Товарна біржа як інфраструктурний елемент ринку природокористування

Науковий керівник: Стрішенець О.М

Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia

Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens. Functional polymorphisms exist in at least three genes that encode GSTs, including GSTM1, GSTT1, and GSTP1. We hypothesize, therefore, that polymorphisms in genes that encode GSTs alter susceptibility to chemotherapy-induced carcinogenesis, specifically to therapy-related acute myeloid leukemia (t-AML), a devastating complication of long-term cancer survival. Elucidation of genetic determinants may help to identify individuals at increased risk of developing t-AML. To this end, we have examined 89 cases of t-AML, 420 cases of de novo AML, and 1,022 controls for polymorphisms in GSTM1, GSTT1, and GSTP1. Gene deletion of GSTM1 or GSTT1 was not specifically associated with susceptibility to t-AML. Individuals with at least one GSTP1 codon 105 Val allele were significantly over-represented in t-AML cases compared with de novo AML cases [odds ratio (OR), 1.81; 95% confidence interval (CI), 1.11–2.94]. Moreover, relative to de novo AML, the GSTP1 codon 105 Val allele occurred more often among t-AML patients with prior exposure to chemotherapy (OR, 2.66; 95% CI, 1.39–5.09), particularly among those with prior exposure to known GSTP1 substrates (OR, 4.34; 95% CI, 1.43–13.20), and not among those t-AML patients with prior exposure to radiotherapy alone (OR,1.01; 95% CI, 0.50–2.07). These data suggest that inheritance of at least one Val allele at GSTP1 codon 105 confers a significantly increased risk of developing t-AML after cytotoxic chemotherapy, but not after radiotherapy

Complete asymptotic expansion of the integrated density of states of multidimensional almost-periodic pseudo-differential operators

We obtain a complete asymptotic expansion of the integrated density of states of operators of the form H =(-\Delta)^w +B in R^d. Here w >0, and B belongs to a wide class of almost-periodic self-adjoint pseudo-differential operators of order less than 2w. In particular, we obtain such an expansion for magnetic Schr\"odinger operators with either smooth periodic or generic almost-periodic coefficients.Comment: 47 pages. arXiv admin note: text overlap with arXiv:1004.293

Asymptotic expansion of the integrated density of states of a two-dimensional periodic Schrodinger operator

We prove the complete asymptotic expansion of the integrated density of states of a two-dimensional Schrodinger operator with a smooth periodic potentialComment: 46 pages, 4 figure

Особенности фолликулогенеза в щитовидой железе крыс в условиях влияния солей тяжелых металлов

Целью настоящей работы было исследование механизма фолликулогенеза в щитовидной железе в условиях влияния на организм комбинации солей тяжелых металлов. Исследование было проведено на 24 белых лабораторных крысах. Путем математического моделирования было установлено, что в стенке фолликула эллипсоидной формы большее напряжение возникает по продольному разрезу эллипса, а в поперечном разрезе напряжение уменьшается. Обращается внимание на существенную роль внутрифолликулярного коллоидного давления в процессах фолликулогенеза. В работе делается предположение о том, что разница между периферическим и центральным фолликулогенезом возникает вследствии разных значений внутрифолликулярного давления, что в свою очередь является производным от разной функциональной активности фолликулярного эпителия. Ключевые слова: щитовидная железа, фолликулогенез, коллоид, напряжение, внутрифолликулярное давление, математическое моделирование. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/20475The pecularities of folliculogenesis of thyroid gland under the influence of heavy metal salts The purpose of this study was to investigate the mechanism of folliculogenesis in the thyroid gland under the influence of combinations of heavy metals salts on the organism. The study was conducted on 24 white laboratory rats. Mathematical modelling shows that in the wall of the follicle ellipsoid greater tension arises from the longitudinal section of an ellipse and a cross-sectional voltage decreases. The paper attention to the important role of intraluminal colloidal pressure in the process of folliculogenesis. The paper makes the assumption that the difference between peripheral and central folliculogenesises arises as a result of the different of intraluminal pressure, which in turn is derived from different functional activity of the follicular epithelium. Key words: thyroid gland, folliculogenesis, colloid, voltage, intraluminal pressure, mathematical modeling. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/2047

Spontaneous Magnetization of the O(3) Ferromagnet at Low Temperatures

We investigate the low-temperature behavior of ferromagnets with a spontaneously broken symmetry O(3) $\to$ O(2). The analysis is performed within the perspective of nonrelativistic effective Lagrangians, where the dynamics of the system is formulated in terms of Goldstone bosons. Unlike in a Lorentz-invariant framework (chiral perturbation theory), where loop graphs are suppressed by two powers of momentum, loops involving ferromagnetic spin waves are suppressed by three momentum powers. The leading coefficients of the low-temperature expansion for the partition function are calculated up to order $p^{10}$. In agreement with Dyson's pioneering microscopic analysis of the cubic ferromagnet, we find that, in the spontaneous magnetization, the magnon-magnon interaction starts manifesting itself only at order $T^4$. The striking difference with respect to the low-temperature properties of the O(3) antiferromagnet is discussed from a unified point of view, relying on the effective Lagrangian technique.Comment: 23 pages, 4 figure

Исследование и оценка воздействия угольной шахты на окружающую среду

The paper deals with the causes of the ecological crisis on the ground as a result of industrial development around the world. The coal industry will inevitably have a negative effect on the environment, polluting and disrupting it. To solve this problem have been identified promising clean technology, environmental services and equipment.В работе рассматриваются причины возникновения на земле экологического кризиса как результат промышленного развития стран мира. Угольная промышленность неизбежно негативно влияет на окружающую среду, загрязняя и нарушая ее. Для решения данной задачи были определены перспективные экологически чистые технологии, экологические процессы и оборудования

Природное выщелачивание урана и механизм разрушения рудных тел и пород

Leaching of the metal begins after the filing of a working solution to the array and ends in a short time. The process of leaching in the microcracks is long, and the process of leaching in the mikropores is longer. An important parameters of leaching of uranium are: the area of actively surface cultivating of minerals, which means а destruction of ores and rocks.Выщелачивание металла начинается после подачи рабочего раствора в массив и заканчивается в короткие сроки. Длительным является процесс выщелачивания в микротрещинах, и более продолжительным - процесс выщелачивания в микропоровом пространстве. Важным параметром выщелачивания урана является площадь активной поверхности обрабатываемых минералов, что означает разрушение руд и пород

Nonhuman primates across sub-Saharan Africa are infected with the yaws bacterium Treponema pallidum subsp. pertenue

Dear Editor, The bacterium Treponema pallidum (TP) causes human syphilis (subsp. pallidum; TPA), bejel (subsp. endemicum; TEN), and yaws (subsp. pertenue; TPE) (1). Although syphilis has reached a worldwide distribution (2), bejel and yaws have remained endemic diseases. Bejel affects individuals in dry areas of Sahelian Africa and Saudi Arabia, whereas yaws affects those living in the humid tropics (1). Yaws is currently reported as endemic in 14 countries, and an additional 84 countries have a known history of yaws but lack recent epidemiological data (3,4). Although this disease was subject to global eradication efforts in the mid-20th century, it later reemerged in West Africa, Southern Asia, and the Pacific region (5). New large-scale treatment options triggered the ongoing second eradication campaign, the goal of which is to eradicate yaws globally by 2020 (5). References: (1) Giacani, L. & Lukehart, S.A. The endemic treponematoses. Clin. Microbiol. Rev. 27, 89–115 (2014). (2) Arora, N. et al. Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. Nat. Microbiol. 2, 16245 (2016). (3) Marks, M. Yaws: towards the WHO eradication target. Trans. R Soc. Trop. Med. Hyg. 110, 319–320 (2016). (4) World Health Organization. Eradication of yaws: procedures for verification and certification of interruption of transmission (World Health Organization, Geneva, 2018). (5) Asiedu, K., Fitzpatrick, C. & Jannin, J. Eradication of yaws: historical efforts and achieving WHO’s 2020 target. PLoS Negl. Trop. Dis. 8, e3016 (2014)

Biopsy-sectional course

Цей навчальний посібник рекомендований для студентів вищих медичних навчальних закладів IV рівня акредитації, які вивчають біопсійно-секційний курс англійською мовою.This study guide is intended for the students of medical higher educational institutions of IV accreditation level, who study biopsy-sectional course in English