdoctoral Fellowship granted under application reference IJC 2018–035056-I. The authors would also like to thank to Prof. Edward D. Burton, Ph.D (Editor) and three anonymous reviewers for the support and comments that notably improved the quality of the original paper