Reports of the Workshops Held at the 2018 International AAAI Conference on Web and Social Media

The Workshop Program of the Association for the Advancement of Artificial Intelligence’s 12th International Conference on Web and Social Media (AAAI-18) was held at Stanford University, Stanford, California USA, on Monday, June 25, 2018. There were fourteen workshops in the program: Algorithmic Personalization and News: Risks and Opportunities; Beyond Online Data: Tackling Challenging Social Science Questions; Bridging the Gaps: Social Media, Use and Well-Being; Chatbot; Data-Driven Personas and Human-Driven Analytics: Automating Customer Insights in the Era of Social Media;  Designed Data for Bridging the Lab and the Field: Tools, Methods, and Challenges in Social Media Experiments; Emoji Understanding and Applications in Social Media; Event Analytics Using Social Media Data; Exploring Ethical Trade-Offs in Social Media Research; Making Sense of Online Data for Population Research; News and Public Opinion; Social Media and Health: A Focus on Methods for Linking Online and Offline Data; Social Web for Environmental and Ecological Monitoring and The ICWSM Science Slam. Workshops were held on the first day of the conference. Workshop participants met and discussed issues with a selected focus — providing an informal setting for active exchange among researchers, developers, and users on topics of current interest. Organizers from nine of the  workshops submitted reports, which are reproduced in this report. Brief summaries of the other five workshops have been reproduced from their website descriptions

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele