Adjusting farm production in Cheshire County, N.H., to market demands, Bulletin, no. 217

The Bulletin is a publication of the New Hampshire Agricultural Experiment Station, College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire

The Emerging Epigenetic Landscape in Melanoma

Melanoma is the deadliest form of skin cancer. The disease is driven by molecular alterations in oncogenic signaling pathways, such as mitogen‐activated protein kinase (MAPK) and phosphatidylinositol 3‐kinase (PI3K). Activating mutations in oncogenes, such as BRAF and NRAS, and inactivating mutations in tumor suppressors genes, such as PTEN, promote this disease by altering cellular processes involved in growth, survival, and migration. Therapies targeting critical nodes in these pathways have demonstrated efficacy in clinical trials, but their therapeutic potential has been limited by the rapid onset of drug resistance. Durable therapeutic responses have also been observed in patients receiving immunotherapy. However, this activity appears to be confined to a subset of patients, and combinations with targeted therapies have raised safety concerns. Accumulating evidence strongly suggests that the pathogenesis of melanoma is also shaped by the aberrant activity of epigenetic factors that regulate gene expression through the modification of DNA and chromatin. This chapter provides a comprehensive review of the epigenetic alterations in melanoma and highlights the roles played by specific chromatin regulators during disease progression. We also discuss the clinical utility of both first and second generation epigenetic therapies in the melanoma setting, placing emphasis on the potential to overcome resistance to targeted therapies and to serve as priming agents for immunotherapies

Commercial apple industry of New Hampshire, Bulletin, no. 223

The Bulletin is a publication of the New Hampshire Agricultural Experiment Station, College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire

Steady Hall Magnetohydrodynamics Near a X-type Magnetic Neutral Line

Hall magnetohydrodynamics (MHD) properties near a two-dimensional (2D) X-type magnetic neutral line in the steady state are considered via heuristic and rigorous developments. Upon considering the steady-state as the asymptotic limit of the corresponding \textit{time-dependent} problem and using a rigorous development, Hall effects are shown to be able to sustain the hyperbolicity of the magnetic field (and hence a more open X-point configuration) near the neutral line in the steady state. The heuristic development misses this subtle connection of the steady state with the corresponding \textit{time-dependent} problem and predicts only an elongated current-sheet configuration (as in resistive MHD). However, the heuristic development turns out to be useful in providing insight into the lack of dependence of the reconnection rate on the mechanism breaking the frozen-in condition of the magnetic field lines. The latter result can be understood in terms of the ability of the ions and electrons to transport equal amounts of magnetic flux per unit time out of the reconnection region.Comment: 1-10 page

Analysis of auditory functions in grades one, two, and three.

Thesis (Ed.M.)--Boston Universit

Parametric Amplification of Nonlinear Response of Single Crystal Niobium

Giant enhancement of the nonlinear response of a single crystal Nb sample, placed in {\it a pumping ac magnetic field}, has been observed experimentally. The experimentally observed amplitude of the output signal is about three orders of magnitude higher than that seen without parametric pumping. The theoretical analysis based on the extended double well potential model provides a qualitative explanation of the experimental results as well as new predictions of two bifurcations for specific values of the pumping signal.Comment: 6 pages, 10 figure

Messages about dual contraception in areas of high HIV prevalence are not heeded

Background. Dual protection is recommended for prevention of unwanted pregnancies and protection against sexually transmitted infections, including HIV. It is critical for HIV-negative women to prevent seroconversion and HIV transmission to their infants during pregnancy and breastfeeding. Methods. Women were followed up after delivery, monthly for the first 9 months and then 3-monthly to 24 months, in a cohort study investigating postnatal HIV transmission. Study nurses discussed family planning, including condom use, at each visit. Contraceptive methods used since the last visit were recorded. All women knew their HIV status, and most women breastfed for a minimum of 6 months. Results. Among 1 137 HIV-positive and 1 220 HIV-negative women the most common contraceptive method was the hormonal injectable; few women used condoms alone or as dual contraception (0 - 3 months 6.8%; 7 - 12 months 16.3%; 19 - 24 months 14.4%). Compared with uninfected women, HIV-positive women were more likely to use condoms in years 1 and 2 after delivery (adjusted odds ratio (AOR) 1.72, 95% confidence interval (CI) 1.38 - 2.14,

Development of a lightweight cryogenic insulating system Final report, 30 Jun. 1964 - 31 May 1966

Lightweight external panel insulation systems for thermal protection of cryogenic launch vehicle propellant tank

Cohort Profile: Mamanengane or the Africa Centre Vertical Transmission Study

How did the study come about? From the mid-1990s, the success of antiretroviral prophylaxis to reduce HIV RNA viral load in plasma and avoidance of breastfeeding provided the real possibility that mother-to-child transmission (MTCT) of HIV-1 could be markedly reduced, 1 with an implicit understanding that these measures could be effectively applied to all HIV-infected women in developing countries. 2,3 The latter constitute the overwhelming majority of HIV-positive pregnancies resulting in approximately half a million new infant infections annually. 4 However, the inappropriate use of formula milks amongst impoverished populations resulted in major adverse effects; without the nutritiona