La motivación como eje central en el proceso de enseñanza-aprendizaje

Este trabajo se centra en la propuesta de un diseño de instrucción, dirigido al profesorado, para promover en el alumnado la motivación autodeterminada y el compromiso en el proceso de enseñanza- aprendizaje. Además, ofrece una nueva metodología de trabajo, tomando como referencia la Teoría de la Autodeterminación y la filosofía del sistema educativo finlandés, ya que recoge un modelo de aprendizaje basado en la práctica aplicada, trasladando contextos y situaciones reales al aula. El objetivo es fomentar el entusiasmo, la motivación autónoma y en consecuencia, el compromiso en los estudiantes. Y todo ello, en un ambiente favorable, motivando y despertando en los niños un sentimiento de seguridad. Para ello, se han articulado las aportaciones, tanto teóricas como empíricas, desde planteamientos pedagógicos y psicológicos. El informe presenta el desarrollo de una nueva propuesta educativa, ya que se fusiona el diseño de los rincones de aprendizaje, la metodología basada en el trabajo por proyectos y el juego lúdico como técnicas de enseñanza-aprendizaje. Tomando al niño como eje central, así como sus necesidades, gustos, preferencias, características y nivel evolutivo. Como conclusión, se destaca el papel que juega el profesorado porque influye de manera significativa en la consecución de la motivación de los estudiantes

Funerary practices in megalithic tombs during the Argaric Bronze Age in South-Eastern Iberia: The cemetery of Los Eriales

The transition between the Copper Age and the Argaric Bronze Age in south-eastern Iberia has traditionally been understood in an evolutionary framework that would have involved the replacement of some cultural forms by others. The chronology of megalithic societies has changed this assumption, revealing that the continuity of ancestral funerary practices is also a key feature of the Bronze Age. In this context, the new radiocarbon series from Los Eriales discussed in this paper can be considered a key contribution. Three main aspects stand out according to their statistical analysis: i) Los Eriales should be considered the most recent Iberian megalithic cemetery, as ritual activity began in the last centuries of the third millennium cal BC; ii) funerary activity took place during short events of intensive ritual depositions spanning a few decades, mainly in the 21st and 18th centuries; and iii) Los Eriales cemetery was mainly used during the Argaric period, which means the coexistence of two very different funerary practices: collective megalithic rituals and individual intramural inhumations. The continuity of megalithic rituals can be explained in terms of resilience to the social fragmentation that characterised Argaric societies.FEDER programme–University of Granada (A-HUM-123-UGR18 and B-HUM-174-UGR20)Regional Government of Andalusia (P18-FR-4123)Spanish Ministry of Science and Innovation (PID2020-114282GB-I00)Universidad de Málaga / CBU

Funerary practices in megalithic tombs during the Argaric Bronze Age in South-Eastern Iberia: the cemetery of Los Eriales

The transition between the Copper Age and the Argaric Bronze Age in south-eastern Iberia has traditionally been understood in an evolutionary framework that would have involved the replacement of some cultural forms by others. The chronology of megalithic societies has changed this assumption, revealing that the continuity of ancestral funerary practices is also a key feature of the Bronze Age. In this context, the new radiocarbon series from Los Eriales discussed in this paper can be considered a key contribution. Three main aspects stand out according to their statistical analysis: i) Los Eriales should be considered the most recent Iberian megalithic cemetery, as ritual activity began in the last centuries of the third millennium cal BC; ii) funerary activity took place during short events of intensive ritual depositions spanning a few decades, mainly in the 21st and 18th centuries; and iii) Los Eriales cemetery was mainly used during the Argaric period, which means the coexistence of two very different funerary practices: collective megalithic rituals and individual intramural inhumations. The continuity of megalithic rituals can be explained in terms of resilience to the social fragmentation that characterised Argaric societies.Funding for open access charge: Universidad de Málaga / CBUA. This research was supported by the FEDER programme–University of Granada (A-HUM-123-UGR18 and B-HUM-174-UGR20), the Regional Government of Andalusia (P18-FR-4123), and the Spanish Ministry of Science and Innovation (PID2020-114282GB-I00)

Burial taphonomy and megalithic ritual practices in Iberia: the Panoría cemetery

Supplementary Information The online version contains supplemen- tary material available at https://doi.org/10.1007/s12520-023-01716-5.Our ability to build precise narratives regarding megalithic funerary rituals largely depends on an accurate understanding of bone assemblage formation. The cemetery of Panoría offers an excellent opportunity for exploring the ritual variability through the study of funerary taphonomy, as four of the nine recently excavated dolmens are remarkably well-preserved. Based on a multi-proxy approach that includes the contextual archaeological features, skeletal preservation and representation indexes, taphonomic processes, and radiocarbon chronology, three main ritual practices can be outlined: (i) primary sequential inhumations followed by the differential in situ decomposition of skeletal remains; (ii) the selective removal of crania and long bones; and (iii) the curation of subadult crania and probably long bones. The use-life of tombs, the intensity of mortuary depositions, and the intentional protection of specific bones appear as key aspects for understanding the variability in bone assemblage formation.Funding for open access publishing: Universidad de Granada/ CBUAEuropean Regional Development Fund FEDER–programme–University of Granada (A-HUM- 123-UGR18 and B-HUM-174-UGR20)Regional Government of Andalusia (P18-FR-4123)Spanish Ministry of Science and Innovation (PID2020-114282 GB-I00

Distribution and genotype-phenotype correlation of GDAP1 mutations in Spain

Mutations in the GDAP1 gene can cause Charcot-Marie-Tooth disease. These mutations are quite rare in most Western countries but not so in certain regions of Spain or other Mediterranean countries. This cross-sectional retrospective multicenter study analyzed the clinical and genetic characteristics of patients with GDAP1 mutations across Spain. 99 patients were identified, which were distributed across most of Spain, but especially in the Northwest and Mediterranean regions. The most common genotypes were p.R120W (in 81% of patients with autosomal dominant inheritance) and p.Q163X (in 73% of autosomal recessive patients). Patients with recessively inherited mutations had a more severe phenotype, and certain clinical features, like dysphonia or respiratory dysfunction, were exclusively detected in this group. Dominantly inherited mutations had prominent clinical variability regarding severity, including 29% of patients who were asymptomatic. There were minor clinical differences between patients harboring specific mutations but not when grouped according to localization or type of mutation. This is the largest clinical series to date of patients with GDAP1 mutations, and it contributes to define the genetic distribution and genotype-phenotype correlation in this rare form of CMT

Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases : multicentre study of 80 patients

Objectives To evaluate effectiveness and safety of certolizumab pegol (CZP) in uveitis due to immune-mediated inflammatory diseases (IMID). Methods Multicentre study of CZP-treated patients with IMID uveitis refractory to conventional immunosuppressant. Effectiveness was assessed through the following ocular parameters: best-corrected visual acuity, anterior chamber cells, vitritis, macular thickness and retinal vasculitis. These variables were compared between the baseline, and first week, first, third, sixth months, first and second year. Results We studied 80 (33 men/47 women) patients (111 affected eyes) with a mean age of 41.6±11.7 years. The IMID included were: spondyloarthritis (n=43), Behçet's disease (n=10), psoriatic arthritis (n=8), Crohn's disease (n=4), sarcoidosis (n=2), juvenile idiopathic arthritis (n=1), reactive arthritis (n=1), rheumatoid arthritis (n=1), relapsing polychondritis (n=1), Conclusions CZP seems to be effective and safe in uveitis related to different IMID, even in patients refractory to previous biological drugs

Incident type 2 diabetes attributable to suboptimal diet in 184 countries

The global burden of diet-attributable type 2 diabetes (T2D) is not well established. This risk assessment model estimated T2D incidence among adults attributable to direct and body weight-mediated effects of 11 dietary factors in 184 countries in 1990 and 2018. In 2018, suboptimal intake of these dietary factors was estimated to be attributable to 14.1 million (95% uncertainty interval (UI), 13.8–14.4 million) incident T2D cases, representing 70.3% (68.8–71.8%) of new cases globally. Largest T2D burdens were attributable to insufficient whole-grain intake (26.1% (25.0–27.1%)), excess refined rice and wheat intake (24.6% (22.3–27.2%)) and excess processed meat intake (20.3% (18.3–23.5%)). Across regions, highest proportional burdens were in central and eastern Europe and central Asia (85.6% (83.4–87.7%)) and Latin America and the Caribbean (81.8% (80.1–83.4%)); and lowest proportional burdens were in South Asia (55.4% (52.1–60.7%)). Proportions of diet-attributable T2D were generally larger in men than in women and were inversely correlated with age. Diet-attributable T2D was generally larger among urban versus rural residents and higher versus lower educated individuals, except in high-income countries, central and eastern Europe and central Asia, where burdens were larger in rural residents and in lower educated individuals. Compared with 1990, global diet-attributable T2D increased by 2.6 absolute percentage points (8.6 million more cases) in 2018, with variation in these trends by world region and dietary factor. These findings inform nutritional priorities and clinical and public health planning to improve dietary quality and reduce T2D globally.publishedVersio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality