Influence of endocrine disrupting chemicals on adipogénesis

Indexación: Scopus; Scielo.A raíz del incremento a nivel mundial de la prevalencia de sobrepeso y obesidad tanto en adultos como en niños, con consecuencias en la salud pública, la obesidad se ha convertido en un blanco de estudio de diferentes grupos de investigación, lo que a su vez involucra el entendimiento del proceso de adipogénesis. El proceso de diferenciación de adipocitos es complejo e incluye varios pasos altamente regulados que inducen al fenotipo característico de adipocito maduro, proceso promovido por la activación de los reguladores maestros de las familias de PPARƳ y C/EBPs. La adipogénesis es afectada por diversos factores que incluyen el estado nutricional, mecanismos fisiológicos y también por factores ambientales. Por otra parte, se ha propuesto que diversos contaminantes ambientales, especialmente aquellos con actividades disruptivas endocrinas, están emergiendo como nuevos factores de riesgo para desarrollar obesidad. Químicos disruptores endocrinos son sustancias ambientales que presentan actividad biológica cuyo blanco es la alteración de la función del sistema endocrino, influyendo también en la regulación fisiológica del tejido adiposo. En la presente revisión se expondrán los diferentes disruptores endocrinos a los cuales se les ha comprobado experimentalmente que influyen en la regulación del proceso de adipogénesis.http://www.revistaavft.com/images/revistas/2018/avft_1_2018/influencia_disruptores_endocrinos.pd

FTO gene: Historic background and its relationship with chronic-degenerative diseases

Indexación: Scopus; Latindex.Alteraciones en el desarrollo de la atención y la organización conductual pueden configurar cuadros clínicos como el trastorno déficit de atención (TDA) que puede estar acompañado o no de hiperactividad (TDAH), este último parece tener una relación directa con otros diagnósticos de tipo endocrino como la obesidad. El objetivo del estudio es analizar la relación que existe entre el TDAH y la obesidad. Es por ello que se realiza una revisión sistemática de estudios científicos revelando relaciones y diferencias entre ambos trastornos desde una mirada fisiológica, cognoscitiva y comportamental. Se concluye que la relación entre el TDAH y la obesidad se da por factores genéticos, por variaciones dopaminérgicas, cambios en patrones de sueño, desajustes emocionales y por alteraciones en la regulación de la conducta; igualmente influyen factores sociales relacionados con el cuidado en el embarazo y la alimentación de las mujeres antes y durante la gestación.http://www.revhipertension.com/rlh_2_2018/5_fto_gene.pd

The Milky Way Bulge: Observed properties and a comparison to external galaxies

The Milky Way bulge offers a unique opportunity to investigate in detail the role that different processes such as dynamical instabilities, hierarchical merging, and dissipational collapse may have played in the history of the Galaxy formation and evolution based on its resolved stellar population properties. Large observation programmes and surveys of the bulge are providing for the first time a look into the global view of the Milky Way bulge that can be compared with the bulges of other galaxies, and be used as a template for detailed comparison with models. The Milky Way has been shown to have a box/peanut (B/P) bulge and recent evidence seems to suggest the presence of an additional spheroidal component. In this review we summarise the global chemical abundances, kinematics and structural properties that allow us to disentangle these multiple components and provide constraints to understand their origin. The investigation of both detailed and global properties of the bulge now provide us with the opportunity to characterise the bulge as observed in models, and to place the mixed component bulge scenario in the general context of external galaxies. When writing this review, we considered the perspectives of researchers working with the Milky Way and researchers working with external galaxies. It is an attempt to approach both communities for a fruitful exchange of ideas.Comment: Review article to appear in "Galactic Bulges", Editors: Laurikainen E., Peletier R., Gadotti D., Springer Publishing. 36 pages, 10 figure

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Prevalence of Frailty in European Emergency Departments (FEED): an international flash mob study

Introduction Current emergency care systems are not optimized to respond to multiple and complex problems associated with frailty. Services may require reconfiguration to effectively deliver comprehensive frailty care, yet its prevalence and variation are poorly understood. This study primarily determined the prevalence of frailty among older people attending emergency care. Methods This cross-sectional study used a flash mob approach to collect observational European emergency care data over a 24-h period (04 July 2023). Sites were identified through the European Task Force for Geriatric Emergency Medicine collaboration and social media. Data were collected for all individuals aged 65 + who attended emergency care, and for all adults aged 18 + at a subset of sites. Variables included demographics, Clinical Frailty Scale (CFS), vital signs, and disposition. European and national frailty prevalence was determined with proportions with each CFS level and with dichotomized CFS 5 + (mild or more severe frailty). Results Sixty-two sites in fourteen European countries recruited five thousand seven hundred eighty-five individuals. 40% of 3479 older people had at least mild frailty, with countries ranging from 26 to 51%. They had median age 77 (IQR, 13) years and 53% were female. Across 22 sites observing all adult attenders, older people living with frailty comprised 14%. Conclusion 40% of older people using European emergency care had CFS 5 + . Frailty prevalence varied widely among European care systems. These differences likely reflected entrance selection and provide windows of opportunity for system configuration and workforce planning

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease

Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database

The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013

Euclid: The Early Release Observations Lens Search Experiment

International audienceWe investigate the ability of the Euclid telescope to detect galaxy-scale gravitational lenses. To do so, we perform a systematic visual inspection of the $0.7\,\rm{deg}^2$ Euclid ERO data towards the Perseus cluster using both the high-resolution VIS $I_{\scriptscriptstyle\rm E}$ band, and the lower resolution NISP bands. We inspect every extended source brighter than magnitude $23$ in $I_{\scriptscriptstyle\rm E}$ with $41$ expert human classifiers. This amounts to $12\,086$ stamps of $10^{\prime\prime}\,\times\,10^{\prime\prime}$. We find $3$ grade A and $13$ grade B candidates. We assess the validity of these $16$ candidates by modelling them and checking that they are consistent with a single source lensed by a plausible mass distribution. Five of the candidates pass this check, five others are rejected by the modelling and six are inconclusive. Extrapolating from the five successfully modelled candidates, we infer that the full $14\,000\,{\rm deg}^2$ of the Euclid Wide Survey should contain $100\,000^{+70\,000}_{-30\,000}$ galaxy-galaxy lenses that are both discoverable through visual inspection and have valid lens models. This is consistent with theoretical forecasts of $170\,000$ discoverable galaxy-galaxy lenses in Euclid. Our five modelled lenses have Einstein radii in the range 0.\!\!^{\prime\prime}68\,<\,\theta_\mathrm{E}\,<1.\!\!^{\prime\prime}24, but their Einstein radius distribution is on the higher side when compared to theoretical forecasts. This suggests that our methodology is likely missing small Einstein radius systems. Whilst it is implausible to visually inspect the full Euclid data set, our results corroborate the promise that Euclid will ultimately deliver a sample of around $10^5$ galaxy-scale lenses

Euclid: The Early Release Observations Lens Search Experiment

International audienceWe investigate the ability of the Euclid telescope to detect galaxy-scale gravitational lenses. To do so, we perform a systematic visual inspection of the $0.7\,\rm{deg}^2$ Euclid ERO data towards the Perseus cluster using both the high-resolution VIS $I_{\scriptscriptstyle\rm E}$ band, and the lower resolution NISP bands. We inspect every extended source brighter than magnitude $23$ in $I_{\scriptscriptstyle\rm E}$ with $41$ expert human classifiers. This amounts to $12\,086$ stamps of $10^{\prime\prime}\,\times\,10^{\prime\prime}$. We find $3$ grade A and $13$ grade B candidates. We assess the validity of these $16$ candidates by modelling them and checking that they are consistent with a single source lensed by a plausible mass distribution. Five of the candidates pass this check, five others are rejected by the modelling and six are inconclusive. Extrapolating from the five successfully modelled candidates, we infer that the full $14\,000\,{\rm deg}^2$ of the Euclid Wide Survey should contain $100\,000^{+70\,000}_{-30\,000}$ galaxy-galaxy lenses that are both discoverable through visual inspection and have valid lens models. This is consistent with theoretical forecasts of $170\,000$ discoverable galaxy-galaxy lenses in Euclid. Our five modelled lenses have Einstein radii in the range 0.\!\!^{\prime\prime}68\,<\,\theta_\mathrm{E}\,<1.\!\!^{\prime\prime}24, but their Einstein radius distribution is on the higher side when compared to theoretical forecasts. This suggests that our methodology is likely missing small Einstein radius systems. Whilst it is implausible to visually inspect the full Euclid data set, our results corroborate the promise that Euclid will ultimately deliver a sample of around $10^5$ galaxy-scale lenses