Incarcerated Mothers\u27 Communication While Separated

The separation and re-unification of the mother and child requires the attention of scholars. Re-establishing a relationship with his or her mother alleviates the threat of the consequences that a child experiences when his or her mother is incarcerated. Fifty three incarcerated mothers were interviewed on their communication with their children while separated. A content analysis was used to gain insight on the types of conflict, conflict strategies, conflict styles, and cause of conflict. Using an interpersonal skill deficiency model this study found that there was a difference between conflicts described as ending negatively and conflicts described as ending positively. During conflicts that ended negatively, incarcerated mothers used less strategies and conflict styles indicating a lack of constructive skills during times of frustration and anger. Relationships were also found between incarcerated mothers\u27 attitudes toward parenting and verbal aggressive messages, parenting style and incarcerated mothers\u27 attitudes toward parenting, and verbal aggressive messages and incarcerated mothers\u27 socio-communicative style. By giving incarcerated mothers competent and constructive skills to deal with conflict management, especially the conflict topic of incarceration, the mother-child relationship may be strengthene

An Eye-Tracking Investigation of Consumer’s Real-Time Behaviors in Professional Minor League Hockey

Minor league hockey provides a unique setting to investigate consumers’ marketingcontrolled activities in a natural environment. Consumers’ visual attention to sponsorship information has been shown to influence their explicit memory of sponsor brands and their purchase intentions. The current research builds on the sponsorship information processing framework of previous scholars by examining consumers’ real-time behaviors to sponsorship information in a natural setting. To analyze consumers’ behaviors at minor league hockey sporting events, qualitative and quantitative data were collected from 16 participants. The qualitative data related to the patterns and observations of consumers’ visual attention behaviors. The quantitative data measured consumers’ fixation duration, fixation frequency, explicit memory (i.e., recall and recognition), and sponsorship response. Through the utilization of a Structural Equation Model (SEM) analysis, the current study constructed a comprehensive understanding of consumers’ information search processes to sponsorship signage. Results indicated that consumers’ fixation frequency influences their ability to recall and recognize sponsorship information, resulting in a positive sponsorship response. The results of this study provide tangible evidence to sport and corporate marketers, indicating expected consumption outcomes based on consumers’ visual attention in a natural environment. The current study highlights sponsorship strategies for marketers to increase sponsors’ return on investment

Intercollegiate Athletics Marketing-Generated Revenue: Within Autonomy Football Bowl Subdivision

Intercollegiate athletic market-generating revenue (MGR) is of interest to administrators for increasing institution revenue. The driving factors of MGR (i.e., conference, facilities, and finances) need to be understood to allow target level planning for increasing MGR. Multiple linear regression was used to assess MGR on a sample of U.S. autonomy Football Bowl Subdivision institutions. Per capita attendance by designated marketing area, capacity, and contributions were shown to have a strong, quantifiable influence on MGR. By setting the levels of the facility and financial determinant variables, and adjusting for conference, the MGR may be predicted or targeted for institution revenue goals

Evaluation of Bleeding Disorders in Patients With Noonan Syndrome: A Systematic Review

Background: Noonan syndrome (NS) is an autosomal dominant genetic condition that has a number of clinical features, including bleeding diathesis and a number of hematological abnormalities including clotting factor deficiencies, von Willebrand disease and abnormal platelet count/function. Methods: We evaluated the frequency/types of bleeding disorders, and associated hematological laboratory findings, in patients with NS, using published data from 1965 to 2014. Results: Of 45 studies identified, 31 included data for 428 patients with NS. Of these patients, 43% had reported bleeding, 26% had no reported bleeding and no bleed data was reported for 31%. Most patients (90%) had bleeding-related laboratory test abnormalities, but only 194 (45%) had a confirmed diagnosis of a specific bleeding disorder. Abnormal laboratory tests included: prolonged prothrombin time, activated partial thromboplastin time, and other platelet-related disorders. Of the 194 patients with a confirmed diagnosis of a specific bleeding disorder, 153 (79%) had single clotting factor deficiencies, von Willebrand disease or platelet-related disorders, and 41 (21%) had multiple deficiencies including platelet-related disorders. Conclusion: As patients with NS can experience multiple bleeding disorders, including abnormal platelet function, clinical evaluations should be performed at diagnosis, after diagnosis, before any surgery is undertaken, and if patients become symptomatic

Implementacion de un modelo matemático para evaluar la calidad de agua del río Paraná de las Palmas

En la ciudad de Campana, el Río Paraná de Las Palmas es utilizado para el desarrollo de diferentes actividades recreativas, resultando una oferta turística de notable valor. El vuelco de efluentes de industrias de la zona y descargas de plantas de tratamiento de cloacales resulta un peligro para su calidad como aguas recreativas. El trabajo aborda: establecer el impacto de la carga de contaminantes debido a vuelco de efluentes y analizar la situación legal para aguas de recreación. Se utilizó un modelo matemático para evaluar el impacto de dichas descargas. El modelo indica que el impacto costero es bajo y solo medible cerca de cada punto de vuelco.In Campana city, Paraná de Las Palmas River is used for the development of different recreational activities, resulting in a notable tourist offer value. The shift of industrial effluents in the area and discharge of sewage treatment plants is a threat to recreational water quality. The paper addresses: to establish the impact of the pollution load due to overturning of effluent and analyze the legal situation for water recreation. We used a mathematical model to evaluate the impact of these discharges. The model indicates that the coastal impact is low and only measurable near each point of overturning.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Resistance from Afar: Distal Mutation V36M Allosterically Modulates the Active Site to Accentuate Drug Resistance in HCV NS3/4A Protease [preprint]

Hepatitis C virus rapidly evolves, conferring resistance to direct acting antivirals. While resistance via active site mutations in the viral NS3/4A protease has been well characterized, the mechanism for resistance of non-active site mutations is unclear. R155K and V36M often co-evolve and while R155K alters the electrostatic network at the binding site, V36M is more than 13 Angstrom away. In this study the mechanism by which V36M confers resistance, in the context of R155K, is elucidated with drug susceptibility assays, crystal structures, and molecular dynamics (MD) simulations for three protease inhibitors: telaprevir, boceprevir and danoprevir. The R155K and R155K/V36M crystal structures differ in the α-2 helix and E2 strand near the active site, with alternative conformations at M36 and side chains of active site residues D168 and R123, revealing an allosteric coupling, which persists dynamically in MD simulations, between the distal mutation and the active site. This allosteric modulation validates the network hypothesis and elucidates how distal mutations confer resistance through propagation of conformational changes to the active site

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral therapies cause severe side effects and are effective only for a subset of patients, though treatment outcomes have recently been improved by the combination therapy now including boceprevir and telaprevir, which inhibit the viral NS3/4A protease. Despite extensive efforts to develop more potent next-generation protease inhibitors, however, the long-term efficacy of this drug class is challenged by the rapid emergence of resistance. Single-site mutations at protease residues R155, A156 and D168 confer resistance to nearly all inhibitors in clinical development. Thus, developing the next-generation of drugs that retain activity against a broader spectrum of resistant viral variants requires a comprehensive understanding of the molecular basis of drug resistance. In this study, 16 high-resolution crystal structures of four representative protease inhibitors - telaprevir, danoprevir, vaniprevir and MK-5172 - in complex with the wild-type protease and three major drug-resistant variants R155K, A156T and D168A, reveal unique molecular underpinnings of resistance to each drug. The drugs exhibit differential susceptibilities to these protease variants in both enzymatic and antiviral assays. Telaprevir, danoprevir and vaniprevir interact directly with sites that confer resistance upon mutation, while MK-5172 interacts in a unique conformation with the catalytic triad. This novel mode of MK-5172 binding explains its retained potency against two multi-drug-resistant variants, R155K and D168A. These findings define the molecular basis of HCV N3/4A protease inhibitor resistance and provide potential strategies for designing robust therapies against this rapidly evolving virus

Accuracy assessment and screening of a dairy herd with paratuberculosis by three different ELISAs

Although the culture of Mycobacterium avium subsp. paratuberculosisis is the gold standard for the diagnosis of paratuberculosis, this bacterium is difficult to grow. In contrast, serological tests like ELISAs are inexpensive, rapid, and easy to perform. The aims of this study were to evaluate the accuracy of three different ELISAs: one with the commercial antigen PPA-3, another one with L5P (a recently described lipopentapeptide), and a third one with an in-house antigen whole cell lysates (WCL) of M. avium (MAA) strain D4ER (Study 1), and to compare them with other tests for paratuberculosis (PTB) diagnosis (Study 2). In Study 1, the sensitivities of the three ELISAs tested were 74.1%, 37% and 74.1%, respectively, whereas their specificities were 98.9%, 100% and 100%, respectively. In Study 2, we compared the three above-mentioned ELISAs with the intradermal reaction test using Avian PPD (PPDa) and fecal culture associated with Ziehl-Neelsen stain and PCR tests, in a dairy herd with 4.6% of cows with clinical signs of PTB. The results showed that fecal samples from 14 cows (16%) were culture-positive and that fecal samples from nine cows (10%) were PPDa-positive. Most of these animals (culture-positive and PPDa-positive) were detected as positive with any of the three ELISAs tested. Serological results showed that 31% of the animals were positive to ELISA-PPA-3, 17% to ELISA-L5P and 42.5% to ELISA-WCL. The combination of these three ELISAs identified 50.6% of the animals as positive in the infected herd. In particular, the results show that the locally developed ELISA seems to be useful for identifying many infected animals in a herd.Fil: Costanzo, Gabriel. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Alvarado Pinedo, María Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Centro de Diagnóstico e Investigaciones Veterinarias; ArgentinaFil: Mon, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Viale, Mariana Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Gil, Andres. Universidad de la Republica. Facultad de Veterinaria.; UruguayFil: Carrica Illia, Mariano. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Gioffré, Andrea Karina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Arese, Alicia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Travería, Gabriel Eduardo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Centro de Diagnóstico e Investigaciones Veterinarias; ArgentinaFil: Romano, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentin

Mythos (II): Mito e imagen en la antigüedad clásica y sus pervivencias

Mythos: mito e imagen en la antigüedad clásica y sus pervivencias (II)) es una Base de Datos cuyos primeros resultados se alojaron en el repositorio de Filología OdA. Con dicho proyecto iniciábamos una andadura con la que pretendemos renovar materiales didácticos tradicionales y poner dichos materiales al servicio de los estudiantes, que pudiera servir de apoyo a la docencia tanto presencial, como semipresencial o virtual