Brain levels of neuropeptide Y in experimental pneumococcal meningitis

Neuropeptide Y (NPY), which is found in high concentrations in several regions of the brain including nuclei of the brain stem and in nerve fibers surrounding cerebral vessels, has been proposed to play a role in regulating cerebral blood flow (CBF) and systemic vegetative functions. Since CBF is altered during meningitis, we examined whether NPY concentrations changed in various regions of the rabbit brain in response to experimental pneumococcal meningitis. Changes were most pronounced in the medulla, where NPY concentration increased threefold after 48 h of infection. Concomitantly, there was an increase in NPY immunoreactive fibers surrounding small vessels in the dorsolateral medulla, especially in the nucleus tractus solitarius. These results suggest that NPY may play a role in inducing some of the hemodynamic changes seen during pneumococcal meningitis

Inteligencia emocional para mejorar el pensamiento crítico

The objective of the research was to propose an emotional intelligence program to improve the critical thinking of second year high school science students of the Aida León de Rodríguez Lara Educational Unit, Guayaquil 2021. The research methodology was of applied type, with a quantitative approach; and non-experimental design of transactional scope, the sample was a census of 60 students, the technique employee for data collection was the survey and as an instrument a questionnaire was used for the two research variables, the instruments were validated according to expert judgment and then proceeded with the reliability test of Cronbach’s Alpha resulting for the independent variable a level of 0.092 and for the dependent variable 0.896 concluding that the instruments are truthful. The most significant conclusion is that students expose their thoughts as they conceive them without stopping to think about the consequences of their statements or those who may be harmed, causing problems in the interrelationship with the peers, they do not usually contribute with solutions to a problem due to lack of initiative. Finally, they do not know how to influence people to get out of any circumstance achieving things a favor.La investigación tuvo como objetivo plantear un programa de inteligencia emocional para mejorar el pensamiento crítico de los estudiantes de segundo año de bachillerato en ciencias de la Unidad Educativa Aida León Rodríguez Lara, Guayaquil 2021. La metodología de investigación fue de tipo aplicado, con un enfoque cuantitativo; y diseño no experimental de alcance transaccional, la muestra fue censal de 60 estudiantes, la técnica empleada para la recolección de datos fue la encuesta y como instrumento se utilizó un cuestionario para las dos variables de investigación, los instrumentos fueron validados según juicio de expertos y luego se procedió con la prueba de confiabilidad del Alfa Cronbach resultando para la variable independiente un nivel de 0,902 y para la variable dependiente 0,896 concluyéndose que los instrumentos son confiables. La conclusión más significativa es que los estudiantes exponen sus pensamientos tal cual los conciben sin detenerse a pensar acerca de las consecuencias de sus declaraciones ni a quienes pueden vulnerar originando problemas en la interrelación con sus compañeros, no suelen contribuir con soluciones frente a un problema debido a la falta de iniciativa, y, por último, no saben influir sobre las personas para lograr salir de cualquier circunstancia logrando cosas a favor

Análisis de la conservación de las casonas coloniales en el Centro Histórico de Lima - 2014 / Analysis of the conservation of the colonial mansionsin the Historic Center of Lima - 2014

ResumenObjetivo: El presente trabajo explora los efectos de la conservación de las casonas coloniales en el turismo cultural y tiene como objetivo determinar en qué medida la conservación afecta el desarrollo del turismo cultural en el Centro Histórico de Lima.Materiales y métodos:Se aplicó  el diseño Descriptivo comparativo, con un enfoque cuantitativo de cortetransversal. El estudio se centra en el Centro Histórico de Lima, los datos fueron recopilados de fuentes de instituciones y comparados con la realidad actual por medio de visitas y/o recorridos.Resultados:La distribución del total de los monumentos en el Centro Histórico de Lima por tipo de deterioro - 2014: Apunto de colapsar (83%) y Relativamente estable (17%). Distribución de los monumentos en el Centro Histórico de Lima por categoría - 2014: Solo casonas (76%) y Plazas, iglesias, hospicios y conventos (24%).  Distribución de alertas de atentados en Lima, por tipo de monumentos - 2014: Histórico (21%) y Arqueológico (79%). Flujo de alertas de atentados contra el patrimonio en Lima, por tipo de monumento - 2014: Enero: Histórico (5) y Arqueológico (16); Febrero: Histórico (2) y Arqueológico (12); Marzo: Histórico (5) y Arqueológico (12); Abril: Histórico (3) y Arqueológico (17); Mayo: Histórico (4) y Arqueológico (18). Casonas coloniales en el Centro Histórico de Lima que son integrados en city tours: Palacio de Torre Tagle, Casa Goyeneche, Casa de Pilatos, Casa Aliaga, Casa de las Trece Monedas, Casa de la Riva, Casa Oquendo o Palacio de Osambela, Casa de Riva Agüero, Quinta Heeren y la Casa del Oidor. Conclusiones: El Centro Histórico de Lima tiene mucha riqueza cultural dado en nuestro legado patrimonial como son nuestras casonas coloniales y debemos velar por su bienestar al paso del tiempo y lo que implique ello.Palabras claves: Patrimonio, Centro Histórico de Lima, casonas coloniales, conservación. AbstractObjective: This work explores the effects of the conservation of colonial mansions in cultural tourism and aims to determine to what extent conservation affects the development of cultural tourism in the historic center of Lima. Materials and methods:Applied design comparative descriptive, with a quantitative approach to cross-cutting. The study focuses on the Historic Center of Lima, data were collected from institutions and sources compared to the current situation through visits and / or tours. Results: The distribution of all the monuments in the historic center of Lima by type of impairment - 2014: About to collapse (83%) and relatively stable (17%). Distribution of landmarks in the Historic Center of Lima by category - 2014: Only houses (76%) and parking, churches, convents and hospices (24%). Distribution alerts of attacks in Lima, by type of monuments - 2014: Historical (21%) and Archaeological (79%). Flow alerts of attacks against property in Lima, by type of monument - 2014: January: Historical (5) and Archaeology (16); February: Historical (2) and Archaeology (12); March: History (5) and Archaeology (12); April: History (3) and Archaeological (17); May: Historical (4) and Archaeology (18). Colonial houses in the historic center of Lima which are integrated into city tours: Palace of Torre Tagle, Casa Goyeneche, House of Pilate, Casa Aliaga, House of Thirteen Coins, Riva House, House or Palace OsambelaOquendo, House Riva Agüero, and Quinta Heeren House Oidor. Conclusions: The Historic Center of Lima has given much to our rich cultural heritage legacy are like our colonial houses and we must ensure their well-being over time and what it involves.Keywords: Heritage, Historic Center of Lima, colonial mansions, conservation

Las relaciones interpersonales en el desempeño laboral docente

The general objective of this research was to design a program of strategies based on interpersonal relationships to optimize teacher work performance in the Juan Bautista Aguirre Educational Unit, Daule 2020 District. The quantitative approach was used, applied type, non-experimental, cross-sectional, descriptive design; For data collection, the survey and questionnaire with 24 questions applied to 72 teachers from the three ordinary days were used, then it was processed in Microsoft Excel and the SPSS version 26 program was used for the analysis. The data in the tables show that interpersonal relationships are not appropriate and this affects teacher job performance. The results related to the variable interpersonal relationships, teachers rated 78% poor, 19% fair and 3% good; It is appreciated that teachers do not relate easily and this contributes to the emergence of complications in the development of their work activities; Regarding the variable teacher job performance, 69% rate a poor level, 28% regular and 3% good, they consider that the job performance of teachers in the different pedagogical activities is not optimal.La presente investigación tuvo como objetivo general diseñar un programa de estrategias basadas en relaciones interpersonales para optimizar el desempeño laboral docente en la Unidad Educativa Juan Bautista Aguirre, Distrito Daule 2020. Se empleó el enfoque cuantitativo, tipo aplicada, diseño no experimental, transversal, descriptivo; para la recolección de los datos se utilizó la encuesta y el cuestionario con 24 interrogantes   aplicado a 72 docentes de las tres jornadas ordinarias, luego se procesaron en Microsoft Excel y para el análisis se empleó el programa SPSS versión 26. Los datos de las tablas evidencian que las relaciones interpersonales no son apropiadas y ello afecta el desempeño laboral docente. Los resultados relacionados a la variable relaciones interpersonales, los docentes calificaron el 78% deficiente, el 19% regular y el 3% bueno; se aprecia que los docentes no se relacionan fácilmente y ello contribuye al surgimiento de complicaciones en el desarrollo de sus actividades laborales; en torno a la variable desempeño laboral docente el 69% califica nivel deficiente, el 28% regular y el 3% bueno, consideran que el desempeño laboral de los docentes en las diferentes actividades pedagógicas no es óptimo

Estudio del efecto solvatocrómico en derivados fenólicos naturales

Se describen las características espectrofluorimétricas de dos derivados de quercetina aislados de las hojas deFlaveria bidentis, un derivado de 6-prenilpinocembrina, aislado de las raíces de Dalea elegans y un compuesto deestructura antraquinónica aislado de las hojas de Heterophyllaea pustulata. Todos ellos presentan espectros deabsorción con máximos en la región UV-visible acordes con los grupos cromóforos presentes en su estructura. Loscuatro compuestos estudiados presentan fluorescencia nativa. La posición de los máximos de emisión de fluorescenciase modifica en función del disolvente. Los desplazamientos producidos están relacionados con el diferente gradode solvatación de las moléculas en estado excitado según la polaridad del disolvente. La adición de ácidos mineralesprovoca desplazamientos en los máximos de fluorescencia concordantes con los ya descritos para compuestos deestructura similar. Estas modificaciones espectrales tienen un gran interés analítico desde el punto de vista de laidentificación y caracterización de productos naturales de estructura fenólica

A institucionalização da Medicina Legal no Brasil

The authors described the history of forensic medicine in Brazil, since its institution at the Bahia School of Medicine by Nina Rodriguez, to the contribution of Oscar Freire in bringing the scientific forensic work to Sao Paulo and to the University of Sao Paulo School of Medicine, where the subject became, in time, an independent discipline, by the hands of Dr. Freire’s disciple, Flaminio Fávero.Os autores traçam um panorama da chegada da Medicina Legal no Brasil, desde sua introdução, por intermédio de Nina Rodrigues na Faculdade de Medicina da Bahia, passando pela vinda de Oscar Freire a São Paulo e a consequente criação da disciplina junto à Faculdade de Medicina e Cirurgia de São Paulo, futura Faculdade de Medicina da Universidade de São Paulo, até a institucionalização da mesma, realizada por seu principal discípulo Flamínio Fávero

Local structure study of the orbital order/disorder transition in LaMnO3

We use a combination of neutron and X-ray total scattering measurements together with pair distribution function (PDF) analysis to characterise the variation in local structure across the orbital order--disorder transition in LaMnO$_3$. Our experimental data are inconsistent with a conventional order--disorder description of the transition, and reflect instead the existence of a discontinuous change in local structure between ordered and disordered states. Within the orbital-ordered regime, the neutron and X-ray PDFs are best described by a local structure model with the same local orbital arrangements as those observed in the average (long-range) crystal structure. We show that a variety of meaningfully-different local orbital arrangement models can give fits of comparable quality to the experimental PDFs collected within the disordered regime; nevertheless, our data show a subtle but consistent preference for the anisotropic Potts model proposed in \emph{Phys Rev.\ B} {\bf 79}, 174106 (2009). The key implications of this model are electronic and magnetic isotropy together with the loss of local inversion symmetry at the Mn site. We conclude with a critical assessment of the interpretation of PDF measurements when characterising local symmetry breaking in functional materials.Comment: 14 pages, 8 figures, 3 table

Impact of arterial load on the agreement between pulse pressure analysis and esophageal Doppler.

INTRODUCTION: The reliability of pulse pressure analysis to estimate cardiac output is known to be affected by arterial load changes. However, the contribution of each aspect of arterial load could be substantially different. In this study, we evaluated the agreement of eight non-commercial algorithms of pulse pressure analysis for estimating cardiac output (PPCO) with esophageal Doppler cardiac output (EDCO) during acute changes of arterial load. In addition, we aimed to determine the optimal arterial load parameter that could detect a clinically significant difference between PPCO and the EDCO. METHODS: We included mechanically ventilated patients monitored with a prototype esophageal Doppler (CardioQ-Combi™, Deltex Medical, Chichester, UK) and an indwelling arterial catheter who received a fluid challenge or in whom the vasoactive medication was introduced or modified. Initial calibration of PPCO was made with the baseline value of EDCO. We evaluated several aspects of arterial load: total systemic vascular resistance (TSVR=mean arterial pressure [MAP]/EDCO*80), net arterial compliance (C=EDCO-derived stroke volume/pulse pressure), and effective arterial elastance (Ea=0.9*systolic blood pressure/EDCO-derived stroke volume). We compared CO values with Bland-Altman analysis, four-quadrant plot and a modified polar plot (with least significant change analysis). RESULTS: A total of 16,964-paired measurements in 53 patients were performed (median 271; interquartile range: 180-415). Agreement of all PPCO algorithms with EDCO was significantly affected by changes in arterial load, although the impact was more pronounced during changes in vasopressor therapy. When looking at different parameters of arterial load, the predictive abilities of Ea and C were superior to TSVR and MAP changes to detect a PPCO-EDCO discrepancy≥10% in all PPCO algorithms. An absolute Ea change>8.9±1.7% was associated with a PPCO-EDCO discrepancy≥10% in most algorithms. CONCLUSIONS: Changes in arterial load profoundly affected the agreement of PPCO and EDCO, although the contribution of each aspect of arterial load to the PPCO-EDCO discrepancies was significantly different. Changes in Ea and C mainly determined PPCO-EDCO discrepancy

Implementación de un CircuitoTurístico Oscuro en Lima Metropolitana y sus efectos en las Motivaciones del Turista. Implementation of a Dark Tourist Circuit in Lima and its effects on, the Tourist Motivations.

ResumenObjetivo: La presente investigación tiene como objetivo la implementación de un circuito turístico oscuro para el fortalecimiento  de la motivación en Lima Metropolitana. Materiales y métodos: La investigación es aplicada de nivel experimental con un diseñoPre- experimental porque se medirá la motivación antes y después del circuito turístico oscuro.Se trabajó con una  muestra de 40 personas en la cualse midió la motivación del turista antes y después de haber recibido dicho circuito en Lima Metropolitana – Barrios Altos.La técnica a emplearse en la presente investigación será la encuesta por medio  de cuestionarios.Resultados:PLANIFICACIÓN: Participaríanenuninventariode selección delosatractivos (83.3%),Turismooscuro,modalidadde turismo desuagrado(73.3%),Planificación con anticipación la visita a dicho lugar (70,0%).EJECUCIÓN Y DESARROLLO: De acuerdo que el circuito dure entre 1 a 2 horas (70.7%), Los circuitos oscuros se están dando a conocer a la población de una forma adecuada (73.3%), Estarían dispuestos a realizar recorridos de circuitos turísticos con más frecuencia (73.3%).EFECTOS: Su motivación influye a la hora de escoger un circuito (76.7%), Visitas anteriormente a sitios relacionados con el turismo oscuro (63.3%), Siente fascinación por los lugares relacionados con el turismo oscuro (60.0%).NIVELES: Elegiría en su próxima visita el museo cementerio Presbítero Matías Maestro (63.3%), El nivel de motivación es alto o promedio por visitar sitios relacionados con el turismo oscuro (63.3%), Siente algún temor por realizar este tipo de circuito turístico oscuro (63.3%).Conclusiones:Existe una alta aceptación por el turismo oscuro a pesar de no difundirse masivamente. Palabras claves: Turismo oscuro, circuito turístico, Lima Metropolitana.AbstractObjective: This research aims at implementing a dark beaten path for the strengthening of motivation in Lima. Materials and Methods: The research is applied experimentally with a pre-experimental design because motivation is measured before and after dark beaten track. We worked with a sample of 40 people in the tourist motivation which was measured before and after receiving the circuit in Lima - Barrios Altos. The technique used in this research is the survey through questionnaires. Results: PLANNING: inventory participate in a selection of attractive (83.3%), dark tourism, tourism modality to your liking (73.3%), planning ahead the visit to that place (70.0%) EXECUTION AND DEVELOPMENT. : According to the circuit last between 1-2 hours (70.7%), Dark circuits are being released to the public in an appropriate manner (73.3%) will be willing to take tours of tourist circuits more often (73.3 .%) EFFECTS: His motivation influences when choosing a circuit (76.7%), visits to related previously dark tourism (63.3%) sites, a fascination for the dark places related to tourism (60.0%) levels. : I would choose on their next visit the cemetery museum Priest Matías Maestro (63.3%), motivation level is high or average per visit related to dark tourism (63.3%) sites, feel any fear for performing this type of tourist circuit dark ( 63.3%). Conclusions: There is a high acceptance by the dark tourism despite not spread widely.. Keywords:DarkTourism,touristcircuit,Lima