Qualidade de Vida no Trabalho: Um estudo realizado em uma organização de coleta de resíduos não perigosos

Incluir o resumo em inglês. This article aims to elaborate a diagnosis of a not dangerous waste collection organization, that seeks to analyze which factors determine the quality of life of the employees of the organization. Nadler and Lawler (1983) affirm that Quality of Life at Work is a way of thinking about individuals, work and the company itself. This research is characterized as exploratory, descriptive and quantitative with the use of statistics and application of a questionnaire aiming to identify the Quality of Life at Work of this specific company. The questionnaire applied was created through the interpretation and analysis of the eight dimensions of QWL presented by Walton (1973). As for the population, an intentional sample was used, comprising the employees of the administrative sector. As for the analysis carried out from the graphs, it was verified that the organization provides a good quality of life to its employees, since just a small percentages of respondents did not agree in part or did not agree with some of the affirmative questions obtained.El artículo pretende elaborar un diagnóstico de una organización de recolección de residuos no peligrosos, donde se busca analizar cuáles son los factores determinantes de la calidad de vida en el trabajo para los colaboradores de la organización. Nadler y Lawler (1983) afirman que la calidad de vida en el trabajo es una manera de pensar en los individuos, en el trabajo y en la propia empresa. Esta investigación se caracteriza como exploratoria, descriptiva y cuantitativa, con el uso de estadística y aplicación de un cuestionario con el objetivo de identificar la Calidad de Vida en el trabajo de la empresa en cuestión. El cuestionario aplicado fue creado por medio de la interpretación y análisis de los ochos dimensiones de QVT presentados por Walton (1973). En cuanto a la población, se utilizó una muestra intencional que comprende a los funcionarios del sector administrativo. En cuanto a los análisis realizados a partir de los gráficos, se constató que la organización transmite a sus funcionarios una buena calidad de vida, pues se obtuvo un pequeño porcentaje de respondedores que no concordaban en parte, o no concordaban con algunas de las afirmativas indagadas.O artigo visa elaborar um diagnóstico de uma organização de coleta de resíduos não perigosos, onde se busca analisar quais os fatores determinantes da qualidade de vida no trabalho para os colaboradores da organização.  Nadler e Lawler (1983) afirmam que a Qualidade de Vida no Trabalho é uma maneira de pensar nos indivíduos, no trabalho e na própria empresa. Esta pesquisa caracteriza-se como exploratória, descritiva e quantitativa, com o uso de estatística e aplicação de um questionário objetivando identificar a Qualidade de Vida no Trabalho da empresa em questão. O questionário aplicado foi criado por meio da interpretação e análise das oitos dimensões de QVT apresentadas por Walton (1973). Quanto à população, utilizou-se uma amostra intencional compreendendo os funcionários do setor administrativo. Quanto às análises realizadas a partir dos gráficos, constatou-se que a organização transmite aos seus funcionários uma boa qualidade de vida, pois se obteve um pequeno percentual de respondentes que não concordavam em parte, ou não concordavam com algumas das afirmativas indagadas

Autophagy in Preeclampsia

Autophagy may be involved in gestation complicated by preeclampsia (PE) due to the presence of placental lesions caused by hypoxia at fetomaternal interphase. Autophagy is a lysosomal degradation pathway, removing protein aggregates and organelles damaged and thereby maintaining cell integrity. In preeclampsia, deficient myometrial penetration by extravillous cytotrophoblast occurs during the first trimester of pregnancy, leading to placental insufficiency. Several placental functions, like nutrient and oxygen input to the fetus during pregnancy, might benefit or even rely on autophagy and related material recycling within the cell. Deficiency in autophagy mechanism has been correlated to inflammatory responses. Autophagy is regulated during placentation and appears to be a possible factor in the development of preeclampsia. In this chapter, we intend to discuss evidence on autophagy pathway in pregnancy and the crosstalk between autophagy and inflammation in preeclampsia

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio

Analysis of fuels by photometry, portable NIRS and 1H NMR - a comparison with standard techniques

It has been recurring adulterations in fuels (such as gasoline, ethanol and diesel), being necessary the exploration of the use of more modern analytical techniques capable of controlling the quality of these fuels, since some regulated tests may be inefficient to detect the adulteration. Among them, it is highlighted proton nuclear magnetic resonance (1H NMR) spectroscopy, and portable near infrared spectroscopy (microNIR). In this work, it was studied the conformities of 115 samples of seized fuels (76 of gasoline, 23 of ethanol, and 16 of diesel) by means of standardized techniques with parameters established by the ANP. Results obtained were compared to photometer, MicroNIR and 1H NMR analyzes. The analyzes carried out by ANP showed four nonconforming samples (one of gasoline and three of ethanol). By the photometric technique, only 14 gasoline samples had ethanol content permitted by legislation (i.e ≈ 27 %v/v). By 1H NMR analysis, it was possible to verify nonconformities by presence of aromatics and olefins compounds in the gasoline and diesel samples as well as of methanol in fuel ethanol samples. It is also worth noting the efficiency of MicroNIR when combined with unsupervised chemometric methods to indicate nonconformities presented by 1H NMR and photometry techniques432CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES23038.007083/2014-40422555/2018-5; 422515/2016-7; 305359/2017-

IL-1β (A) and IL-18 (B) production by monocytes.

<p>Monocytes from pregnant women with preeclampsia (PE), normotensive pregnant women (NT) and non-pregnant women (NP), were cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Results are shown as median. *<i>P<0</i>.<i>05</i> shows significant difference between MSU^- groups; ⁺<i>P<0</i>.<i>05</i> shows significant difference between MSU⁺ groups; # <i>P<0</i>.<i>05 vs</i> MSU⁺.</p

Gene expression of NLRP1 (A), NLRP3 (B) and caspase-1 (C) by monocytes.

<p>Monocytes from pregnant women with preeclampsia (PE), normotensive pregnant women (NT) and non-pregnant women (NP), were cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Expression of caspase-1 (D) by monocytes from non-pregnant women treated with 50 μM or 200 μM of Glybenclamide and cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Results are shown as median. *<i>P<0</i>.<i>05</i> shows significant difference between MSU^- groups; ⁺<i>P<0</i>.<i>05</i> shows significant difference between MSU⁺ groups; # <i>P<0</i>.<i>05vs</i>MSU⁺; ^●<i>P<0</i>.<i>05</i>(MSU^-<i>vs</i>MSU^- + G200), (MSU50 <i>vs</i> MSU50+G200), (MSU100 <i>vs</i> MSU100+G200).</p

Gene expression of IL-1β (A) and IL-18 (B) by monocytes.

<p>Monocytes from pregnant women with preeclampsia (PE), normotensive pregnant women (NT) and non-pregnant women (NP), were cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Expression of IL-1 β (C) by monocytes from non-pregnant women treated with 50 μM and 200 μM of Glybenclamide, in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Results are shown as median.*<i>P<0</i>.<i>05</i> shows significant difference between MSU^- groups; ⁺<i>P<0</i>.<i>05</i> shows significant difference between MSU⁺ groups; # <i>P<0</i>.<i>05vs</i>MSU⁺; ^●<i>P<0</i>.<i>05</i> (MSU^-<i>vs</i>MSU^- + G200), (MSU50 <i>vs</i> MSU50+G200), (MSU100 <i>vs</i> MSU100+G200).</p

TNF-α production by monocytes.

<p>Monocytes from pregnant women with preeclampsia (PE), normotensive pregnant women (NT) and non-pregnant women (NP), were cultured in the presence (MSU⁺) or absence (MSU^-) of monosodium urate. Results are shown as median. *<i>P<0</i>.<i>05</i> shows significant difference between MSU^- groups; ⁺<i>P<0</i>.<i>05</i> shows significant difference between MSU⁺ groups; # <i>P<0</i>.<i>05 vs</i> MSU⁺.</p