Heat Transfer and Flow on the First Stage Blade Tip of a Power Generation Gas Turbine

A combined computational and experimental study has been performed to investigate the detailed distribution of convective heat transfer coefficients on the first stage blade tip surface for a geometry typical of large power generation turbines(>100MW). This paper is concerned with the design and execution of the experimental portion of the study. A stationary blade cascade experiment has been run consisting of three airfoils, the center airfoil having a variable tip gap clearance. The airfoil models the aerodynamic tip section of a high pressure turbine blade with inlet Mach number of 0.30, exit Mach number of 0.75, pressure ratio of 1.45, exit Reynolds number based on axial chord of 2.57 x 10(exp 6), and total turning of about 110 degrees. A hue detection based liquid crystal method is used to obtain the detailed heat transfer coefficient distribution on the blade tip surface for flat, smooth tip surfaces with both sharp and rounded edges. The cascade inlet turbulence intensity level took on values of either 5% or 9%. The cascade also models the casing recess in the shroud surface ahead of the blade. Experimental results are shown for the pressure distribution measurements on the airfoil near the tip gap, on the blade tip surface, and on the opposite shroud surface. Tip surface heat transfer coefficient distributions are shown for sharp-edge and rounded-edge tip geometries at each of the inlet turbulence intensity levels

Turbine airfoil net heat flux reduction with cylindrical holes embedded in a transverse trench.

ABSRACT Film cooling adiabatic effectiveness and heat transfer coefficients for cylindrical holes embedded in a 1d transverse trench on the suction side of a simulated turbine vane were investigated to determine the net heat flux reduction. For reference, measurements were also conducted with standard inclined, cylindrical holes. Heat transfer coefficients were determined with and without upstream heating to isolate the hydrodynamic effects of the trench and to investigate the effects of the thermal approach boundary layer. Also the effects of a tripped versus an un-tripped boundary layer were explored. For both the cylindrical holes and the trench, heat transfer augmentation was much greater with no tripping of the approach flow. A further increase in heat transfer augmentation was caused by use of upstream heating, with as much as a 150% augmentation with the trench. With a tripped approach flow the heat transfer augmentation was much less. The net heat flux reduction for the trench was found to be significantly higher than for the row of cylindrical holes

The Las Campanas Infrared Survey. IV. The Photometric Redshift Survey and the Rest-frame R-band Galaxy Luminosity Function at 0.5 <= z <= 1.5

(Abridged) We present rest-frame R-band galaxy luminosity function measurements for three different redshift ranges: 0.5<=z<=0.75, 0.75<=z<=1.0, and 1.0<=z<=1.5. Our measurements are based on photometric redshifts for ~3000 H-band selected galaxies with apparent magnitudes 17<=H<=20 from the Las Campanas Infrared Survey. We show that our photometric redshifts are accurate with an RMS dispersion between the photometric and spectroscopic redshifts of \sigma_z/(1+z)~0.08. Using galaxies identified in the Hubble Deep Field South and Chandra Deep Field South regions, we find, respectively, that (7.3\pm 0.2) % and (16.7\pm 0.4)% of the H=1. We first demonstrate that the systematic uncertainty inherent in the luminosity function measurements due to uncertainties in photometric redshifts is non-negligible and therefore must be accounted for. We then develop a technique to correct for this systematic error by incorporating the redshift error functions of individual galaxies in the luminosity function analysis. The redshift error functions account for the non-gaussian characteristics of photometric redshift uncertainties. They are the products of a convolution between the corresponding redshift likelihood functions of individual galaxies and a Gaussian distribution function that characterizes template-mismatch variance. We demonstrate, based on a Monte Carlo simulation, that we are able to completely recover the bright end of the intrinsic galaxy luminosity function using this technique. Finally, we calculate the luminosity function separately for the total H-band selected sample and for a sub-sample of early-type galaxies that have a best-fit spectral type of E/S0 or Sab from the photometric redshift analysis.Comment: 42 pages and 12 figures; Accepted for publication in the Astrophysical Journa

Evaluation of Glycine max mRNA clusters

BACKGROUND: Clustering the ESTs from a large dataset representing a single species is a convenient starting point for a number of investigations into gene discovery, genome evolution, expression patterns, and alternatively spliced transcripts. Several methods have been developed to accomplish this, the most widely available being UniGene, a public domain collection of gene-oriented clusters for over 45 different species created and maintained by NCBI. The goal is for each cluster to represent a unique gene, but currently it is not known how closely the overall results represent that reality. UniGene's build procedure begins with initial mRNA clusters before joining ESTs. UniGene's results for soybean indicate a significant amount of redundancy among some sequences reported to be unique mRNAs. To establish a valid non-redundant known gene set for Glycine max we applied our algorithm to the clustering of only mRNA sequences. The mRNA dataset was run through the algorithm using two different matching stringencies. The resulting cluster compositions were compared to each other and to UniGene. Clusters exhibiting differences among the three methods were analyzed by 1) nucleotide and amino acid alignment and 2) submitting authors conclusions to determine whether members of a single cluster represented the same gene or not. RESULTS: Of the 12 clusters that were examined closely most contained examples of sequences that did not belong in the same cluster. However, neither the two stringencies of PECT nor UniGene had a significantly greater record of accuracy in placing paralogs into separate clusters. CONCLUSION: Our results reveal that, although each method produces some errors, using multiple stringencies for matching or a sequential hierarchical method of increasing stringencies can provide more reliable results and therefore allow greater confidence in the vast majority of clusters that contain only ESTs and no mRNA sequences

Measuring personal networks and their relationship with scientific production

The analysis of social networks has remained a crucial and yet understudied aspect of the efforts to measure Triple Helix linkages. The Triple Helix model aims to explain, among other aspects of knowledge-based societies, ¿the current research system in its social context. This paper develops a novel approach to study the research system from the perspective of the individual, through the analysis of the relationships among researchers, and between them and other social actors. We develop a new set of techniques and show how they can be applied to the study of a specific case (a group of academics within a university department). We analyse their informal social networks and show how a relationship exists between the characteristics of an individual¿s network of social links and his or her research output

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

In mammals, ∼100 deubiquitinases act on ∼20,000 intracellular ubiquitination sites. Deubiquitinases are commonly regarded as constitutively active, with limited regulatory and targeting capacity. The BRCA1-A and BRISC complexes serve in DNA double-strand break repair and immune signaling and contain the lysine-63 linkage-specific BRCC36 subunit that is functionalized by scaffold subunits ABRAXAS and ABRO1, respectively. The molecular basis underlying BRCA1-A and BRISC function is currently unknown. Here we show that in the BRCA1-A complex structure, ABRAXAS integrates the DNA repair protein RAP80 and provides a high-affinity binding site that sequesters the tumor suppressor BRCA1 away from the break site. In the BRISC structure, ABRO1 binds SHMT2α, a metabolic enzyme enabling cancer growth in hypoxic environments, which we find prevents BRCC36 from binding and cleaving ubiquitin chains. Our work explains modularity in the BRCC36 DUB family, with different adaptor subunits conferring diversified targeting and regulatory functions.ISSN:1097-2765ISSN:1097-416

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure